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Author Changzheng Chen

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Presence of SARS-CoV-2 RNA in isolation ward environment 28 days after exposure.

Yunyun Zhou, Yuyang Zeng, Changzheng Chen,

Recent studies have reported that surfaces and objects in the rooms of infected patients that are frequently touched by both medical staff and patients could be contaminated with SARS-CoV-2. In December 2019, Wuhan China suffered the earliest from this COVID-19 pandemic, and we took that opportunity to investigate whether the ... Read more >>

Int. J. Infect. Dis. (International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases)
[2020, 97:258-259]

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Observation of the far peripheral retina of normal eyes by ultra-wide field fluorescein angiography.

Xiaoling Wang, A'min Xu, Zuohuizi Yi, Lu He, Juejun Liu, Hongmei Zheng, Changzheng Chen,

PURPOSE:The appearance of the far peripheral retina in normal eyes was observed using an Optos ultra-wide field fluorescein angiography imaging system. METHODS:A cross-sectional study of ultra-wide field pseudocolor and angiography images obtained using the Optos 200Tx. Four different non-vascular and six vascular-associated fluorescence features in far peripheral retina were analyzed. ... Read more >>

Eur J Ophthalmol (European journal of ophthalmology)
[2020, :1120672120926453]

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Retinal Microvascular Changes in Hypertensive Patients with Different Levels of Blood Pressure Control and without Hypertensive Retinopathy.

Dihao Hua, Yishuang Xu, Xiao Zhang, Tao He, Changzheng Chen, Zhen Chen, Yiqiao Xing,

PURPOSE:To determine possible correlations between different levels of blood pressure (BP) control and retinal microvascular changes in the macula and optic nerve head, using coherence tomography angiography (OCTA) in hypertensive patients without hypertensive retinopathy. METHODS:This was an observational, cross-sectional study. Seventy-three patients and 40 healthy volunteers were included in this ... Read more >>

Curr. Eye Res. (Current eye research)
[2020, :1-8]

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Symptomatic COVID-19 in Eye Professionals in Wuhan, China.

Chunyan Qiao, Hui Zhang, Mingguang He, Guishuang Ying, Changzheng Chen, Yanping Song, Julius Oatts, Zhonghua Liu, Yiqiao Xing, Zefeng Xiao, Min Ke, Ya Ye, Xiaoniao Chen, Jihong Luo, Ying Han, Ningli Wang,

Ophthalmology (Ophthalmology)
[2020, :]

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Ocular Findings and Proportion with Conjunctival SARS-COV-2 in COVID-19 Patients.

Yunyun Zhou, Chaoye Duan, Yuyang Zeng, Yongqing Tong, Yuhong Nie, Yang Yang, Zhen Chen, Changzheng Chen,

Ophthalmology (Ophthalmology)
[2020, 127(7):982-983]

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Positive Epstein-Barr virus detection in corona virus disease 2019 (COVID-19) patients

Ting Chen, Jiayi Song, Hongli Liu, Hongmei Zheng, Changzheng Chen,

Abstract Background Since December 2019, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) caused an outbreak of corona virus disease 2019 (COVID-19) in Wuhan, China. The Objective of this study was to detect the EBV coinfection in COVID-19. Methods In this retrospective single-center study, we included 67 patients with confirmed COVID-19 ... Read more >>

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Bilateral and multiple sub-internal limiting membrane hemorrhages in a familial retinal arteriolar tortuosity patient by Valsalva-like mechanism: an observational case report.

Ting Chen, Hongmei Zheng, Yunyun Wang, Junyi Hu, Changzheng Chen,

BACKGROUND:Bilateral and multiple Valsalva-related sub-internal limiting membrane (ILM) hemorrhages in a familial retinal arteriolar tortuosity (FRAT) patient is rare, and we treated this patient by both observation and Neodymium yttrium aluminum garnet (Nd: YAG) laser membranotomy methods. CASE PRESENTATION:A 13-year-old female student presented with sudden visual loss and central scotoma ... Read more >>

BMC Ophthalmol (BMC ophthalmology)
[2020, 20(1):151]

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CLINICAL APPLICATION OF MULTICOLOR IMAGING IN CENTRAL SEROUS CHORIORETINOPATHY.

