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Author Changzheng Zhang

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A collaborative online AI engine for CT-based COVID-19 diagnosis

Yongchao Xu, Liya Ma, Yang Fan, Yanyan Chen, Ke Ma, Jiehua Yang, Xian Yang, Yaobing Chen, Chang Shu, Ziwei Fan, Jiefeng Gan, Xinyu Zou, Renhao Huang, Changzheng Zhang, Xiaowu Liu, Dandan Tu, Chuou Xu, Wenqing Zhang, Dehua Yang, Ming-Wei Wang, Xi Wang, Xiaoliang Xie, Hongxiang Leng, Nagaraj Holalkere, Neil Halin, Ihab Roushdy Kamel, Jia Wu, Xuehua Peng, Xiang Wang, Jianbo Shao, Pattanasak Mongkolwat, Jianjun Zhang, Daniel Rubin, Guoping Wang, Chuangsheng Zheng, Zhen Li, Xiang Bai, Tian Xia,

Artificial intelligence can potentially provide a substantial role in streamlining chest computed tomography (CT) diagnosis of COVID-19 patients. However, several critical hurdles have impeded the development of robust AI model, which include deficiency, isolation, and heterogeneity of CT data generated from diverse institutions. These bring about lack of generalization of ... Read more >>

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Predicting COVID-19 malignant progression with AI techniques

Xiang Bai, Cong Fang, Yu Zhou, Song Bai, Zaiyi Liu, Qianlan Chen, Yongchao Xu, Tian Xia, Shi Gong, Xudong Xie, Dejia Song, Ronghui Du, Chunhua Zhou, Chengyang Chen, Dianer Nie, Dandan Tu, Changzheng Zhang, Xiaowu Liu, Lixin Qin, Weiwei Chen,

Background: The coronavirus disease 2019 (COVID-19) has become a worldwide pandemic since mid-December 2019, which greatly challenge public medical systems. With limited medical resources, it is a natural strategy, while adopted, to access the severity of patients then determine the treatment priority. However, our work observes the fact that the ... Read more >>

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Heroin exposure and withdrawal differentially influence expression of NMDA receptor NR2 subunits in the prelimbic region of rat medial prefrontal cortex.

Zaiman Zhu, Hui Wang, Yuxin Jiang, Tianmiao Hua, Changzheng Zhang,

It is widely reported that drug addiction involves the strengthening of specific reward circuits through N-methyl-d-aspartic acid receptor (NMDAR)-dependent synaptic potentiation, and several lines of evidence strongly implicate NMDA receptor 2 (NR2) subunits in drug abuse. To explore the potential mechanism of heroin dependence, this study examined changes in the ... Read more >>

Neurosci. Lett. (Neuroscience letters)
[2020, 721:134819]

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Current Progress in CAR-T Cell Therapy for Solid Tumors.

Shuo Ma, Xinchun Li, Xinyue Wang, Liang Cheng, Zhong Li, Changzheng Zhang, Zhenlong Ye, Qijun Qian,

Cancer immunotherapy by chimeric antigen receptor-modified T (CAR-T) cells has shown exhilarative clinical efficacy for hematological malignancies. Recently two CAR-T cell based therapeutics, Kymriah (Tisagenlecleucel) and Yescarta (Axicabtagene ciloleucel) approved by US FDA (US Food and Drug Administration) are now used for treatment of B cell acute lymphoblastic leukemia (B-ALL) ... Read more >>

Int. J. Biol. Sci. (International journal of biological sciences)
[2019, 15(12):2548-2560]

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Application of immune repertoire sequencing in cancer immunotherapy.

Yuan Zhuang, Changzheng Zhang, Qiong Wu, Jing Zhang, Zhenlong Ye, Qijun Qian,

With the prominent breakthrough in the field of tumor immunology, diverse cancer immunotherapies have attracted great attention in the last decade. The immune checkpoint inhibitors, adoptive cell therapies, and therapeutic cancer vaccines have already achieved impressive clinical success. However, the fact that only a small subset of patients with specific ... Read more >>

Int. Immunopharmacol. (International immunopharmacology)
[2019, 74:105688]

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Theta-gamma coupling in the prelimbic area is associated with heroin addiction.

