Full Text Journal Articles by
Author Charles Berde

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Trends in Gabapentin and Pregabalin Prescribing in a Tertiary Pediatric Medical Center.

Carolina Donado, Kristina Nedeljkovic, Suratsawadee Wangnamthip, Jean C Solodiuk, Florence T Bourgeois, Charles B Berde,

<h4>Objectives</h4>Analgesic medications are commonly prescribed in pediatrics, with prescribing practices frequently extrapolated from adult trials. Gabapentinoids (gabapentin and pregabalin) are widely used as analgesics but are labeled in pediatrics only for epilepsy. We aim to (1) define trends in pediatric gabapentinoid prescribing (label and off-label) over 7 years, and (2) ... Read more >>

Hosp Pediatr (Hospital pediatrics)
[2021, :]

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Intrathecal catheter and port placement for nusinersen infusion in children with spinal muscular atrophy and spinal fusion.

Kumar K Shashi, Scellig S D Stone, Charles B Berde, Horacio M Padua,

<h4>Background</h4>Spinal administration of medications is challenging in patients with complete posterior spinal fusion. We describe percutaneous image-guided intrathecal port placement for administration of the antisense oligonucleotide nusinersen for children and young adults with spinal muscular atrophy.<h4>Objective</h4>To describe and present our initial experience with a new technique for administering nusinersen in ... Read more >>

Pediatr Radiol (Pediatric radiology)
[2021, :]

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Explicit and implicit bias based on race, ethnicity, and weight among pediatric emergency physicians.

Romain Guedj, Maddalena Marini, Joe Kossowsky, Charles Berde, Camila Mateo, Eric W Fleegler,

Acad Emerg Med (Academic emergency medicine : official journal of the Society for Academic Emergency Medicine)
[2021, :]

Cited: 0 times

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Nonpharmacological Interventions for Pediatric Migraine: A Network Meta-analysis.

Helen Koechlin, Joe Kossowsky, Thanh Lan Lam, Johannes Barthel, Jens Gaab, Charles B Berde, Guido Schwarzer, Klaus Linde, Karin Meissner, Cosima Locher,

<h4>Context</h4>Migraine is a common neurologic disorder in children and adolescents. However, a comparison of multiple nonpharmacological treatments is lacking.<h4>Objective</h4>To examine whether nonpharmacological treatments are more effective than waiting list and whether there are differences between interventions regarding efficacy.<h4>Data sources</h4>Systematic review and network meta-analysis of studies in Medline, Cochrane, Embase, and ... Read more >>

Pediatrics (Pediatrics)
[2021, 147(4):]

Cited: 1 time

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Epidural catheter placement in children with baclofen pumps.

Susan E Eklund, Aneesh V Samineni, Anjali Koka, Bobbie L Riley, Roland R Brusseau, Benjamin J Shore, Patricia E Miller, Scellig S Stone, Charles B Berde, Walid Alrayashi,

<h4>Background</h4>Children with cerebral palsy often suffer from increased tone, which can be treated with intrathecal baclofen via implanted pump. Additionally, they often require major orthopedic surgery for hip reconstruction; however, the presence of an intrathecal baclofen pump is a relative contraindication to regional anesthesia due to concerns about damaging the ... Read more >>

Paediatr Anaesth (Paediatric anaesthesia)
[2021, 31(2):178-185]

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Case Studies Using the Electroencephalogram to Monitor Anesthesia-Induced Brain States in Children.

Steven P Brandt, Elisa C Walsh, Laura Cornelissen, Johanna M Lee, Charles Berde, Erik S Shank, Patrick L Purdon,

For this child, at this particular moment, how much anesthesia should I give? Determining the drug requirements of a specific patient is a fundamental problem in medicine. Our current approach uses population-based pharmacological models to establish dosing. However, individual patients, and children in particular, may respond to drugs differently. In ... Read more >>

Anesth Analg (Anesthesia and analgesia)
[2020, 131(4):1043-1056]

Cited: 1 time

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Neurophysiological Assessment of Prolonged Recovery From Neuromuscular Blockade in the Neonatal Intensive Care Unit.

Omri David Soffer, Angela Kim, Ellen Underwood, Anne Hansen, Laura Cornelissen, Charles Berde,

<b>Objective:</b> To evaluate recovery from neuromuscular blockade in infants using Train-of-Four nerve stimulation. <b>Study Design:</b> Ulnar nerve stimulation was used to evoke thumb twitch and reported as Train-of-Four ratio. Thumb twitch was also recorded visually in real-time. Primary outcome was time to near recovery of muscle function (Train-of-Four ratio >70%). ... Read more >>

Front Pediatr (Frontiers in pediatrics)
[2020, 8:580]

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Genome-wide association analysis of opioid use disorder: A novel approach using clinical data.

