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Repurposing existing drugs: identification of SARS-CoV-2 3C-like protease inhibitors.

Wei-Chung Chiou, Meng-Shiuan Hsu, Yun-Ti Chen, Jinn-Moon Yang, Yeou-Guang Tsay, Hsiu-Chen Huang, Cheng Huang,

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is responsible for coronavirus disease 2019 (COVID-19). Since its emergence, the COVID-19 pandemic has not only distressed medical services but also caused economic upheavals, marking urgent the need for effective therapeutics. The experience of combating SARS-CoV and MERS-CoV has shown that inhibiting the ... Read more >>

J Enzyme Inhib Med Chem (Journal of enzyme inhibition and medicinal chemistry)
[2021, 36(1):147-153]

Cited: 3 times

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[Characteristics and Control Strategies on Summertime Peak Ozone Concentration in Shanghai].

Ru-Sha Yan, Hong-Li Wang, Cheng Huang, Qian Wang, Jing-Yu An,

With the continuous development of air pollution control measures, the concentration of PM<sub>2.5</sub> in Shanghai has shown a conspicuous downward trend in recent years. However, frequent O<sub>3</sub> pollution events have highlighted the urgent need to explore the occurrence patterns of O<sub>3</sub> pollution and develop scientific strategies for reducing O<sub>3</sub> peaks. ... Read more >>

Huan Jing Ke Xue (Huan jing ke xue= Huanjing kexue)
[2021, 42(8):3577-3584]

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Transition from N to P limited soil nutrients over time since restoration in degraded subtropical broadleaved mixed forests

Shaobo Yang, Chun Feng, Yuhua Ma, Wenjing Wang, Cheng Huang, Changjian Qi, Songling Fu, Han Y H Chen,

Soil stoichiometry (C:N:P ratio) is an important indicator of soil fertility and plant nutrient status. To understand the impacts of the long-term restoration of degraded subtropical broadleaved mixed forests on soil stoichiometry, we employed a chronosequence to examine the responses of soil nutrient and C-N-P stoichiometry at three soil depths ... Read more >>

For Ecol Manage (Forest ecology and management.)
[2021, 494:Not Available]

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CircRNA UBAP2 serves as a sponge of miR-1294 to increase tumorigenesis in hepatocellular carcinoma through regulating c-Myc expression.

Min-Cheng Yu, Guang-Yu Ding, Peng Ma, Yue-Da Chen, Xiao-Dong Zhu, Jia-Bin Cai, Ying-Hao Shen, Jian Zhou, Jia Fan, Hui-Chuan Sun, Ming Kuang, Cheng Huang,

Circular RNAs (circRNAs) are a class of regulatory RNAs with complex roles in healthy and diseased tissues. However, the oncogenic role of circRNAs in hepatocellular carcinoma (HCC) remains poorly understood, including the mechanisms by which the circular ubiquitin binding associated protein 2 (circUBAP2) contributes to tumorigenesis. We analyzed the expression ... Read more >>

Carcinogenesis (Carcinogenesis)
[2021, :]

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Trifluoro-icaritin alleviates mechanical hypersensitivity and improves motor coordination and balance in rats with spared nerve injury-induced neuropathic pain.

Dandan Jia, Yalan Sun, Guangsen Liu, Meng Xue, Zhihua Huang, Cheng Huang,

Neuropathic pain is still one of the unsolved public health problems worldwide. Although the current reagents can attenuate neuropathic pain to a certain extent, their clinical application is very limited owing to larger toxicity and serious side effects. Trifluoro-icaritin (ICTF) has been documented to possess profound anti-inflammatory and neuroprotective activities, ... Read more >>

Neurosci Lett (Neuroscience letters)
[2021, :136125]

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Cu2+-modified MOF as laccase-mimicking material for colorimetric determination and discrimination of phenolic compounds with 4-aminoantipyrine.

Cong Yi Hu, Zhong Wei Jiang, Cheng Zhi Huang, Yuan Fang Li,

Based on the laccase-mimicking activity of Cu<sup>2+</sup>-modified University of Oslo (UiO) metal-organic framework (UiO-67-Cu<sup>2+</sup>), we developed a colorimetric sensor array for distinguishing a series of phenols with different number and position of substituted hydroxyl group (-OH) and different substituent group on the benzene ring, including phenol, catechol, quinol, resorcinol, pyrogallol, phloroglucinol, ... Read more >>

Mikrochim Acta (Mikrochimica acta)
[2021, 188(8):272]

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The Influence of Varicocele and Microsurgical Varicocelectomy on Semen Quality, as Determined by Metabolic Analysis

Xinzong Zhang, Cuncan Deng, Wujiang Liu, Huang Liu, Yu Zhou, Qianyi Li, Houbin Zheng, Qiling Wang, Min Jiang, Tao Pang, Chunjie Ma, Cheng Huang, qingguo Zhao, Yunge Tang,

The influence of varicocele and microsurgical varicocelectomy on semen quality remains unclear. No previous study has investigated the relationship between semen metabolism and the abnormalities in reproductive function caused by varicocele. Here, we used the non-targeted and targeted metabolic analysis to investigate the different metabolites in seminal plasma within normal, ... Read more >>

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Rev-erbα exacerbates hepatic steatosis in alcoholic liver diseases through regulating autophagy.

