Full Text Journal Articles by
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Surviving Sepsis Campaign: International Guidelines for Management of Sepsis and Septic Shock 2021.

Laura Evans, Andrew Rhodes, Waleed Alhazzani, Massimo Antonelli, Craig M Coopersmith, Craig French, Flávia R Machado, Lauralyn Mcintyre, Marlies Ostermann, Hallie C Prescott, Christa Schorr, Steven Simpson, W Joost Wiersinga, Fayez Alshamsi, Derek C Angus, Yaseen Arabi, Luciano Azevedo, Richard Beale, Gregory Beilman, Emilie Belley-Cote, Lisa Burry, Maurizio Cecconi, John Centofanti, Angel Coz Yataco, Jan De Waele, R Phillip Dellinger, Kent Doi, Bin Du, Elisa Estenssoro, Ricard Ferrer, Charles Gomersall, Carol Hodgson, Morten Hylander Møller, Theodore Iwashyna, Shevin Jacob, Ruth Kleinpell, Michael Klompas, Younsuck Koh, Anand Kumar, Arthur Kwizera, Suzana Lobo, Henry Masur, Steven McGloughlin, Sangeeta Mehta, Yatin Mehta, Mervyn Mer, Mark Nunnally, Simon Oczkowski, Tiffany Osborn, Elizabeth Papathanassoglou, Anders Perner, Michael Puskarich, Jason Roberts, William Schweickert, Maureen Seckel, Jonathan Sevransky, Charles L Sprung, Tobias Welte, Janice Zimmerman, Mitchell Levy,

Crit Care Med (Critical care medicine)
[2021, 49(11):e1063-e1143]

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Executive Summary: Surviving Sepsis Campaign: International Guidelines for the Management of Sepsis and Septic Shock 2021.

Laura Evans, Andrew Rhodes, Waleed Alhazzani, Massimo Antonelli, Craig M Coopersmith, Craig French, Flávia R Machado, Lauralyn Mcintyre, Marlies Ostermann, Hallie C Prescott, Christa Schorr, Steven Simpson, W Joost Wiersinga, Fayez Alshamsi, Derek C Angus, Yaseen Arabi, Luciano Azevedo, Richard Beale, Gregory Beilman, Emilie Belley-Cote, Lisa Burry, Maurizio Cecconi, John Centofanti, Angel Coz Yataco, Jan De Waele, R Phillip Dellinger, Kent Doi, Bin Du, Elisa Estenssoro, Ricard Ferrer, Charles Gomersall, Carol Hodgson, Morten Hylander Møller, Theodore Iwashyna, Shevin Jacob, Ruth Kleinpell, Michael Klompas, Younsuck Koh, Anand Kumar, Arthur Kwizera, Suzana Lobo, Henry Masur, Steven McGloughlin, Sangeeta Mehta, Yatin Mehta, Mervyn Mer, Mark Nunnally, Simon Oczkowski, Tiffany Osborn, Elizabeth Papathanassoglou, Anders Perner, Michael Puskarich, Jason Roberts, William Schweickert, Maureen Seckel, Jonathan Sevransky, Charles L Sprung, Tobias Welte, Janice Zimmerman, Mitchell Levy,

Crit Care Med (Critical care medicine)
[2021, 49(11):1974-1982]

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The story of critical care in Asia: a narrative review.

Jason Phua, Chae-Man Lim, Mohammad Omar Faruq, Khalid Mahmood Khan Nafees, Bin Du, Charles D Gomersall, Lowell Ling, Jigeeshu Vasishtha Divatia, Seyed Mohammad Reza Hashemian, Moritoki Egi, Aidos Konkayev, Mohd Basri Mat-Nor, Gentle Sunder Shrestha, Madiha Hashmi, Jose Emmanuel M Palo, Yaseen M Arabi, Hon Liang Tan, Rohan Dissanayake, Ming-Cheng Chan, Chairat Permpikul, Boonsong Patjanasoontorn, Do Ngoc Son, Masaji Nishimura, Younsuck Koh, ,

<h4>Background</h4>Asia has more critically ill people than any other part of our planet. The aim of this article is to review the development of critical care as a specialty, critical care societies and education and research, the epidemiology of critical illness as well as epidemics and pandemics, accessibility and cost ... Read more >>

J Intensive Care (Journal of intensive care)
[2021, 9(1):60]

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Surviving sepsis campaign: international guidelines for management of sepsis and septic shock 2021.

