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Author Chantal Dessy

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Beta 3 adrenoreceptors protect from hypertrophic remodelling through AMP-activated protein kinase and autophagy.

Emilie Dubois-Deruy, Roselle Gelinas, Christophe Beauloye, Hrag Esfahani, Lauriane Y M Michel, Chantal Dessy, Luc Bertrand, Jean-Luc Balligand,

AIMS:The abundance of beta 3-adrenergic receptors (β3-ARs) is upregulated in diseased human myocardium. We previously showed that cardiac-specific expression of β3-AR inhibits the hypertrophic response to neurohormonal stimulation. Here, we further analysed signalling pathways involved in the anti-hypertrophic effect of β3-AR. METHODS AND RESULTS:In vitro hypertrophic responses to phenylephrine (PE) ... Read more >>

ESC Heart Fail (ESC heart failure)
[2020, 7(3):920-932]

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Influence of Different Partial Pressures of Oxygen During Continuous Hypothermic Machine Perfusion in a Pig Kidney Ischemia-reperfusion Autotransplant Model.

Tom Darius, Martial Vergauwen, Thomas B Smith, Kamlesh Patel, Julie Craps, Virginie Joris, Selda Aydin, Benoît Ury, Antoine Buemi, Martine De Meyer, Jay Nath, Christian Ludwig, Chantal Dessy, Marie-Christine Many, Pierre Gianello, Michel Mourad,

BACKGROUND:The optimal perfusate partial pressure of oxygen (PO2) during hypothermic machine perfusion (HMP) is unknown. The aims of the study were to determine the functional, metabolic, structural, and flow dynamic effects of low and high perfusate PO2 during continuous HMP in a pig kidney ischemia-reperfusion autotransplant model. METHODS:The left kidneys ... Read more >>

Transplantation (Transplantation)
[2020, 104(4):731-743]

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Beta-3 Adrenoreceptors protect from hypertrophic remodelling through AMP-Activated Protein Kinase and Autophagy

Emilie Dubois-Deruy, Roselle Gelinas, Christophe Beauloye, Hrag Esfahani, Chantal Dessy, Luc Bertrand, Jean-Luc Balligand,

ABSTRACT Aims The abundance of beta3-adrenergic receptors (β3-ARs) is upregulated in diseased human myocardium. We previously showed that cardiac-specific expression of β3-AR inhibits the hypertrophic response to neurohormonal stimulation. Here, we further analyzed signalling pathways involved in the anti-hypertrophic effect of β3-AR. Methods In vitro hypertrophic responses to phenylephrine (PE) ... Read more >>

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Brief O2 uploading during continuous hypothermic machine perfusion is simple yet effective oxygenation method to improve initial kidney function in a porcine autotransplant model.

Tom Darius, Martial Vergauwen, Thomas Smith, Isabelle Gerin, Virginie Joris, Matteo Mueller, Selda Aydin, Xavier Muller, Andrea Schlegel, Jay Nath, Christian Ludwig, Chantal Dessy, Marie-Christine Many, Guido Bommer, Philipp Dutkowski, Pierre Gianello, Michel Mourad,

With oxygenation proposed as a resuscitative measure during hypothermic models of preservation, the aim of this study was to evaluate the optimal start time of oxygenation during continuous hypothermic machine perfusion (HMP). In this porcine ischemia-reperfusion autotransplant model, the left kidney of a ±40 kg pig was exposed to 30 minutes of ... Read more >>

Am. J. Transplant. (American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons)
[2020, :]

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Chitin-glucan and pomegranate polyphenols improve endothelial dysfunction.

Audrey M Neyrinck, Emilie Catry, Bernard Taminiau, Patrice D Cani, Laure B Bindels, Georges Daube, Chantal Dessy, Nathalie M Delzenne,

The vascular dysfunction is the primary event in the occurrence of cardio-vascular risk, and no treatment exists until now. We tested for the first time the hypothesis that chitin-glucan (CG) - an insoluble fibre with prebiotic properties- and polyphenol-rich pomegranate peel extract (PPE) can improve endothelial and inflammatory disorders in ... Read more >>

Sci Rep (Scientific reports)
[2019, 9(1):14150]

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MicroRNA-199a-3p and MicroRNA-199a-5p Take Part to a Redundant Network of Regulation of the NOS (NO Synthase)/NO Pathway in the Endothelium.