Qingxue Liu, Lei Xu, Meifei Wu, Yiwen Zhou, Junfa Yang, Cheng Huang, Tao Xu, Jun Li, Lei Zhang,

<h4>Background and aims</h4>Alcoholic fatty liver (AFL) is a liver disease caused by long-term excessive drinking and is characterized by hepatic steatosis. Understanding the regulatory mechanism of steatosis is essential for the treatment of AFL. Rev-erbα is a member of the Rev-erbs family of nuclear receptors, playing an important role in ... Read more >>

Cell Biosci (Cell & bioscience)
[2021, 11(1):129]

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Super-Enhancer-Associated TMEM44-AS1 Aggravated Glioma Progression by Forming a Positive Feedback Loop With Myc

Erbao Bian, Xueran Chen, Li Cheng, Meng Cheng, Zhigang Chen, Xiaoyu Yue, Zhengwei Zhang, Jie Chen, Libo Sun, Kebing Huang, Cheng Huang, Zhiyou Fang, Bing Zhao, Jun Li,

<h4>Background: </h4> Long non-coding RNAs (lncRNAs) have been considered as one type of gene expression regulator for cancer development, but it is not clear how these are regulated. This study aimed to identify a specific lncRNA that promotes the glioma progression.MethodsRNA sequencing (RNA-seq) and quantitative real-time PCR were performed to ... Read more >>

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METTL3 Promotes Activation and Inflammation of FLSs Through the NF-κB Signaling Pathway in Rheumatoid Arthritis.

Wen Shi, Yan Zheng, Shuai Luo, Xiaofeng Li, Yilong Zhang, Xiaoming Meng, Cheng Huang, Jun Li,

Rheumatoid arthritis (RA), a common autoimmune disease, is extremely damaging to human health. Fibroblast-like synoviocytes (FLSs) have a vital role in the occurrence and development of RA. Methyltransferase-like 3 (METTL3), which is a crucial component of the <i>N</i> <sup>6</sup>-methyladenosine (m<sup>6</sup>A) methyltransferase complex, is involved in the progression of many diseases. ... Read more >>

Front Med (Lausanne) (Frontiers in medicine)
[2021, 8:607585]

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Combination Foretinib and Anti-PD-1 Antibody Immunotherapy for Colorectal Carcinoma.

Yuyin Fu, Yujia Peng, Shengyan Zhao, Jun Mou, Lishi Zeng, Xiaohua Jiang, Chengli Yang, Cheng Huang, Yuyan Li, Yin Lu, Mengdan Wu, Yanfang Yang, Ting Kong, Qinhuai Lai, Yangping Wu, Yuqin Yao, Yuxi Wang, Lantu Gou, Jinliang Yang,

Immune checkpoint inhibitors have achieved unprecedented success in cancer immunotherapy. However, the overall response rate to immune checkpoint inhibitor therapy for many cancers is only between 20 and 40%, and even less for colorectal cancer (CRC) patients. Thus, there is an urgent need to develop an efficient immunotherapeutic strategy for ... Read more >>

Front Cell Dev Biol (Frontiers in cell and developmental biology)
[2021, 9:689727]

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Safety but Limited Efficacy of Ensartinib in ROS1-Positive Non-small Cell Lung Cancer: A Single-arm, Multicenter Phase II study.

Xinghao Ai, Qiming Wang, Ying Cheng, Xiaoqing Liu, Lejie Cao, Jianhua Chen, Xiaorong Dong, Jianying Zhou, Yun Fan, Cheng Huang, Jiuwei Cui, Yan Wang, Gongyan Chen, Cuimin Ding, Beili Gao, Xingya Li, Ziping Wang, Helong Zhang, Lieming Ding, Yang Wang, Xiaobin Yuan, Hongke Cheng, Tao Wang, Shun Lu,

<h4>Introduction</h4>Some Anaplastic lymphoma kinase (ALK) inhibitors with good inhibition of ROS1 in preclinical studies has been reported possibly beneficial in ROS1-positive non-small cell lung cancer (NSCLC). In this work, we studied the efficacy and safety of ensartinib in the treatment of patients with ROS1-positive NSCLC.<h4>Methods</h4>The exploratory study was a phase ... Read more >>

J Thorac Oncol (Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer)
[2021, :]

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Macrophages-Derived, LRG1-Enriched Extracellular Vesicles Exacerbate Aristolochic Acid Nephropathy Via A TGFβR1-Dependent Manner

Wenjuan Jiang, Jiahui Dong, Changlin Du, Chuanting Xu, Songbing Xu, Rui Feng, Cheng Huang, Jun Li, Taotao Ma,

Aristolochic acid nephropathy (AAN) is a progressive kidney disease caused by some herbal medicines, but treatment remains ineffective. We previously found NADPH oxidases 4 (NOX4), which regulates oxidative stress, play an important role in kidney injury model. However, its regulatory mechanism of action in AAN is still obscure. In this ... Read more >>

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Tumor-Associated Macrophages in Hepatocellular Carcinoma: Friend or Foe?

