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Author Charles L Sprung

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Executive Summary: Surviving Sepsis Campaign: International Guidelines for the Management of Sepsis and Septic Shock 2021.

Laura Evans, Andrew Rhodes, Waleed Alhazzani, Massimo Antonelli, Craig M Coopersmith, Craig French, Flávia R Machado, Lauralyn Mcintyre, Marlies Ostermann, Hallie C Prescott, Christa Schorr, Steven Simpson, W Joost Wiersinga, Fayez Alshamsi, Derek C Angus, Yaseen Arabi, Luciano Azevedo, Richard Beale, Gregory Beilman, Emilie Belley-Cote, Lisa Burry, Maurizio Cecconi, John Centofanti, Angel Coz Yataco, Jan De Waele, R Phillip Dellinger, Kent Doi, Bin Du, Elisa Estenssoro, Ricard Ferrer, Charles Gomersall, Carol Hodgson, Morten Hylander Møller, Theodore Iwashyna, Shevin Jacob, Ruth Kleinpell, Michael Klompas, Younsuck Koh, Anand Kumar, Arthur Kwizera, Suzana Lobo, Henry Masur, Steven McGloughlin, Sangeeta Mehta, Yatin Mehta, Mervyn Mer, Mark Nunnally, Simon Oczkowski, Tiffany Osborn, Elizabeth Papathanassoglou, Anders Perner, Michael Puskarich, Jason Roberts, William Schweickert, Maureen Seckel, Jonathan Sevransky, Charles L Sprung, Tobias Welte, Janice Zimmerman, Mitchell Levy,

Crit Care Med (Critical care medicine)
[2021, 49(11):1974-1982]

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Surviving Sepsis Campaign: International Guidelines for Management of Sepsis and Septic Shock 2021.

Laura Evans, Andrew Rhodes, Waleed Alhazzani, Massimo Antonelli, Craig M Coopersmith, Craig French, Flávia R Machado, Lauralyn Mcintyre, Marlies Ostermann, Hallie C Prescott, Christa Schorr, Steven Simpson, W Joost Wiersinga, Fayez Alshamsi, Derek C Angus, Yaseen Arabi, Luciano Azevedo, Richard Beale, Gregory Beilman, Emilie Belley-Cote, Lisa Burry, Maurizio Cecconi, John Centofanti, Angel Coz Yataco, Jan De Waele, R Phillip Dellinger, Kent Doi, Bin Du, Elisa Estenssoro, Ricard Ferrer, Charles Gomersall, Carol Hodgson, Morten Hylander Møller, Theodore Iwashyna, Shevin Jacob, Ruth Kleinpell, Michael Klompas, Younsuck Koh, Anand Kumar, Arthur Kwizera, Suzana Lobo, Henry Masur, Steven McGloughlin, Sangeeta Mehta, Yatin Mehta, Mervyn Mer, Mark Nunnally, Simon Oczkowski, Tiffany Osborn, Elizabeth Papathanassoglou, Anders Perner, Michael Puskarich, Jason Roberts, William Schweickert, Maureen Seckel, Jonathan Sevransky, Charles L Sprung, Tobias Welte, Janice Zimmerman, Mitchell Levy,

Crit Care Med (Critical care medicine)
[2021, 49(11):e1063-e1143]

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Surviving sepsis campaign: international guidelines for management of sepsis and septic shock 2021.

Laura Evans, Andrew Rhodes, Waleed Alhazzani, Massimo Antonelli, Craig M Coopersmith, Craig French, Flávia R Machado, Lauralyn Mcintyre, Marlies Ostermann, Hallie C Prescott, Christa Schorr, Steven Simpson, W Joost Wiersinga, Fayez Alshamsi, Derek C Angus, Yaseen Arabi, Luciano Azevedo, Richard Beale, Gregory Beilman, Emilie Belley-Cote, Lisa Burry, Maurizio Cecconi, John Centofanti, Angel Coz Yataco, Jan De Waele, R Phillip Dellinger, Kent Doi, Bin Du, Elisa Estenssoro, Ricard Ferrer, Charles Gomersall, Carol Hodgson, Morten Hylander Møller, Theodore Iwashyna, Shevin Jacob, Ruth Kleinpell, Michael Klompas, Younsuck Koh, Anand Kumar, Arthur Kwizera, Suzana Lobo, Henry Masur, Steven McGloughlin, Sangeeta Mehta, Yatin Mehta, Mervyn Mer, Mark Nunnally, Simon Oczkowski, Tiffany Osborn, Elizabeth Papathanassoglou, Anders Perner, Michael Puskarich, Jason Roberts, William Schweickert, Maureen Seckel, Jonathan Sevransky, Charles L Sprung, Tobias Welte, Janice Zimmerman, Mitchell Levy,

Intensive Care Med (Intensive care medicine)
[2021, :]

Cited: 0 times

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Extracorporeal cardiopulmonary resuscitation: The need for high-quality research and the association legal, ethical and pandemic-related challenges.

