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Effect of Composite Nanoparticle CeO₂ on Myocardial Ischemic Re-Infusion of Cardio Myocyte Apoptosis in Mouse.

Chengbin Wang, Lin Ding, Jiamei Zhao, Beibei Cao, Mingwei He,

The myocardial I/R damage is very complicated. Apoptosis is considered to its a critical mechanism. During the cardiac muscle I/R process, oxygen-free radicals play a pivotal role. Arrhythmias, as well as enlargement of the area of myocardial infarction after cardiac muscle I/R process, are caused by adequate blast generated O<sup>2-</sup> ... Read more >>

J Nanosci Nanotechnol (Journal of nanoscience and nanotechnology)
[2021, 21(2):1397-1402]

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Analysis of Risk Factors and Clinical Indicators in Bloodstream Infections Among Patients with Hematological Malignancy.

Yating Ma, Shijian Wang, Ming Yang, Jinfeng Bao, Chengbin Wang,

<h4>Purpose</h4>The incidence of bloodstream infection (BSI) is more common in patients with hematological malignancy. It is important to distinguish infectious episodes from noninfectious episodes. The present study was aimed to describe the epidemiology, clinical indexes, and antibiotic use for in-hospital bloodstream infections of hematological malignancy patients.<h4>Patients and methods</h4>Single-center retrospective research ... Read more >>

Cancer Manag Res (Cancer management and research)
[2020, 12:13579-13588]

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Late-onset Hearing Loss From Congenital Cytomegalovirus Infection After Newborn Period in a Highly Immune Population in China.

Chengbin Wang, Xiaolin Liu, Shiwen Wang, Wenqiang Zhang, Haiyan Wang, Wei Ma, Xiangxin Meng, Xingqu Xu, Zhan Li, Qiang Pan, Shuxia Zhang, Ping Wang, Qian Lin, Xiaofang Wang, Minal Amin, Sheila Dollard, Aiqiang Xu, Winnie Chung,

After following 141 children with likely asymptomatic congenital cytomegalovirus infection in a highly immune population in China, four children (2.8%) were found to have late-onset hearing loss. No maternal or childhood factors, except higher saliva cytomegalovirus viral load at birth (P = 0.03), were associated with increased risk of developing ... Read more >>

Pediatr Infect Dis J (The Pediatric infectious disease journal)
[2021, 40(1):70-73]

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Upregulation of ATIC in multiple myeloma tissues based on tissue microarray and gene microarrays.

Ruolin Li, Gang Chen, Yiwu Dang, Rongquan He, Angui Liu, Jie Ma, Chengbin Wang,

<h4>Purpose</h4>Multiple myeloma (MM) is characterized by the malignant proliferation of plasma cells, which produce a monoclonal immunoglobulin protein. The role of 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase (ATIC) has not yet been well studied in the area of MM. Thus, in the current study, we sought to examine the expression levels, including ... Read more >>

Int J Lab Hematol (International journal of laboratory hematology)
[2020, :]

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ITIH4, as an inflammation biomarker, mainly increases in bacterial bloodstream infection.

Yating Ma, Ruibing Li, Jianan Wang, Wencan Jiang, Xiaozhou Yuan, Jiayue Cui, Chengbin Wang,

Bloodstream infection (BSI) is usually accompanied with the changes of varieties of inflammation proteins. In our previous study, we identified that inter-α-trypsin inhibitor heavy chain H4 (ITIH4) was highly expressed in the infection arms than the normal control arm. However, the correlated verification and mechanism remain obscure. Escherichia coli infected ... Read more >>

Cytokine (Cytokine)
[2021, 138:155377]

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Evaluation of an Element-Tagged Duplex Immunoassay Coupled with Inductively Coupled Plasma Mass Spectrometry Detection: A Further Study for the Application of the New Assay in Clinical Laboratory.

Wencan Jiang, Gongwei Sun, Wenbin Cui, Shasha Men, Miao Jing, Danna Pu, Sichun Zhang, Xiaozhou Yuan, Xinrong Zhang, Chengbin Wang,

<h4>Background</h4>Element-tagged immunoassay coupled with inductively coupled plasma mass spectrometry (ICP-MS) detection has the potential to revolutionize immunoassay analysis for multiplex detection. However, a further study referring to the standard evaluation and clinical sample verification is needed to ensure its reliability for simultaneous analysis in clinical laboratories.<h4>Methods</h4>Carcinoembryonic antigen (CEA) and α-fetoprotein ... Read more >>

Molecules (Molecules (Basel, Switzerland))
[2020, 25(22):]

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Single-cell RNA-Seq revealed profound immune alteration in the peripheral blood of patients with bacterial infection.

