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In Vivo Evolution of CTX-M-215, a Novel Narrow-Spectrum β-Lactamase in an Escherichia coli Clinical Isolate Conferring Resistance to Mecillinam.

Mengyun Yin, Guoping Hu, Zhen Shen, Chengli Fang, Xuefei Zhang, Dan Li, Yohei Doi, Yu Zhang, Minggui Wang, Qinglan Guo,

Here, we report a novel narrow-spectrum β-lactamase CTX-M-215 identified in an Escherichia coli clinical isolate in China and conferring high-level resistance to mecillinam but not to cefotaxime. CTX-M-215 differed from CTX-M-125, a CTX-M extended-spectrum β-lactamase (ESBL), by an N132D substitution, which decreased hydrolytic activities toward penicillins and cephalosporins except for ... Read more >>

Antimicrob Agents Chemother (Antimicrobial agents and chemotherapy)
[2020, 64(11):]

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CueR activates transcription through a DNA distortion mechanism.

Chengli Fang, Steven J Philips, Xiaoxian Wu, Kui Chen, Jing Shi, Liqiang Shen, Juncao Xu, Yu Feng, Thomas V O'Halloran, Yu Zhang,

The MerR-family transcription factors (TFs) are a large group of bacterial proteins responding to cellular metal ions and multiple antibiotics by binding within central RNA polymerase-binding regions of a promoter. While most TFs alter transcription through protein-protein interactions, MerR TFs are capable of reshaping promoter DNA. To address the question ... Read more >>

Nat Chem Biol (Nature chemical biology)
[2020, :]

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Crl activates transcription by stabilizing the active conformation of the master stress factor σS

Juncao Xu, Kaijie Cui, Liqiang Shen, Jing Shi, Lingting Li, Linlin You, Chengli Fang, Guoping Zhao, Yu Feng, Bei Yang, Yu Zhang,

SUMMARY σ S is a master transcription initiation factor that protects bacterial cells from various harmful environmental stresses and antibiotic pressure. Although its mechanism remains unclear, it is known that full activation of σ S -mediated transcription requires a σ S -specific activator, Crl. In this study, we determined a ... Read more >>

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Structural basis for transcription initiation by bacterial ECF σ factors.

Lingting Li, Chengli Fang, Ningning Zhuang, Tiantian Wang, Yu Zhang,

Bacterial RNA polymerase employs extra-cytoplasmic function (ECF) σ factors to regulate context-specific gene expression programs. Despite being the most abundant and divergent σ factor class, the structural basis of ECF σ factor-mediated transcription initiation remains unknown. Here, we determine a crystal structure of Mycobacterium tuberculosis (Mtb) RNAP holoenzyme comprising an ... Read more >>

Nat Commun (Nature communications)
[2019, 10(1):1153]

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Structural basis for transcription initiation by bacterial ECF σ factors

Lingting Li, Chengli Fang, Ningning Zhuang, Tiantian Wang, Yu Zhang,

Abstract Bacterial RNA polymerase employs extra-cytoplasmic function (ECF) σ factors to regulate context-specific gene expression programs. Despite being the most abundant and divergent σ factor class, the structural basis of ECF σ factor-mediated transcription initiation remains unknown. Here, we determine a crystal structure of Mycobacterium tuberculosis ( Mtb ) RNAP ... Read more >>

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