Full Text Journal Articles by
Author Changyi Wang

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A comprehensive association analysis between homocysteine metabolic pathway gene methylation and ischemic stroke in a Chinese hypertensive population.

Bo Li, Yuying Li, Shan Xu, Hongen Chen, Shudong Dai, Xiaoling Peng, Li Wang, Yaping Liang, Cheng Li, Biwei Tang, Liqing Zhu, Tao Zhang, Chunfang Lv, Changyi Wang, Liyuan Han,

<h4>Background</h4>Ischemic stroke (IS) is a serious global health burden. In order to improve our understanding of the risk factors associated with IS, we investigated the combined effect of the methylation of five genes related to the metabolism of homocysteine on developing IS.<h4>Methods</h4>Quantitative methylation-specific PCR was used to measure the levels ... Read more >>

J Clin Lab Anal (Journal of clinical laboratory analysis)
[2020, :e23689]

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Ideal Cardiovascular Health Metrics and Incidence of Ischemic Stroke Among Hypertensive Patients: A Prospective Cohort Study.

Yuchen Ying, Shaoyi Lin, Fanqian Kong, Yuying Li, Shujun Xu, Xiaofeng Liang, Changyi Wang, Liyuan Han,

<b>Background:</b> This study aimed to assess the relationship between ideal cardiovascular health (CVH) metrics and incident ischemic stroke (IS) in hypertensive patients, especially those with hyperhomocysteinemia (HHcy). <b>Methods:</b> A prospective cohort study enrolled 5,488 hypertensive patients in Nanshan District of Shenzhen City in southern China from September 2011 to December ... Read more >>

Front Cardiovasc Med (Frontiers in cardiovascular medicine)
[2020, 7:590809]

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High MTHFR promoter methylation levels in men confer protection against ischemic stroke.

Shan Xu, Qianping Shi, Bo Li, Liyuan Han, Guodong Xu, Xiaolin Peng, Hongen Chen, Shuhong Dai, Wancheng Ma, Changyi Wang, Jianping Ma,

The MTHFR gene encodes methylenetetrahydrofolate reductase required for the metabolism of homocysteine (Hcy) - a previously reported independent risk factor for ischemic stroke (IS). In this study, we first aimed to clarify the association between DNA methylation levels in the MTHFR promoter and the risk of IS, followed by the ... Read more >>

Bosn J Basic Med Sci (Bosnian journal of basic medical sciences)
[2020, 20(4):477-486]

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Prognostic significance of uric acid change in acute ischemic stroke patients with reperfusion therapy.

Changyi Wang, Ting Cui, Lu Wang, Qiange Zhu, Anmo Wang, Ye Yuan, Zilong Hao, Bo Wu,

<h4>Background</h4>Uric acid (UA) is an important endogenous free radical scavenger that has been found to have a neuroprotective effect. However, there is uncertainty about the relationship between UA change and outcome in acute ischemic stroke (AIS) patients with reperfusion therapy.<h4>Methods</h4>We consecutively enrolled AIS patients with reperfusion therapy. UA was measured ... Read more >>

Eur J Neurol (European journal of neurology)
[2020, :]

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Effect of Anthocyanins Supplementation on Serum IGFBP-4 Fragments and Glycemic Control in Patients with Fasting Hyperglycemia: A Randomized Controlled Trial.

Liping Yang, Zhaomin Liu, Wenhua Ling, Li Wang, Changyi Wang, Jianping Ma, Xiaolin Peng, Jianying Chen,

<h4>Background</h4>Insulin-like growth factor binding protein-4 (IGFBP-4) fragments have been shown to be associated with cardiometabolic diseases. Anthocyanins as a subgroup of natural polyphenols could have benefits on treating cardiometabolic diseases. The aim of this study was to examine the effects of purified anthocyanins on serum IGFBP-4 fragments and glycemic control ... Read more >>

Diabetes Metab Syndr Obes (Diabetes, metabolic syndrome and obesity : targets and therapy)
[2020, 13:3395-3404]

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Association of TG/HDLC ratio trajectory and risk of type 2 diabetes: A retrospective cohort study in China.