Hongxing Lei, Chi Wang, Yunlai Wang, Chengbin Wang,

<h4>Objectives</h4>Bacterial infection remains one of the greatest threats to human health. However, how human hosts respond to bacterial infection has not been thoroughly understood. Better understanding of this response will improve human health.<h4>Methods</h4>Here, we conducted an investigation on host response to bacterial infection using unperturbed clinical samples and single-cell RNA-Seq ... Read more >>

Int J Infect Dis (International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases)
[2020, 103:527-535]

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Plasma Metabolomic Profiling of Individuals Susceptible to High Altitude through Gas Chromatograph- mass Spectrometry

Chi Wang, Hui Jiang, Jingwen Chen, Jinyan Duan, Chengbin Wang,

<h4>Objective: </h4> We aimed to characterize metabolic alterations of people ascending to high altitude and susceptible to acute mountain sickness (AMS). <h4>Methods: </h4> Peripheral blood samples were collected from 36 healthy volunteers on the 3 rd day ascending to high altitude (4300m). AMS status was assessed using the Lake Louise ... Read more >>

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Respiratory Syncytial Virus-associated Acute Otitis Media in Infants and Children.

Matthew Phillips, Lyn Finelli, Lisa Saiman, Chengbin Wang, Yoonyoung Choi, Janak Patel,

Despite recent declines in the incidence of acute otitis media (AOM), more than 5 million cases and 5-6 million primary AOM visits still occur in young children in the United States, resulting in $4.4 billion direct medical costs annually. Our aims in this review are to describe the role of ... Read more >>

J Pediatric Infect Dis Soc (Journal of the Pediatric Infectious Diseases Society)
[2020, 9(5):544-550]

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Ultrasmall [email protected]3O4 nanoparticles as T1-T2 dual-mode MRI contrast agents for targeted tumor imaging.

Donglin Liu, Jiaojiao Li, Chengbin Wang, Lu An, Jiaomin Lin, Qiwei Tian, Shiping Yang,

Targeted T<sub>1</sub>-T<sub>2</sub> MRI contrast agents, which can eliminate the difficulty of image matching across multiple imaging instruments and permit specific localization of lesions, are promising candidates for more accurate diagnosis of tumors. In this study, ultrasmall [email protected]<sub>3</sub>O<sub>4</sub> nanoparticles were designed and synthesized as T<sub>1</sub>-T<sub>2</sub> dual-mode MRI contrast agents for accurate ... Read more >>

Nanomedicine (Nanomedicine : nanotechnology, biology, and medicine)
[2020, 32:102335]

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MicroRNAs in urine as diagnostic biomarkers for multiple myeloma.

Jia Li, Chengbin Wang, Qian Meng, Zhiying Hu, Mei Hu, Man Zhang,

<h4>Introduction</h4>Multiple myeloma (MM) is a hematological malignancy. It is of great clinical significance to screen microRNAs (miRNAs) in urine as noninvasive diagnostic biomarkers for MM.<h4>Methods</h4>Urinary miRNAs in MM were performed by Agilent Bioanalyzer 2100 and verified by quantitative real-time PCR (qRT-PCR). Receiver operator characteristic (ROC) was used to evaluate the ... Read more >>

Int J Lab Hematol (International journal of laboratory hematology)
[2020, :]

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A Novel Zero Velocity Detection Method Based on the Plantar Pressure

Chengbin Wang, Meifeng Guo, Juan Wu, Bin Zhou, Qi Wei,

The zero velocity update(ZUPT) algorithm is the core of a foot-mounted pedestrian navigation system. The zero velocity detection method is the premise and guarantee of the effective application of the ZUPT algorithm. To make ZUPT work properly, it is necessary to detect zero velocity intervals correctly. The detection accuracy of ... Read more >>

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Research and progress on biomarkers of neuromyelitis optica spectrum disorders.