Wenyu Song, Joe Kossowsky, John Torous, Chia-Yen Chen, Hailiang Huang, Kenneth J Mukamal, Charles B Berde, David W Bates, Adam Wright,

<h4>Background</h4>Opioid use disorder (OUD) represents a large and pervasive global public health challenge. Previous genetic studies have demonstrated the significant heritability of OUD and identified several single-nucleotide polymorphisms (SNPs) associated with its prevalence.<h4>Methods</h4>In this paper, we conducted a genome-wide association analysis on opioid use disorder that leveraged genetic and clinical ... Read more >>

Drug Alcohol Depend (Drug and alcohol dependence)
[2020, 217:108276]

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Effect of lumbar medial branch blocks on extension-related axial chronic low back pain in a pediatric population: a retrospective chart review and prospective follow-up.

Carolina Donado, Genevieve M Spagnuolo, Kimberly Lobo, Charles Berde, Pradeep Dinakar,

Reg Anesth Pain Med (Regional anesthesia and pain medicine)
[2020, 45(12):1019-1020]

Cited: 0 times

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Efficacy, Safety, and Acceptability of Pharmacologic Treatments for Pediatric Migraine Prophylaxis: A Systematic Review and Network Meta-analysis.

Cosima Locher, Joe Kossowsky, Helen Koechlin, Thanh Lan Lam, Johannes Barthel, Charles B Berde, Jens Gaab, Guido Schwarzer, Klaus Linde, Karin Meissner,

<h4>Importance</h4>Migraine is one of the most common neurologic disorders in children and adolescents. However, a quantitative comparison of multiple preventive pharmacologic treatments in the pediatric population is lacking.<h4>Objective</h4>To examine whether prophylactic pharmacologic treatments are more effective than placebo and whether there are differences between drugs regarding efficacy, safety, and acceptability.<h4>Data ... Read more >>

JAMA Pediatr (JAMA pediatrics)
[2020, 174(4):341-349]

Cited: 7 times

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Off-label use of prescription analgesics among hospitalized children in the United States.

Mary Carmack, Charles Berde, Michael C Monuteaux, Shannon Manzi, Florence T Bourgeois,

<h4>Purpose</h4>Analgesics are the most frequently administered medications among hospitalized children. However, current analgesic prescribing patterns have not been well defined among hospitalized children. In addition, it is unknown what proportion of prescription analgesics is approved for use in children and what proportion is used "off-label."<h4>Methods</h4>Nationally representative data from 52 tertiary ... Read more >>

Pharmacoepidemiol Drug Saf (Pharmacoepidemiology and drug safety)
[2020, 29(4):474-481]

Cited: 1 time

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Developing a pediatric pain data repository.

Carolina Donado, Kimberly Lobo, Charles B Berde, Florence T Bourgeois,

The management of pediatric pain typically consists of individualized treatment plans and interventions that have not been systematically evaluated. There is an emerging need to create systems that can support the translation of clinical discoveries, facilitate the assessment of current interventions, and improve the collection of patient-centered data beyond routine ... Read more >>

JAMIA Open (JAMIA open)
[2020, 3(1):31-36]

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Association of Genetic Variants With Migraine Subclassified by Clinical Symptoms in Adult Females.

Joe Kossowsky, Megan S Schuler, Franco Giulianini, Charles B Berde, Ben Reis, Paul M Ridker, Julie E Buring, Tobias Kurth, Daniel I Chasman,

Migraine is heritable and formally diagnosed by structured criteria that require presence of some but not all possible migraine symptoms which include aura, several distinct manifestations of pain, nausea/vomiting, and sensitivity to light or sound. The most recent genome-wide genetic association study (GWAS) for migraine identified 38 loci. We investigated ... Read more >>

Front Neurol (Frontiers in neurology)
[2020, 11:617472]

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δ-Oscillation Correlates of Anesthesia-induced Unconsciousness in Large-scale Brain Networks of Human Infants.

Ioannis Pappas, Laura Cornelissen, David K Menon, Charles B Berde, Emmanuel A Stamatakis,

<h4>Background</h4>Functional brain connectivity studies can provide important information about changes in brain-state dynamics during general anesthesia. In adults, γ-aminobutyric acid-mediated agents disrupt integration of information from local to the whole-brain scale. Beginning around 3 to 4 months postnatal age, γ-aminobutyric acid-mediated anesthetics such as sevoflurane generate α-electroencephalography oscillations. In previous ... Read more >>

Anesthesiology (Anesthesiology)
[2019, 131(6):1239-1253]

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Patient-Customized Oligonucleotide Therapy for a Rare Genetic Disease.