Lu He, Changzheng Chen, Zuohuizi Yi, Xiaoling Wang, Juejun Liu, Hongmei Zheng,

PURPOSE:To characterize features of central serous chorioretinopathy (CSC) using multicolor (MC) imaging and to compare the efficacy of using MC imaging and traditional color fundus photography (CFP) for detecting features of CSC. METHODS:A retrospective review of 75 eyes of 69 participants with CSC from the Eye Center of the Renmin ... Read more >>

Retina (Philadelphia, Pa.) (Retina (Philadelphia, Pa.))
[2020, 40(4):743-749]

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Precautions are Needed for COVID-19 Patients with Coinfection of Common Respiratory Pathogens

Quansheng Xing, Guoju Li, Yuhan Xing, Ting Chen, Wenjie Li, Wei Ni, Kai Deng, Ruqin Gao, Changzheng Chen, Yang Gao, Qiang Li, Guiling Yu, Jianning Tong, Wei Li, Guiliang Hao, Yue Sun, Ai Zhang, Qin Wu, Zipu Li, Silin Pan,

Background: With the ongoing outbreak of Coronavirus Disease 2019 (COVID-19), infected patients within and beyond the epidemic area, Wuhan, China, showed different epidemiological and clinical characteristics. There is a paucity of data concerning coinfection with other common respiratory pathogens in COVID-19 patients outside of Wuhan. Methods: We conducted a double-centre ... Read more >>

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Ophthalmologic evidence against the interpersonal transmission of 2019 novel coronavirus through conjunctiva

Yunyun Zhou, Yuyang Zeng, Yongqing Tong, ChangZheng Chen,

Background: The emerging 2019 novel coronavirus (2019−nCoV) has pushed several countries into state of emergency all over the world. The possible transmission of 2019−nCoV by conjunctiva is controversial and has substantial public health implications. Methods: A retrospective cohort study was initiated to investigate the possible transmission of 2019−nCoV through aerosol ... Read more >>

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Assessment of choriocapillary blood flow changes in response to half-dose PDT in chronic central serous chorioretinopathy using OCTA

Juejun Liu, Changzheng Chen, Lu Li, Yishuang Xu, Zuohuizi Yi, Lu He, Hongmei Zheng,

Abstract Background: To quantify flow changes in choriocapillaris (CC) in patients with chronic central serous chorioretinopathy (CCSC) in the treatment of half-dose photodynamic therapy (PDT) using optical coherence tomography angiography (OCTA) . Methods : A total of 28 affected eyes and 24 unaffected eyes of 26 CCSC patients receiving half-dose ... Read more >>

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Follow-up of nonarteritic anterior ischemic optic neuropathy with optical coherence tomography angiography

Juejun Liu, Changzheng Chen, Li Lu, Zuohuizi Yi, Hongmei Zheng,

Abstract Background To analyze the blood flow changes of radial peripapillary capillaries (RPC) and macula with time procession in patients with non-arteritic anterior ischemic optic neuropathy (NAION) using optical coherence tomography angiography (OCT-A).Methods A total of 21 affected eyes and 19 unaffected eyes from 21 NAION patients, and 40 eyes ... Read more >>

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Assessment of the Dynamic Alteration of Choriocapillaris Vessel Density after Focal Laser Photocoagulation with OCT Angiography.

Zuohuizi Yi, Yiqiao Xing, Changzheng Chen, Xiaoling Wang, Juejun Liu, Lu He, Hongmei Zheng,

Purpose:To evaluate the changes of choriocapillaris blood flow beneath laser lesions in noncenter-involved diabetic macular edema patients using optical coherence tomography angiography (OCTA). Methods:This was a retrospective case-series study. We used OCTA to analyze the characteristics of the choriocapillaris blood flow beneath laser lesions before laser treatment and at several ... Read more >>

J Ophthalmol (Journal of ophthalmology)
[2020, 2020:6213189]

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Traditional two-dimensional mesenchymal stem cells (MSCs) are better than spheroid MSCs on promoting retinal ganglion cells survival and axon regeneration.

