Full Text Journal Articles by
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Human nail bed extracellular matrix facilitates bone regeneration via macrophage polarization mediated by the JAK2/STAT3 pathway.

Yaling Yu, Haomin Cui, Cheng Zhang, Demin Zhang, Jun Yin, Gen Wen, Yimin Chai,

Critical-sized bone defects caused by trauma, tumor resection or serious infection represent one of the most challenging problems faced by orthopedic surgeons. However, the construction of bone grafts with good osteointegration and osteoinductivity is a clinical challenge. It has been elaborated that the nail bed tissue is an essential element ... Read more >>

J Mater Chem B (Journal of materials chemistry. B)
[2020, 8(18):4067-4079]

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A comparative study on the NOx storage and reduction performance of Pt/Ni1Mg2Al1Ox and Pt/Mn1Mg2Al1Ox catalysts.

Cheng Zhang, Yanshan Gao, Naveed Altaf, Qiang Wang,

A series of Ni1Mg2Al1Ox, Mn1Mg2Al1Ox, 0.5Pt/Ni1Mg2Al1Ox and 0.5Pt/Mn1Mg2Al1Ox catalysts were carefully prepared and their NOx storage and reduction (NSR) performance including NOx oxidation efficiency (NOE), NOx storage capacity (NSC), NOx conversion rate (XNO), N2 selectivity (SN2), N2O selectivity (SN2O) and NH3 selectivity (SNH3), was systematically investigated. A SO2 resistance test ... Read more >>

Dalton Trans (Dalton transactions (Cambridge, England : 2003))
[2020, 49(13):3970-3980]

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Conjugation-broken thiophene-based electropolymerized polymers with well-defined structures: effect of conjugation lengths on electrochromic properties.

Ling Zhang, Feifei Luo, Weijun Li, Shuanma Yan, Zhangxin Chen, Ruiyang Zhao, Ning Ren, Yizhao Wu, Yuliang Chen, Cheng Zhang,

A series of monomers containing tetraphenylsilane connected to different thiophenes such as thiophene, bithiophene and terthiophene were designed and synthesized and were further used to prepare the corresponding polymers via electrochemical polymerization (pSiTPTP, pSiTPBTP and pSiTPTTP). From the polymers, the effective conjugate elements were well defined as bithiophene, quaterthiophene and ... Read more >>

Phys Chem Chem Phys (Physical chemistry chemical physics : PCCP)
[2019, 21(43):24092-24100]

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Two-dimensional ZrB2C2 with multiple tunable Dirac states.

Bingwen Zhang, Yuliang Li, Cheng Zhang, Jun Wang,

In this paper, we designed a two-dimensional honeycomb monolayer ZrB2C2, which is predicted to be a stable nanosheet and exhibits favorable mechanical and thermal properties. The Young's modulus of ZrB2C2 is 122.3 N m-1, which is about one third of that of graphene. The ab initio molecular dynamics (AIMD) results ... Read more >>

Phys Chem Chem Phys (Physical chemistry chemical physics : PCCP)
[2019, 21(43):24212-24217]

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Multi-color electrochromism from coordination nanosheets based on a terpyridine-Fe(ii) complex.

Yu Kuai, Weijun Li, Yujie Dong, Wai-Yeung Wong, Shuanma Yan, Yuyu Dai, Cheng Zhang,

A metal complex nanosheet was synthesized by the liquid-liquid interface self-assembly method from a star-shaped ligand of tris[4-(4'-2,2':6',2''-terpyridyl)-phenyl]amine in organic solvents and metal ion Fe(ii) in water solution. The as-prepared nanosheet possessed excessively smooth morphology with a thickness of hundreds of nanometers. Adhering to an ITO glass, the nanosheet showed ... Read more >>

Dalton Trans (Dalton transactions (Cambridge, England : 2003))
[2019, 48(40):15121-15126]

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Mitochondria-targeted [email protected] as bifunctional therapeutic agents for hypoxia imaging and photothermal therapy.

Libing Ke, Cheng Zhang, Xinxing Liao, Kangqiang Qiu, Thomas W Rees, Yu Chen, Zizhuo Zhao, Liangnian Ji, Hui Chao,

Ir(iii) complex modified gold nanorods, [email protected], were developed as mitochondria-targeted theranostic nanoagents. Their hypoxia imaging and photothermal therapeutic properties were demonstrated in vitro and in vivo. ... Read more >>

Chem. Commun. (Camb.) (Chemical communications (Cambridge, England))
[2019, 55(69):10273-10276]

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A metal-free desulfurizing radical reductive C-C coupling of thiols and alkenes.