Jinkuk Kim, Chunguang Hu, Christelle Moufawad El Achkar, Lauren E Black, Julie Douville, Austin Larson, Mary K Pendergast, Sara F Goldkind, Eunjung A Lee, Ashley Kuniholm, Aubrie Soucy, Jai Vaze, Nandkishore R Belur, Kristina Fredriksen, Iva Stojkovska, Alla Tsytsykova, Myriam Armant, Renata L DiDonato, Jaejoon Choi, Laura Cornelissen, Luis M Pereira, Erika F Augustine, Casie A Genetti, Kira Dies, Brenda Barton, Lucinda Williams, Benjamin D Goodlett, Bobbie L Riley, Amy Pasternak, Emily R Berry, Kelly A Pflock, Stephen Chu, Chantal Reed, Kimberly Tyndall, Pankaj B Agrawal, Alan H Beggs, P Ellen Grant, David K Urion, Richard O Snyder, Susan E Waisbren, Annapurna Poduri, Peter J Park, Al Patterson, Alessandra Biffi, Joseph R Mazzulli, Olaf Bodamer, Charles B Berde, Timothy W Yu,

Genome sequencing is often pivotal in the diagnosis of rare diseases, but many of these conditions lack specific treatments. We describe how molecular diagnosis of a rare, fatal neurodegenerative condition led to the rational design, testing, and manufacture of milasen, a splice-modulating antisense oligonucleotide drug tailored to a particular patient. ... Read more >>

N Engl J Med (The New England journal of medicine)
[2019, 381(17):1644-1652]

Cited: 70 times

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Electroencephalographic features of discontinuous activity in anesthetized infants and children.

Uday Agrawal, Charles B Berde, Laura Cornelissen,

<h4>Background</h4>Discontinuous electroencephalographic activity in children is thought to reflect brain inactivation. Discontinuity has been observed in states of pathology, where it is predictive of adverse neurological outcome, as well as under general anesthesia. Though in preterm-infants discontinuity reflects normal brain development, less is known regarding its role in term children, ... Read more >>

PLoS One (PloS one)
[2019, 14(10):e0223324]

Cited: 1 time

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Morphine compared to placebo for procedural pain in preterm infants: safety, efficacy and equipoise.

Omri David Soffer, Laura Cornelissen, Christy Cummings, Charles Berde,

J Perinatol (Journal of perinatology : official journal of the California Perinatal Association)
[2019, 39(10):1428-1431]

Cited: 1 time

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The effect of suprainguinal fascia iliaca block on the recovery of patients after arthroscopic hip surgery.

Walid Alrayashi, David Zurakowski, Cornelius Arthur Sullivan, Charles B Berde, Nissa Askins, Sean Sinnott, Joseph P Cravero,

<h4>Background</h4>Adolescent and young adult patients undergoing arthroscopic hip surgery experience significant pain in the immediate postoperative period. There is a small body of evidence that indicates suprainguinal fascia iliaca blocks can improve comfort during recovery from this intervention. Our hypothesis was that patients undergoing hip surgery would consume fewer opioids ... Read more >>

Paediatr Anaesth (Paediatric anaesthesia)
[2019, 29(8):829-834]

Cited: 1 time

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The Society for Pediatric Anesthesia recommendations for the use of opioids in children during the perioperative period.

Joseph P Cravero, Rita Agarwal, Charles Berde, Patrick Birmingham, Charles J Coté, Jeffrey Galinkin, Lisa Isaac, Sabine Kost-Byerly, David Krodel, Lynne Maxwell, Terri Voepel-Lewis, Navil Sethna, Robert Wilder,

Opioids have long held a prominent role in the management of perioperative pain in adults and children. Published reports concerning the appropriate, and inappropriate, use of these medications in pediatric patients have appeared in various publications over the last 50 years. For this document, the Society for Pediatric Anesthesia appointed a ... Read more >>

Paediatr Anaesth (Paediatric anaesthesia)
[2019, 29(6):547-571]

Cited: 3 times

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Neural Correlates of Anesthesia in Newborn Mice and Humans.

