Full Text Journal Articles by
Author Chenyu Huang

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Asporin inhibits collagen matrix-mediated intercellular mechanocommunications between fibroblasts during keloid progression.

Longwei Liu, Hongsheng Yu, Yi Long, Zhifeng You, Rei Ogawa, Yanan Du, Chenyu Huang,

Keloids are fibrotic lesions that grow unceasingly and invasively and are driven by local mechanical stimuli. Unlike other fibrotic diseases and normal wound healing, keloids exhibit little transformation of dermal fibroblasts into α-SMA<sup>+</sup> myofibroblasts. This study showed that asporin is the most strongly expressed gene in keloids and its gene-ontology ... Read more >>

FASEB J (FASEB journal : official publication of the Federation of American Societies for Experimental Biology)
[2021, 35(7):e21705]

Cited: 0 times

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The Combined Application of Augmented Reality and Guide Template Technology in the Treatment of Nasal Deformities.

Chenyu Huang, Wei Zeng, Juntian Chen, Chang Liu, Yutao Xiong, Dan Luo, Wei Tang,

<h4>Objective</h4>The purpose of this study is to propose a surgical plan based on augmented reality (AR) and guide template technology for restoration of nasal deformities, and evaluate its feasibility and clinical efficacy.<h4>Methods</h4>Patients were scanned with a FaceScan to obtain the three-dimensional (3D) facial model, and computed tomography was also performed ... Read more >>

J Craniofac Surg (The Journal of craniofacial surgery)
[2021, :]

Cited: 0 times

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Prescribed performance incremental adaptive optimal fault-tolerant control for nonlinear systems with actuator faults.

Shaojie Zhang, Chenyu Huang, Kun Ji, Han Zhang,

In this paper, a model-free incremental adaptive optimal fault-tolerant controller with prescribed performance is proposed for nonlinear systems subject to actuator faults. Considering the system actuator redundancy, an actuator grouping scheme is introduced according to the actuator functions. An incremental adaptive fault observer is designed to estimate the faults. The ... Read more >>

ISA Trans (ISA transactions)
[2021, :]

Cited: 0 times

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The application of 3D printing technology in the classification and preoperative planning of complex tibial plateau fractures

Fuyang Chen, Chenyu Huang, Chen Ling, Jinming Zhou, Yufeng Wang, Po Zhang, Xiao Jiang, Xiaoming Xu, Jian Jian, Liming Wang, Qingqiang Yao,

<h4>Background: </h4> Tibial plateau fracture is one of the common intra-articular fractures in clinic. And its accurate classification and treatment is a difficult problem for orthopedic surgeons. Our research aims to investigate the application value of 3D printing in the classification and preoperative planning of complex tibial plateau fractures. <h4>Methods: ... Read more >>

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Plastic Surgery Fellowship at Nippon Medical School Hospital: An Integrative Approach to Modern Plastic Surgery Education.

Mohamed Abdelhakim, Carolina Soto Diez, Chenyu Huang, Ioannis Goutos, Dennis P Orgill, Rei Ogawa,

Plastic surgery requires extensive wide-ranging surgical knowledge, special technical dexterity, and personal skills in order to achieve improved quality of life and satisfying outcomes for patients. For decades, international plastic surgery fellowship programs have offered opportunities to enhance the subspecialty training of young plastic surgeons abroad and promote international exchange ... Read more >>

Plast Reconstr Surg Glob Open (Plastic and reconstructive surgery. Global open)
[2021, 9(1):e3367]

Cited: 1 time

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The use of 3D printing pelvis and hip in a complex THA: clinical experience and reports of literature

Chenyu Huang, Qingqiang Yao, Wei Liu, Yan Xu, Cheng Tang, Bo Wei, Jiayi Li, Liming Wang,

<h4>Background: </h4> Total hip arthroplasty(THA) is a good solution of developmental dysplasia of the hip(DDH). However, patients diagnosed with Crowe type IV are difficult to deal with. With traditional operation skills, the operation time is quite long and the patients will lose a lot of blood. Case presentation : We ... Read more >>

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Systemic factors that shape cutaneous pathological scarring.

Chenyu Huang, Rei Ogawa,

Cutaneous pathological scars are fibrotic lesions that grow continuously, invade the adjacent skin, and are erythematous, itchy, and painful. Their etiology remains unclear but may involve genetic, local mechanical, and systemic factors. Here, we will summarize the main systemic factors that shape cutaneous pathological scarring, especially keloid formation and aggravation. ... Read more >>

FASEB J (FASEB journal : official publication of the Federation of American Societies for Experimental Biology)
[2020, 34(10):13171-13184]

Cited: 2 times

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Neuron-derived exosomes-transmitted miR-124-3p protect traumatically injured spinal cord by suppressing the activation of neurotoxic microglia and astrocytes.

