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Author Chenqing Zheng

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Updates on Clinical and Genetic Heterogeneity of ASPM in 12 Autosomal Recessive Primary Microcephaly Families in Pakistani Population.

Niaz Muhammad Khan, Basharat Hussain, Chenqing Zheng, Ayaz Khan, Muhammad Shareef Masoud, Qingquan Gu, Linhui Qiu, Naveed Altaf Malik, Muhammad Qasim, Muhammad Tariq, Junlei Chang,

Microcephaly (MCPH) is a genetically heterogeneous disorder characterized by non-progressive intellectual disability, small head circumference, and small brain size compared with the age- and sex-matched population. MCPH manifests as an isolated condition or part of another clinical syndrome; so far, 25 genes have been linked with MCPH. Many of these ... Read more >>

Front Pediatr (Frontiers in pediatrics)
[2021, 9:695133]

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Total genetic contribution assessment across the human genome.

Ting Li, Zheng Ning, Zhijian Yang, Ranran Zhai, Chenqing Zheng, Wenzheng Xu, Yipeng Wang, Kejun Ying, Yiwen Chen, Xia Shen,

Quantifying the overall magnitude of every single locus' genetic effect on the widely measured human phenome is of great challenge. We introduce a unified modelling technique that can consistently provide a total genetic contribution assessment (TGCA) of a gene or genetic variant without thresholding genetic association signals. Genome-wide TGCA in ... Read more >>

Nat Commun (Nature communications)
[2021, 12(1):2845]

Cited: 1 time

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Integrative analyses identify potential key genes and pathways in Keshan disease using whole-exome sequencing

Jichang Huang, Chenqing Zheng, Rong Luo, Mingjiang Liu, Qingquan Gu, Jinshu Li, Xiushan Wu, Zhenglin Yang, Xia Shen, Xiaoping Li,

Keshan disease (KD), an endemic heart disease with multifocal necrosis and replacement fibrosis of the myocardium,is still a nightmare situation for human health. However, molecular mechanism in the pathogenesis of KD remains unclear. Herein, blood samples were collected from 68 KD patients and 100 controls, and we systematically analyzed mutation ... Read more >>

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Genetic mechanisms of critical illness in Covid-19

Erola Pairo-Castineira, Sara Clohisey, Lucija Klaric, Andrew Bretherick, Konrad Rawlik, Nick Parkinson, Dorota Pasko, Susan Walker, Anne Richmond, Max Head Fourman, Clark Russell, Andrew Law, James Furniss, Elvina Gountouna, Nicola Wrobel, Loukas Moutsianas, Bo Wang, Alison Meynert, Zhijian Yang, Ranran Zhai, Chenqing Zheng, Fiona Griffiths, Wilna Oosthuyzen, Graeme Grimes, Barbara Shih, Sean Keating, Marie Zechner, Chris Haley, David Porteous, Caroline Hayward, Julian Knight, Charlotte Summers, Manu Shankar-Hari, Paul Klenerman, Lance Turtle, Antonia Ho, Charles Hinds, Peter Horby, Alistair Nichol, David Maslove, Lowell Ling, Danny McAuley, Hugh Montgomery, Timothy Walsh, Xia Shen, Kathy Rowan, Angie Fawkes, Lee Murphy, Chris Ponting, Albert Tenesa, Mark Caulfield, Richard Scott, Peter J.M. Openshaw, Malcolm Semple, Veronique Vitart, James Wilson, Kenneth Baillie, , , ,

The subset of patients who develop critical illness in Covid-19 have extensive inflammation affecting the lungs 1 and are strikingly different from other patients: immunosuppressive therapy benefits critically-ill patients, but may harm some non-critical cases. 2 Since susceptibility to life-threatening infections and immune-mediated diseases are both strongly heritable traits, we ... Read more >>

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Genetic mechanisms of critical illness in COVID-19.

Erola Pairo-Castineira, Sara Clohisey, Lucija Klaric, Andrew D Bretherick, Konrad Rawlik, Dorota Pasko, Susan Walker, Nick Parkinson, Max Head Fourman, Clark D Russell, James Furniss, Anne Richmond, Elvina Gountouna, Nicola Wrobel, David Harrison, Bo Wang, Yang Wu, Alison Meynert, Fiona Griffiths, Wilna Oosthuyzen, Athanasios Kousathanas, Loukas Moutsianas, Zhijian Yang, Ranran Zhai, Chenqing Zheng, Graeme Grimes, Rupert Beale, Jonathan Millar, Barbara Shih, Sean Keating, Marie Zechner, Chris Haley, David J Porteous, Caroline Hayward, Jian Yang, Julian Knight, Charlotte Summers, Manu Shankar-Hari, Paul Klenerman, Lance Turtle, Antonia Ho, Shona C Moore, Charles Hinds, Peter Horby, Alistair Nichol, David Maslove, Lowell Ling, Danny McAuley, Hugh Montgomery, Timothy Walsh, Alexandre C Pereira, Alessandra Renieri, , , , , , , Xia Shen, Chris P Ponting, Angie Fawkes, Albert Tenesa, Mark Caulfield, Richard Scott, Kathy Rowan, Lee Murphy, Peter J M Openshaw, Malcolm G Semple, Andrew Law, Veronique Vitart, James F Wilson, J Kenneth Baillie,

