Full Text Journal Articles by
Author Chandra Srinivasan


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An SCN1B Variant Affects Both Cardiac-Type (NaV1.5) and Brain-Type (NaV1.1) Sodium Currents and Contributes to Complex Concomitant Brain and Cardiac Disorders.

Rebecca Martinez-Moreno, Elisabet Selga, Helena Riuró, David Carreras, Mered Parnes, Chandra Srinivasan, Michael F Wangler, Guillermo J Pérez, Fabiana S Scornik, Ramon Brugada,

Voltage-gated sodium (NaV) channels are transmembrane proteins that initiate and propagate neuronal and cardiac action potentials. NaV channel β subunits have been widely studied due to their modulatory role. Mice null for Scn1b, which encodes NaV β1 and β1b subunits, have defects in neuronal development and excitability, spontaneous generalized seizures, ... Read more >>

Front Cell Dev Biol (Frontiers in cell and developmental biology)
[2020, 8:528742]

Cited: 0 times

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Neonatal supraventricular tachycardia.

Chandra Srinivasan, Seshadri Balaji,

Supraventricular tachycardia (SVT) is one of the most common conditions requiring emergency cardiac care in neonates. Atrioventricular reentrant tachycardia utilizing an atrioventricular bypass tract is the most common form of SVT presenting in the neonatal period. There is high likelihood for spontaneous resolution for most of the common arrhythmia substrates ... Read more >>

Indian Pacing Electrophysiol J (Indian pacing and electrophysiology journal)
[2019, 19(6):222-231]

Cited: 0 times

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Preincision Initiation of Dexmedetomidine Maximally Reduces the Risk of Junctional Ectopic Tachycardia in Children Undergoing Ventricular Septal Defect Repairs.

Nischal K Gautam, Yuliya Turiy, Chandra Srinivasan,

To evaluate whether initiation of dexmedetomidine (DEX) infusion before surgical incision and cardiopulmonary bypass (CPB) versus initiation after CPB had an impact on the incidence of junctional ectopic tachycardia (JET).Retrospective cohort study.Single tertiary-care cardiac center.Children undergoing cardiopulmonary bypass for repair of congenital heart disease involving ventricular septal defects between January ... Read more >>

J. Cardiothorac. Vasc. Anesth. (Journal of cardiothoracic and vascular anesthesia)
[2017, 31(6):1960-1965]

Cited: 6 times

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Cognitive impairments following cranial irradiation can be mitigated by treatment with a tropomyosin receptor kinase B agonist.

Phillip Yang, David Leu, Keqiang Ye, Chandra Srinivasan, John R Fike, Ting-Ting Huang,

Brain radiotherapy is frequently used successfully to treat brain tumors. However, radiotherapy is often associated with declines in short-term and long-term memory, learning ability, and verbal fluency. We previously identified a downregulation of the brain-derived neurotrophic factor (BDNF) following cranial irradiation in experimental animals. In the present study, we investigated ... Read more >>

Exp Neurol (Experimental neurology)
[2016, 279:178-186]

Cited: 3 times

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Relationship between PCO2 and unfavorable outcome in infants with moderate-to-severe hypoxic ischemic encephalopathy.

Krithika Lingappan, Jeffrey R Kaiser, Chandra Srinivasan, Alistair J Gunn,

Abnormal PCO2 is common in infants with hypoxic ischemic encephalopathy (HIE). The objective was to determine whether hypocapnia was independently associated with unfavorable outcome (death or severe neurodevelopmental disability at 18 mo) in infants with moderate-to-severe HIE.This was a post hoc analysis of the CoolCap Study in which infants were ... Read more >>

Pediatr Res (Pediatric research)
[2016, 80(2):204-208]

Cited: 9 times

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Yeast Coq9 controls deamination of coenzyme Q intermediates that derive from para-aminobenzoic acid.

Cuiwen H He, Dylan S Black, Theresa P T Nguyen, Charles Wang, Chandra Srinivasan, Catherine F Clarke,

Coq9 is a polypeptide subunit in a mitochondrial multi-subunit complex, termed the CoQ-synthome, required for biosynthesis of coenzyme Q (ubiquinone or Q). Deletion of COQ9 results in dissociation of the CoQ-synthome, but over-expression of Coq8 putative kinase stabilizes the CoQ-synthome in the coq9 null mutant and leads to the accumulation ... Read more >>

Biochim Biophys Acta (Biochimica et biophysica acta)
[2015, 1851(9):1227-1239]

Cited: 15 times

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Diagnosis and Acute Management of Tachyarrhythmias in Children.

Chandra Srinivasan,

Tachyarrhythmias form a significant majority of the cardiac emergencies encountered in the pediatric age group. While the initial management often depends on the hemodynamic status of the patient at presentation, a systematic approach that follows the stabilization of the patient with the tools available at bedside, specifically the surface electrocardiogram ... Read more >>

Indian J Pediatr (Indian journal of pediatrics)
[2015, 82(12):1157-1163]

Cited: 1 time

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Analysis of the transcriptome in hyperoxic lung injury and sex-specific alterations in gene expression.

Krithika Lingappan, Chandra Srinivasan, Weiwu Jiang, Lihua Wang, Xanthi I Couroucli, Bhagavatula Moorthy,

Exposure to high concentration of oxygen (hyperoxia) leads to lung injury in experimental animal models and plays a role in the pathogenesis of diseases such as Acute Respiratory Distress Syndrome (ARDS) and Bronchopulmonary dysplasia (BPD) in humans. The mechanisms responsible for sex differences in the susceptibility towards hyperoxic lung injury ... Read more >>

PLoS One (PloS one)
[2014, 9(7):e101581]

Cited: 16 times

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Delayed accumulation of intestinal coliform bacteria enhances life span and stress resistance in Caenorhabditis elegans fed respiratory deficient E. coli.