Zaiman Zhu, Zheng Ye, Hui Wang, Tianmiao Hua, Qingyun Wen, Changzheng Zhang,

The medial prefrontal cortex (mPFC) is implicated in the regulation of drug-seeking behavior, but the specific contributions of the mPFC prelimbic (PL) subdivision and the precise mechanisms underlying heroin abuse remain largely unclear. In the present study, we examined changes in the rhythmic ensemble activity of PL neurons after induction ... Read more >>

Neurosci. Lett. (Neuroscience letters)
[2019, 701:26-31]

Cited: 1 time

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Saikosaponin‑D improves fear memory deficits in ovariectomized rats via the action of estrogen receptor‑α in the hippocampus.

Lina Liu, Jing Yan, Fei Ge, Xiangtao Xu, Jun Lu, Huilian Shi, Shuihong Li, Yue Zhao, Changzheng Zhang,

Saikosaponin‑D (SSD), which is the main bioactive component in the traditional Chinese medicine Chai Hu (Bupleurum falcatum L), possesses estrogen‑like properties and is widely used in treating estrogen‑related neurological disorders. The current study aimed to investigate the protective effects of SSD on the fear memory deficit in ovariectomized (OVX) rats and ... Read more >>

Mol Med Rep (Molecular medicine reports)
[2019, 20(1):332-340]

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Commentary: Let the Time Fly: Dopamine is the Arbiter.

Xiaodong Liu, Changzheng Zhang, Oscar Arias-Carrion, Ti-Fei Yuan,

CNS Neurol Disord Drug Targets (CNS & neurological disorders drug targets)
[2018, 17(1):3-5]

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Cholinergic tone in ventral tegmental area: Functional organization and behavioral implications.

Changzheng Zhang, Xiaodong Liu, Peiling Zhou, Junjie Zhang, Wuming He, Ti-Fei Yuan,

The ventral tegmental area (VTA), a pivotal brain region of the mesocorticolimbic dopaminergic system, is substantially innervated and modulated by cholinergic projections from the pedunculopontine tegmental nucleus and laterodorsal tegmental nucleus. In this review, we focus mainly on the current findings on VTA cholinergic compositions and functions, including VTA cholinergic ... Read more >>

Neurochem. Int. (Neurochemistry international)
[2018, 114:127-133]

Cited: 1 time

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Calcium-Impermeable NMDA Receptor: A Novel Target for Addiction.

Xiaodan Huang, Wei Ni, Changzheng Zhang,

Neurosci Bull (Neuroscience bulletin)
[2017, 33(3):357-358]

Cited: 1 time

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The cholinergic system in the cerebellum: from structure to function.

Changzheng Zhang, Peiling Zhou, Tifei Yuan,

The cerebellar cholinergic system belongs to the third type of afferent nerve fiber system (after the climbing and mossy fibers), and has important modulatory effects on cerebellar circuits and cerebellar-mediated functions. In this report, we review the cerebellar cholinergic system, including cholinergic origins and innervations, acetylcholine receptor expression and distributions, ... Read more >>

Rev Neurosci (Reviews in the neurosciences)
[2016, 27(8):769-776]

Cited: 3 times

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Microinjection of acetylcholine into cerebellar fastigial nucleus induces blood depressor response in anesthetized rats.

Changzheng Zhang, Wen Luo, Peiling Zhou, Tingzhe Sun,

It is well known that the cerebellar fastigial nucleus (FN) is involved in cardiovascular modulation, and has direct evidence of cholinergic activity; however, whether and how acetylcholine (ACh) in the FN modulates blood pressure has not been investigated. In this study, we analyzed mean arterial pressure, maximal change in mean ... Read more >>

Neurosci. Lett. (Neuroscience letters)
[2016, 629:79-84]

Cited: 1 time

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Penis Allotransplantation in Beagle Dog.

Yongbin Zhao, Weilie Hu, Lichao Zhang, Fei Guo, Wei Wang, Bangqi Wang, Changzheng Zhang,

This is an original research of penis allotransplantation. The paper presents an experiment allogenic penis transplantation model in Beagles, with a focus on recovery of blood supply and changes in tissue architecture. Twenty adult Beagles were allocated to 10 pairs for penile transplantation. After operation, the skin and glans were ... Read more >>

Biomed Res Int (BioMed research international)
[2016, 2016:1489204]

Cited: 5 times

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Role of Muscarinic Acetylcholine Receptor-2 in the Cerebellar Cortex in Cardiovascular Modulation in Anaesthetized Rats.

Changzheng Zhang, Tingzhe Sun, Peiling Zhou, Qingfeng Zhu, Liefeng Zhang,

Our previous investigations have demonstrated that microinjection of acetylcholine (ACh) or muscarinic ACh receptor activation in the cerebellar cortex induces a systemic blood pressure depressor response. This study aimed to determine the role of muscarinic ACh receptor-2 (M2 receptor) in the cerebellar cortex in cardiovascular function regulation in rats. A ... Read more >>

Neurochem. Res. (Neurochemical research)
[2016, 41(4):804-812]

Cited: 1 time

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Muscarinic acetylcholine receptor in cerebellar cortex participates in acetylcholine-mediated blood depressor response in rats.