Dexi Zhou, Jiajie Luan, Cheng Huang, Jun Li,

Hepatocellular carcinoma (HCC) is one of the most common malignancies worldwide, and it has diverse etiologies with multiple mechanisms. The diagnosis of HCC typically occurs at advanced stages when there are limited therapeutic options. Hepatocarcinogenesis is considered a multistep process, and hepatic macrophages play a critical role in the inflammatory ... Read more >>

Gut Liver (Gut and liver)
[2021, 15(4):500-516]

Cited: 5 times

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Delayed Discharge after Thoracic Surgery under the Guidance of ERAS Protocols.

Lei Liu, Jiaqi Zhang, Guige Wang, Chao Guo, Yeye Chen, Cheng Huang, Shanqing Li,

<h4>Background</h4> Enhanced recovery after surgery (ERAS) protocols have been applied in thoracic surgery and are beneficial to patients. However, some issues about ERAS are still pending.<h4>Methods</h4> A total of 1,654 patients who underwent thoracic surgery under the guidance of ERAS protocols were enrolled in this study. We set the length of postoperative ... Read more >>

Thorac Cardiovasc Surg (The Thoracic and cardiovascular surgeon)
[2021, :]

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Role of the F-BAR Family Member PSTPIP2 in Autoinflammatory Diseases.

Jie-Jie Xu, Hai-Di Li, Xiao-Sa Du, Juan-Juan Li, Xiao-Ming Meng, Cheng Huang, Jun Li,

Proline-serine-threonine-phosphatase-interacting protein 2 (PSTPIP2) belongs to the Fes/CIP4 homology-Bin/Amphiphysin/Rvs (F-BAR) domain family. It exhibits lipid-binding, membrane deformation, and F-actin binding activity, suggesting broader roles at the membrane-cytoskeleton interface. PSTPIP2 is known to participate in macrophage activation, neutrophil migration, cytokine production, and osteoclast differentiation. In recent years, it has been observed ... Read more >>

Front Immunol (Frontiers in immunology)
[2021, 12:585412]

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The miR-455-3p/HDAC2 axis plays a pivotal role in the progression and reversal of liver fibrosis and is regulated by epigenetics.

Hongmei You, Ling Wang, Fangtian Bu, Hongwu Meng, Xueyin Pan, Juanjuan Li, Yafei Zhang, Ao Wang, Nana Yin, Cheng Huang, Jun Li,

Histone deacetylases (HDACs), especially HDAC2, play a role in alleviating liver fibrosis; however, the specific upstream regulation mechanism is unknown. Herein, TargetScan was used to predict the potential upstream targets of HDAC2, and the role of miR-455-3p was explored. The dual luciferase reporter assay showed that miR-455-3p binds to the ... Read more >>

FASEB J (FASEB journal : official publication of the Federation of American Societies for Experimental Biology)
[2021, 35(7):e21700]

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Ultrasensitive detection of circulating tumour DNA via deep methylation sequencing aided by machine learning.

Naixin Liang, Bingsi Li, Ziqi Jia, Chenyang Wang, Pancheng Wu, Tao Zheng, Yanyu Wang, Fujun Qiu, Yijun Wu, Jing Su, Jiayue Xu, Feng Xu, Huiling Chu, Shuai Fang, Xingyu Yang, Chengju Wu, Zhili Cao, Lei Cao, Zhongxing Bing, Hongsheng Liu, Li Li, Cheng Huang, Yingzhi Qin, Yushang Cui, Han Han-Zhang, Jianxing Xiang, Hao Liu, Xin Guo, Shanqing Li, Heng Zhao, Zhihong Zhang,

The low abundance of circulating tumour DNA (ctDNA) in plasma samples makes the analysis of ctDNA biomarkers for the detection or monitoring of early-stage cancers challenging. Here we show that deep methylation sequencing aided by a machine-learning classifier of methylation patterns enables the detection of tumour-derived signals at dilution factors ... Read more >>

Nat Biomed Eng (Nature biomedical engineering)
[2021, 5(6):586-599]

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Red blood cell distribution width predicts residual renal function decline in patients undergoing continuous ambulatory peritoneal dialysis.