Qixue Qin, Weijing Wang, Cheng Zhang, Song Song, Ning Jiao,

An intermolecular reductive C-C coupling of electrophilic alkyl radicals and alkenes has been developed. Thiols were used as both hydrogen-donating reagents and alkyl radical precursors in the presence of triethyl phosphite and radical initiator. A wide range of alkenes, including styrenes, and aliphatic olefins were well tolerated in this transformation. ... Read more >>

Chem. Commun. (Camb.) (Chemical communications (Cambridge, England))
[2019, 55(71):10583-10586]

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Aptamer-based regulation of transcription circuits.

Linqiang Pan, Yingxin Hu, Taoli Ding, Chun Xie, Zhiyu Wang, Zhekun Chen, Jing Yang, Cheng Zhang,

We propose synthetic DNA/RNA transcription circuits based on specific aptamer recognition. By mimicking transcription factor regulation, combined with specific enzyme/DNA aptamer binding, multiple biomolecules including DNA, RNA, polymerase, restriction enzymes and methylase were used as regulators. In addition, multi-level cascading networks and methylation-switch circuits were also established. This regulation strategy ... Read more >>

Chem. Commun. (Camb.) (Chemical communications (Cambridge, England))
[2019, 55(51):7378-7381]

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Effects of omega-3 polyunsaturated fatty acids on steroidogenesis and cellular development in PCOS rats.

Xusong Hu, Xuechun Weng, Ye Tian, Chengtao Wang, Yanzhou Yang, Kaili Xu, Cheng Zhang,

Polycystic ovary syndrome (PCOS) is a common endocrine disorder, which is characterized by hyperandrogenism. Polyunsaturated fatty acids (PUFAs) are necessary for the body's metabolism, growth and development. Despite the well-known benefits of omega-3 polyunsaturated fatty acid supplementation on the modulation of PCOS ovarian function, relatively little is known about the ... Read more >>

Food Funct (Food & function)
[2019, 10(5):2504-2514]

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Dramatic impact of auxiliary ligands on the two-step magnetic relaxation process in Dy4(iii) single-molecule magnets.

Kun Zhang, Gao-Peng Li, Cheng Zhang, Yao-Yu Wang,

To better understand the factors determining the multi-step relaxation processes in polynuclear lanthanide single molecule magnets (SMMs), two Dy(iii)4 SMMs showing two-step relaxation processes were elaborately designed and investigated for their structure-dependent magnetic properties. Through targetedly fine-tuning the auxiliary ligand (from the anion of 1-phenylbutane-1,3-dione to 2-acetylcyclopentanone) on specific Dy(iii) ... Read more >>

Dalton Trans (Dalton transactions (Cambridge, England : 2003))
[2019, 48(17):5793-5799]

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Shen-ling-bai-zhu-san ameliorates inflammation and lung injury by increasing the gut microbiota in the murine model of Streptococcus pneumonia-induced pneumonia.

Jinli Feng, Weibo Dai, Cheng Zhang, Houjun Chen, Ziliang Chen, Yongfeng Chen, Qianyi Pan, Yongmao Zhou,

BACKGROUND:Shen-ling-bai-zhu-san (SLBZS) regulates inflammation and gut microbiota which are associated with Streptococcus pneumoniae (Spn)-induced pneumonia. So, we studied the therapeutic effect of SLBZS and evaluated whether gut microbiota is associated with the effects of SLBZS in improving Spn-induced pneumonia. METHODS:Spn-induced pneumonia NIH mice were treated by SLBZS and cefixime. A ... Read more >>

BMC Complement Med Ther (BMC complementary medicine and therapies)
[2020, 20(1):159]

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Posttranslational regulation of the exon skipping machinery controls aberrant splicing in leukemia.

Yalu Zhou, Cuijuan Han, Eric Wang, Adam H Lorch, Valentina Serafin, Byoung-Kyu Cho, Blanca T Guttierrez Diaz, Julien Calvo, Celestia Fang, Alireza Khodadadi-Jamayran, Tommaso Tabaglio, Christian Marier, Anna Kuchmiy, Limin Sun, George Yacu, Szymon K Filip, Qi Jin, Yoh-Hei Takahashi, David R Amici, Emily J Rendleman, Radhika Rawat, Silvia Bresolin, Maddalena Paganin, Cheng Zhang, Hu Li, Irawati Kandela, Yuliya Politanska, Hiam Abdala-Valencia, Marc L Mendillo, Ping Zhu, Bruno Palhais, Pieter Van Vlierberghe, Tom Taghon, Iannis Aifantis, Young Ah Goo, Ernesto Guccione, Adriana Heguy, Aristotelis Tsirigos, Keng Boon Wee, Rama K Mishra, Francoise Pflumio, Benedetta Accordi, Giuseppe Basso, Panagiotis Ntziachristos,