Spyros D Mentzelopoulos, Charles L Sprung, Charikleia S Vrettou,

Resuscitation (Resuscitation)
[2021, :]

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Mass Critical Care Surge Response during COVID-19: Implementation of Contingency Strategies A Preliminary Report of findings from the Task Force for Mass Critical Care.

Jeffrey R Dichter, Asha V Devereaux, Charles L Sprung, Vikramjit Mukherjee, Jason Persoff, Karyn D Baum, Douglas Ornoff, Amit Uppal, Tanzib Hossain, Kiersten N Henry, Marya Ghazipura, Kasey R Bowden, Henry J Feldman, Mitchell T Hamele, Lisa D Burry, Anne Marie O Martland, Meredith Huffines, Pritish K Tosh, James Downar, John L Hick, Michael D Christian, Ryan C Maves, ,

<h4>Background</h4>Following the publication of 2014 consensus statement regarding mass critical care during public health emergencies, much has been learned about surge responses and the care of overwhelming numbers of patients during the COVID-19 pandemic.<sup>1</sup> Gaps in prior pandemic planning were identified and require modification in the midst of ongoing surge ... Read more >>

Chest (Chest)
[2021, :]

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Variations in end-of-life practices in intensive care units worldwide (Ethicus-2): a prospective observational study.

Alexander Avidan, Charles L Sprung, Joerg C Schefold, Bara Ricou, Christiane S Hartog, Joseph L Nates, Ulrich Jaschinski, Suzana M Lobo, Gavin M Joynt, Olivier Lesieur, Manfred Weiss, Massimo Antonelli, Hans-Henrik Bülow, Maria G Bocci, Annette Robertsen, Matthew H Anstey, Belén Estébanez-Montiel, Alexandre Lautrette, Anastasiia Gruber, Angel Estella, Sudakshina Mullick, Roshni Sreedharan, Andrej Michalsen, Charles Feldman, Kai Tisljar, Martin Posch, Steven Ovu, Barbara Tamowicz, Alexandre Demoule, Freda DeKeyser Ganz, Hans Pargger, Alberto Noto, Philipp Metnitz, Laszlo Zubek, Veronica de la Guardia, Christopher M Danbury, Orsolya Szűcs, Alessandro Protti, Mario Filipe, Steven Q Simpson, Cameron Green, Alberto M Giannini, Ivo W Soliman, Claudio Piras, Eliana B Caser, Manuel Hache-Marliere, Spyros D Mentzelopoulos, ,

<h4>Background</h4>End-of-life practices vary among intensive care units (ICUs) worldwide. Differences can result in variable use of disproportionate or non-beneficial life-sustaining interventions across diverse world regions. This study investigated global disparities in end-of-life practices.<h4>Methods</h4>In this prospective, multinational, observational study, consecutive adult ICU patients who died or had a limitation of life-sustaining ... Read more >>

Lancet Respir Med (The Lancet. Respiratory medicine)
[2021, 9(10):1101-1110]

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Hints and advice on end-of-life communication in the ICU, also during pandemics.

Hans-Henrik Bülow, Helle Petersen, Julie Benbenishty, Charles L Sprung,

Acta Anaesthesiol Scand (Acta anaesthesiologica Scandinavica)
[2021, 65(8):1143-1146]

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Reassessing Cardiopulmonary Resuscitation in Hospitalized Patients With Coronavirus Disease 2019.

Charles L Sprung,

Crit Care Med (Critical care medicine)
[2021, 49(6):988-993]

Cited: 0 times

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The Influence of Geography, Religion, Religiosity and Institutional Factors on Worldwide End-of-Life Care for the Critically Ill: The WELPICUS Study.