Virginie Joris, Elvira Leon Gomez, Lisa Menchi, Irina Lobysheva, Vittoria Di Mauro, Hrag Esfahani, Gianluigi Condorelli, Jean-Luc Balligand, Daniele Catalucci, Chantal Dessy,

Objective- Members of the microRNA (miR)-199a family, namely miR-199a-5p and miR-199a-3p, have been recently identified as potential regulators of cardiac homeostasis. Also, upregulation of miR-199a expression in cardiomyocytes was reported to influence endothelial cells. Whether miR-199a is expressed by endothelial cells and, if so, whether it directly regulates endothelial function ... Read more >>

Arterioscler. Thromb. Vasc. Biol. (Arteriosclerosis, thrombosis, and vascular biology)
[2018, 38(10):2345-2357]

Cited: 4 times

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Perfusion-decellularization of human ear grafts enables ECM-based scaffolds for auricular vascularized composite tissue engineering.

Jérôme Duisit, Hadrien Amiel, Tsering Wüthrich, Adriano Taddeo, Adeline Dedriche, Vincent Destoop, Thomas Pardoen, Caroline Bouzin, Virginie Joris, Derek Magee, Esther Vögelin, David Harriman, Chantal Dessy, Giuseppe Orlando, Catherine Behets, Robert Rieben, Pierre Gianello, Benoît Lengelé,

INTRODUCTION:Human ear reconstruction is recognized as the emblematic enterprise in tissue engineering. Up to now, it has failed to reach human applications requiring appropriate tissue complexity along with an accessible vascular tree. We hereby propose a new method to process human auricles in order to provide a poorly immunogenic, complex ... Read more >>

Acta Biomater (Acta biomaterialia)
[2018, 73:339-354]

Cited: 4 times

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Bioengineering a Human Face Graft: The Matrix of Identity.

Jérôme Duisit, Louis Maistriaux, Adriano Taddeo, Giuseppe Orlando, Virginie Joris, Emmanuel Coche, Catherine Behets, Jan Lerut, Chantal Dessy, Giulio Cossu, Esther Vögelin, Robert Rieben, Pierre Gianello, Benoît Lengelé,

During the last decade, face allotransplantation has been shown to be a revolutionary reconstructive procedure for severe disfigurements. However, offer to patients remains limited due to lifelong immunosuppression. To move forward in the field, a new pathway in tissue engineering is proposed.Our previously reported technique of matrix production of a ... Read more >>

Ann. Surg. (Annals of surgery)
[2017, 266(5):754-764]

Cited: 8 times

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Targeting the gut microbiota with inulin-type fructans: preclinical demonstration of a novel approach in the management of endothelial dysfunction.

Emilie Catry, Laure B Bindels, Anne Tailleux, Sophie Lestavel, Audrey M Neyrinck, Jean-François Goossens, Irina Lobysheva, Hubert Plovier, Ahmed Essaghir, Jean-Baptiste Demoulin, Caroline Bouzin, Barbara D Pachikian, Patrice D Cani, Bart Staels, Chantal Dessy, Nathalie M Delzenne,

OBJECTIVE:To investigate the beneficial role of prebiotics on endothelial dysfunction, an early key marker of cardiovascular diseases, in an original mouse model linking steatosis and endothelial dysfunction. DESIGN:We examined the contribution of the gut microbiota to vascular dysfunction observed in apolipoprotein E knockout (Apoe-/-) mice fed an n-3 polyunsaturated fatty ... Read more >>

Gut (Gut)
[2018, 67(2):271-283]

Cited: 24 times

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MRI Assessment of Cardiomyopathy Induced by β1-Adrenoreceptor Autoantibodies and Protection Through β3-Adrenoreceptor Overexpression.