Wei Huang, Cong Wang, Lili Xie, Xiaoling Wang, Lusi Zhang, Changzheng Chen, Bing Jiang,

The loss of retinal ganglion cells (RGCs) is one of the common pathological features associated with optic nerve diseases leading to blindness. The aims of our study were to compare the neuroprotection of two forms of human umbilical cord blood-derived mesenchymal stem cells (hUCB-MSCs) on RGCs and axon regeneration after ... Read more >>

Exp. Eye Res. (Experimental eye research)
[2019, 185:107699]

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Relapse prevention with levomilnacipran ER in adults with major depressive disorder: A multicenter, randomized, double-blind, placebo-controlled study.

Suresh Durgam, Changzheng Chen, Raffaele Migliore, Chandran Prakash, Michael E Thase,

BACKGROUND:Levomilnacipran extended release (ER) is a serotonin and norepinephrine reuptake inhibitor approved for major depressive disorder (MDD) in adults. This study was designed to evaluate relapse prevention with levomilnacipran ER in patients with MDD. METHODS:Patients (≥18 years) with MDD (N = 644) received 20 weeks of open-label treatment with levomilnacipran ER 40, 80, ... Read more >>

Depress Anxiety (Depression and anxiety)
[2019, 36(3):225-234]

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Applications of Artificial Intelligence in Ophthalmology: General Overview.

Wei Lu, Yan Tong, Yue Yu, Yiqiao Xing, Changzheng Chen, Yin Shen,

With the emergence of unmanned plane, autonomous vehicles, face recognition, and language processing, the artificial intelligence (AI) has remarkably revolutionized our lifestyle. Recent studies indicate that AI has astounding potential to perform much better than human beings in some tasks, especially in the image recognition field. As the amount of ... Read more >>

J Ophthalmol (Journal of ophthalmology)
[2018, 2018:5278196]

Cited: 2 times

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Deep Learning-Based Automated Classification of Multi-Categorical Abnormalities From Optical Coherence Tomography Images.

Wei Lu, Yan Tong, Yue Yu, Yiqiao Xing, Changzheng Chen, Yin Shen,

Purpose:To develop a new intelligent system based on deep learning for automatically optical coherence tomography (OCT) images categorization. Methods:A total of 60,407 OCT images were labeled by 17 licensed retinal experts and 25,134 images were included. One hundred one-layer convolutional neural networks (ResNet) were trained for the categorization. We applied ... Read more >>

Transl Vis Sci Technol (Translational vision science & technology)
[2018, 7(6):41]

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Relapse prevention in adults with major depressive disorder treated with vilazodone: a randomized, double-blind, placebo-controlled trial.

Suresh Durgam, Carl Gommoll, Raffaele Migliore, Changzheng Chen, Cheng-Tao Chang, Michelle Aguirre, Michael E Thase,

This randomized withdrawal study assessed relapse prevention with vilazodone in adults with major depressive disorder. After 20 weeks of open-label treatment with vilazodone 40 mg/day, responders were randomized (1 : 1 : 1) to 28 weeks of double-blind, fixed-dose treatment with vilazodone 20 mg/day, vilazodone 40 mg/day, or placebo. The primary efficacy endpoint was time to first ... Read more >>

Int Clin Psychopharmacol (International clinical psychopharmacology)
[2018, 33(6):304-311]

Cited: 1 time

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A Phase 3, Double-Blind, Randomized, Placebo-Controlled Study of Vilazodone in Adolescents with Major Depressive Disorder.

Suresh Durgam, Changzheng Chen, Raffaele Migliore, Chandran Prakash, John Edwards, Robert L Findling,

Major depressive disorder (MDD) is a serious illness in children and adolescents. Vilazodone is a selective serotonin reuptake inhibitor approved for MDD in adults. This study evaluated the efficacy, safety, and tolerability of vilazodone in adolescent patients, ages 12-17 years, with MDD (NCT01878292).This double-blind, randomized, placebo-controlled, parallel-group, fixed-dose study was ... Read more >>

Paediatr Drugs (Paediatric drugs)
[2018, 20(4):353-363]

Cited: 3 times

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A Fast and On-Machine Measuring System Using the Laser Displacement Sensor for the Contour Parameters of the Drill Pipe Thread.