Yanyan Zhang, Pei Qin, Yanmei Lou, Ping Zhao, Xue Li, Ranran Qie, Xiaoyan Wu, Minghui Han, Shengbing Huang, Yang Zhao, Dechen Liu, Yuying Wu, Yang Li, Xingjin Yang, Yang Zhao, Yifei Feng, Changyi Wang, Jianping Ma, Xiaolin Peng, Hongen Chen, Dan Zhao, Shan Xu, Li Wang, Xinping Luo, Ming Zhang, Dongsheng Hu, Fulan Hu,

<h4>Background</h4>The association of ratio of triglycerides to high-density lipoprotein cholesterol (TG/HDL-C ratio) change trajectory with risk of type 2 diabetes mellitus (T2DM) remains unknown. The aim of this study was to evaluate the association between risk of T2DM and TG/HDL-C ratio change trajectory.<h4>Methods</h4>A total of 18 444 participants aged 18-80 years old ... Read more >>

J Diabetes (Journal of diabetes)
[2020, :]

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Dose-response association of the ZJU index and fatty liver disease risk: A large cohort in China.

Xue Li, Pei Qin, Liming Cao, Yanmei Lou, Jing Shi, Ping Zhao, Changyi Wang, Jianping Ma, Shan Xu, Xiaolin Peng, Hongen Chen, Dan Zhao, Fulan Hu, Yashuang Zhao,

<h4>Aims</h4>To investigate the sex-specific association between the ZJU index and risk of fatty liver disease in a large Chinese cohort.<h4>Methods</h4>Totally 28,729 adults without fatty liver disease at baseline and who completed at least one follow-up of annual examinations between 2009 and 2016 were included in this study. Cox proportional hazards ... Read more >>

J Gastroenterol Hepatol (Journal of gastroenterology and hepatology)
[2020, :]

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Low-Density Lipoprotein Cholesterol/High-Density Lipoprotein Cholesterol Ratio and Carotid Intima-Media Thickness: A Cohort Study in China.

Pei Qin, Jing Shi, Liming Cao, Xue Li, Yanmei Lou, Changyi Wang, Jianping Ma, Li Wang, Xiaolin Peng, Hongen Chen, Shan Xu, Ping Zhao, Dongsheng Hu, Fulan Hu,

Low-density lipoprotein cholesterol to high-density lipoprotein cholesterol (LDL-C/HDL-C) ratio may carry additional information and has been suggested as a better predictor for atherosclerosis progression and cardiovascular disease (CVD) than LDL-C and HDL-C alone. Therefore, we aim to explore the association between LDL-C/HDL-C ratio and high carotid intima-media thickness (CIMT) risk ... Read more >>

Lipids (Lipids)
[2021, 56(1):59-68]

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Anthocyanins regulate serum adipsin and visfatin in patients with prediabetes or newly diagnosed diabetes: a randomized controlled trial.

Liping Yang, Yun Qiu, Wenhua Ling, Zhaomin Liu, Lili Yang, Changyi Wang, Xiaolin Peng, Li Wang, Jianying Chen,

<h4>Background</h4>Epidemiological studies have suggested that adipsin and visfatin are associated with the development of type 2 diabetes. This is the first study to investigate the effects of supplementation with purified anthocyanins on serum adipsin and visfatin in patients with prediabetes or newly diagnosed diabetes.<h4>Methods</h4>A total of 160 participants with prediabetes ... Read more >>

Eur J Nutr (European journal of nutrition)
[2020, :]

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Anthocyanins increase serum adiponectin in newly diagnosed diabetes but not in prediabetes: a randomized controlled trial.