Laetitia Vanhoutte, Céline Guilbaud, Ruben Martherus, Caroline Bouzin, Bernard Gallez, Chantal Dessy, Jean-Luc Balligand, Stéphane Moniotte, Olivier Feron,

The cardiopathogenic role of autoantibodies (aabs) directed against β1-adrenoreceptors (β1-AR) is well established. In mouse models, they cause progressive dilated cardiomyopathy (DCM) whose characterization with echocardiography requires prolonged protocols with numerous animals, complicating the evaluation of new treatments. Here, we report on the characterization of β1-aabs-induced DCM in mice using ... Read more >>

Sci Rep (Scientific reports)
[2017, 7:43951]

Cited: 2 times

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Nutritional depletion in n-3 PUFA in apoE knock-out mice: A new model of endothelial dysfunction associated with fatty liver disease.

Emilie Catry, Audrey M Neyrinck, Irina Lobysheva, Barbara D Pachikian, Matthias Van Hul, Patrice D Cani, Chantal Dessy, Nathalie M Delzenne,

Western diets are characterized by low intake of n-3 PUFA compensated by constant amounts of n-6 PUFA. Reduced intake of n-3 PUFA is associated with increased cardiovascular risk, as observed in nonalcoholic fatty liver disease patients. The study aimed to evaluating the impact of dietary n-3 PUFA depletion on endothelial ... Read more >>

Mol Nutr Food Res (Molecular nutrition & food research)
[2016, 60(10):2198-2207]

Cited: 3 times

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Vascular and Central Activation of Peroxisome Proliferator-Activated Receptor-β Attenuates Angiotensin II-Induced Hypertension: Role of RGS-5.

Miguel Romero, Rosario Jiménez, Marta Toral, Elvira León-Gómez, Manuel Gómez-Gúzman, Manuel Sánchez, María José Zarzuelo, Isabel Rodríguez-Gómez, Geraldine Rath, Juan Tamargo, Francisco Pérez-Vizcaíno, Chantal Dessy, Juan Duarte,

Activation of peroxisome proliferator-activated receptor-β/δ (PPARβ) lowers blood pressure in genetic and mineralocorticoid-induced hypertension. Regulator of G-protein-coupled receptor signaling 5 (RGS5) protein, which interferes in angiotensin II (AngII) signaling, is a target gene to PPARβ The aim of the present study was to examine whether PPARβ activation in resistance arteries ... Read more >>

J. Pharmacol. Exp. Ther. (The Journal of pharmacology and experimental therapeutics)
[2016, 358(1):151-163]

Cited: 8 times

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Effects of BM-573 on Endothelial Dependent Relaxation and Increased Blood Pressure at Early Stages of Atherosclerosis.

Miguel Romero, Elvira Leon-Gomez, Irina Lobysheva, Géraldine Rath, Jean-Michel Dogné, Olivier Feron, Chantal Dessy,

Endothelial dysfunction is considered to be an early event in atherosclerosis and plays a pivotal role in the development, progression and clinical complications of atherosclerosis. Previous studies have shown the beneficial effects of combined inhibition of thromboxane synthase and antagonism of thromboxane receptors by BM-573 on atherosclerosis; however our knowledge ... Read more >>

PLoS ONE (PloS one)
[2016, 11(3):e0152579]

Cited: 4 times

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Hyaluronidase 1 Deficiency Preserves Endothelial Function and Glycocalyx Integrity in Early Streptozotocin-Induced Diabetes.

Sophie Dogné, Géraldine Rath, François Jouret, Nathalie Caron, Chantal Dessy, Bruno Flamion,

Hyaluronic acid (HA) is a major component of the glycocalyx involved in the vascular wall and endothelial glomerular permeability barrier. Endocytosed hyaluronidase HYAL1 is known to degrade HA into small fragments in different cell types, including endothelial cells. In diabetes, the size and permeability of the glycocalyx are altered. In ... Read more >>

Diabetes (Diabetes)
[2016, 65(9):2742-2753]

Cited: 9 times

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Vascular Endothelium-Dependent and Independent Actions of Oleanolic Acid and Its Synthetic Oleanane Derivatives as Possible Mechanisms for Hypotensive Effects.