Dongdong Jiang, Fangyi Gong, Xuhui Ge, Chengtang Lv, Chenyu Huang, Shuang Feng, Zheng Zhou, Yuluo Rong, Jiaxing Wang, Chengyue Ji, Jian Chen, Wene Zhao, Jin Fan, Wei Liu, Weihua Cai,

<h4>Background</h4>Spinal cord injury (SCI) is a catastrophic injury that can cause irreversible motor dysfunction with high disability. Exosomes participate in the transport of miRNAs and play an essential role in intercellular communication via transfer of genetic material. However, the miRNAs in exosomes which derived from neurons, and the underlying mechanisms ... Read more >>

J Nanobiotechnology (Journal of nanobiotechnology)
[2020, 18(1):105]

Cited: 4 times

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TGase-Enhanced Microtissue Assembly in 3D-Printed-Template-Scaffold (3D-MAPS) for Large Tissue Defect Reparation.

Hongsheng Yu, Zhifeng You, Xiaojun Yan, Wei Liu, Zhirui Nan, Dan Xing, Chenyu Huang, Yanan Du,

Engineering large and functional tissue constructs with complex structures (e.g., external ear or nose) for reparation and reconstruction of tissue defects remains one of the major challenges in regenerative medicine, which demands abundant cell sources, advanced biofabrication schemes, and satisfactory integration with the host for long-term efficacy post implantation. Here ... Read more >>

Adv Healthc Mater (Advanced healthcare materials)
[2020, 9(18):e2000531]

Cited: 0 times

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The Vascular Involvement in Soft Tissue Fibrosis-Lessons Learned from Pathological Scarring.

Chenyu Huang, Rei Ogawa,

Soft tissue fibrosis in important organs such as the heart, liver, lung, and kidney is a serious pathological process that is characterized by excessive connective tissue deposition. It is the result of chronic but progressive accumulation of fibroblasts and their production of extracellular matrix components such as collagens. Research on ... Read more >>

Int J Mol Sci (International journal of molecular sciences)
[2020, 21(7):]

Cited: 2 times

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Manipulating spin polarization of titanium dioxide for efficient photocatalysis.

Lun Pan, Minhua Ai, Chenyu Huang, Li Yin, Xiang Liu, Rongrong Zhang, Songbo Wang, Zheng Jiang, Xiangwen Zhang, Ji-Jun Zou, Wenbo Mi,

Photocatalysis has been regarded as a promising strategy for hydrogen production and high-value-added chemicals synthesis, in which the activity of photocatalyst depends significantly on their electronic structures, however the effect of electron spin polarization has been rarely considered. Here we report a controllable method to manipulate its electron spin polarization ... Read more >>

Nat Commun (Nature communications)
[2020, 11(1):418]

Cited: 2 times

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Augmented Reality Technology Could Be an Alternative Method to Treat Craniomaxillofacial Foreign Bodies: A Comparative Study Between Augmented Reality Technology and Navigation Technology.

Jie Yao, Wei Zeng, Shanluo Zhou, Jie Cheng, Chenyu Huang, Wei Tang,

<h4>Purpose</h4>Removal of foreign bodies in the craniomaxillofacial region can be challenging. The purpose of the present study was to explore the feasibility of using augmented reality (AR) technology to remove craniomaxillofacial foreign bodies.<h4>Patients and methods</h4>A prospective study of patients with granular metal foreign bodies retained in the craniomaxillofacial region from ... Read more >>

J Oral Maxillofac Surg (Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons)
[2020, 78(4):578-587]

Cited: 0 times

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Managing keloid scars: From radiation therapy to actual and potential drug deliveries.

Chenyu Huang, Longwei Liu, Zhifeng You, Yanan Du, Rei Ogawa,

The aetiology of keloids is becoming clearer, but many questions remain, including about the most optimal treatment. Current therapies include surgical excision, radiotherapy, and various pharmaceutical drugs. However, none of these drugs are keloid-specific. Moreover, all current interventions are associated with high recurrence rates. Here, we review the pharmaceutical interventions ... Read more >>

Int Wound J (International wound journal)
[2019, 16(3):852-859]

Cited: 6 times

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A Net Mold-based Method of Scaffold-free Three-Dimensional Cardiac Tissue Creation.