Liping Yang, Wenhua Ling, Yun Qiu, Yong Liu, Li Wang, Jing Yang, Changyi Wang, Jianping Ma,

<h4>Background</h4>Epidemiological studies have suggested that adiponectin is associated with the development of insulin resistance and type 2 diabetes. This study first examined the effect of purified anthocyanins, a group of dietary flavonoids, on serum adiponectin in patients with prediabetes and newly diagnosed diabetes.<h4>Methods</h4>A total of 160 patients with prediabetes (n = 90) ... Read more >>

Nutr Metab (Lond) (Nutrition & metabolism)
[2020, 17:78]

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Plaque Distribution Correlates With Morphology of Lenticulostriate Arteries in Single Subcortical Infarctions.

Shuai Jiang, Yuying Yan, Tang Yang, Qiange Zhu, Changyi Wang, Xueling Bai, Zilong Hao, Shihong Zhang, Qi Yang, Zhaoyang Fan, Jiayu Sun, Bo Wu,

<h4>Background and purpose</h4>We aimed to use novel whole-brain vessel-wall magnetic resonance imaging (WB-VWI) to investigate the association between plaque distribution of middle cerebral artery (MCA) and morphological changes of the lenticulostriate arteries (LSAs) in single subcortical infarctions.<h4>Methods</h4>Forty single subcortical infarction patients with no relevant MCA disease on magnetic resonance angiography ... Read more >>

Stroke (Stroke)
[2020, 51(9):2801-2809]

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Anthocyanins increase serum adiponectin in newly diagnosed diabetes but not in prediabetes: a randomized controlled trial

LiPing Yang, Wenhua Ling, Yun Qiu, Yong Liu, Li Wang, Jing Yang, Changyi Wang, Jianping Ma,

<h4>Background: </h4> Epidemiological studies have suggested that adiponectin is associated with the development of insulin resistance and type 2 diabetes. This study first examined the effect of purified anthocyanins, a group of dietary flavonoids, on serum adiponectin in patients with prediabetes and newly diagnosed diabetes. <h4>Methods: </h4> A total of ... Read more >>

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The contribution of plasma uric acid to the risk of stroke in hypertensive populations.

Jing Shi, Guanyun Yan, Liming Cao, Xue Li, Yiwei Zhang, Suhua Zhao, Changyi Wang, Jianping Ma, Xiaolin Peng, Hongen Chen, Fulan Hu, Ran Wang,

<h4>Background</h4>There is limited available evidence of a relationship between uric acid (UA) level and stroke in hypertensive populations worldwide. We aimed to estimate the relationship between UA level and stroke in Chinese hypertensive populations.<h4>Methods</h4>A total of 4 710 essentially hypertensive Chinese patients, including 307 with stroke, were recruited consecutively by ... Read more >>

Cardiovasc J Afr (Cardiovascular journal of Africa)
[2020, 31(6):298-303]

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Balanced Genome Triplication in Wheat Causes Premature Growth Arrest and an Upheaval of Genome-Wide Gene Regulation.

Xiaowan Gou, Ruili Lv, Changyi Wang, Tiansi Fu, Yan Sha, Lei Gong, Huakun Zhang, Bao Liu,

Polyploidy, or whole genome duplication (WGD), is a driving evolutionary force across the tree of life and has played a pervasive role in the evolution of the plant kingdom. It is generally believed that a major genetic attribute contributing to the success of polyploidy is increased gene and genome dosage. ... Read more >>

Front Genet (Frontiers in genetics)
[2020, 11:687]

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Sex-Specific Association of Serum Uric Acid Level and Change in Hyperuricemia Status with Risk of Type 2 Diabetes Mellitus: A Large Cohort Study in China.