Splicing alterations are common in disease, such as cancer, where mutations in splicing factor genes are frequently responsible for aberrant splicing. Here we present an alternative mechanism for splicing regulation in T cell acute lymphoblastic leukemia (T-ALL), that involves posttranslational stabilization of the splicing machinery via deubiquitination. We demonstrate there ... Read more >>

Cancer Discov (Cancer discovery)
[2020, :]

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Pathways of the COVID-19 Pandemic with Human Mobility across Countries

Cheng Zhang, Li-Xian Qian, Jian-Qiang Hu,

This study develops a holistic view of the novel coronavirus (COVID-19) transmission worldwide through a spatial-temporal model with network dynamics. By using a unique human mobility dataset containing 547,166 flights with a total capacity of 101,455,913 passengers among 22 countries during the past three months, we analyze the associations between ... Read more >>

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Comprehensive analysis of DNA methylation and gene expression profiles in rectal cancer

Cheng Zhang, Di Meng, Songjie Chao, Chunlin Ge,

Abstract Background Abnormal hypomethylation of oncogenes and hypermethylation of tumor suppressor genes play important roles in human tumorigenesis and cancer progression, including those of rectal cancer (RC). However, conjoint analysis of RC involving both gene expression and methylation profiling datasets remains rare. This study aimed to identify methylation-regulated differentially expressed ... Read more >>

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Rapid Generation of Block Copolymer Libraries Using Automated Chromatographic Separation.

Cheng Zhang, Morgan W Bates, Zhishuai Geng, Adam E Levi, Daniel Vigil, Stephanie M Barbon, Tessa Loman, Kris T Delaney, Glenn H Fredrickson, Christopher M Bates, Andrew K Whittaker, Craig J Hawker,

A versatile and scalable strategy is reported for the rapid generation of block copolymer libraries spanning a wide range of compositions starting from a single parent copolymer. This strategy employs automated and operationally simple chromatographic separation that is demonstrated to be applicable to a variety of block copolymer chemistries on ... Read more >>

J. Am. Chem. Soc. (Journal of the American Chemical Society)
[2020, 142(21):9843-9849]

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A systems biology approach for studying neurodegenerative diseases.

Simon Lam, Abdulahad Bayraktar, Cheng Zhang, Hasan Turkez, Jens Nielsen, Jan Boren, Saeed Shoaie, Mathias Uhlen, Adil Mardinoglu,

Neurodegenerative diseases (NDDs), such as Alzheimer's (AD) and Parkinson's (PD), are among the leading causes of lost years of healthy life and exert a great strain on public healthcare systems. Despite being first described more than a century ago, no effective cure exists for AD or PD. Although extensively characterised ... Read more >>

Drug Discov. Today (Drug discovery today)
[2020, :]

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Herbal Medicine in the Treatment of Non-Alcoholic Fatty Liver Diseases-Efficacy, Action Mechanism, and Clinical Application.

Yu Xu, Wei Guo, Cheng Zhang, Feiyu Chen, Hor Yue Tan, Sha Li, Ning Wang, Yibin Feng,

Non-alcoholic fatty liver disease (NAFLD) is a common chronic liver disease with high prevalence in the developed countries. NAFLD has been considered as one of the leading causes of cryptogenic cirrhosis and chronic liver disease. The individuals with obesity, insulin resistance and diabetes mellitus, hyperlipidaemia, and hypertension cardiovascular disease have ... Read more >>

Front Pharmacol (Frontiers in pharmacology)
[2020, 11:]

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Highly Transparent TiO2 Nanowires as Charge-balancing Layers for Assembling Electrochromic Devices: Effect of Thickness on Electrode Potentials and Electrochromic Performance.

Xiaojing Lv, Xinjia Xu, Yujian Zhang, Dominic S Wright, Yongfu Zhang, Cheng Zhang,

TiO2 nanowires with high transparency and good ion storage capacity were explored as the charge-balancing layer for assembling electrochromic devices (ECDs). Increase thickness of TiO2 nanowires layer lowers the driving potential of the entire ECDs accompanied with reduced potential at the EC layer electrode, which further leads to decreased optical ... Read more >>

Nanotechnology (Nanotechnology)
[2020, :]

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An efficient electrochromic supercapacitor based on solution-processable nanoporous poly(tris[4-(3,4-ethylenedioxythiophene) phenyl]amine).

Yaokang Lv, Xing Yang, Weishi Du, Peihua Ma, Antoine Bonnefont, Dominic Wright, Laurent Ruhlmann, Cheng Zhang,

A new green-synthetic route to the tris[4-(3,4-ethylenedioxythiophene)phenyl]amine (TEPA) monomer has been developed and the molecular structure of TEPA determined by a single-crystal X-ray study for the first time. Solution-processable nanoporous poly(tris[4-(3,4-ethylenedioxythiophene)phenyl]amine) (PTEPA) was prepared via chemical-oxidative polymerization in a microemulsion. Based on the distorted structure of TEPA found in the ... Read more >>

ChemSusChem (ChemSusChem)
[2020, :]

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Transvesical robot-assisted radical prostatectomy: initial experience and surgical outcomes.

