Full Text Journal Articles by
Author Chel Hun Choi

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Survival Effects of Cytoreductive Surgery for Refractory Patients after Neoadjuvant Chemotherapy in Advanced Epithelial Ovarian Cancer.

Wonkyo Shin, Joseph J Noh, Sang Soo Seo, Sokbom Kang, Chel Hun Choi, Sang Yoon Park, Byoung Gie Kim, Myong Cheol Lim,

<h4>Purpose</h4>Salvage second-line chemotherapy is usually recommended for patients with advanced epithelial ovarian cancer (AEOC) who develop progressive disease (PD) after neoadjuvant chemotherapy (NAC). Herein, we investigated the role of cytoreductive surgery (CRS) for such patients.<h4>Materials and methods</h4>We retrospectively reviewed the medical records of 36 patients with AEOC who developed PD ... Read more >>

Yonsei Med J (Yonsei medical journal)
[2020, 61(11):935-941]

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Olaparib tablets as maintenance therapy in patients with platinum-sensitive relapsed ovarian cancer and a BRCA1/2 mutation (SOLO2/ENGOT-Ov21): a final analysis of a double-blind, randomised, placebo-controlled, phase 3 trial.

Andrés Poveda, Anne Floquet, Jonathan A Ledermann, Rebecca Asher, Richard T Penson, Amit M Oza, Jacob Korach, Tomasz Huzarski, Sandro Pignata, Michael Friedlander, Alessandra Baldoni, Tjoung-Won Park-Simon, Kenji Tamura, Gabe S Sonke, Alla Lisyanskaya, Jae-Hoon Kim, Elias Abdo Filho, Tsveta Milenkova, Elizabeth S Lowe, Phil Rowe, Ignace Vergote, Eric Pujade-Lauraine, ,

<h4>Background</h4>Olaparib, a poly (ADP-ribose) polymerase (PARP) inhibitor, has previously been shown to extend progression-free survival versus placebo when given to patients with relapsed high-grade serous or endometrioid ovarian cancer who were platinum sensitive and who had a BRCA1 or BRCA2 (BRCA1/2) mutation, as part of the SOLO2/ENGOT-Ov21 trial. The aim ... Read more >>

Lancet Oncol (The Lancet. Oncology)
[2021, :]

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Metabolic syndrome and persistent cervical human papillomavirus infection.

Jieun Lee, Hye Seung Kim, Kyunga Kim, Duk-Soo Bae, Byoung-Gie Kim, Chel Hun Choi,

<h4>Objective</h4>Few studies have been conducted on the relationship between metabolic syndrome (MetS) and persistent human papillomavirus (HPV) infection. We investigated whether MetS and associated factors can predict the persistence of HPV infection.<h4>Patients and methods</h4>We performed a retrospective cohort study of 80,993 female cases undergoing general medical screenings at Samsung Medical ... Read more >>

Gynecol Oncol (Gynecologic oncology)
[2021, :]

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A single-arm phase II study of olaparib maintenance with pembrolizumab and bevacizumab in BRCA non-mutated patients with platinum-sensitive recurrent ovarian cancer (OPEB-01).

Yong Jae Lee, Myong Cheol Lim, Byoung Gie Kim, Natalie Yl Ngoi, Chel Hun Choi, Sang Yoon Park, David Sp Tan, Yunjung Go, Jung Yun Lee,

<h4>Background</h4>The optimal treatment of <i>BRCA</i> wild-type patients with platinum-sensitive recurrent ovarian cancer remains unknown. Recently, there is an increase in the evidence to support the role of the combination of a poly(adenosine diphosphate-ribose) polymerase inhibitor, anti-angiogenic agents, and immunotherapy as maintenance therapy in <i>BRCA</i> wild-type patients with platinum-sensitive recurrence. We ... Read more >>

J Gynecol Oncol (Journal of gynecologic oncology)
[2021, 32(2):e31]

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Vulvar epithelioid sarcoma: A case report with literature review.

Joseph J Noh, Jung-Eun Jeon, Hera Jung, Hyun-Soo Kim, Yoo-Young Lee, Chel Hun Choi, Jeong-Won Lee,

<h4>Objective</h4>To report a case of vulvar epithelioid sarcoma, a rare type of tumor that has been reported in 37 cases in the English literature to date.<h4>Case report</h4>We report three cases of vulvar epithelioid sarcoma, proximal type. Wide excisions of the mass were performed with margins free of tumor in all ... Read more >>

Taiwan J Obstet Gynecol (Taiwanese journal of obstetrics & gynecology)
[2021, 60(1):132-135]

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Early Metabolic Response Assessed Using 18F-FDG-PET/CT for Image-Guided Intracavitary Brachytherapy Can Better Predict Treatment Outcomes in Patients with Cervical Cancer.