Yanmei Lou, Pei Qin, Changyi Wang, Jianping Ma, Xiaolin Peng, Shan Xu, Hongen Chen, Dan Zhao, Li Wang, Dechen Liu, Yang Li, Ping Zhao, Dezhu Han, Dongsheng Hu, Fulan Hu,

Background:Conflicting findings have been reported regarding the sex-specific association between serum uric acid (SUA) level and type 2 diabetes mellitus (T2DM) risk, and no study has explored the association between the change in hyperuricemia status and T2DM risk. The study was aimed at exploring the sex-specific association of baseline SUA ... Read more >>

J Diabetes Res (Journal of diabetes research)
[2020, 2020:9637365]

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Dose-response associations between serum creatinine and type 2 diabetes mellitus risk: A Chinese cohort study and meta-analysis of cohort studies.

Pei Qin, Yanmei Lou, Liming Cao, Jing Shi, Gang Tian, Dechen Liu, Qionggui Zhou, Chunmei Guo, Quanman Li, Yang Zhao, Feiyan Liu, Xiaoyan Wu, Ranran Qie, Minghui Han, Shengbing Huang, Ping Zhao, Changyi Wang, Jianping Ma, Xiaolin Peng, Shan Xu, Hongen Chen, Dan Zhao, Ming Zhang, Dongsheng Hu, Fulan Hu,

BACKGROUND:This study aims to investigate the association between serum creatinine and risk of type 2 diabetes mellitus (T2DM) based on a cohort analysis and meta-analysis of cohort studies. METHODS:We enrolled 41 439 participants aged ≥18 years without T2DM at baseline, who had ≥2 health examinations based on an ongoing prospective cohort in ... Read more >>

J Diabetes (Journal of diabetes)
[2020, 12(8):594-604]

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Baseline serum albumin and its dynamic change is associated with type 2 diabetes risk: A large cohort study in China.

Fulan Hu, Yanmei Lou, Jing Shi, Liming Cao, Changyi Wang, Jianping Ma, Xiaolin Peng, Shan Xu, Hongen Chen, Dan Zhao, Yang Zhao, Chunmei Guo, Dechen Liu, Qionggui Zhou, Quanman Li, Feiyan Liu, Gang Tian, Xiaoyan Wu, Ranran Qie, Minghui Han, Shengbing Huang, Ping Zhao, Ming Zhang, Dongsheng Hu, Pei Qin,

BACKGROUND:The study aimed to investigate the associations of baseline serum albumin level and its dynamic change with type 2 diabetes mellitus (T2DM) risk in a large Chinese cohort study. METHODS:This cohort study included 30 442 adults without T2DM at first entry, who completed at least one follow-up of annual examinations between ... Read more >>

Diabetes Metab Res Rev (Diabetes/metabolism research and reviews)
[2020, 36(5):e3296]

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Effects of lutein supplementation on inflammatory biomarkers and metabolic risk factors in adults with central obesity: study protocol for a randomised controlled study.

Juan Zhou, Dan Zhao, Ning Wang, Zhiwei Zeng, Changyi Wang, Liping Hao, Xiaolin Peng,

BACKGROUND:The prevalence of central obesity is constantly increasing, and visceral fat is associated with increased production of inflammatory factors and metabolic risk factors. Lutein might retard the development of metabolic disease through its antioxidant and anti-inflammatory properties. Furthermore, epidemiological studies have associated higher dietary intake and serum levels of lutein ... Read more >>

Trials (Trials)
[2020, 21(1):32]

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Red blood cell distribution width is associated with mortality after acute ischemic stroke: a cohort study and systematic review.

Lu Wang, Changyi Wang, Simiao Wu, Yuxiao Li, Wen Guo, Ming Liu,

Background:Whether red blood cell distribution width (RDW) is associated with the prognosis of acute ischemic stroke is inconclusive according to recent studies. We performed a cohort study and meta-analysis to explore the association between RDW and functional outcome. Methods:Patients with ischemic stroke admitted to the Department of Neurology within 24 ... Read more >>

Ann Transl Med (Annals of translational medicine)
[2020, 8(4):81]

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CpG single nucleotide polymorphisms of the insulin signaling pathway associated with the risk of prediabetic status/type 2 diabetes in Chinese population