Charles L Sprung, Ann L Jennerich, Gavin M Joynt, Andrej Michalsen, J Randall Curtis, Linda S Efferen, Sara Leonard, Barbara Metnitz, Adam Mikstacki, Namrata Patil, Robert C McDermid, Philipp Metnitz, Richard A Mularski, Pierre Bulpa, Alexander Avidan,

<h4>Purpose</h4>To evaluate the association between provider religion and religiosity and consensus about end-of-life care and explore if geographical and institutional factors contribute to variability in practice.<h4>Materials and methods</h4>Using a modified Delphi method 22 end-of-life issues consisting of 35 definitions and 46 statements were evaluated in 32 countries in North America, ... Read more >>

J Palliat Care (Journal of palliative care)
[2021, :8258597211002308]

Cited: 1 time

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Use of IFNγ/IL10 Ratio for Stratification of Hydrocortisone Therapy in Patients With Septic Shock.

Rainer König, Amol Kolte, Olaf Ahlers, Marcus Oswald, Veiko Krauss, Daniela Roell, Oliver Sommerfeld, George Dimopoulos, Iraklis Tsangaris, Eleni Antoniadou, Neeraja Jaishankar, Holger Bogatsch, Markus Löffler, Markus Rödel, Marina Garcia-Moreno, Lorena Tuchscherr, Charles L Sprung, Mervyn Singer, Frank Brunkhorst, Michael Oppert, Herwig Gerlach, Ralf A Claus, Sina M Coldewey, Josef Briegel, Evangelos J Giamarellos-Bourboulis, Didier Keh, Michael Bauer,

Large clinical trials testing hydrocortisone therapy in septic shock have produced conflicting results. Subgroups may benefit of hydrocortisone treatment depending on their individual immune response. We performed an exploratory analysis of the database from the international randomized controlled clinical trial Corticosteroid Therapy of Septic Shock (CORTICUS) employing machine learning to ... Read more >>

Front Immunol (Frontiers in immunology)
[2021, 12:607217]

Cited: 0 times

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Crisis Level ICU Triage Is About Saving Lives.

Charles L Sprung, Gavin M Joynt, Michael D Christian, Robert D Truog, Jordi Rello, Joseph L Nates,

Crit Care Med (Critical care medicine)
[2021, 49(1):e102-e103]

Cited: 0 times

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Assessment of Machine Learning to Estimate the Individual Treatment Effect of Corticosteroids in Septic Shock.

Romain Pirracchio, Alan Hubbard, Charles L Sprung, Sylvie Chevret, Djillali Annane, ,

<h4>Importance</h4>The survival benefit of corticosteroids in septic shock remains uncertain.<h4>Objective</h4>To estimate the individual treatment effect (ITE) of corticosteroids in adults with septic shock in intensive care units using machine learning and to evaluate the net benefit of corticosteroids when the decision to treat is based on the individual estimated absolute ... Read more >>

JAMA Netw Open (JAMA network open)
[2020, 3(12):e2029050]

Cited: 1 time

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Pain management during the withholding and withdrawal of life support in critically ill patients at the end-of-life: a systematic review and meta-analysis.

Andres Laserna, Alejandro Durán-Crane, María A López-Olivo, John A Cuenca, Cosmo Fowler, Diana Paola Díaz, Yenny R Cardenas, Catherine Urso, Keara O'Connell, Clara Fowler, Kristen J Price, Charles L Sprung, Joseph L Nates,

<h4>Purpose</h4>To review and summarize the most frequent medications and dosages used during withholding and withdrawal of life-prolonging measures in critically ill patients in the intensive care unit.<h4>Methods</h4>We searched PubMed, EMBASE, the Cochrane Database of Systematic Reviews, and the Virtual Health Library from inception through March 2019. We considered any study ... Read more >>

Intensive Care Med (Intensive care medicine)
[2020, 46(9):1671-1682]

Cited: 3 times

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Adult ICU Triage During the Coronavirus Disease 2019 Pandemic: Who Will Live and Who Will Die? Recommendations to Improve Survival.

Charles L Sprung, Gavin M Joynt, Michael D Christian, Robert D Truog, Jordi Rello, Joseph L Nates,

<h4>Objectives</h4>Coronavirus disease 2019 patients are currently overwhelming the world's healthcare systems. This article provides practical guidance to front-line physicians forced to make critical rationing decisions.<h4>Data sources</h4>PubMed and Medline search for scientific literature, reviews, and guidance documents related to epidemic ICU triage including from professional bodies.<h4>Study selection</h4>Clinical studies, reviews, and guidelines ... Read more >>

Crit Care Med (Critical care medicine)
[2020, 48(8):1196-1202]

Cited: 32 times

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Israeli Position Paper: Triage Decisions for Severely Ill Patients During the COVID-19 Pandemic.