Hlengiwe P Madlala, Thomas Metzinger, Fanie R van Heerden, Cephas T Musabayane, Kanigula Mubagwa, Chantal Dessy,

PURPOSE:Plant-derived oleanolic acid (OA) and its related synthetic derivatives (Br-OA and Me-OA) possess antihypertensive effects in experimental animals. The present study investigated possible underlying mechanisms in rat isolated single ventricular myocytes and in vascular smooth muscles superfused at 37°C. METHODS:Cell shortening was assessed at 1 Hz using a video-based edge-detection ... Read more >>

PLoS ONE (PloS one)
[2016, 11(1):e0147395]

Cited: 4 times

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Loss of mouse P2Y4 nucleotide receptor protects against myocardial infarction through endothelin-1 downregulation.

Michael Horckmans, Hrag Esfahani, Christophe Beauloye, Sophie Clouet, Larissa di Pietrantonio, Bernard Robaye, Jean-Luc Balligand, Jean-Marie Boeynaems, Chantal Dessy, Didier Communi,

Nucleotides are released in the heart under pathological conditions, but little is known about their contribution to cardiac inflammation. The present study defines the P2Y4 nucleotide receptor, expressed on cardiac microvascular endothelial cells and involved in postnatal heart development, as an important regulator of the inflammatory response to cardiac ischemia. ... Read more >>

J. Immunol. (Journal of immunology (Baltimore, Md. : 1950))
[2015, 194(4):1874-1881]

Cited: 8 times

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AMPK activation by glucagon-like peptide-1 prevents NADPH oxidase activation induced by hyperglycemia in adult cardiomyocytes.

Magali Balteau, Anne Van Steenbergen, Aurélie D Timmermans, Chantal Dessy, Gaetane Behets-Wydemans, Nicolas Tajeddine, Diego Castanares-Zapatero, Patrick Gilon, Jean-Louis Vanoverschelde, Sandrine Horman, Louis Hue, Luc Bertrand, Christophe Beauloye,

Exposure of cardiomyocytes to high glucose concentrations (HG) stimulates reactive oxygen species (ROS) production by NADPH oxidase (NOX2). NOX2 activation is triggered by enhanced glucose transport through a sodium-glucose cotransporter (SGLT) but not by a stimulation of glucose metabolism. The aim of this work was to identify potential therapeutic approaches ... Read more >>

Am. J. Physiol. Heart Circ. Physiol. (American journal of physiology. Heart and circulatory physiology)
[2014, 307(8):H1120-33]

Cited: 39 times

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Prebiotics supplementation improves the endothelial dysfunction in n-3 PUFA-depleted ApoE mice.

Emilie Catry, Géraldine Rath, Barbara D Pachikian, Audrey M Neyrinck, Patrice D Cani, Chantal Dessy, Nathalie M Delzenne,

(Archives of Public Health)
[2014, 72(Suppl 1):O5-O5]

Cited: 0 times

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Enhanced expression of β3-adrenoceptors in cardiac myocytes attenuates neurohormone-induced hypertrophic remodeling through nitric oxide synthase.

Catharina Belge, Joanna Hammond, Emilie Dubois-Deruy, Boris Manoury, Julien Hamelet, Christophe Beauloye, Andreas Markl, Anne-Catherine Pouleur, Luc Bertrand, Hrag Esfahani, Karima Jnaoui, Konrad R Götz, Viacheslav O Nikolaev, Annelies Vanderper, Paul Herijgers, Irina Lobysheva, Guido Iaccarino, Denise Hilfiker-Kleiner, Geneviève Tavernier, Dominique Langin, Chantal Dessy, Jean-Luc Balligand,

BACKGROUND: β1-2-adrenergic receptors (AR) are key regulators of cardiac contractility and remodeling in response to catecholamines. β3-AR expression is enhanced in diseased human myocardium, but its impact on remodeling is unknown. METHODS AND RESULTS: Mice with cardiac myocyte-specific expression of human β3-AR (β3-TG) and wild-type (WT) littermates were used to ... Read more >>

Circulation (Circulation)
[2014, 129(4):451-462]

Cited: 47 times

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Gene deletion of P2Y4 receptor lowers exercise capacity and reduces myocardial hypertrophy with swimming exercise.