Yang Bai, Enoch Yeung, Cecillia Lui, Chin Siang Ong, Isaree Pitaktong, Chenyu Huang, Takahiro Inoue, Hiroshi Matsushita, Chunye Ma, Narutoshi Hibino,

This protocol describes a novel and easy net mold-based method to create three-dimensional (3-D) cardiac tissues without additional scaffold material. Human-induced pluripotent stem-cell-derived cardiomyocytes (iPSC-CMs), human cardiac fibroblasts (HCFs), and human umbilical vein endothelial cells (HUVECs) are isolated and used to generate a cell suspension with 70% iPSC-CMs, 15% HCFs, ... Read more >>

J Vis Exp (Journal of visualized experiments : JoVE)
[2018, (138):]

Cited: 1 time

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Physical Properties of Implanted Porous Bioscaffolds Regulate Skin Repair: Focusing on Mechanical and Structural Features.

Shumeng Jiang, Sabrina Cloud Li, Chenyu Huang, Barbara Pui Chan, Yanan Du,

Porous bioscaffolds are applied to facilitate skin repair since the early 1990s, but a perfect regeneration outcome has yet to be achieved. Until now, most efforts have focused on modulating the chemical properties of bioscaffolds, while physical properties are traditionally overlooked. Recent advances in mechanobiology and mechanotherapy have highlighted the ... Read more >>

Adv Healthc Mater (Advanced healthcare materials)
[2018, 7(6):e1700894]

Cited: 2 times

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Investigations of Cartilage Matrix Degeneration in Patients with Early-Stage Femoral Head Necrosis.

Ronghua Xu, Bo Wei, Jiayi Li, Chenyu Huang, Rongcai Lin, Cheng Tang, Yan Xu, Qingqiang Yao, Liming Wang,

BACKGROUND The purpose of this study was to explore changes in cartilage matrix in early-stage femoral head necrosis (FHN). MATERIAL AND METHODS Femoral head samples of patients with early FHN were collected during total hip arthroplasty (THA), high-field 7.0T MRI scans were performed in vitro, and the average T2 values ... Read more >>

Med Sci Monit (Medical science monitor : international medical journal of experimental and clinical research)
[2017, 23:5783-5792]

Cited: 1 time

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Mechanotransduction-modulated fibrotic microniches reveal the contribution of angiogenesis in liver fibrosis.

Longwei Liu, Zhifeng You, Hongsheng Yu, Lyu Zhou, Hui Zhao, Xiaojun Yan, Dulei Li, Bingjie Wang, Lu Zhu, Yuzhou Xu, Tie Xia, Yan Shi, Chenyu Huang, Wei Hou, Yanan Du,

The role of pathological angiogenesis on liver fibrogenesis is still unknown. Here, we developed fibrotic microniches (FμNs) that recapitulate the interaction of liver sinusoid endothelial cells (LSECs) and hepatic stellate cells (HSCs). We investigated how the mechanical properties of their substrates affect the formation of capillary-like structures and how they ... Read more >>

Nat Mater (Nature materials)
[2017, 16(12):1252-1261]

Cited: 25 times

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Mechanically and Electrically Enhanced CNT-Collagen Hydrogels As Potential Scaffolds for Engineered Cardiac Constructs.

Hongsheng Yu, Hui Zhao, Chenyu Huang, Yanan Du,

With the development of biomimetic scaffolds for engineered cardiac constructs, a considerable number of biomaterials has been evaluated. However, in most previously reported cardiac constructs, the function of the cardiomyocytes (CMs) is restricted because of mismatches in the mechanics, conductivity, and submicrometer structure of the matrix. In this work, type ... Read more >>

ACS Biomater Sci Eng (ACS biomaterials science & engineering)
[2017, 3(11):3017-3021]

Cited: 4 times

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Pathology-targeted cell delivery via injectable micro-scaffold capsule mediated by endogenous TGase.

Chunxiao Qi, Yaqian Li, Patrick Badger, Hongsheng Yu, Zhifeng You, Xiaojun Yan, Wei Liu, Yan Shi, Tie Xia, Jiahong Dong, Chenyu Huang, Yanan Du,

Targeted cell delivery to lesion sites via minimally invasive approach remains an unmet need in regenerative medicine to endow satisfactory therapeutic efficacy and minimized side-effects. Here, we rationally designed a pathology-targeted cell delivery strategy leveraging injectable micro-scaffolds as cell-loading capsule and endogenous tissue transglutaminase (TGase) at lesion site as adhesive. ... Read more >>

Biomaterials (Biomaterials)
[2017, 126:1-9]

Cited: 3 times

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Keloid progression: a stiffness gap hypothesis.