Nalee Kim, Won Park, Won Kyung Cho, Duk-Soo Bae, Byoung-Gie Kim, Jeong-Won Lee, Tae-Joong Kim, Chel Hun Choi, Yoo-Young Lee, Young Seok Cho,

<h4>Purpose</h4>This study aimed to identify the prognostic value of early metabolic response assessed using 18F-fluorodeoxyglucose positron emission tomography/computed tomography (FDG-PET/CT) during radiation therapy (RT) for cervical cancer.<h4>Materials and methods</h4>We identified 116 patients treated with definitive RT, including FDG-PET/CT-guided intracavitary brachytherapy, between 2009 and 2018. We calculated parameters including maximum (SUVmax) ... Read more >>

Cancer Res Treat (Cancer research and treatment)
[2020, :]

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Prognostic Significance of Tumor Regression Rate during Concurrent Chemoradiotherapy in Locally Advanced Cervix Cancer: Analysis by Radiation Phase and Histologic Type.

Jun-Hyeok Kang, Won Kyung Cho, Hie Jun Yeo, Soo Young Jeong, Joseph J Noh, Jung In Shim, Yoo-Young Lee, Tae-Joong Kim, Jeong-Won Lee, Byoung-Gie Kim, Duk-Soo Bae, Won Park, Chel Hun Choi,

This study aimed to evaluate the prognostic significance of tumor regression rate according to radiation phase and histologic subtype in patients with locally advanced cervical cancer (LACC) treated with chemoradiation. We retrospectively reviewed the medical records of 398 patients with FIGO stage IIB-IVA cervical cancer treated with concurrent chemoradiotherapy (CCRT) ... Read more >>

J Clin Med (Journal of clinical medicine)
[2020, 9(11):]

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Feasibility of Single-Port Access (SPA) Laparoscopy for Large Ovarian Tumor Suspected to Be Borderline Ovarian Tumor.

Jun-Hyeok Kang, Joseph J Noh, Soo Young Jeong, Jung In Shim, Yoo-Young Lee, Chel Hun Choi, Jeong-Won Lee, Byoung-Gie Kim, Duk-Soo Bae, Hyun-Soo Kim, Tae-Joong Kim,

<h4>Objectives</h4>To compare the surgical, pathological and oncological outcomes of single-port access (SPA) laparoscopy against laparotomy for large ovarian tumor (>15 cm) suspected to be a borderline ovarian tumor (BOT) on preoperative imaging.<h4>Methods</h4>A retrospective review of the patients who underwent SPA laparoscopy (SPA Group) or laparotomy (Laparotomy Group) for suspected BOT ... Read more >>

Front Oncol (Frontiers in oncology)
[2020, 10:583515]

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The Prognostic Model of Pre-Treatment Complete Blood Count (CBC) for Recurrence in Early Cervical Cancer.

Joseph J Noh, Myong Cheol Lim, Moon-Hong Kim, Yun Hwan Kim, Eun Seop Song, Seok Ju Seong, Dong Hoon Suh, Jong-Min Lee, Chulmin Lee, Chel Hun Choi,

The aim of the present study was to investigate the prognostic role of the pre-treatment complete blood count (CBC) profile as a predictive marker of survival, recurrence, and death in early stage squamous cell carcinoma and adenocarcinoma of the cervix. The pre-treatment CBC profiles of the patients from nine tertiary ... Read more >>

J Clin Med (Journal of clinical medicine)
[2020, 9(9):]

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A multicenter phase II randomized trial of durvalumab (MEDI-4736) versus physician's choice chemotherapy in recurrent ovarian clear cell adenocarcinoma (MOCCA).

Natalie Yl Ngoi, Valerie Heong, Samuel Ow, Wen Yee Chay, Hee Seung Kim, Chel Hun Choi, Geraldine Goss, Jeffrey C Goh, Bee Choo Tai, Diana Gz Lim, Nivashini Kaliaperumal, Veonice B Au, John E Connolly, Jae-Weon Kim, Michael Friedlander, Kidong Kim, David Sp Tan,

<h4>Background</h4>The optimal treatment of recurrent ovarian clear cell carcinoma remains unknown. There is increasing rationale to support the role of immune checkpoint inhibitors targeting the programmed cell death protein 1 (PD<i>-</i>1)/programmed death-ligand 1 (PD-L1) axis in ovarian clear cell carcinoma.<h4>Primary objective</h4>To evaluate the efficacy of durvalumab (MEDI-4736) compared with standard ... Read more >>

Int J Gynecol Cancer (International journal of gynecological cancer : official journal of the International Gynecological Cancer Society)
[2020, 30(8):1239-1242]

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Comparison of Laparoscopy and Laparotomy for Para-Aortic Lymphadenectomy in Women With Presumed Stage I-II High-Risk Endometrial Cancer.