Xiaochen Zhou, Bin Fu, Cheng Zhang, Weipeng Liu, Ju Guo, Luyao Chen, Enjun Lei, Xu Zhang, Gongxian Wang,

OBJECTIVES:To describe in detail the techniques for transvesical robot-assisted radical prostatectomy (RARP) using the da Vinci Si/Xi system (Intuitive Surgical, Sunnyvale, CA, USA) and to evaluate functional and oncological outcomes in 35 patients with prostate cancer. PATIENTS AND METHODS:Thirty-five patients with localized prostate cancer were enrolled for transvesical RARP. The ... Read more >>

BJU Int. (BJU international)
[2020, :]

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Herbal Medicine in the Treatment of Non-Alcoholic Fatty Liver Diseases-Efficacy, Action Mechanism, and Clinical Application.

Yu Xu, Wei Guo, Cheng Zhang, Feiyu Chen, Hor Yue Tan, Sha Li, Ning Wang, Yibin Feng,

Non-alcoholic fatty liver disease (NAFLD) is a common chronic liver disease with high prevalence in the developed countries. NAFLD has been considered as one of the leading causes of cryptogenic cirrhosis and chronic liver disease. The individuals with obesity, insulin resistance and diabetes mellitus, hyperlipidaemia, and hypertension cardiovascular disease have ... Read more >>

Front Pharmacol (Frontiers in pharmacology)
[2020, 11:601]

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Tuning of the Aggregation Behavior of Fluorinated Polymeric Nanoparticles for Improved Therapeutic Efficacy.

Cheng Zhang, Tianqing Liu, Wenqian Wang, Craig A Bell, Yanxiao Han, Changkui Fu, Hui Peng, Xiao Tan, Petr Král, Katharina Gaus, J Justin Gooding, Andrew K Whittaker,

Incorporation of fluorinated moieties in polymeric nanoparticles has been shown in many instances to increase their uptake by living cells and, hence, has proven to be a useful approach to enhancing delivery to cells. However, it remains unclear how incorporation of fluorine affects critical transport processes, such as interactions with ... Read more >>

ACS Nano (ACS nano)
[2020, :]

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Hsa_circ_0068307 mediates bladder cancer stem cell-like properties via miR-147/c-Myc axis regulation.

Qi Chen, Qiuping Yin, Yemeng Mao, Zheyu Zhang, Siqi Wu, Zhang Cheng, Xinan Chen, Hanren Xu, Shengming Jin, Haowen Jiang, Chen Yang,

Background:Circular RNAs (circRNAs) play an essential role in the regulation of gene expression. However, the underlying mechanisms remain unknown. This study aimed to evaluate the role of hsa_circ_0068307 in bladder cancer (BCa). Methods:Rt-qPCR was used to detect hsa_circ_0068307 expression in BCa cell lines. The CCK8, colony formation, and Transwell assays ... Read more >>

Cancer Cell Int. (Cancer Cell International)
[2020, 20:151]

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Endoscopic Endonasal Approach for Resection of Tuberculum Sellae Meningioma: A Promising Surgical Approach.

Cheng Zhang, Jianling Ding, Ye Liu, Maimaitiyiming Tuoheti, Xiaopeng Yang, Jichao Wang, Yonggang Wu,

BACKGROUND:Over the past decade, endoscopic approaches have been increasingly successful in removing various types of extra-dural lesions from the skull base. Resection of tuberculum sellae meningiomas (TSMs) is challenging. The endoscopic endonasal approach (EEA) for the removal of TSMs is currently an acceptable surgical approach in neurosurgery and, despite the ... Read more >>

J Craniofac Surg (The Journal of craniofacial surgery)
[2020, :]

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Rho/SMAD/mTOR triple inhibition enables long-term expansion of human neonatal tracheal aspirate-derived airway basal cell-like cells.

Junjie Lu, Xiaobo Zhu, Jessica E Shui, Linjie Xiong, Todd Gierahn, Cheng Zhang, Michael Wood, Suzanne Hally, J Christopher Love, Hu Li, Benjamin C Crawford, Hongmei Mou, Paul H Lerou,

BACKGROUND:Bronchopulmonary dysplasia remains one of the most common complications of prematurity, despite significant improvements in perinatal care. Functional modeling of human lung development and disease, like BPD, is limited by our ability to access the lung and to maintain relevant progenitor cell populations in culture. METHODS:We supplemented Rho/SMAD signaling inhibition ... Read more >>

Pediatr. Res. (Pediatric research)
[2020, :]

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