Jinyang Wang, Jiayu Liu, Ruibing Li, Chengbin Wang,

Neuromyelitis optica spectrum disorders (NMOSD) are a demyelinating disorder of the central nervous system based on the involvement of the optic nerve and/or spinal cord. The disease is characterized by high recurrence and disability. NMOSD is mainly diagnosed by AQP4-IgG and MOG-IgG. However, there are still some patients with negative ... Read more >>

J Recept Signal Transduct Res (Journal of receptor and signal transduction research)
[2020, :1-8]

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Development and Evaluation of a Combined Immunoassay Method Based on a Stable Isotope Tagging Strategy and Inductively Coupled Plasma Mass Spectrometry for Detecting Human Chorionic Gonadotropin.

Danna Pu, Wencan Jiang, Guanghong Guo, Xinyu Wen, Wenbin Cui, Miao Jing, Chengbin Wang, Ping Li,

<h4>Background</h4>The development of a combined immunoassay method, based on a stable isotope tagging strategy and inductively coupled plasma mass spectrometry (ICP-MS), has created options for quantitative bioanalysis. The aim of the study was to develop a combined immunoassay, featuring ICP-MS and a stable element labeling strategy, for the detection of ... Read more >>

Clin Lab (Clinical laboratory)
[2020, 66(11):]

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Analysis of risk factors and clinical indicators in bloodstream infections among patients with hematological malignancy : a retrospective study

Yating Ma, Ming Yang, Jinfeng Bao, Chengbin Wang,

<h4>Background: </h4> The incidence of bloodstream infection caused by bacteremia is more common in patients with hematological malignancy. It is important to distinguish infectious episodes from non-infectious episodes. The present study was aimed to describe epidemiology and clinical indexes for in-hospital infection of hematological malignancy patients. <h4>Methods: </h4> Single-center retrospective ... Read more >>

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Fibronectin and colorectal cancer: signaling pathways and clinical implications.

Jianan Wang, Ruibing Li, Mianyang Li, Chengbin Wang,

Colorectal cancer (CRC) is the fourth leading cause of cancer deaths worldwide, with poor prognosis mainly related to metastasis. Fibronectin (FN), a vital component of the extracellular matrix (ECM), has been found involved in tumorigenesis and malignant progression in different types of malignancy. Numerous studies have indicated the distinct expression ... Read more >>

J Recept Signal Transduct Res (Journal of receptor and signal transduction research)
[2020, :1-8]

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UCHL1 from serum and CSF is a candidate biomarker for amyotrophic lateral sclerosis.

Ruibing Li, Jianan Wang, Wei Xie, Jiayu Liu, Chengbin Wang,

<h4>Objective</h4>To identify potential ALS biomarkers in patients and to evaluate their diagnostic performance using cerebrospinal fluid (CSF) and serum.<h4>Method</h4>We recruited a discovery cohort, comprising 20 ALS patients and 20 controls to screen for potential CSF biomarker, UCHL1, using a Luminex neurodegenerative disease panel. To validate UCHL1's diagnostic performance, we used ... Read more >>

Ann Clin Transl Neurol (Annals of clinical and translational neurology)
[2020, 7(8):1420-1428]

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GGTA1/iGb3S Double Knockout Mice: Immunological Properties and Immunogenicity Response to Xenogeneic Bone Matrix.

Anliang Shao, You Ling, Liang Chen, Lina Wei, Changfa Fan, Dan Lei, Liming Xu, Chengbin Wang,

<h4>Background</h4>Animal tissues and tissue-derived biomaterials are widely used in the field of xenotransplantation and regenerative medicine. A potential immunogenic risk that affects the safety and effectiveness of xenografts is the presence of remnant <i>α</i>-Gal antigen (synthesized by <i>GGTA1</i> or/and <i>iGb3S</i>). <i>GGTA1</i> knockout mice have been developed as a suitable model ... Read more >>

Biomed Res Int (BioMed research international)
[2020, 2020:9680474]

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A Compound Heterozygosis of Two Novel Mutations Causes Factor X Deficiency in a Chinese Pedigree.

Songsong Lu, Weicheng Lin, Huijuan Ji, Ming Su, Xiaotao Zhao, Chengbin Wang,

<h4>Background</h4>Mutations in the F10-coding gene can cause factor X (FX) deficiency, leading to abnormal coagulation activity and severe tendency for hemorrhage. Therefore, identifying mutations in F10 is important for diagnosing congenital FX deficiency.<h4>Methods</h4>We studied a 63-year-old male patient with FX deficiency and 10 of his family members. Clotting and immunological ... Read more >>

Acta Haematol (Acta haematologica)
[2020, :1-6]

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Characterization of a multidrug-resistant Klebsiella pneumoniae ST3330 clone responsible for a nosocomial outbreak in a neonatal intensive care unit.