Avraham Steinberg, Ephrat Levy-Lahad, Tami Karni, Charles L Sprung,

Chest (Chest)
[2020, 158(6):2278-2281]

Cited: 1 time

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Israeli Position Paper: Triage Decisions for Severely Ill Patients During the COVID-19 Pandemic. Joint Commission of the Israel National Bioethics Council, the Ethics Bureau of the Israel Medical Association and Representatives from the Israeli Ministry of Health.

Avraham Steinberg, Ephrat Levy-Lahad, Tami Karni, Noam Zohar, Gil Siegal, Charles L Sprung, ,

OBJECTIVES:This document provides an English translation of the Israeli Joint Commission's national guidelines for triaging severely ill patients during the coronavirus disease 2019 (COVID-19) pandemic. METHODS:Four subcommittees of medical, legal, ethical-social, and religious experts developed the general principles and practical medical criteria for triaging scarce life-saving resources. RESULTS:The guidelines provide ... Read more >>

Rambam Maimonides Med J (Rambam Maimonides medical journal)
[2020, 11(3):]

Cited: 0 times

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What can be learned from crude intensive care unit mortality? Methodological implications.

Charles Weissman, Peter Vernon van Heerden, Charles L Sprung,

<h4>Purpose</h4>Demonstrate the practical range of information that can be obtained about ICU mortality/survival from limited administrative data.<h4>Materials and methods</h4>Prospectively collected administrative data (length-of stay, survival/mortality, referring service) from a university medical center's General ICU was subjected to retrospective analysis to demonstrate ways of presenting and analyzing mortality/survival information.<h4>Results</h4>16,022 patients (87,624 ... Read more >>

J Crit Care (Journal of critical care)
[2020, 59:130-135]

Cited: 0 times

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Triage of Scarce Critical Care Resources in COVID-19 An Implementation Guide for Regional Allocation: An Expert Panel Report of the Task Force for Mass Critical Care and the American College of Chest Physicians.

Ryan C Maves, James Downar, Jeffrey R Dichter, John L Hick, Asha Devereaux, James A Geiling, Niranjan Kissoon, Nathaniel Hupert, Alexander S Niven, Mary A King, Lewis L Rubinson, Dan Hanfling, James G Hodge, Mary Faith Marshall, Katherine Fischkoff, Laura E Evans, Mark R Tonelli, Randy S Wax, Gilbert Seda, John S Parrish, Robert D Truog, Charles L Sprung, Michael D Christian, ,

Public health emergencies have the potential to place enormous strain on health systems. The current pandemic of the novel 2019 coronavirus disease has required hospitals in numerous countries to expand their surge capacity to meet the needs of patients with critical illness. When even surge capacity is exceeded, however, principles ... Read more >>

Chest (Chest)
[2020, 158(1):212-225]

Cited: 59 times

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Changes in End-of-Life Practices in European Intensive Care Units From 1999 to 2016.

Charles L Sprung, Bara Ricou, Christiane S Hartog, Paulo Maia, Spyros D Mentzelopoulos, Manfred Weiss, Phillip D Levin, Laura Galarza, Veronica de la Guardia, Joerg C Schefold, Mario Baras, Gavin M Joynt, Hans-Henrik Bülow, Georgios Nakos, Vladimir Cerny, Stephan Marsch, Armand R Girbes, Catherine Ingels, Orsolya Miskolci, Didier Ledoux, Sudakshina Mullick, Maria G Bocci, Jakob Gjedsted, Belén Estébanez, Joseph L Nates, Olivier Lesieur, Roshni Sreedharan, Alberto M Giannini, Lucía Cachafeiro Fuciños, Christopher M Danbury, Andrej Michalsen, Ivo W Soliman, Angel Estella, Alexander Avidan,

<h4>Importance</h4>End-of-life decisions occur daily in intensive care units (ICUs) around the world, and these practices could change over time.<h4>Objective</h4>To determine the changes in end-of-life practices in European ICUs after 16 years.<h4>Design, setting, and participants</h4>Ethicus-2 was a prospective observational study of 22 European ICUs previously included in the Ethicus-1 study (1999-2000). ... Read more >>

JAMA (JAMA)
[2019, 322(17):1692-1704]

Cited: 26 times

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Clinical Practice Guidelines and Consensus Statements About Pain Management in Critically Ill End-of-Life Patients: A Systematic Review.

