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Integrative serum metabolomic analysis for preventive effects of Yaobitong capsule in adjuvant-induced rheumatoid arthritis rat based on RP/HILIC-UHPLC-Q-TOF MS.

Wei Shi, Yajie Deng, Chenyang Zhao, Wei Xiao, Zhenzhong Wang, Zhili Xiong, Longshan Zhao,

Yaobitong capsule (YBTC) has been used for the prevention and treatment of inflammation-related lumbago and leg pain. However, its intervention mechanism still remains unclear. This study was aimed to evaluate the control efficiency of YBTC on adjuvant-induced rheumatoid arthritis (RA) rats by metabonomic method and to explore its possible anti-arthritis ... Read more >>

Anal Biochem (Analytical biochemistry)
[2021, 637:114474]

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Engineering of Annealing and Surface Passivation toward Efficient and Stable Quasi-2D Perovskite Light-Emitting Diodes.

Yunxing Fu, Dezhong Zhang, Hongmei Zhan, Chenyang Zhao, Yanxiang Cheng, Chuanjiang Qin, Lixiang Wang,

Solution-processed quasi-two-dimensional (quasi-2D) perovskites with self-assembled multiple quantum well (QW) structures exhibit enhanced exciton binding energy, which is ideal for use as light emitters. Here, we have found that postannealing is important to promoting the QWs' composition transfer, and we explored the correlation among the annealing time, the external quantum ... Read more >>

J Phys Chem Lett (The journal of physical chemistry letters)
[2021, :11645-11651]

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Bclaf1 regulates c-FLIP expression and protects cells from TNF-induced apoptosis and tissue injury.

Rui Zhang, Teng Xue, Anwen Shao, Yue Lang, Chao Qin, Mingliang Zhao, Yu Kuang, Zhengquan Yu, Yunyun Geng, Chenyang Zhao, Jun Tang,

TNF stimulation generates pro-survival signals through activation of NF-κB that restrict the build-in death signaling triggered by TNF. The competition between TNF-induced survival and death signals ultimately determines the fate of a cell. Here, we report the identification of Bclaf1 as a novel component of the anti-apoptotic program of TNF. ... Read more >>

EMBO Rep (EMBO reports)
[2021, :e52702]

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A Dynamic and Self-Adapting Interface Coating for Stable Zn-Metal Anodes.

Zhikun Guo, Lishuang Fan, Chenyang Zhao, Aosai Chen, Nannan Liu, Yu Zhang, Naiqing Zhang,

The zinc (Zn)-ion battery has attracted much attention due to its high safety and environmental protection. At present, the critical issues of the generation of dendrites and the accumulation of dead Zn on the surface will lead to a sharp decline of the battery life. Zn dendrites can be inhibited ... Read more >>

Adv Mater (Advanced materials (Deerfield Beach, Fla.))
[2021, :e2105133]

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Factors affecting the efficacy and safety of docetaxel combined with platinum in the treatment of advanced non-small cell lung cancer.

FengLi Wang, ChenYang Zhao, Xin Wen, Qingshan Zheng, Lujin Li,

<h4>Background</h4>This study aimed to quantitatively evaluate factors influencing the efficacy and safety of the docetaxel-platinum regimen to provide reliable information for optimizing chemotherapy regimens.<h4>Research design and methods</h4>A parametric survival function model was used to describe the time course of overall survival (OS) of patients with advanced non-small cell lung cancer ... Read more >>

Expert Rev Clin Pharmacol (Expert review of clinical pharmacology)
[2021, 14(10):1295-1303]

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Using one–to–many urine proteome comparisons to provide clues for fever of unknown origin

Chenyang Zhao, Lilong Wei, Jing Wei, Youhe Gao,

<h4>Objective</h4> To provide diagnostic evidence and clues for patients with fever of unknown origin (FUO) through urine proteomics analysis. <h4>Methods</h4> Urine samples of FUO were one–to–many analysed by using liquid chromatography tandem mass spectrometry(LC–MS/MS) to identify differential proteins and related biological pathways. One–to–many analysis means a comparative analysis of one ... Read more >>

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Cyclin G2 reverses immunosuppressive tumor microenvironment and potentiates PD-1 blockade in glioma.

Sen Li, Chenyang Zhao, Jinlan Gao, Xinbin Zhuang, Shuang Liu, Xuesha Xing, Qi Liu, Chen Chen, Shusen Wang, Yang Luo,

<h4>Background</h4>Expression of aberrant cyclin G2 is a key factor contributing to cancer biological processes, including glioma. However, the potential underlying mechanisms of cyclin G2 in the glioma tumor immune microenvironment remain unclear.<h4>Methods</h4>Co-immunoprecipitation (co-IP), in situ proximity ligation assay (PLA), and in vitro kinase assay were conducted to reveal the underlying ... Read more >>

J Exp Clin Cancer Res (Journal of experimental & clinical cancer research : CR)
[2021, 40(1):273]

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Optimization of pseudo-continuous arterial spin labeling at 7T with parallel transmission B1 shimming.