Mattia Chini, Sabine Gretenkord, Johanna K Kostka, Jastyn A Pöpplau, Laura Cornelissen, Charles B Berde, Ileana L Hanganu-Opatz, Sebastian H Bitzenhofer,

Monitoring the hypnotic component of anesthesia during surgeries is critical to prevent intraoperative awareness and reduce adverse side effects. For this purpose, electroencephalographic (EEG) methods complementing measures of autonomic functions and behavioral responses are in use in clinical practice. However, in human neonates and infants existing methods may be unreliable ... Read more >>

Front Neural Circuits (Frontiers in neural circuits)
[2019, 13:38]

Cited: 7 times

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Neurodevelopmental outcome at 5 years of age after general anaesthesia or awake-regional anaesthesia in infancy (GAS): an international, multicentre, randomised, controlled equivalence trial.

Mary Ellen McCann, Jurgen C de Graaff, Liam Dorris, Nicola Disma, Davinia Withington, Graham Bell, Anneke Grobler, Robyn Stargatt, Rodney W Hunt, Suzette J Sheppard, Jacki Marmor, Gaia Giribaldi, David C Bellinger, Penelope L Hartmann, Pollyanna Hardy, Geoff Frawley, Francesca Izzo, Britta S von Ungern Sternberg, Anne Lynn, Niall Wilton, Martin Mueller, David M Polaner, Anthony R Absalom, Peter Szmuk, Neil Morton, Charles Berde, Sulpicio Soriano, Andrew J Davidson, ,

<h4>Background</h4>In laboratory animals, exposure to most general anaesthetics leads to neurotoxicity manifested by neuronal cell death and abnormal behaviour and cognition. Some large human cohort studies have shown an association between general anaesthesia at a young age and subsequent neurodevelopmental deficits, but these studies are prone to bias. Others have ... Read more >>

Lancet (Lancet (London, England))
[2019, 393(10172):664-677]

Cited: 62 times

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Patient- and Nurse-Controlled Analgesia: 22-Year Experience in a Pediatric Hospital.

Carolina Donado, Jean Solodiuk, Shawn J Rangel, Caleb P Nelson, Matthew M Heeney, Susan T Mahan, Christina Ullrich, Binyam Tsegaye, Charles B Berde,

<h4>Objectives</h4>Pediatric pain management has rapidly changed over the last 2 decades. In this study, we describe the changing practices and adverse events (AEs) related to patient-controlled analgesia (PCA) and/or nurse-controlled analgesia (NCA) over a 22-year period.<h4>Methods</h4>After institutional review board approval, retrospective data from a single tertiary-care pediatric hospital were collected ... Read more >>

Hosp Pediatr (Hospital pediatrics)
[2019, 9(2):129-133]

Cited: 1 time

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An open label pilot study of a dexmedetomidine-remifentanil-caudal anesthetic for infant lower abdominal/lower extremity surgery: The T REX pilot study.

Peter Szmuk, Dean Andropoulos, Francis McGowan, Ansgar Brambrink, Christopher Lee, Katherine J Lee, Mary Ellen McCann, Yang Liu, Rita Saynhalath, Choon Looi Bong, Brian J Anderson, Charles Berde, Jurgen C De Graaff, Nicola Disma, Dean Kurth, Andreas Loepke, Beverley Orser, Daniel I Sessler, Justin J Skowno, Britta S von Ungern-Sternberg, Laszlo Vutskits, Andrew Davidson,

<h4>Background</h4>Concern over potential neurotoxicity of anesthetics has led to growing interest in prospective clinical trials using potentially less toxic anesthetic regimens, especially for prolonged anesthesia in infants. Preclinical studies suggest that dexmedetomidine may have a reduced neurotoxic profile compared to other conventional anesthetic regimens; however, coadministration with either anesthetic drugs ... Read more >>

Paediatr Anaesth (Paediatric anaesthesia)
[2019, 29(1):59-67]

Cited: 3 times

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Identifying neurophysiological features associated with anesthetic state in newborn mice and humans

Mattia Chini, Sabine Gretenkord, Johanna Kostka, Jastyn Pöpplau, Laura Cornelissen, Charles Berde, Ileana Hanganu-Opatz, Sebastian Bitzenhofer,

<h4>One Sentence Summary</h4> Machine learning reveals consistent features of anesthetic states assessed by intracranial recordings in newborn mice and multichannel EEG in human neonates and infants. Monitoring the hypnotic component of anesthesia during surgeries is critical to prevent intraoperative awareness and reduce adverse side effects. For this purpose, electroencephalographic methods ... Read more >>

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Maximum Recommended Dosage of Ropivacaine and Bupivacaine for Pediatric Regional Anesthesia.

Ban C H Tsui, Karen Boretsky, Charles Berde,

Reg Anesth Pain Med (Regional anesthesia and pain medicine)
[2018, 43(8):895-896]

Cited: 1 time

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