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An ionic liquid-modified RGO/polyaniline composite for high-performance flexible all-solid-state supercapacitors.

Chang Dong, Xiaoling Zhang, Yijia Yu, Liyan Huang, Jun Li, Ying Wu, Zhengping Liu,

An ionic liquid-modified reduced graphene oxide/polyaniline (RGO-IL/PANI) composite was synthesized successfully. The ionic liquid enlarged the interlayer distance of RGO sheets and acted as a PANI dopant to improve the orderly establishment of PANI. The supercapacitor based on RGO-IL/PANI presented outstanding energy density (24.1 W h kg<sup>-1</sup> at 501 W ... Read more >>

Chem Commun (Camb) (Chemical communications (Cambridge, England))
[2020, 56(80):11993-11996]

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Cloning and Characterization of a Panel of Mitochondrial Targeting Sequences for Compartmentalization Engineering in Saccharomyces cerevisiae.

Chang Dong, Zhuwei Shi, Lei Huang, Huimin Zhao, Zhinan Xu, Jiazhang Lian,

Mitochondrion is generally considered as the most promising subcellular organelle for compartmentalization engineering. Much progress has been made in reconstituting whole metabolic pathways in the mitochondria of yeast to harness the precursor pools (i.e. pyruvate and acetyl-CoA), bypass competing pathways, and minimize transportation limitations. However, only a few mitochondrial targeting ... Read more >>

Biotechnol Bioeng (Biotechnology and bioengineering)
[2021, :]

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Sensitive detection of prostate-specific antigen based on dual signal amplification of [email protected] and NH2-MIL-101(Fe).

Yingcong Zhang, Ze Zhang, Zhangmin Wang, Hongzhi Pan, Yong Lin, Dong Chang,

An electrochemiluminescence sensor was proposed for detection of prostate-specific antigen (PSA) based on dual-amplification strategy of ferrocenecarboxylic [email protected] layered double hydroxides ([email protected]) and NH<sub>2</sub>-MIL-101(Fe). An (Au NPs/[email protected])<sub>n</sub> multilayer nanofilm was fabricated by a layer-by-layer self-assembly between positively charged [email protected] nanosheets and negatively charged Au NPs. The multilayer nanofilms acted as ... Read more >>

Biosens Bioelectron (Biosensors & bioelectronics)
[2021, 190:113437]

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A case of variant angina associated with syncope detected by an implantable loop recorder.

Yingjian Deng, Xingcai Wan, Xin Su, Guiyang Li, Dong Chang, Qiang Li,

The implantable loop recorder (ILR) is a small device used to monitor the electrical activity of the heart by recording a single‑lead bipolar electrocardiograph signal over a long period of time. The ILR is a valid diagnostic tool but has been vastly underused. In addition to arrhythmia, the ILR may ... Read more >>

J Electrocardiol (Journal of electrocardiology)
[2021, 67:115-118]

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A sandwich-configuration electrochemiluminescence immunoassay based on Cu2[email protected] nanocrystals and OMC-MoS2 nanocomposites for determination of alpha-fetoprotein.

Ze Zhang, Hongwei Yu, Yingcong Zhang, Zhangmin Wang, Hongmin Gao, Shengzhong Rong, Lingqiang Meng, Jianmin Dai, Hongzhi Pan, Dong Chang,

A sandwich-format electrochemiluminescence (ECL) immunosensor has been developed for alpha-fetoprotein (AFP) detection based on the use of ordered mesoporous carbon-molybdenum disulfide (OMC-MoS<sub>2</sub>) as a sensor platform and cuprous oxide @ ordered mesoporous carbon-Ru(bpy)<sub>3</sub><sup>2+</sup> (Cu<sub>2</sub>[email protected]) composites as signal tags. OMC alongside MoS<sub>2</sub> plays a synergistic role in improving the electrochemical performance of ... Read more >>

Mikrochim Acta (Mikrochimica acta)
[2021, 188(6):213]

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Evaluation of Time-Limited Trials Among Critically Ill Patients With Advanced Medical Illnesses and Reduction of Nonbeneficial ICU Treatments.