Kai Wang, Samantha J Ma, Xingfeng Shao, Chenyang Zhao, Qinyang Shou, Lirong Yan, Danny J J Wang,

<h4>Purpose</h4>To optimize pseudo-continuous arterial spin labeling (pCASL) for 7 T, and to further improve the labeling efficiency with parallel RF transmission transmit B<sub>1</sub> ( B1+ ) shimming.<h4>Methods</h4>pCASL parameters were optimized based on B1+/B0 field distributions at 7 T with simulation. To increase labeling efficiency, the B1+ amplitude at inflowing arteries ... Read more >>

Magn Reson Med (Magnetic resonance in medicine)
[2022, 87(1):249-262]

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Activity of keloids evaluated by multimodal photoacoustic/ultrasonic imaging system.

Cheng Chen, Sirui Liu, Chenyang Zhao, Ruojiao Wang, Nanze Yu, Xiao Long, Youbin Wang, Fang Yang, Jie Sun, Zhao Ling Lu, Yu Xia, Yuxin Jiang, Meng Yang,

Multiple objective assessments have been used to assess the activity of keloids to compare different therapeutic regimens and facilitate the best individual treatment choice for patients, but none of them are standardized. A multimodal photoacoustic/ultrasonic (PA/US) imaging system, including photoacoustic imaging, elastography, ultra-micro-angiography, and conventional US technologies (gray scale US, ... Read more >>

Photoacoustics (Photoacoustics)
[2021, 24:100302]

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C644-0303, a small-molecule inhibitor of the Wnt/β-catenin pathway, suppresses colorectal cancer growth.

Yu Yan, Yidan Zhang, Mengyuan Li, Yazhuo Zhang, Xinxin Zhang, Xiaonan Zhang, Yuting Xu, Wei Wei, Jie Wang, Xiaohan Xu, Qiaoling Song, Chenyang Zhao,

The Wnt/β-catenin signaling pathway plays an important role in tissue homeostasis, and its malignant activation is closely related to the occurrence and development of many cancers, especially colorectal cancer with adenomatous polyposis coli (APC) and CTNNB1 mutations. By applying a TCF/lymphoid-enhancing factor (LEF) luciferase reporter system, the high-throughput screening of ... Read more >>

Cancer Sci (Cancer science)
[2021, 112(11):4722-4735]

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Calcitonin increases hepatic hepcidin expression through the BMP6 of kidney in mice.

Yuhua Lei, Chenyang Zhao, Hengrui Chang, Dong Zhang, Yaru Li, Gregory J Anderson, Yongqing Shen, Xianglin Duan, Yan-Zhong Chang,

<h4>Background</h4>Osteoporosis is frequently accompanied by iron disorders. Calcitonin (CT) was approved as a clinical drug to treat osteoporosis. Hepcidin is a peptide hormone that is secreted by the liver and controls body iron homeostasis. Hepcidin deficiency leads to iron overload diseases. This study was aimed at investigating the effect of ... Read more >>

J Trace Elem Med Biol (Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS))
[2021, 68:126796]

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Surfactant-Free Synthesis of Three-Dimensional Metallic Nanonetworks via Nanobubble-Assisted Self-Assembly.

Jun Li, Xiaosi Liang, Liying Cai, Chenyang Zhao,

Three-dimensional metallic nanonetworks (3D-MNWs) demonstrate unique performances across a wide range of fields, and their facile and green synthetic method is of high significance. Herein, we report a self-generated-nanobubble scaffolding strategy for the fabrication of 3D-MNWs, which employs aqua ammonia (AA) as a nanobubble reservoir and avoids the use of ... Read more >>

Langmuir (Langmuir : the ACS journal of surfaces and colloids)
[2021, 37(27):8323-8330]

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Dynamic urine proteome changes in a rat model of simvastatin-induced skeletal muscle injury

Jing Wei, Yuhang Huan, Ziqi Heng, Chenyang Zhao, Youhe Gao,

<h4>Background</h4> Statin-associated muscle symptoms (SAMS) are the main side effects of statins. Currently, there are no effective biomarkers for accurate clinical diagnosis. Urine is not subject to homeostatic control and therefore accumulates early changes, making it an ideal biomarker source. We therefore examined urine proteome changes associated with SAMS in ... Read more >>

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Flexible and Filter-Free Color-Imaging Sensors with Multicomponent Perovskites Deposited Using Enhanced Vapor Technology.