Laura Evans, Andrew Rhodes, Waleed Alhazzani, Massimo Antonelli, Craig M Coopersmith, Craig French, Flávia R Machado, Lauralyn Mcintyre, Marlies Ostermann, Hallie C Prescott, Christa Schorr, Steven Simpson, W Joost Wiersinga, Fayez Alshamsi, Derek C Angus, Yaseen Arabi, Luciano Azevedo, Richard Beale, Gregory Beilman, Emilie Belley-Cote, Lisa Burry, Maurizio Cecconi, John Centofanti, Angel Coz Yataco, Jan De Waele, R Phillip Dellinger, Kent Doi, Bin Du, Elisa Estenssoro, Ricard Ferrer, Charles Gomersall, Carol Hodgson, Morten Hylander Møller, Theodore Iwashyna, Shevin Jacob, Ruth Kleinpell, Michael Klompas, Younsuck Koh, Anand Kumar, Arthur Kwizera, Suzana Lobo, Henry Masur, Steven McGloughlin, Sangeeta Mehta, Yatin Mehta, Mervyn Mer, Mark Nunnally, Simon Oczkowski, Tiffany Osborn, Elizabeth Papathanassoglou, Anders Perner, Michael Puskarich, Jason Roberts, William Schweickert, Maureen Seckel, Jonathan Sevransky, Charles L Sprung, Tobias Welte, Janice Zimmerman, Mitchell Levy,

Intensive Care Med (Intensive care medicine)
[2021, :]

Cited: 0 times

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Society of Critical Care Medicine 50th Anniversary Review Series: Critical Care Education.

Julian Bion, Celia Brown, Charles Gomersall, Carole Boulanger, Peter Isherwood, David Schulman,

Crit Care Med (Critical care medicine)
[2021, 49(8):1241-1253]

Cited: 0 times

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Mechanical Ventilation Discontinuation Practices in Asia: A Multinational Survey.

Chi Hung Czarina Leung, Anna Lee, Yaseen M Arabi, Jason Phua, Jigeeshu V Divatia, Younsuck Koh, Bin Du, Cheng Cheng Tan, Jose Emmanuel M Palo, Karen E A Burns, Tae-Hyung Kim, Moritoki Egi, Mohammad Omar Faruq, Babu Raja Shrestha, Shih-Feng Liu, Tuan Dang Nguyen, Bambang Wahjuprajitno, Madiha Hashmi, Boonsong Patjanasoontorn, Zulaidi Latif, Kanishka Indraratna, Hussain N Al Rahma, Seyed Mohammad Reza Hashemian, Charles D Gomersall,

<b>Rationale:</b> There are limited data on mechanical discontinuation practices in Asia. <b>Objectives:</b> To document self-reported mechanical discontinuation practices and determine whether there is clinical equipoise regarding protocolized weaning among Asian Intensive Care specialists. <b>Methods:</b> A survey using a validated questionnaire, distributed using a snowball method to Asian Intensive Care specialists. ... Read more >>

Ann Am Thorac Soc (Annals of the American Thoracic Society)
[2021, 18(8):1352-1359]

Cited: 2 times

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Death in hospital following ICU discharge: insights from the LUNG SAFE study.