E Sun Paik, Seung Hun Baek, Jun Hyeok Kang, Soo Young Jeong, Myeong Seon Kim, Woo Young Kim, Yoo-Young Lee, Chel Hun Choi, Jeong-Won Lee, Byoung-Gie Kim, Duk-Soo Bae, Tae-Joong Kim,

<b>Objective:</b> To compare laparoscopic surgery to laparotomy for harvesting para-aortic lymph nodes in presumed stage I-II, high-risk endometrial cancer patients. <b>Methods:</b> Patients with histologically proven endometrial cancer, presumed stage I-II with high-risk tumor features who had undergone hysterectomy, bilateral salpingoophorectomy, or pelvic and para-aortic lymphadenectomy by either laparoscopy or laparotomy ... Read more >>

Front Oncol (Frontiers in oncology)
[2020, 10:451]

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Prognostic significance of USP10 and p14ARF expression in patients with colorectal cancer.

Kyungeun Kim, Tom Huh, Yoonho Park, Dong-Hoe Koo, Hungdai Kim, Ilseon Hwang, Chel Hun Choi, Joo Mi Yi, Joon-Yong Chung,

Ubiquitin-specific proteases (USPs) play an important role in fundamental cellular processes. Among these, USP10 is known for its association with tumor development and progression of multiple cancers. We aimed to investigate the clinical significance of USP10 expression in colorectal cancer and examined the potential link between USP10 and p14ARF in ... Read more >>

Pathol Res Pract (Pathology, research and practice)
[2020, 216(6):152988]

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Identification of Candidate Genes Associated with Susceptibility to Ovarian Clear Cell Adenocarcinoma Using cis-eQTL Analysis.

Jihye Kim, Joon-Yong Chung, Jae Ryoung Hwang, Yoo-Young Lee, Tae-Joong Kim, Jeong-Won Lee, Byoung-Gie Kim, Duk-Soo Bae, Chel Hun Choi, Stephen M Hewitt,

Ovarian clear cell adenocarcinoma (Ov-CCA) has a higher prevalence in the Japanese ancestry than other populations. The ancestral disparities in Ov-CCA prevalence suggests the presence of Ov-CCA-specific genetic alterations and may provide an opportunity to identify the novel genes associated with Ov-CCA tumorigenesis. Using 94 previously reported genes as the ... Read more >>

J Clin Med (Journal of clinical medicine)
[2020, 9(4):]

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Chemoradiotherapy response prediction model by proteomic expressional profiling in patients with locally advanced cervical cancer.

Chel Hun Choi, Joon-Yong Chung, Jun Hyeok Kang, E Sun Paik, Yoo-Young Lee, Won Park, Sun-Ju Byeon, Eun Joo Chung, Byoung-Gie Kim, Stephen M Hewitt, Duk-Soo Bae,

<h4>Objective</h4>Resistance to chemo-radiation therapy is a substantial obstacle that compromises treatment of advanced cervical cancer. The objective of this study was to investigate if a proteomic panel associated with radioresistance could predict survival of patients with locally advanced cervical cancer.<h4>Methods</h4>A total of 181 frozen tissue samples were prospectively obtained from ... Read more >>

Gynecol Oncol (Gynecologic oncology)
[2020, 157(2):437-443]

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Decreased expression of ubiquitin-specific protease 10 correlates unfavorable prognosis in colorectal cancer

Kyungeun Kim, Tom Huh, Yoonho Park, Dong-Hoe Koo, Hungdai Kim, Ilseon Hwang, Chel Hun Choi, Joo Mi Yi, Joon-Yong Chung,

<h4>Background: </h4> Ubiquitin-specific proteases (USPs) play an important role in fundamental cellular processes. Among these, USP10 is known for its association with tumor development and progression of multiple cancers. Here, we found a potential link between USP10 and p14ARF in colorectal cancer. <h4>Methods:</h4> USP10 and p14ARF protein expression was assessed ... Read more >>

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Preclinical assessment of the VEGFR inhibitor axitinib as a therapeutic agent for epithelial ovarian cancer.