Dong W Chang, Thanh H Neville, Jennifer Parrish, Lian Ewing, Christy Rico, Liliacna Jara, Danielle Sim, Chi-Hong Tseng, Carin van Zyl, Aaron D Storms, Nader Kamangar, Janice M Liebler, May M Lee, Hal F Yee,

<h4>Importance</h4>For critically ill patients with advanced medical illnesses and poor prognoses, overuse of invasive intensive care unit (ICU) treatments may prolong suffering without benefit.<h4>Objective</h4>To examine whether use of time-limited trials (TLTs) as the default care-planning approach for critically ill patients with advanced medical illnesses was associated with decreased duration and ... Read more >>

JAMA Intern Med (JAMA internal medicine)
[2021, 181(6):786-794]

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Epithelial Regeneration Ability of Crohn's Disease Assessed Using Patient-Derived Intestinal Organoids

Chansu Lee, Sung Noh Hong, Eun Ran Kim, Dong Kyung Chang, Young-Ho Kim,

<h4>Background: </h4> Little is known about the ability of epithelial regeneration and wound healing in patients with inflammatory bowel disease, since the ethical issue of clinical trials and the inherent limitations of tumor-derived epithelial cell lines and animal models. We evaluated the epithelial proliferation and wound healing ability of the ... Read more >>

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An ultrasensitive disposable sandwich-configuration electrochemical immunosensor based on [email protected] composites and AuPt-MB for alpha-fetoprotein detection.

Shengzhong Rong, Lina Zou, Yang Li, Yue Guan, Huilin Guan, Ze Zhang, Yingcong Zhang, Hongmin Gao, Hongwei Yu, Fuyang Zhao, Hongzhi Pan, Dong Chang,

Early finding and diagnosis are critical for prevention and treatment of hepatocellular carcinoma (HCC). Alpha-fetoprotein (AFP) is a typical biomarker of HCC. Since AFP level can reflect the severity of HCC, it is essential to ensure the accurate detection of AFP. In this study, through a combination of the advantages ... Read more >>

Bioelectrochemistry (Bioelectrochemistry (Amsterdam, Netherlands))
[2021, 141:107846]

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The impact of post-operative atrial fibrillation on outcomes in coronary artery bypass graft and combined procedures.

Yau-Lam Alex Chau, Ji Won Yoo, Ho Chuen Yuen, Khalid Bin Waleed, Dong Chang, Tong Liu, Fang Zhou Liu, Gary Tse, Sharen Lee, Ka Hou Christien Li,

<h4>Background</h4>Post-operative atrial fibrillation (POAF) is a common yet understudied clinical issue after coronary artery bypass graft (CABG) leading to higher mortality rates and stroke. This systematic review and meta-analysis evaluated the rates of adverse outcomes between patients with and without POAF in patients treated with CABG or combined procedures.<h4>Methods</h4>The search ... Read more >>

J Geriatr Cardiol (Journal of geriatric cardiology : JGC)
[2021, 18(5):319-326]

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Clinical Significance of Residual Nonrectal Inflammation in Ulcerative Colitis Patients in Clinical Remission.

Jongbeom Shin, Sung Min Kong, Tae Jun Kim, Eun Ran Kim, Sung Noh Hong, Dong Kyung Chang, Young-Ho Kim,

<h4>Background/aims</h4>The treatment goal of ulcerative colitis (UC) has been changed to achieve endoscopic remission (ER). However, there is insufficient clinical evidence to determine whether a step-up treatment should be performed to achieve ER in clinical remission (CR) without ER, and there are inadequate data on the need to consider the ... Read more >>

Gut Liver (Gut and liver)
[2021, 15(3):401-409]

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[Metabolic engineering tools for Saccharomyces cerevisiae].

Lihong Jiang, Chang Dong, Lei Huang, Zhinan Xu, Jiazhang Lian,

Since its birth in the early 1990s, metabolic engineering technology has gone 30 years rapid development. As one of the preferred chassis for metabolic engineering, S. cerevisiae cells have been engineered into microbial cell factories for the production of a variety of bulk chemicals and novel high value-added bioactive compounds. ... Read more >>

Sheng Wu Gong Cheng Xue Bao (Sheng wu gong cheng xue bao = Chinese journal of biotechnology)
[2021, 37(5):1578-1602]

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Enteroscopy in Crohn's Disease: Are There Any Changes in Role or Outcomes Over Time? A KASID Multicenter Study.

Seong Ran Jeon, Jin-Oh Kim, Jeong-Sik Byeon, Dong-Hoon Yang, Bong Min Ko, Hyeon Jeong Goong, Hyun Joo Jang, Soo Jung Park, Eun Ran Kim, Sung Noh Hong, Jong Pil Im, Seong-Eun Kim, Ja Seol Koo, Chang Soo Eun, Dong Kyung Chang, ,

<h4>Background/aims</h4>Although balloon-assisted enteroscopy (BAE) enables endoscopic visualization of small bowel (SB) involvement in Crohn's disease (CD), there is no data on the changes in outcomes over time. We therefore investigated the changes in BAE use on CD patients over different time periods in terms of its role and clinical outcomes.<h4>Methods</h4>We ... Read more >>

Gut Liver (Gut and liver)
[2021, 15(3):375-382]

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Left atrial thickness and acute thermal injury in patients undergoing ablation for atrial fibrillation: Laser versus radiofrequency energies.