Lingli Shao, Bei Yao, Jiyong Yang, Xin Li, Kun Ye, Yanping Zhang, Chengbin Wang,

BACKGROUND:The incidence of Klebsiella pneumonia (Kp), which has often been found to produce, extended spectrum beta-lactamase (ESBL), is rising rapidly and poses a serious risk to neonates. To date, the mechanisms related to the spread of ESBL-Kp have not been fully elucidated. This study aimed to investigate the phenotypes, genotypes, ... Read more >>

Ann Palliat Med (Annals of palliative medicine)
[2020, 9(3):1092-1102]

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Diagnostic efficacy of serum cytokines and chemokines in patients with candidemia and bacteremia.

Qi Wang, Chi Wang, Ming Yang, Xinjun Li, Jiayue Cui, Chengbin Wang,

BACKGROUND:The role of serum cytokines/chemokines in differential diagnosis between fungal infections and bacterial infections have not been fully understood. This study aims to measure the serum levels of cytokines/chemokines in cases of candidemia and to compare them with those observed in cases of bacteremia. MATERIAL AND METHODS:Patients with febrile episodes ... Read more >>

Cytokine (Cytokine)
[2020, 130:155081]

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Simultaneous determination of gastric cancer biomarkers pepsinogen PGI/PGII using element tagged immunoassay coupled with inductively coupled plasma mass spectrometry detection.

Wencan Jiang, Gongwei Sun, Yuqing Zhang, Zhian Hu, Xinyu Wen, Shasha Men, Zhi Xing, Sichun Zhang, Biao Huang, Chengbin Wang,

<h4>Objectives</h4>In this study, a new immunoassay for the simultaneous determination of pepsinogen I (PGI) and pepsinogen II (PGII) in serum based on element labeling strategy coupled with inductively coupled plasma mass spectrometry (ICP-MS) detection was proposed.<h4>Methods</h4>The sandwich-type immunoassay was used to simultaneously detect PGI and PGII in serum. PGI and ... Read more >>

J Clin Lab Anal (Journal of clinical laboratory analysis)
[2020, 34(7):e23287]

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Circulating miRNAs as diagnostic biomarkers for multiple myeloma and monoclonal gammopathy of undetermined significance.

Jia Li, Man Zhang, Chengbin Wang,

BACKGROUND:Multiple myeloma (MM) is still an incurable hematological malignancy evolved from asymptomatic monoclonal gammopathy of undetermined significance (MGUS). New evidence suggests that circulating microRNAs (miRNAs) can serve as stable diagnostic biomarkers for MM and MUGS. METHODS:Serum miRNAs in MM patients, MUGS patients, and healthy controls (HC) were performed by Agilent ... Read more >>

J Clin Lab Anal (Journal of clinical laboratory analysis)
[2020, 34(6):e23233]

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Diagnostic efficacy of serum cytokines and chemokines in fungal bloodstream infection in febrile patients.

Qi Wang, Ming Yang, Chi Wang, Jiayue Cui, Xinjun Li, Chengbin Wang,

BACKGROUND:The role of serum cytokines/chemokines in early diagnosis of fungal infections has not been clearly clarified yet. This study aims to measure the serum levels of cytokines/chemokines in cases of fungemia and to compare them with culture-negative controls. METHODS:In total, fourteen types of serum cytokines and chemokines from 41 patients ... Read more >>

J Clin Lab Anal (Journal of clinical laboratory analysis)
[2020, 34(4):e23149]

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A preliminary study for the establishment of a reference interval for vitamin B12 in China after performance verification of a second-generation ECLIA kit.

Wencan Jiang, Shasha Men, Xinyu Wen, Xiaozhou Yuan, Danna Pu, Xiaoting Liu, Xingwang Jia, Chengbin Wang,

BACKGROUND:The second-generation electrochemiluminescence immunoassay (ECLIA) kit of vitamin B12 is widely used in clinical laboratories, and the establishment of a reference interval (RI) is essential to provide the basis for clinical monitoring. The purpose of this study was to establish a laboratory RI for vitamin B12 in China and at ... Read more >>

J Clin Lab Anal (Journal of clinical laboratory analysis)
[2020, 34(5):e23165]

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