Fabiana Madotto, Bairbre McNicholas, Emanuele Rezoagli, Tài Pham, John G Laffey, Giacomo Bellani, , ,

<h4>Background</h4>To determine the frequency of, and factors associated with, death in hospital following ICU discharge to the ward.<h4>Methods</h4>The Large observational study to UNderstand the Global impact of Severe Acute respiratory FailurE study was an international, multicenter, prospective cohort study of patients with severe respiratory failure, conducted across 459 ICUs from ... Read more >>

Crit Care (Critical care (London, England))
[2021, 25(1):144]

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The Effect of Renal Replacement Therapy and Antibiotic Dose on Antibiotic Concentrations in Critically Ill Patients: Data From the Multinational Sampling Antibiotics in Renal Replacement Therapy Study.

Jason A Roberts, Gavin M Joynt, Anna Lee, Gordon Choi, Rinaldo Bellomo, Salmaan Kanji, M Yugan Mudaliar, Sandra L Peake, Dianne Stephens, Fabio Silvio Taccone, Marta Ulldemolins, Miia Maaria Valkonen, Julius Agbeve, João P Baptista, Vasileios Bekos, Clement Boidin, Alexander Brinkmann, Luke Buizen, Pedro Castro, C Louise Cole, Jacques Creteur, Jan J De Waele, Renae Deans, Glenn M Eastwood, Leslie Escobar, Charles Gomersall, Rebecca Gresham, Janattul Ain Jamal, Stefan Kluge, Christina König, Vasilios P Koulouras, Melissa Lassig-Smith, Pierre-Francois Laterre, Katie Lei, Patricia Leung, Jean-Yves Lefrant, Mireia Llauradó-Serra, Ignacio Martin-Loeches, Mohd Basri Mat Nor, Marlies Ostermann, Suzanne L Parker, Jordi Rello, Darren M Roberts, Michael S Roberts, Brent Richards, Alejandro Rodríguez, Anka C Roehr, Claire Roger, Leonardo Seoane, Mahipal Sinnollareddy, Eduardo Sousa, Dolors Soy, Anna Spring, Therese Starr, Jane Thomas, John Turnidge, Steven C Wallis, Tricia Williams, Xavier Wittebole, Xanthi T Zikou, Sanjoy K Paul, Jeffrey Lipman, ,

<h4>Background</h4>The optimal dosing of antibiotics in critically ill patients receiving renal replacement therapy (RRT) remains unclear. In this study, we describe the variability in RRT techniques and antibiotic dosing in critically ill patients receiving RRT and relate observed trough antibiotic concentrations to optimal targets.<h4>Methods</h4>We performed a prospective, observational, multinational, pharmacokinetic ... Read more >>

Clin Infect Dis (Clinical infectious diseases : an official publication of the Infectious Diseases Society of America)
[2021, 72(8):1369-1378]

Cited: 13 times

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How the COVID-19 pandemic will change the future of critical care.

Yaseen M Arabi, Elie Azoulay, Hasan M Al-Dorzi, Jason Phua, Jorge Salluh, Alexandra Binnie, Carol Hodgson, Derek C Angus, Maurizio Cecconi, Bin Du, Rob Fowler, Charles D Gomersall, Peter Horby, Nicole P Juffermans, Jozef Kesecioglu, Ruth M Kleinpell, Flavia R Machado, Greg S Martin, Geert Meyfroidt, Andrew Rhodes, Kathryn Rowan, Jean-François Timsit, Jean-Louis Vincent, Giuseppe Citerio,

Coronavirus disease 19 (COVID-19) has posed unprecedented healthcare system challenges, some of which will lead to transformative change. It is obvious to healthcare workers and policymakers alike that an effective critical care surge response must be nested within the overall care delivery model. The COVID-19 pandemic has highlighted key elements ... Read more >>

Intensive Care Med (Intensive care medicine)
[2021, 47(3):282-291]

Cited: 7 times

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The role for high flow nasal cannula as a respiratory support strategy in adults: a clinical practice guideline.