Xu Gao, Dong Chang, Kenneth C Bilchick, Sarah K Hussain, Jan Petru, Jan Skoda, Luci Sediva, Petr Neuzil, J Michael Mangrum,

<h4>Introduction</h4>Thermally induced cardiac lesions result in necrosis, edema, and inflammation. This tissue change may be seen with ultrasound. In this study, we sought to use intracardiac echocardiography (ICE) to evaluate pulmonary vein tissue morphology and assess the acute tissue changes that occur following radiofrequency (RF) or laser ablation for atrial ... Read more >>

J Cardiovasc Electrophysiol (Journal of cardiovascular electrophysiology)
[2021, 32(5):1259-1267]

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Depletion of Intestinal Stem Cell Niche Factors Contributes to the Alteration of Epithelial Differentiation in SAMP1/YitFcsJ Mice With Crohn Disease-Like Ileitis.

Chansu Lee, Sung Noh Hong, Eun Ran Kim, Dong Kyung Chang, Young-Ho Kim,

<h4>Background</h4>SAMP1/YitFcsJ (SAMP1) mice spontaneously develop terminal ileitis resembling human Crohn disease. SAMP1 mice have exhibited alteration of epithelial cell lineage distribution and an overall proliferation of the crypt cell population; however, it has not been evaluated whether epithelial differentiation is impaired because of dysfunction of intestinal stem cells (ISCs) or ... Read more >>

Inflamm Bowel Dis (Inflammatory bowel diseases)
[2021, 27(5):667-676]

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Epithelial Regeneration Ability of Crohn’s Disease Assessed Using Patient-Derived Intestinal Organoids

Chnasu Lee, Sung Noh Hong, Eun Ran Kim, Dong Kyung Chang, Young-Ho Kim,

<h4>Background</h4> The intrinsic limitation of cell lines and animal models limits our understanding of epithelial regeneration capability in Crohn’s disease (CD). Therefore, we aimed to study epithelial regeneration ability in CD using an intestinal organoid model. Further, since tumor necrosis factor alpha (TNFα) is a major proinflammatory effector during CD ... Read more >>

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Machine learning prediction of pathologic myopia using tomographic elevation of the posterior sclera.

Yong Chan Kim, Dong Jin Chang, So Jin Park, In Young Choi, Ye Seul Gong, Hyun-Ah Kim, Hyung Bin Hwang, Kyung In Jung, Hae-Young Lopilly Park, Chan Kee Park, Kui Dong Kang,

Qualitative analysis of fundus photographs enables straightforward pattern recognition of advanced pathologic myopia. However, it has limitations in defining the classification of the degree or extent of early disease, such that it may be biased by subjective interpretation. In this study, we used the fovea, optic disc, and deepest point ... Read more >>

Sci Rep (Scientific reports)
[2021, 11(1):6950]

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Identification of novel metabolic engineering targets for S-adenosyl-L-methionine production in Saccharomyces cerevisiae via genome-scale engineering.

Chang Dong, J Carl Schultz, Wei Liu, Jiazhang Lian, Lei Huang, Zhinan Xu, Huimin Zhao,

S-Adenosyl-L-methionine (SAM) is an important intracellular metabolite and widely used for treatment of various diseases. Although high level production of SAM had been achieved in yeast, novel metabolic engineering strategies are needed to further enhance SAM production for industrial applications. Here genome-scale engineering (GSE) was performed to identify new targets ... Read more >>

Metab Eng (Metabolic engineering)
[2021, 66:319-327]

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Effect of Heat-killed Lactobacillus casei DKGF7 on a Rat Model of Irritable Bowel Syndrome.