Peiling Zhou, Qingfeng Zhu, Ming Liu, Jing Li, Yong Wang, Changzheng Zhang, Tianmiao Hua,

Our previous investigations have revealed that cerebellar cholinergic innervation is involved in cardiovascular regulation. This study was performed to examine the effects of the muscarinic cholinergic receptor (mAChR) in the cerebellar cortex on blood pressure (BP) modulation in rats. Acetylcholine (ACh, 100mM), nonselective mAChR agonist (oxotremorine M; Oxo-M, 10, 30 and ... Read more >>

Neurosci. Lett. (Neuroscience letters)
[2015, 593:129-133]

Cited: 2 times

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A preliminary study on cerebellar acetylcholine-mediated blood pressure regulation in young and old rats.

Qingfeng Zhu, Peiling Zhou, Shengnan Wang, Changzheng Zhang, Tianmiao Hua,

Cholinergic innervation of the cerebellar cortex can modulate cerebellar functions. However, the role of acetylcholine (ACh) in cerebellar regulation of blood pressure (BP) has not been examined. Moreover, the effect of aging on this regulation remains unexplored. In this study, carotid arterial pressure was measured in young (2 months) and ... Read more >>

Exp. Gerontol. (Experimental gerontology)
[2015, 63:76-80]

Cited: 2 times

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Improving intestinal insulin absorption efficiency through coadministration of cell-penetrating peptide and hydroxypropyl-β-cyclodextrin

Liefeng Zhang, Lingling Song, Changzheng Zhang, Yong Ren,

The effects of a cell-penetrating peptide (CPP) and hydroxypropyl-β-cyclodextrin (HP-β-CD) on intestinal insulin absorption efficiency were investigated in this study. CPP (R8) and HP-β-CD were added to insulin and the in vitro absorption efficiency in a Caco-2 cell monolayer and in vivo absorption efficiency in diabetic rats were tested. The ... Read more >>

(Carbohydrate Polymers)
[2012, 87(2):1822-1827]

Cited: 5 times

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Aging of cerebellar Purkinje cells.

Changzheng Zhang, Qingfeng Zhu, Tianmiao Hua,

Cerebellar Purkinje cells (PCs), the sole output neurons in the cerebellar cortex, play an important role in the cerebellar circuit. PCs appear to be rather sensitive to aging, exhibiting significant changes in both morphology and function during senescence. This article reviews such changes during the normal aging process, including a ... Read more >>

Cell Tissue Res. (Cell and tissue research)
[2010, 341(3):341-347]

Cited: 20 times

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Age-related changes of structures in cerebellar cortex of cat.

Changzheng Zhang, Tianmiao Hua, Zaiman Zhu, Xun Luo,

We studied the structures of the cerebellar cortex of young adult and old cats for age-related changes, which were statistically analysed. Nissl staining was used to visualize the cortical neurons. The immunohistochemical method was used to display glial fibrillary acidic protein (GFAP)-immunoreactive (IR) astrocytes and neurofilament-immunoreactive (NF-IR) neurons. Under the ... Read more >>

J. Biosci. (Journal of Biosciences)
[2006, 31(1):55-60]

Cited: 20 times

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New types of the flexible self-assembled metal-organic coordination polymers constructed by aliphatic dicarboxylates and rigid bidentate nitrogen ligands.

Hongyan Mao, Changzheng Zhang, Gang Li, Hongyun Zhang, Hongwei Hou, Linke Li, Qingan Wu, Yu Zhu, Enbo Wang,

The reaction of metal ions, flexible aliphatic dicarboxylates and rigid bidentate linear ligands under mild conditions in water afford four novel metal-organic coordination polymers, [Cd(mu-mal)(mu-pyz)(0.5)(H(2)O)](n) 1 (mal = malonate dianion, pyz = pyrazine), [Cd(2)(mu-suc)(2)(mu-pyz)(H(2)O)(2)](n) 2 (suc = succinate dianion), and ([M(mu-bipy)(H(2)O)4][suc].4H(2)O)(n)(M = Co, 3, M = Zn, 4, bipy = ... Read more >>

Dalton Trans (Dalton transactions (Cambridge, England : 2003))
[2004, (22):3918-3925]

Cited: 1 time

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