Bram Rochwerg, Sharon Einav, Dipayan Chaudhuri, Jordi Mancebo, Tommaso Mauri, Yigal Helviz, Ewan C Goligher, Samir Jaber, Jean-Damien Ricard, Nuttapol Rittayamai, Oriol Roca, Massimo Antonelli, Salvatore Maurizio Maggiore, Alexandre Demoule, Carol L Hodgson, Alain Mercat, M Elizabeth Wilcox, David Granton, Dominic Wang, Elie Azoulay, Lamia Ouanes-Besbes, Gilda Cinnella, Michela Rauseo, Carlos Carvalho, Armand Dessap-Mekontso, John Fraser, Jean-Pierre Frat, Charles Gomersall, Giacomo Grasselli, Gonzalo Hernandez, Sameer Jog, Antonio Pesenti, Elisabeth D Riviello, Arthur S Slutsky, Renee D Stapleton, Daniel Talmor, Arnaud W Thille, Laurent Brochard, Karen E A Burns,

<h4>Purpose</h4>High flow nasal cannula (HFNC) is a relatively recent respiratory support technique which delivers high flow, heated and humidified controlled concentration of oxygen via the nasal route. Recently, its use has increased for a variety of clinical indications. To guide clinical practice, we developed evidence-based recommendations regarding use of HFNC ... Read more >>

Intensive Care Med (Intensive care medicine)
[2020, 46(12):2226-2237]

Cited: 15 times

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A surveillance method to identify patients with sepsis from electronic health records in Hong Kong: a single centre retrospective study.

Ying Zhi Liu, Raymond Chu, Anna Lee, Charles David Gomersall, Lin Zhang, Tony Gin, Matthew T V Chan, William K K Wu, Lowell Ling,

<h4>Background</h4>Currently there are only two population studies on sepsis incidence in Asia. The burden of sepsis in Hong Kong is unknown. We developed a sepsis surveillance method to estimate sepsis incidence from a population electronic health record (EHR) in Hong Kong using objective clinical data. The study objective was to ... Read more >>

BMC Infect Dis (BMC infectious diseases)
[2020, 20(1):652]

Cited: 0 times

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A minimal common outcome measure set for COVID-19 clinical research.

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Clinical research is necessary for an effective response to an emerging infectious disease outbreak. However, research efforts are often hastily organised and done using various research tools, with the result that pooling data across studies is challenging. In response to the needs of the rapidly evolving COVID-19 outbreak, the Clinical ... Read more >>

Lancet Infect Dis (The Lancet. Infectious diseases)
[2020, 20(8):e192-e197]

Cited: 161 times

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Global outbreak research: harmony not hegemony.

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Lancet Infect Dis (The Lancet. Infectious diseases)
[2020, 20(7):770-772]

Cited: 12 times

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Effect of preoperative education and ICU tour on patient and family satisfaction and anxiety in the intensive care unit after elective cardiac surgery: a randomised controlled trial.

Veronica Ka Wai Lai, Ka Man Ho, Wai Tat Wong, Patricia Leung, Charles David Gomersall, Malcolm John Underwood, Gavin Matthew Joynt, Anna Lee,

<h4>Background</h4>Preoperative education may help participants to psychologically prepare themselves for surgery, but the outcomes of such preparation have rarely been assessed in patients requiring postoperative care in the intensive care unit (ICU) as well as in family members.<h4>Objective</h4>To assess the effect of a preoperative multifaceted education intervention on patient and ... Read more >>

BMJ Qual Saf (BMJ quality & safety)
[2021, 30(3):228-235]

Cited: 0 times

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Intensive care management of coronavirus disease 2019 (COVID-19): challenges and recommendations.