Chenyu Huang, Longwei Liu, Zhifeng You, Bingjie Wang, Yanan Du, Rei Ogawa,

Keloids are fibroproliferative skin disorders characterised clinically by continuous horizontal progression and post-surgical recurrence and histologically by the accumulation of collagen and fibroblast ingredients. Till now, their aetiology remains clear, which may cover genetic, environmental and metabolic factors. Evidence in the involvement of local mechanics (e.g. predilection site and typical ... Read more >>

Int Wound J (International wound journal)
[2017, 14(5):764-771]

Cited: 8 times

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Regeneration of hair and other skin appendages: A microenvironment-centric view.

Chenyu Huang, Yanan Du, Christoph S Nabzdyk, Rei Ogawa, Taro Koyama, Dennis P Orgill, Xiaobing Fu,

Advances in skin regeneration have resulted in techniques and products that have allowed regeneration of both the dermis and epidermis. Yet complete skin regeneration requires the adnexal skin structures. Thus it is crucial to understand the regenerative potential of hair follicles where genetic, nutritional, and hormonal influences have important effects ... Read more >>

Wound Repair Regen (Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society)
[2016, 24(5):759-766]

Cited: 5 times

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A new strategy for total auricular reconstruction using prelamination of an extended retroauricular flap with tissue expansion.

Chuan Li, Haiyue Jiang, Chenyu Huang, Jingning Chen, Rongwei Wu, Ye Bi, Meirong Yang, Ye Zhang, Bo Pan,

<h4>Background and aim</h4>To accomplish total ear reconstruction with aesthetic appearance is a great challenge for plastic surgeons worldwide due to insufficient skin coverage. A retroauricular fascial flap and skin graft technique are commonly used, but the results obtained are not satisfactory due to color mismatch, severe edema, and donor-site morbidity. ... Read more >>

J Plast Reconstr Aesthet Surg (Journal of plastic, reconstructive & aesthetic surgery : JPRAS)
[2016, 69(6):819-826]

Cited: 3 times

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Engineering EMT using 3D micro-scaffold to promote hepatic functions for drug hepatotoxicity evaluation.

Jingyu Wang, Fengling Chen, Longwei Liu, Chunxiao Qi, Bingjie Wang, Xiaojun Yan, Chenyu Huang, Wei Hou, Michael Q Zhang, Yang Chen, Yanan Du,

Accompanied by decreased hepatic functions, epithelial-mesenchymal transition (EMT) was observed in two dimensional (2D) cultured hepatocytes with elongated morphology, loss of polarity and weakened cell-cell interaction, while upgrading to 3D culture has been considered as significant improvement of its 2D counterpart for hepatocyte maintenance. Here we hypothesize that 3D culture ... Read more >>

Biomaterials (Biomaterials)
[2016, 91:11-22]

Cited: 18 times

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Substrate stiffness orchestrates epithelial cellular heterogeneity with controlled proliferative pattern via E-cadherin/β-catenin mechanotransduction.

Bingjie Wang, Peng Qin, Hui Zhao, Tie Xia, Jingyu Wang, Longwei Liu, Lu Zhu, Jing Xu, Chenyu Huang, Yan Shi, Yanan Du,

<h4>Unlabelled</h4>Epithelial cellular heterogeneity has been observed in pathological tissues with abnormal matrix stiffness and cells cultured on rigid substrates. However, it remains unclear how matrix stiffness influences cellular heterogeneity formation in multi-cellular population. Here, we demonstrated that cellular heterogeneity regulated by substrate stiffness is evident starting from the initial single-cell ... Read more >>

Acta Biomater (Acta biomaterialia)
[2016, 41:169-180]

Cited: 9 times

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PKCδ inhibition normalizes the wound-healing capacity of diabetic human fibroblasts.

Mogher Khamaisi, Sayaka Katagiri, Hillary Keenan, Kyoungmin Park, Yasutaka Maeda, Qian Li, Weier Qi, Thomas Thomou, Danielle Eschuk, Ana Tellechea, Aris Veves, Chenyu Huang, Dennis Paul Orgill, Amy Wagers, George L King,

Abnormal fibroblast function underlies poor wound healing in patients with diabetes; however, the mechanisms that impair wound healing are poorly defined. Here, we evaluated fibroblasts from individuals who had type 1 diabetes (T1D) for 50 years or more (Medalists, n = 26) and from age-matched controls (n = 7). Compared ... Read more >>

J Clin Invest (The Journal of clinical investigation)
[2016, 126(3):837-853]

Cited: 22 times

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