Zhixu Dong, Xingwei Sun, Changzheng Chen, Mengnan Sun,

The inconvenient loading and unloading of a long and heavy drill pipe gives rise to the difficulty in measuring the contour parameters of its threads at both ends. To solve this problem, in this paper we take the SCK230 drill pipe thread-repairing machine tool as a carrier to design and ... Read more >>

Sensors (Basel) (Sensors (Basel, Switzerland))
[2018, 18(4):]

Cited: 5 times

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Effects of vilazodone on suicidal ideation and behavior in adults with major depressive disorder or generalized anxiety disorder: post-hoc analysis of randomized, double-blind, placebo-controlled trials.

Michael E Thase, John Edwards, Suresh Durgam, Changzheng Chen, Cheng-Tao Chang, Maju Mathews, Carl P Gommoll,

Treatment-emergent suicidal ideation and behavior are ongoing concerns with antidepressants. Vilazodone, currently approved for the treatment of major depressive disorder (MDD) in adults, has also been evaluated in generalized anxiety disorder (GAD). Post-hoc analyses of vilazodone trials were carried out to examine its effects on suicidal ideation and behavior in ... Read more >>

Int Clin Psychopharmacol (International clinical psychopharmacology)
[2017, 32(5):281-288]

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Measures of suicidality in phase 3 clinical trials of levomilnacipran ER in adults with major depressive disorder.

Michael E Thase, Carl Gommoll, Changzheng Chen, Kenneth Kramer, Arif Khan, Suresh Durgam,

OBJECTIVE:To evaluate the effects of levomilnacipran extended-release (ER) on suicidal ideation and behavior in adults with major depressive disorder (MDD). METHODS:Post hoc analyses were conducted in patients from 4 randomized, double-blind, placebo-controlled trials and a long-term, open-label extension study of levomilnacipran ER (40-120 mg/d) in adults with MDD. Analyses included ... Read more >>

CNS Spectr (CNS spectrums)
[2017, 22(6):475-483]

Cited: 1 time

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Effect of Photodynamic Therapy on Optical Coherence Tomography Angiography in Eyes with Chronic Central Serous Chorioretinopathy.

Yishuang Xu, Yu Su, Lu Li, Hang Qi, Hongmei Zheng, Changzheng Chen,

To analyze the use of optical coherence tomography angiography (OCTA) in order to observe the changes in chronic central serous chorioretinopathy (CCSC) after half-dose photodynamic therapy (PDT).This is a retrospective study evaluating an imaging technique in a cohort of patients. Fundus photography, fluorescein angiography (FA), indocyanine green angiography (ICGA) (Heidelberg ... Read more >>

Ophthalmologica (Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift fur Augenheilkunde)
[2017, 237(3):167-172]

Cited: 7 times

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Effects of vilazodone on sexual functioning in healthy adults: results from a randomized, double-blind, placebo-controlled, and active-controlled study.

Anita H Clayton, Suresh Durgam, Dayong Li, Changzheng Chen, Laishun Chen, Maju Mathews, Carl P Gommoll, Armin Szegedi,

The aim of this study is to evaluate the effects of vilazodone on sexual functioning in healthy, sexually active adults and assess the impact of medication nonadherence in this type of trial. Participants were randomized to vilazodone (20 or 40 mg/day), paroxetine (20 mg/day), or placebo for 5 weeks of double-blind treatment. ... Read more >>

Int Clin Psychopharmacol (International clinical psychopharmacology)
[2017, 32(1):27-35]

Cited: 2 times

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Effects of levomilnacipran extended-release on major depressive disorder patients with cognitive impairments: post-hoc analysis of a phase III study.

Keith A Wesnes, Carl Gommoll, Changzheng Chen, Angelo Sambunaris, Roger S McIntyre, Philip D Harvey,

Performance-based cognitive data were collected using the Cognitive Drug Research System in a study of levomilnacipran extended-release (ER) 40-120 mg/day (NCT01034462) in adults with major depressive disorder. These data were analyzed post-hoc to explore the relationship between cognitive measures, depression symptoms (Montgomery-Åsberg Depression Rating Scale, MADRS), and self-reported psychosocial functioning (Sheehan ... Read more >>

Int Clin Psychopharmacol (International clinical psychopharmacology)
[2017, 32(2):72-79]

Cited: 3 times

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