Jason Phua, Li Weng, Lowell Ling, Moritoki Egi, Chae-Man Lim, Jigeeshu Vasishtha Divatia, Babu Raja Shrestha, Yaseen M Arabi, Jensen Ng, Charles D Gomersall, Masaji Nishimura, Younsuck Koh, Bin Du, ,

As coronavirus disease 2019 (COVID-19) spreads across the world, the intensive care unit (ICU) community must prepare for the challenges associated with this pandemic. Streamlining of workflows for rapid diagnosis and isolation, clinical management, and infection prevention will matter not only to patients with COVID-19, but also to health-care workers ... Read more >>

Lancet Respir Med (The Lancet. Respiratory medicine)
[2020, 8(5):506-517]

Cited: 409 times

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Critically ill patients with COVID-19 in Hong Kong: a multicentre retrospective observational cohort study

Lowell Ling, Christina So, Hoi Ping Shum, Paul K S Chan, Christopher K C Lai, Darshana H Kandamby, Eunise Ho, Dominic So, Wing Wa Yan, Grace Lui, Wai Shing Leung, Man Chun Chan, Charles D Gomersall,

Objective:To report the first eight cases of critically ill patients with coronavirus disease 2019 (COVID-19) in Hong Kong, describing the treatments and supportive care they received and their 28-day outcomes. Design:Multicentre retrospective observational cohort study. Setting:Three multidisciplinary intensive care units (ICUs) in Hong Kong. Participants:All adult critically ill patients with ... Read more >>

Crit Care Resusc (Critical care and resuscitation : journal of the Australasian Academy of Critical Care Medicine)
[2020, 22(2):119-125]

Cited: 22 times

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Care for Critically Ill Patients With COVID-19.

Srinivas Murthy, Charles D Gomersall, Robert A Fowler,

JAMA (JAMA)
[2020, 323(15):1499-1500]

Cited: 198 times

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In-vitro adsorption and sieving coefficient of ticarcillin-clavulanate during continuous haemofiltration.

Winnie T P Wan, Yarmarly Guerra Valero, Gordon Y S Choi, Jenny L Ordóñez Mejia, Steven C Wallis, Gavin M Joynt, Jeffrey Lipman, Charles D Gomersall, Jason A Roberts,

There are very limited data on ticarcillin-clavulanate elimination by haemofiltration. We measured in vitro ticarcillin-clavulanate adsorption to polyacrylonitrile (PAN) filters and the sieving coefficient using a well-described bench model of haemofiltration. The dose of ticarcillin-clavulanate was 60/2 mg or 180/3 mg, and 0 or 12 g albumin was added to ... Read more >>

Int J Antimicrob Agents (International journal of antimicrobial agents)
[2019, 54(2):261-264]

Cited: 4 times

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Correction to: White paper: statement on conflicts of interest.

Julian Bion, Massimo Antonelli, LLuis Blanch, J Randall Curtis, Christiane Druml, Bin Du, Flavia R Machado, Charles Gomersall, Christiane Hartog, Mitchell Levy, John Myburgh, Gordon Rubenfeld, Charles Sprung,

The original version of this article unfortunately contained a mistake. ... Read more >>

Intensive Care Med (Intensive care medicine)
[2018, 44(11):2021]

Cited: 0 times

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Identifying associations between diabetes and acute respiratory distress syndrome in patients with acute hypoxemic respiratory failure: an analysis of the LUNG SAFE database.

Andrew J Boyle, Fabiana Madotto, John G Laffey, Giacomo Bellani, Tài Pham, Antonio Pesenti, B Taylor Thompson, Cecilia M O'Kane, Adam M Deane, Daniel F McAuley, , ,

<h4>Background</h4>Diabetes mellitus is a common co-existing disease in the critically ill. Diabetes mellitus may reduce the risk of acute respiratory distress syndrome (ARDS), but data from previous studies are conflicting. The objective of this study was to evaluate associations between pre-existing diabetes mellitus and ARDS in critically ill patients with ... Read more >>

Crit Care (Critical care (London, England))
[2018, 22(1):268]

Cited: 11 times

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White paper: statement on conflicts of interest.