Alejandro Durán-Crane, Andrés Laserna, María A López-Olivo, John A Cuenca, Diana Paola Díaz, Yenny Rocío Cardenas, Catherine Urso, Keara O'Connell, Kian Azimpoor, Clara Fowler, Kristen J Price, Charles L Sprung, Joseph L Nates,

<h4>Objectives</h4>To identify and synthesize available recommendations from scientific societies and experts on pain management at the end-of-life in the ICU.<h4>Data sources</h4>We conducted a systematic review of PubMed, EMBASE, the Cochrane Database of Systematic Reviews, and Biblioteca Virtual en Salud from their inception until March 28, 2019.<h4>Study selection</h4>We included all clinical ... Read more >>

Crit Care Med (Critical care medicine)
[2019, 47(11):1619-1626]

Cited: 2 times

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Agreement With Consensus Statements on End-of-Life Care: A Description of Variability at the Level of the Provider, Hospital, and Country.

Ann C Long, Lyndia C Brumback, J Randall Curtis, Alexander Avidan, Mario Baras, Edoardo De Robertis, Linda Efferen, Ruth A Engelberg, Erin K Kross, Andrej Michalsen, Richard A Mularski, Charles L Sprung, ,

<h4>Objectives</h4>To develop an enhanced understanding of factors that influence providers' views about end-of-life care, we examined the contributions of provider, hospital, and country to variability in agreement with consensus statements about end-of-life care.<h4>Design and setting</h4>Data were drawn from a survey of providers' views on principles of end-of-life care obtained during ... Read more >>

Crit Care Med (Critical care medicine)
[2019, 47(10):1396-1401]

Cited: 5 times

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The Effect of Repeated Versus Initial Procalcitonin Measurements on Diagnosis of Infection in the Intensive Care Setting: A Prospective Observational Study.

Phillip D Levin, Matan J Cohen, Eden Ohev-Zion, Samer Tannus, Sheldon Stohl, Alexander Avidan, Ronit Cohen-Poraduso, Allon E Moses, Charles L Sprung, Shmuel Benenson,

Procalcitonin (PCT) measurement has been proposed to direct antibiotic use. We examined whether repeated PCT measurements (0, 6, and/or 12 hours) versus the initial measurement only (time 0) increased the sensitivity and specificity of PCT for diagnosing infection in intensive care unit patients. Infection was identified in 67/176 (38%) patients. ... Read more >>

Anesth Analg (Anesthesia and analgesia)
[2019, 129(4):e114-e117]

Cited: 2 times

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Impact of triage-to-admission time on patient outcome in European intensive care units: A prospective, multi-national study.

Sheldon Stohl, Charles L Sprung, Anne Lippert, Romain Pirracchio, Antonio Artigas, Gaetano Iapichino, Steve Harris, Angelo Pezzi, Malka Schlesinger,

<h4>Purpose</h4>Ubiquitous bed shortages lead to delays in intensive care unit (ICU) admissions worldwide. Assessing the impact of delayed admission must account for illness severity. This study examined both the relationship between triage-to-admission time and 28-day mortality and the impact of controlling for Simplified Acute Physiology Score (SAPS) II scores on ... Read more >>

J Crit Care (Journal of critical care)
[2019, 53:11-17]

Cited: 2 times

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Eight things we would never do regarding end-of-life care in the ICU.

E Wesley Ely, Elie Azoulay, Charles L Sprung,

Intensive Care Med (Intensive care medicine)
[2019, 45(8):1116-1118]

Cited: 5 times

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Obstacles to the successful introduction of an electronic hand hygiene monitoring system, a cohort observational study.

Phillip D Levin, Reut Razon, Carmela Schwartz, Alexander Avidan, Charles L Sprung, Allon E Moses, Shmuel Benenson,

Background:Hand hygiene (HH) compliance remains low in many intensive care units (ICU). Technology has been suggested to improve HH compliance.We describe the introduction of an electronic HH surveillance and intervention system into the general ICU of a tertiary care teaching hospital, the obstacles to success and reasons for the system's ... Read more >>

Antimicrob Resist Infect Control (Antimicrobial resistance and infection control)
[2019, 8:43]

Cited: 2 times

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