Yantao Chen, Chenyang Zhao, Tingting Zhang, Xiaohan Wu, Wenjing Zhang, Shi-Jin Ding,

Halide perovskites are promising photoactive materials for filter-free color-imaging sensors owing to their outstanding optoelectronic properties, tunable bandgaps, and suitability for large-scale fabrication. However, producing patterned perovskite films of sufficiently high quality for such applications poses a challenge for existing fabrication methods: using solution processes to prepare patterned perovskite films ... Read more >>

Small (Small (Weinheim an der Bergstrasse, Germany))
[2021, 17(26):e2007543]

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Scaffold compound L971 exhibits anti-inflammatory activities through inhibition of JAK/STAT and NFκB signalling pathways.

Mengyuan Li, Yu Yan, Xinxin Zhang, Yidan Zhang, Xiaohan Xu, Lei Zhang, Liangliang Lu, Jie Wang, Yazhuo Zhang, Qiaoling Song, Chenyang Zhao,

JAK/STAT and NFκB signalling pathways play essential roles in regulating inflammatory responses, which are important pathogenic factors of various serious immune-related diseases, and function individually or synergistically. To find prodrugs that can treat inflammation, we performed a preliminary high-throughput screening of 18 840 small molecular compounds and identified scaffold compound L971 ... Read more >>

J Cell Mol Med (Journal of cellular and molecular medicine)
[2021, :]

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Unveiling the nonadiabatic photoisomerization mechanism of hemicyanines for UV photoprotection.

Mingshui Zhang, Mengqi Wang, Yurong Guo, Yanan Shi, Jun Wang, Yibing Chen, Chenyang Zhao, Yi Zhou, Yongze Xiao, Haoyue Zhang, Guangjiu Zhao,

In this work, the nonadiabatic energy relaxation mechanism of hemicyanines for UV photoprotection were investigated by using the density functional theory (DFT) and time-dependent density functional theory (TDDFT) method for the first time. The absorption spectra and potential energy surfaces (PESs) of four hemicyanines with different positions of substituents were ... Read more >>

Spectrochim Acta A Mol Biomol Spectrosc (Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy)
[2021, 260:119949]

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An Investigation of the High-Frequency Ultrasonic Vibration-Assisted Cutting of Steel Optical Moulds.

Canbin Zhang, Chifai Cheung, Benjamin Bulla, Chenyang Zhao,

Ultrasonic vibration-assisted cutting (UVAC) has been regarded as a promising technology to machine difficult-to-machine materials such as tungsten carbide, optical glass, and hardened steel in order to achieve superfinished surfaces. To increase vibration stability to achieve optical surface quality of a workpiece, a high-frequency ultrasonic vibration-assisted cutting system with a ... Read more >>

Micromachines (Basel) (Micromachines)
[2021, 12(4):]

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Small-Molecule Inhibitors Targeting the Canonical WNT Signaling Pathway for the Treatment of Cancer.

Zhiqing Liu, Pingyuan Wang, Eric A Wold, Qiaoling Song, Chenyang Zhao, Changyun Wang, Jia Zhou,

Canonical WNT signaling is an important developmental pathway that has attracted increased attention for anticancer drug discovery. From the production and secretion of WNT ligands, their binding to membrane receptors, and the β-catenin destruction complex to the expansive β-catenin transcriptional complex, multiple components have been investigated as drug targets to ... Read more >>

J Med Chem (Journal of medicinal chemistry)
[2021, 64(8):4257-4288]

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The impacts of race and regimens on the efficacy and safety of paclitaxel and platinum combination treatment for patients with advanced non-small cell lung cancer.

Chenyang Zhao, Fengli Wang, Jihan Huang, Yinghua Lv, Fang Yin, Hongxia Liu, Qingshan Zheng, Lujin Li,

<h4>Purpose</h4>Paclitaxel-platinum chemotherapy is the first-line treatment for advanced non-small cell lung cancer (NSCLC) patients. This study quantitatively evaluated the factors influencing the efficacy and safety of the paclitaxel-platinum regimen to provide the necessary reference for the development of clinical practice and clinical trials.<h4>Methods</h4>A literature search was performed using public databases. ... Read more >>

Eur J Clin Pharmacol (European journal of clinical pharmacology)
[2021, 77(5):685-695]

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Serum lncRNAs in early pregnancy as potential biomarkers for the prediction of pregnancy-induced hypertension, including preeclampsia.