Michael Horckmans, Elvira Léon-Gómez, Bernard Robaye, Jean-Luc Balligand, Jean-Marie Boeynaems, Chantal Dessy, Didier Communi,

Nucleotides released within the heart under pathological conditions can be involved in cardioprotection or cardiac fibrosis through the activation purinergic P2Y(2) and P2Y(6) receptors, respectively. We previously demonstrated that adult P2Y(4)-null mice display a microcardia phenotype related to a cardiac angiogenic defect. To evaluate the functional consequences of this defect, ... Read more >>

Am. J. Physiol. Heart Circ. Physiol. (American journal of physiology. Heart and circulatory physiology)
[2012, 303(7):H835-43]

Cited: 10 times

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Different effect of Rho kinase inhibition on calcium signaling in rat isolated large and small arteries.

Anneloes Martinsen, Xavier Yerna, Géraldine Rath, Elvira Leon Gomez, Chantal Dessy, Nicole Morel,

In addition to its role in the regulation of artery contraction, Rho kinase (ROCK) was reported to be involved in the cytosolic calcium response to vasoconstrictor agonists in rat aorta and superior mesenteric artery (SMA). However, it remains to be determined whether ROCK also contributes to calcium signaling in resistance ... Read more >>

J. Vasc. Res. (Journal of vascular research)
[2012, 49(6):522-533]

Cited: 5 times

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Vasodilatory mechanisms of beta receptor blockade.

Géraldine Rath, Jean-Luc Balligand, Chantal Dessy,

Beta-blockers are widely prescribed for the treatment of a variety of cardiovascular pathologies. Compared to traditional beta-adrenergic antagonists, beta-blockers of the new generation exhibit ancillary properties such as vasodilation through different mechanisms. This translates into a more favorable hemodynamic profile. The relative affinities of beta-adrenoreceptor antagonists towards the three beta-adrenoreceptor ... Read more >>

Curr. Hypertens. Rep. (Current hypertension reports)
[2012, 14(4):310-317]

Cited: 8 times

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Vascular hypoxic preconditioning relies on TRPV4-dependent calcium influx and proper intercellular gap junctions communication.

Géraldine Rath, Julie Saliez, Gaëtane Behets, Miguel Romero-Perez, Elvira Leon-Gomez, Caroline Bouzin, Joris Vriens, Bernd Nilius, Olivier Feron, Chantal Dessy,

We investigated the impact of hypoxia-reoxygenation on endothelial relaxation and aimed to clarify the role of transient receptor potential cation channels V4 (TRPV4) and gap junctions in the protective effect associated with hypoxic preconditioning on the vascular function.By mimicking ischemia-reperfusion in C57BL/6 male mice in vivo, we documented a reduced ... Read more >>

Arterioscler. Thromb. Vasc. Biol. (Arteriosclerosis, thrombosis, and vascular biology)
[2012, 32(9):2241-2249]

Cited: 25 times

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Regulation of monocarboxylate transporter MCT1 expression by p53 mediates inward and outward lactate fluxes in tumors.

Romain Boidot, Frédérique Végran, Aline Meulle, Aude Le Breton, Chantal Dessy, Pierre Sonveaux, Sarab Lizard-Nacol, Olivier Feron,

The monocarboxylate transporter (MCT) family member MCT1 can transport lactate into and out of tumor cells. Whereas most oxidative cancer cells import lactate through MCT1 to fuel mitochondrial respiration, the role of MCT1 in glycolysis-derived lactate efflux remains less clear. In this study, we identified a direct link between p53 ... Read more >>

Cancer Res. (Cancer research)
[2012, 72(4):939-948]

Cited: 76 times

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P2Y(4) nucleotide receptor: a novel actor in post-natal cardiac development.

Michael Horckmans, Bernard Robaye, Elvira Léon-Gόmez, Nicolas Lantz, Philippe Unger, Frédérique Dol-Gleizes, Sophie Clouet, Dorothée Cammarata, Paul Schaeffer, Pierre Savi, Christian Gachet, Jean-Luc Balligand, Chantal Dessy, Jean-Marie Boeynaems, Didier Communi,

Communication between endothelial cells and cardiomyocytes is critical for cardiac development and regeneration. However the mechanisms involved in these endothelial-cardiomyocyte interactions remain poorly understood. Nucleotides are released within the heart, especially under ischemia or pressure overload. The function of P2Y nucleotide receptors in cardiac development has never been investigated. Here ... Read more >>

Angiogenesis (Angiogenesis)
[2012, 15(3):349-360]

Cited: 13 times

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