Gyeol Seong, Seungbaek Lee, Yang Won Min, Yeon Sil Jang, Hong Seog Kim, Eui-Joong Kim, So-Young Park, Cheol-Hyun Kim, Dong Kyung Chang,

Non-viable bacteria, referred to as "paraprobiotics," have attracted attention as potentially safer alternatives to probiotics. The aim of this study was to investigate the efficacy of heat-killed <i>Lactobacillus casei</i> DKGF7 on the symptomatic improvement of irritable bowel syndrome (IBS) in a rat disease model and to elucidate the underlying mechanisms ... Read more >>

Nutrients (Nutrients)
[2021, 13(2):]

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Left bundle branch pacing in patients with right bundle branch block

Kailun Zhu, Yali Sun, Binni Cai, Linlin Li, Guiyang Li, Jianghai Liu, Xingcai Wan, Dong Chang, Qiang Li,

Abstract Background The paced morphology of right bundle branch block (RBBB) pattern is one of the parameters which can be used to confirm the left bundle branch capture during left bundle branch pacing (LBBP) implantation. However, changes of paced morphology after LBBP performed in patients with RBBB have not been ... Read more >>

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Risk of venous thromboembolism in Asian patients with inflammatory bowel disease: a nationwide cohort study.

Chan Mi Heo, Tae Jun Kim, Eun Ran Kim, Sung Noh Hong, Dong Kyung Chang, Mi Yang, Seonwoo Kim, Young-Ho Kim,

Routine prophylaxis for venous thromboembolism (VTE) in Asian IBD patients has been controversial. We aimed to estimate the risk of VTE of Asian patients at different phases of IBD by incorporating patient-specific risk factors. In this cohort study, we analyzed the National Health Insurance claims data between 2012 and 2016 ... Read more >>

Sci Rep (Scientific reports)
[2021, 11(1):2025]

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Comparative effects of sodium glucose cotransporter 2 (SGLT2) inhibitors and dipeptidyl peptidase-4 (DPP4) inhibitors on new-onset atrial fibrillation and stroke outcomes

Sharen Lee, Jiandong Zhou, Carlin Chang, Tong Liu, Dong Chang, Wing Tak Wong, Keith SK Leung, Abraham KC Wai, Bernard Man Yung Cheung, Gary Tse, Qingpeng Zhang,

<h4>Background</h4> SGLT2I and DPP4I are medications prescribed for type 2 diabetes mellitus patients. However, there are few population-based studies comparing their effects on incident atrial fibrillation or ischemic stroke. <h4>Methods</h4> This was a territory-wide cohort study of type 2 diabetes mellitus patients prescribed SGLT2I or DPP4I between January 1st, 2015 ... Read more >>

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Long-term Prognosis of Localized Lymphoid Hyperplasia of the Rectum.

Ji Taek Hong, Eun Ran Kim, Sung-Wook Park, Ji Won Kim, Sung Noh Hong, Dong Kyung Chang, Young-Ho Kim, Jun Hun Cho,

<h4>Background/aims</h4>Although localized lymphoid hyperplasia (LLH) of the rectum is occasionally observed, its clinical implications are unclear. This study aimed to investigate the clinical course and significance of LLH of the rectum.<h4>Methods</h4>We identified 65 patients diagnosed with LLH of the rectum using a histopathologic examination and who received follow-up endoscopies between ... Read more >>

Gut Liver (Gut and liver)
[2021, 15(1):77-84]

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An innovative strategy for standardized, structured, and interoperable results in ophthalmic examinations.

Yongseok Mun, Jooyoung Kim, Kyoung Jin Noh, Soochahn Lee, Seok Kim, Soyoung Yi, Kyu Hyung Park, Sooyoung Yoo, Dong Jin Chang, Sang Jun Park,

<h4>Background</h4>Although ophthalmic devices have made remarkable progress and are widely used, most lack standardization of both image review and results reporting systems, making interoperability unachievable. We developed and validated new software for extracting, transforming, and storing information from report images produced by ophthalmic examination devices to generate standardized, structured, and ... Read more >>

BMC Med Inform Decis Mak (BMC medical informatics and decision making)
[2021, 21(1):9]

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Lipid-lowering therapy: Guidelines to precision medicine.

Xin Su, Ye Cheng, Dong Chang,

Dyslipidemia is correlated with a series of health problems, such as obesity, insulin resistance, and the development of cardiovascular disease (CVD). Currently, accumulating evidence sheds light on the fact that β-hydroxy β-methylglutaryl-CoA reductase inhibitors, named statins, could lower circulating lipid-density lipoprotein cholesterol (LDL-C) and represent a revolution for the prevention ... Read more >>

Clin Chim Acta (Clinica chimica acta; international journal of clinical chemistry)
[2021, 514:66-73]

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Successful left bundle branch pacing in a patient with dextrocardia using a modified sheath.

Qiang Li, Linlin Li, Xingcai Wan, Dong Chang,

Kardiol Pol (Kardiologia polska)
[2021, 79(1):87-88]

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