Chenguang Dai, Chenyang Zhao, Minglu Xu, Xinshuang Sui, Li Sun, Yang Liu, Mengqi Su, Hongling Wang, Yue Yuan, Song Zhang, Jing Shi, Jingxia Sun, Yue Li,

Long noncoding RNAs (lncRNAs) are key mediators of biological regulation with diagnostic value as disease biomarkers. We explored serum lncRNA levels in early pregnancy as potential biomarkers of pregnancy-induced hypertension (PIH), including gestational hypertension (GH) and preeclampsia (PE). We performed a two-phase nested case-control study in pregnant women before 20 weeks' ... Read more >>

Mol Ther Nucleic Acids (Molecular therapy. Nucleic acids)
[2021, 24:416-425]

Cited: 3 times

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Antitumor effect of soluble β-glucan as an immune stimulant.

Lijuan Wu, Jun Zhao, Xiaonan Zhang, Shan Liu, Chenyang Zhao,

β-glucans are linear polysaccharides of d-glucose monomers linked through β-glycosidic bonds and are widely present in nature. Different sources lead to their structural differences. β-glucan has long been acknowledged to be a safe and functional component. Its biological activities include lipid-lowering, hypoglycemic, antitumor and immune regulation etc. A large number ... Read more >>

Int J Biol Macromol (International journal of biological macromolecules)
[2021, 179:116-124]

Cited: 2 times

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Functional photoacoustic/ultrasound imaging for the assessment of breast intraductal lesions: preliminary clinical findings.

Ming Wang, Lingyi Zhao, Yao Wei, Jianchu Li, Zhenhong Qi, Na Su, Chenyang Zhao, Rui Zhang, Tianhong Tang, Sirui Liu, Fang Yang, Lei Zhu, Xujin He, Changhui Li, Yuxin Jiang, Meng Yang,

This study aimed to identify features of breast intraductal lesions in photoacoustic/ultrasound (PA/US) imaging and compare PA/US with color Doppler flow/ultrasound (CDFI/US) in the evaluation of breast intraductal lesions. In the nine patients with 10 breast intraductal lesions and 8 patients with 8 benign lesions, total vessel scores evaluated from ... Read more >>

Biomed Opt Express (Biomedical optics express)
[2021, 12(3):1236-1246]

Cited: 2 times

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Ultra-microangiography in evaluating the disease activity of rheumatoid arthritis and enhancing the efficacy of ultrasonography: A preliminary study.

Chenyang Zhao, Qian Wang, Ming Wang, Xixi Tao, Sirui Liu, Zhenhong Qi, Xiang Lanxi, Donald Liu, Xujin He, Xinping Tian, Xiaofeng Zeng, Yuxin Jiang, Meng Yang,

<h4>Objective</h4>Ultra-microangiography (UMA) is a novel Doppler technique that has high sensitivity for low-velocity blood flows. In this study, a distinctive imaging feature, penetrating blood vessels on the surface of eroded bones within the inflamed joints, was observed on UMA. We aimed to investigate the feasibility of UMA in assessing disease ... Read more >>

Eur J Radiol (European journal of radiology)
[2021, 137:109567]

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Improving the structure stabilization of red phosphorus anodes via the shape memory effect of a Ni-Ti alloy for high-performance sodium ion batteries.

Yingtao Wang, Xiaodan Yang, Chenyang Zhao, Yongliang Li, Hongwei Mi, Peixin Zhang,

A Ni-Ti memory alloy was introduced to alleviate the huge volume change in red-P anodes for Na-ion batteries. The Ni-Ti-P delivered a high initial coulombic efficiency of 80%, and retained almost 100% of the initial reversible capacity after 20 cycles. Utilizing the shape memory effect to accommodate a huge volumetric ... Read more >>

Chem Commun (Camb) (Chemical communications (Cambridge, England))
[2019, 55(32):4659-4662]

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The Role of Contrast-Enhanced Ultrasound in Evaluating Gestational Trophoblastic Neoplasia: A Preliminary Study.

Na Su, Chenyang Zhao, Bo Zhang, Zhenhong Qi, Bin Gao, Zhenzhen Liu, Meng Yang, Yuxin Jiang, Qing Dai,

<h4>Objective</h4>We aimed to compare the imaging features of gestational trophoblastic neoplasias (GTNs) and benign pregnancy-related uterine diseases on contrast-enhanced ultrasound (CEUS) to explore the clinical value of CEUS in differentiating these two types of uterine lesions.<h4>Materials and methods</h4>In this prospective study, patients with GTNs before and after chemotherapy and benign ... Read more >>

Cancer Manag Res (Cancer management and research)
[2020, 12:12163-12174]

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