Linlin Tang, Changyi Wang, Liyuan Han, Jianping Ma, Jia Cheng, Shiwei Duan,

<h4>Aims: </h4> Cytosine-phosphate-guanine single nucleotide polymorphisms (CpG SNPs) have been identified as new markers in human diseases. We aimed to evaluate the contribution of 29 CpG SNPs in the insulin signaling pathways to the risk of prediabetes and type 2 diabetes (T2D) in Han Chinese. Materials and methods: We recruited ... Read more >>

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Dynamic Change of Neutrophil to Lymphocyte Ratios and Infection in Patients with Acute Ischemic Stroke.

Lu Wang, Wen Guo, Changyi Wang, Xue Yang, Zilong Hao, Simiao Wu, Shihong Zhang, Bo Wu, Ming Liu,

<h4>Background</h4>Neutrophil to lymphocyte ratio (NLR) on admission was reported to be a predictor of pneumonia after stroke. The aim of this study was to investigate the association between the temporal change of NLR and post-stroke infection and whether infection modified the effect of NLR on the outcome.<h4>Methods</h4>We enrolled patients with ... Read more >>

Curr Neurovasc Res (Current neurovascular research)
[2020, 17(3):294-303]

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Association Between Mean Platelet Volume and Hemorrhagic Transformation in Acute Ischemic Stroke Patients.

Changyi Wang, Lu Wang, Linghui Deng, Shi Qiu, Shihong Zhang, Ming Liu, Bo Wu,

BACKGROUND:Hemorrhagic transformation (HT) is a frequent complication of acute ischemic stroke (AIS). Mean platelet volume (MPV) is a marker of platelet function. The relationship between MPV and HT remains unclear. METHODS:From January 1st, 2012 to December 31st 2016, we consecutively enrolled AIS patients admitted to the Department of Neurology of ... Read more >>

Curr Neurovasc Res (Current neurovascular research)
[2020, 17(1):3-10]

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Effects of lutein supplementation on inflammatory biomarkers and metabolic risk factors in adults with central obesity: study protocol for a randomized controlled study

Juan Zhou, Dan Zhao, Ning Wang, Zhiwei Zeng, Changyi Wang, Liping Hao, Xiaolin Peng,

<h4>Background: </h4> The prevalence of central obesity is increasing consistently, and visceral fat is associated with increased production of inflammatory factors and metabolic risk factors. Lutein might retard the development of metabolic disease through its antioxidant and anti-inflammatory properties. Furthermore, epidemiological studies have associated higher dietary intake and serum levels ... Read more >>

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Association Between Neutrophil to Lymphocyte Ratio and Malignant Brain Edema in Patients With Large Hemispheric Infarction.

Xueling Bai, Changyi Wang, Lu Wang, Shuai Jiang, Shihong Zhang, Ming Liu, Bo Wu,

<h4>Introduction</h4>Malignant brain edema (MBE) is a life-threatening complication for patients with large hemispheric infarction (LHI). Stroke-related inflammatory responses may cause secondary brain injury and lead to brain edema. The neutrophil to lymphocyte ratio (NLR) is a well-known systemic inflammatory biomarker. The aim of this study was to evaluate if NLR ... Read more >>

Curr Neurovasc Res (Current neurovascular research)
[2020, 17(4):429-436]

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Mirror movements induced by hemiballism due to putamen infarction: a case report and literature review.

Shuai Jiang, Di Zhong, Yuying Yan, Qiange Zhu, Changyi Wang, Xueling Bai, Tian Cao, Bo Wu,

Mirror movements (MMs), which are involuntary movements of one limb that synchronously mirror voluntary movements of the contralateral limb, are a relatively uncommon complication of strokes. Here we report what appears to be the first case of putamen infarction manifesting as MMs in one side of the body induced by ... Read more >>

Ann Transl Med (Annals of translational medicine)
[2020, 8(1):19]

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