Host-mediated lung inflammation is present<sup>1</sup>, and drives mortality<sup>2</sup>, in the critical illness caused by coronavirus disease 2019 (COVID-19). Host genetic variants associated with critical illness may identify mechanistic targets for therapeutic development<sup>3</sup>. Here we report the results of the GenOMICC (Genetics Of Mortality In Critical Care) genome-wide association study in ... Read more >>

Nature (Nature)
[2021, 591(7848):92-98]

Cited: 179 times

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Variants of WNT7A and GPR124 are associated with hemorrhagic transformation following intravenous thrombolysis in ischemic stroke.

Song Ta, Xianfang Rong, Zhen-Ni Guo, Hang Jin, Peng Zhang, Fenge Li, Zhihuan Li, Lilong Lin, Chenqing Zheng, Qingquan Gu, Yuan Zhang, Wenlan Liu, Yi Yang, Junlei Chang,

<h4>Aims</h4>The canonical Wnt signaling pathway plays an essential role in blood-brain barrier integrity and intracerebral hemorrhage in preclinical stroke models. Here, we sought to explore the association between canonical Wnt signaling and hemorrhagic transformation (HT) following intravenous thrombolysis (IVT) in acute ischemic stroke (AIS) patients as well as to determine ... Read more >>

CNS Neurosci Ther (CNS neuroscience & therapeutics)
[2021, 27(1):71-81]

Cited: 2 times

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A Novel EMD Mutation Identified by Whole-Exome Sequencing in Twins with Emery-Dreifuss Muscular Dystrophy.

Xiafei Dai, Rong Luo, Yang Chen, Chenqing Zheng, Yibin Tang, Hongmei Zhang, Ye Su, Tao He, Xiaoping Li,

This case reports a novel hemizygous frameshift <i>EMD</i> mutation (c.487delA, p.Ser163fs) in twins of an Emery-Dreifuss muscular dystrophy family with severe cardiac involvement and mild muscle weakness. Their mother carried the same heterozygous mutation. ... Read more >>

Case Rep Genet (Case reports in genetics)
[2020, 2020:2071738]

Cited: 1 time

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Identification of potential candidate genes and pathways in atrioventricular nodal reentry tachycardia by whole-exome sequencing.

Rong Luo, Chenqing Zheng, Hao Yang, Xuepin Chen, Panpan Jiang, Xiushan Wu, Zhenglin Yang, Xia Shen, Xiaoping Li,

<h4>Background</h4>Atrioventricular nodal reentry tachycardia (AVNRT) is the most common manifestation of paroxysmal supraventricular tachycardia (PSVT). Increasing data have indicated familial clustering and participation of genetic factors in AVNRT, and no pathogenic genes related to AVNRT have been reported.<h4>Methods</h4>Whole-exome sequencing (WES) was performed in 82 patients with AVNRT and 100 controls. ... Read more >>

Clin Transl Med (Clinical and translational medicine)
[2020, 10(1):238-257]

Cited: 1 time

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An analysis of abnormalities in the B cell receptor repertoire in patients with systemic sclerosis using high-throughput sequencing.

Xiaodong Shi, Tihong Shao, Feifei Huo, Chenqing Zheng, Wanyu Li, Zhenyu Jiang,

Systemic sclerosis is a chronic multisystem autoimmune disease that is associated with polyclonal B cell hyperreactivity. The CDR3 of BCRs is the major site of antigen recognition. Therefore, we analyzed the BCR repertoire of patients with SSc. The BCR repertoires in 12 subjects including eight SSc patients and four healthy ... Read more >>

PeerJ (PeerJ)
[2020, 8:e8370]

Cited: 2 times

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Demographic Histories and Genome-Wide Patterns of Divergence in Incipient Species of Shorebirds.

Xuejing Wang, Kathryn H Maher, Nan Zhang, Pinjia Que, Chenqing Zheng, Simin Liu, Biao Wang, Qin Huang, De Chen, Xu Yang, Zhengwang Zhang, Tamás Székely, Araxi O Urrutia, Yang Liu,

Understanding how incipient species are maintained with gene flow is a fundamental question in evolutionary biology. Whole genome sequencing of multiple individuals holds great potential to illustrate patterns of genomic differentiation as well as the associated evolutionary histories. Kentish (Charadrius alexandrinus) and the white-faced (C. dealbatus) plovers, which differ in ... Read more >>

Front Genet (Frontiers in genetics)
[2019, 10:919]

Cited: 1 time

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Targeted next-generation sequencing identified a known EMD mutation in a Chinese patient with Emery-Dreifuss muscular dystrophy.