E Sun Paik, Tae-Hyun Kim, Young Jae Cho, Jiyoon Ryu, Jung-Joo Choi, Yoo-Young Lee, Tae-Joong Kim, Chel-Hun Choi, Woo Young Kim, Jason K Sa, Jin-Ku Lee, Byoung-Gie Kim, Duk-Soo Bae, Hee Dong Han, Hyung Jun Ahn, Jeong-Won Lee,

Axitinib, small molecule tyrosine kinase inhibitor, demonstrates anti-cancer activity for various solid tumors. We investigated anti-cancer effect of axitinib in epithelial ovarian cancer (EOC). We treated EOC cells (A2780, HeyA8, RMG1, and HeyA8-MDR) with axitinib to evaluate its effects on cell viabilty, apoptosis and migration. Western blots were performed to ... Read more >>

Sci Rep (Scientific reports)
[2020, 10(1):4904]

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Combination of a pulmonary recruitment maneuver and intraperitoneal bupivacaine for the reduction of postoperative shoulder pain in gynecologic laparoscopy: a randomized, controlled trial.

Minae Cho, Chul Jung Kim, Tae Soo Hahm, Yoo-Young Lee, Tae-Joong Kim, Jeong-Won Lee, Byoung-Gie Kim, Duk-Soo Bae, Chel Hun Choi,

Objective:To compare the efficacy of a pulmonary recruitment maneuver using lower airway pressure (30 cm H2O) and intraperitoneal bupivacaine, alone or in combination, for reducing shoulder pain after gynecologic laparoscopy. Methods:A prospective controlled study was performed in a teaching hospital with patients who underwent elective gynecologic laparoscopic surgery. Two hundred ... Read more >>

Obstet Gynecol Sci (Obstetrics & gynecology science)
[2020, 63(2):187-194]

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Impact of Angiotensin Receptor Blockers, Beta Blockers, Calcium Channel Blockers and Thiazide Diuretics on Survival of Ovarian Cancer Patients.

Min Ae Cho, Soo Young Jeong, Insuk Sohn, Myeong-Seon Kim, Jun Hyeok Kang, E Sun Paik, Yoo-Young Lee, Chel Hun Choi,

<h4>Purpose</h4>We investigated the impact of four types of antihypertensive medications, angiotensin receptor blockers (ARBs), beta blockers (BBs; both selective and non-selective), calcium channel blockers (CCBs), and thiazide diuretics (TDs) on survival outcomes in epithelial ovarian cancer (EOC).<h4>Materials and methods</h4>A single-institutional retrospective chart review of 878 patients with EOC was performed. ... Read more >>

Cancer Res Treat (Cancer research and treatment)
[2020, 52(2):645-654]

Cited: 3 times

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Triplet chemotherapy vs doublet chemotherapy plus bevacizumab in metastatic, recurrent, and persistent cervical cancer.

Hyun-Jin Choi, Yoo-Young Lee, Chel Hun Choi, Tae-Joong Kim, Jeong-Won Lee, Ji Hye Bae, Duk-Soo Bae, Byoung-Gie Kim,

<h4>Objective</h4>The effectiveness of paclitaxel-cisplatin-ifosfamide triplet regimen (TIP) was reported to be superior to that of paclitaxel-cisplatin doublet. However, the efficacy of paclitaxel-cisplatin-bevacizumab triplet (TPA) and TIP has not been compared. Here, we compared the efficacy and safety of TIP and TPA in patients with metastatic, recurrent, or persistent cervical cancer.<h4>Methods</h4>We ... Read more >>

Curr Probl Cancer (Current problems in cancer)
[2020, 44(5):100557]

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Interval between secondary cytoreductive surgery and adjuvant chemotherapy is not associated with survivals in patients with recurrent ovarian cancer.

Soo Young Jeong, Chel Hun Choi, Tae Joong Kim, Jeong Won Lee, Byoung-Gie Kim, Duk Soo Bae, Yoo-Young Lee,

BACKGROUND:Secondary cytoreductive surgery (SCS) is possible in selected patients with recurrent epithelial ovarian cancer (EOC). The goal of SCS is complete resection, although chemotherapy is always followed. Delayed intervals between primary debulking surgery and adjuvant chemotherapy was reported to be associated with poorer survivals, however, the role of intervals in ... Read more >>

J Ovarian Res (Journal of ovarian research)
[2019, 13(1):1]

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Effectiveness of adjuvant treatment for morcellated, International Federation of Gynecology and Obstetrics stage I uterine leiomyosarcoma: A Korean multicenter study.