Julian Bion, Massimo Antonelli, LLuis Blanch, J Randall Curtis, Christiane Druml, Bin Du, Flavia R Machado, Charles Gomersall, Christiane Hartog, Mitchell Levy, John Myburgh, Gordon Rubenfeld, Charles Sprung,

<h4>Introduction</h4>Conflicts of interest are a normal part of human social intercourse. They become problematic when there is a power differential between participants in the setting of relationships requiring a high degree of trust, as in healthcare. In this white paper we consider how these conflicts may be detected and mitigated.<h4>Methods</h4>Following ... Read more >>

Intensive Care Med (Intensive care medicine)
[2018, 44(10):1657-1668]

Cited: 3 times

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Advances in critical care management of patients undergoing cardiac surgery.

Anders Aneman, Nicholas Brechot, Daniel Brodie, Frances Colreavy, John Fraser, Charles Gomersall, Peter McCanny, Peter Hasse Moller-Sorensen, Jukka Takala, Kamen Valchanov, Michael Vallely,

Cardiac surgery has been evolving to include minimally invasive, hybrid and transcatheter techniques. Increasing patient age and medical complexity means that critical care management needs to adapt and evolve. Recent advances have occurred in several areas, including ventilation, haemodynamics and mechanical circulatory support, bleeding and coagulation, acute kidney injury, and ... Read more >>

Intensive Care Med (Intensive care medicine)
[2018, 44(6):799-810]

Cited: 7 times

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Exploring the scope of communication content of mechanically ventilated patients.

Czarina C H Leung, Jack Pun, Graham Lock, Diana Slade, Charles D Gomersall, Wai Tat Wong, Gavin M Joynt,

PURPOSE:Ineffective communication during mechanical ventilation (MV) and critical illness is distressing to many patients. This study aimed to describe the scope of communication content of ventilated critically ill patients. MATERIALS AND METHODS:We performed a prospective qualitative interview study in a multidisciplinary intensive care unit. Ten alert, orientated adult patients who ... Read more >>

J Crit Care (Journal of critical care)
[2018, 44:136-141]

Cited: 1 time

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International Surviving Sepsis Campaign guidelines 2016: the perspective from low-income and middle-income countries.

Gentle S Shrestha, Arthur Kwizera, Ganbold Lundeg, John I Baelani, Luciano C P Azevedo, Rajyabardhan Pattnaik, Rashan Haniffa, Srdjan Gavrilovic, Nguyen Thi Hoang Mai, Niranjan Kissoon, Rakesh Lodha, David Misango, Ary Serpa Neto, Marcus J Schultz, Arjen M Dondorp, Jonarthan Thevanayagam, Martin W Dünser, A K M Shamsul Alam, Ahmed M Mukhtar, Madiha Hashmi, Suchitra Ranjit, Akaninyene Otu, Charles Gomersall, Jacinta Amito, Nicolas Nin Vaeza, Jane Nakibuuka, Pierre Mujyarugamba, Elisa Estenssoro, Gustavo A Ospina-Tascón, Sanjib Mohanty, Mervyn Mer,

Lancet Infect Dis (The Lancet. Infectious diseases)
[2017, 17(9):893-895]

Cited: 12 times

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Association between augmented renal clearance and clinical outcomes in patients receiving β-lactam antibiotic therapy by continuous or intermittent infusion: a nested cohort study of the BLING-II randomised, placebo-controlled, clinical trial.

Andrew A Udy, Joel M Dulhunty, Jason A Roberts, Joshua S Davis, Steven A R Webb, Rinaldo Bellomo, Charles Gomersall, Charudatt Shirwadkar, Glenn M Eastwood, John Myburgh, David L Paterson, Therese Starr, Sanjoy K Paul, Jeffrey Lipman, , ,

Augmented renal clearance (ARC) is known to influence β-lactam antibiotic pharmacokinetics. This substudy of the BLING-II trial aimed to explore the association between ARC and patient outcomes in a large randomised clinical trial. BLING-II enrolled 432 participants with severe sepsis randomised to receive β-lactam therapy by continuous or intermittent infusion. ... Read more >>

Int J Antimicrob Agents (International journal of antimicrobial agents)
[2017, 49(5):624-630]

Cited: 22 times

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