Xiafei Dai, Chenqing Zheng, Xuepin Chen, Yibin Tang, Hongmei Zhang, Chao Yan, Huihui Ma, Xiaoping Li,

Emery-Dreifuss muscular dystrophy (EDMD) is a rare X-linked recessive disease characterized by the clinical triad of early childhood joint contractures, progressive weakness in muscles and cardiac involvement and can result in sudden death. Targeted next-generation sequencing was performed for a Chinese patient with EDMD and the previously reported mutation [NM_000117.2: ... Read more >>

Hum Genome Var (Human genome variation)
[2019, 6:42]

Cited: 1 time

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Two pedigrees with arrhythmogenic right ventricular cardiomyopathy linked with R49H and F531C mutation in DSG2.

Xuepin Chen, Hui Peng, Chenqing Zheng, Hongmei Zhang, Chao Yan, Huihui Ma, Xiafei Dai, Xiaoping Li,

Arrhythmogenic right ventricular cardiomyopathy (ARVC) presents as the progressive fibrofatty replacement of the cardiomyocytes particularly in the right ventricular wall. Here, we report two cases with ARVC. In family A, the proband carries a Desmoglein2 (DSG2) gene complex heterozygous mutation NM_001943.4:c.146G>A/p.(Arg49His)and NM_001943.3:c.1592T>G/p.(Phe531Cys). In family B, the proband carries a homozygous ... Read more >>

Hum Genome Var (Human genome variation)
[2019, 6:38]

Cited: 2 times

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Meta-Analysis of Gene Expression and Identification of Biological Regulatory Mechanisms in Alzheimer's Disease.

Lining Su, Sufen Chen, Chenqing Zheng, Huiping Wei, Xiaoqing Song,

Alzheimer's disease (AD), also known as senile dementia, is a progressive neurodegenerative disease. The etiology and pathogenesis of AD have not yet been elucidated. We examined common differentially expressed genes (DEGs) from different AD tissue microarray datasets by meta-analysis and screened the AD-associated genes from the common DEGs using GCBI. ... Read more >>

Front Neurosci (Frontiers in neuroscience)
[2019, 13:633]

Cited: 8 times

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Low genetic diversity in captive populations of the critically endangered Blue-crowned Laughingthrush (Garrulax courtoisi) revealed by a panel of novel microsatellites.

Guoling Chen, Chenqing Zheng, Nelson Wan, Daoqiang Liu, Vivian Wing Kan Fu, Xu Yang, Yat-Tung Yu, Yang Liu,

Background:Captive populations permit research and conservation of endangered species in which these efforts are hardly implemented in wild populations. Thus, analysing genetic diversity and structure of captive populations offers unique opportunities. One example is the critically endangered Blue-crowned Laughingthrush, Garrulax courtoisi, which has only two known wild populations in Wuyuan, ... Read more >>

PeerJ (PeerJ)
[2019, 7:e6643]

Cited: 0 times

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Demographic histories and genome-wide patterns of divergence in incipient species of shorebirds

Xuejing Wang, Kathryn Maher, Nan Zhang, Pingjia Que, Chenqing Zheng, Simin Liu, Biao Wang, Qin Huang, De Chen, Xu Yang, Zhengwang Zhang, Tamás Székely, Araxi Urrutia, Yang Liu,

Understanding how incipient species are maintained with gene flow is a fundamental question in evolutionary biology. Whole genome sequencing of multiple individuals holds great potential to illustrate patterns of genomic differentiation as well as the associated evolutionary histories. Kentish ( Charadrius alexandrinus ) and the white-faced ( C. dealbatus ) ... Read more >>

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Low genetic diversity in captive populations of the critically endangered Blue-crowned Laughingthrush (Garrulax courtoisi) revealed by a panel of novel microsatellites

Guoling Chen, Chenqing Zheng, Nelson Wan, Daoqiang Liu, Vivian Wing Kan Fu, Xu Yang, Yat-tung Yu, Yang Liu,

<h4>Background: </h4> Understanding genetic diversity and population structure is critically important for the conservation and management of endangered species. These factors are particularly relevant for species with small populations and/or restricted ranges, such as the critically endangered Blue-crowned Laughingthrush, Garrulax courtoisi , which has only two wild populations left in ... Read more >>

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A meta-analysis of public microarray data identifies biological regulatory networks in Parkinson's disease.

Lining Su, Chunjie Wang, Chenqing Zheng, Huiping Wei, Xiaoqing Song,

<h4>Background</h4>Parkinson's disease (PD) is a long-term degenerative disease that is caused by environmental and genetic factors. The networks of genes and their regulators that control the progression and development of PD require further elucidation.<h4>Methods</h4>We examine common differentially expressed genes (DEGs) from several PD blood and substantia nigra (SN) microarray datasets ... Read more >>

BMC Med Genomics (BMC medical genomics)
[2018, 11(1):40]

Cited: 7 times

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