Se Ik Kim, Chel Hun Choi, Kidong Kim, Deok Ho Hong, Jeong-Yeol Park, Byung Su Kwon, Keun Ho Lee, Dae Gy Hong, So-Jin Shin, Sang-Il Park, Yun Hwan Kim, Seung-Ho Lee, Sanghoon Lee, Jin Hwa Hong, Jung-Yun Lee, Yong Beom Kim, Jae Hong No, Dong Hoon Suh,

AIM:To evaluate the effectiveness of adjuvant treatment for morcellated, uterus-confined leiomyosarcoma in a multicenter setting. METHODS:We identified patients with International Federation of Gynecology and Obstetrics stage I uterine leiomyosarcoma primarily treated with surgery between 2003 and 2016. Among them, patients who underwent one of the following morcellation methods were included: ... Read more >>

J Obstet Gynaecol Res (The journal of obstetrics and gynaecology research)
[2020, 46(2):337-346]

Cited: 2 times

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Real-World Experience of Olaparib Maintenance in High-Grade Serous Recurrent Ovarian Cancer Patients with BRCA1/2 Mutation: A Korean Multicenter Study.

E Sun Paik, Yong Jae Lee, Jung-Yun Lee, Wonkyo Shin, Sang-Yoon Park, Se Ik Kim, Jae-Weon Kim, Chel Hun Choi, Byoung-Gie Kim,

<h4>Background</h4>Olaparib maintenance therapy has shown efficacy and tolerability in patients with platinum-sensitive, high-grade serous recurrent ovarian cancer (HSROC) with BRCA1/2 mutation (BRCAm). Our aim was to present real-world experience with olaparib in Korea.<h4>Method</h4>We included HSROC patients with BRCAm treated with olaparib maintenance at four institutions in Korea between 2016 and ... Read more >>

J Clin Med (Journal of clinical medicine)
[2019, 8(11):]

Cited: 1 time

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Pretreatment Lymph Node Metastasis as a Prognostic Significance in Cervical Cancer: Comparison between Disease Status.

Soo Young Jeong, Hyea Park, Myeong Seon Kim, Jun Hyeok Kang, E Sun Paik, Yoo-Young Lee, Tae Joong Kim, Jeong Won Lee, Byoung-Gie Kim, Duk Soo Bae, Chel Hun Choi,

<h4>Purpose</h4>Lymph node metastasis (LNM) is the most significant prognostic factor in cervical cancer that was recently incorporated into the International Federation of Gynecology and Obstetrics (FIGO) staging system. This study was performed to evaluate whether the prognostic significance of LNM differs according to disease status.<h4>Materials and methods</h4>Patients with FIGO stage ... Read more >>

Cancer Res Treat (Cancer research and treatment)
[2020, 52(2):516-523]

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Comparison between Laparoendoscopic Single-Site and Conventional Laparoscopic Surgery in Mature Cystic Teratoma of the Ovary.

Myeong Seon Kim, Chel Hun Choi, Jeong-Won Lee, Byoung-Gie Kim, Duk-Soo Bae, Tae-Joong Kim,

<h4>Objective</h4>The objective of the study is to compare the intra- and post-operative outcomes of laparoendoscopic single-site surgery (LESS) and conventional laparoscopic surgery (CLS) in mature cystic teratoma (MCT) of the ovary.<h4>Methods</h4>We reviewed 254 patients who underwent surgery (cystectomy) for ovarian MCT from March 1, 2014, to August 31, 2016. During ... Read more >>

Gynecol Minim Invasive Ther (Gynecology and minimally invasive therapy)
[2019, 8(4):155-159]

Cited: 1 time

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CDK7 is a reliable prognostic factor and novel therapeutic target in epithelial ovarian cancer.

Jihye Kim, Young-Jae Cho, Ji-Yoon Ryu, Ilseon Hwang, Hee Dong Han, Hyung Jun Ahn, Woo Young Kim, Hanbyoul Cho, Joon-Yong Chung, Stephen M Hewitt, Jae-Hoon Kim, Byoung-Gie Kim, Duk-Soo Bae, Chel Hun Choi, Jeong-Won Lee,

OBJECTIVE:Cyclin-dependent kinase 7 (CDK7) engages tumor growth by acting as a direct link between the regulation of transcription and the cell cycle. Here, we investigated the clinical significance of CDK7 expression and its potential as a therapeutic target in epithelial ovarian cancer (EOC). METHODS:CDK7 expression was examined in 436 ovarian ... Read more >>

Gynecol Oncol (Gynecologic oncology)
[2020, 156(1):211-221]

Cited: 3 times

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