You Q Li, Jian X Bai, Yu F Tang, Ke X Lin, Cheng W Huang, Yong J Shi,

To investigate the relationship between red blood cell distribution width (RDW) and residual renal function (RRF) in patients undergoing continuous ambulatory peritoneal dialysis (CAPD). Seventy-seven CAPD patients were enrolled in this study. According to receiver operator characteristic (ROC) curve analysis, patients were divided into high RDW (RDW > 14.95%) and low RDW ... Read more >>

Ther Apher Dial (Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy)
[2021, :]

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Allometric Models for Aboveground Biomass of Six Common Subtropical Shrubs and Small Trees

Cheng Huang, Chun Feng, Yuhua Ma, Hua Liu, Zhaocheng Wang, Shaobo Yang, Wenjing Wang, Songling Fu, Han Chen,

<h4>Background: </h4> The aboveground biomass (AGB) of shrubs and small trees is the main component for the productivity and carbon storage of understory vegetation in subtropical natural secondary forests. However, few allometric models exist for shrubs and small trees, even though they can accurately evaluate understory vegetative biomass. <h4>Methods: </h4>: ... Read more >>

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Alternative activation of macrophages by prostacyclin synthase ameliorates alcohol induced liver injury.

Xue-Yin Pan, Ling Wang, Hong-Mei You, Miao Cheng, Yang Yang, Cheng Huang, Jun Li,

Alcoholic liver disease (ALD) is a major cause of chronic liver disease worldwide. Macrophages exhibit different functional states and are classified as classically activated (M1) and alternatively activated (M2) macrophages. However, the mechanisms that govern M1/M2 polarization in chronic ALD remain to be elucidated. Prostacyclin (PGI<sub>2</sub>) synthase (PTGIS) is an ... Read more >>

Lab Invest (Laboratory investigation; a journal of technical methods and pathology)
[2021, :]

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Wide-range lifetime-tunable and responsive ultralong organic phosphorescent multi-host/guest system.

Zongliang Xie, Xiayu Zhang, Hailan Wang, Cheng Huang, Haodong Sun, Mengyang Dong, Lei Ji, Zhongfu An, Tao Yu, Wei Huang,

The rational lifetime-tuning strategy of ultralong organic phosphorescence is extraordinarily important but seldom reported. Herein, a series of multi-host/guest ultralong organic phosphorescence materials with dynamic lifetime-tuning properties were reported. By doping a non-room-temperature phosphorescence emitter into various solid host matrices with continuously reduced triplet energy levels, a wide-range lifetime (from ... Read more >>

Nat Commun (Nature communications)
[2021, 12(1):3522]

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Asperuloside ameliorates lipopolysaccharide-induced primary human periodontal ligament cell injury by decreasing TLR4 expression and NF-κB activation.

Xiaodan Fan, Chun Zhou, Cheng Huang, Junye Zhang,

<h4>Objective</h4>The mechanism underlying lipopolysaccharide (LPS)-induced primary human periodontal ligament (PDLC) cell injury is unclear. In this study, we focused on the therapeutic function of asperuloside (ASP) on LPS-induced cell injury.<h4>Design</h4>The study enrolled 41 participants, including 18 healthy controls and 23 CP patients. Western blotting was used to measure the expression ... Read more >>

Arch Oral Biol (Archives of oral biology)
[2021, 129:105199]

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Universal quantum phase transition from superconducting to insulating-like states in pressurized Bi2Sr2CaCu2O8+δ superconductors

Liling Sun, Yazhou Zhou, Jing Guo, Shu Cai, Jinyu Zhao, Genda Gu, Chengtian Lin, Hongtao Yan, Cheng Huang, Chongli Yang, Sijin Long, Yu Gong, Yanchun Li, Xiaodong Li, Qi Wu, Jiangping Hu, Xingjiang Zhou, Tao Xiang,

Copper oxide superconductors have been continually fascinating the communities of condensed matter physics and material sciences because they host the highest ambient-pressure superconducting transition temperature ( T c ) and mysterious physics 1–3. Searching for the universal correlation between the superconducting state and its normal state or neighboring ground state ... Read more >>

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The Emerging Roles of Pericytes in Modulating Tumor Microenvironment.

Ruipu Sun, Xiangzhan Kong, Xiaoyi Qiu, Cheng Huang, Ping-Pui Wong,

Pericytes (PCs), known as mural cells, play an important blood vessel (BV) supporting role in regulating vascular stabilization, permeability and blood flow in microcirculation as well as blood brain barrier. In carcinogenesis, defective interaction between PCs and endothelial cells (ECs) contributes to the formation of leaky, chaotic and dysfunctional vasculature ... Read more >>

Front Cell Dev Biol (Frontiers in cell and developmental biology)
[2021, 9:676342]

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