Fernando Gomez, Gabriela C Monsalve, Vincent Tse, Ryoichi Saiki, Emily Weng, Laura Lee, Chandra Srinivasan, Alison R Frand, Catherine F Clarke,

Studies with the nematode model Caenorhabditis elegans have identified conserved biochemical pathways that act to modulate life span. Life span can also be influenced by the composition of the intestinal microbiome, and C. elegans life span can be dramatically influenced by its diet of Escherichia coli. Although C. elegans is ... Read more >>

BMC Microbiol (BMC microbiology)
[2012, 12:300]

Cited: 20 times

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Restoring de novo coenzyme Q biosynthesis in Caenorhabditis elegans coq-3 mutants yields profound rescue compared to exogenous coenzyme Q supplementation.

Fernando Gomez, Ryoichi Saiki, Randall Chin, Chandra Srinivasan, Catherine F Clarke,

Coenzyme Q (ubiquinone or Q) is an essential lipid component of the mitochondrial electron transport chain. In Caenorhabditis elegans Q biosynthesis involves at least nine steps, including the hydroxylation of the hydroquinone ring by CLK-1 and two O-methylation steps mediated by COQ-3. We characterize two C. elegans coq-3 deletion mutants, ... Read more >>

Gene (Gene)
[2012, 506(1):106-116]

Cited: 14 times

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Unincorporated iron pool is linked to oxidative stress and iron levels in Caenorhabditis elegans.

Natalie A Rangel, Lawrence Lin, Kanyasiri Rakariyatham, Albert Bach, Kim Trinh, Matthew H S Clement, Chandra Srinivasan,

Free radicals or reactive oxygen species (ROS) are relatively short-lived and are difficult to measure directly; so indirect methods have been explored for measuring these transient species. One technique that has been developed using Escherichia coli and Saccharomyces cerevisiae systems, relies on a connection between elevated superoxide levels and the ... Read more >>

Biometals (Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine)
[2012, 25(5):971-985]

Cited: 2 times

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Limitations of standard echocardiographic methods for quantification of right ventricular size and function in children and young adults.

Chandra Srinivasan, Ritu Sachdeva, W Robert Morrow, S Bruce Greenberg, Himesh V Vyas,

OBJECTIVES:The aim of this study was to evaluate correlation of 2-dimensional (2D) echocardiographic assessment of right ventricular (RV) and left ventricular (LV) size and function with magnetic resonance imaging (MRI) in children and young adults. METHODS:Patients with repaired tetralogy of Fallot (n = 23) and those who had normal RV ... Read more >>

J Ultrasound Med (Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine)
[2011, 30(4):487-493]

Cited: 24 times

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Impact of staged palliation on somatic growth in patients with hypoplastic left heart syndrome.

Chandra Srinivasan, Robert D B Jaquiss, W Robert Morrow, Elizabeth A Frazier, Deeann Martin, Michiaki Imamura, Ritu Sachdeva,

BACKGROUND: Somatic growth pattern in infants undergoing staged palliation for hypoplastic left heart syndrome (Norwood procedure [NP], stage 2 palliation [S2P], and Fontan procedure [FP]) during transition toward a more energy efficient series circulation is not well understood. OBJECTIVES: We sought to determine growth pattern in these infants and factors ... Read more >>

Congenit Heart Dis (Congenital heart disease)
[2010, 5(6):546-551]

Cited: 21 times

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Standardized management improves outcomes after the Norwood procedure.

Chandra Srinivasan, Ritu Sachdeva, W Robert Morrow, Jeff Gossett, Carl W Chipman, Michiaki Imamura, Robert D B Jaquiss,

BACKGROUND: In the past decade, many advances in the care of patients undergoing the Norwood procedure (NP) have been reported, but management remains nonstandardized at many institutions. We studied the impact of a standardized management protocol for neonates undergoing NP. METHODS: Care of NP patients has been protocol-driven at our ... Read more >>

Congenit Heart Dis (Congenital heart disease)
[2009, 4(5):329-337]

Cited: 42 times

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Measuring "free" iron levels in Caenorhabditis elegans using low-temperature Fe(III) electron paramagnetic resonance spectroscopy.

Kira T Pate, Natalie A Rangel, Brian Fraser, Matthew H S Clement, Chandra Srinivasan,

Oxidative stress, caused by free radicals within the body, has been associated with the process of aging and many human diseases. Because free radicals, in particular superoxide, are difficult to measure, an alternative indirect method for measuring oxidative stress levels has been used successfully in Escherichia coli and yeast. This ... Read more >>

Anal Biochem (Analytical biochemistry)
[2006, 358(2):199-207]

Cited: 7 times

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Only one of a wide assortment of manganese-containing SOD mimicking compounds rescues the slow aerobic growth phenotypes of both Escherichia coli and Saccharomyces cerevisiae strains lacking superoxide dismutase enzymes.

William Munroe, Carolyn Kingsley, Armando Durazo, Edith Butler Gralla, James A Imlay, Chandra Srinivasan, Joan Selverstone Valentine,

A variety of manganese-containing coordination compounds, frequently termed superoxide dismutase (SOD) mimics, have been reported to have SOD activity in vitro and to be effective at improving conditions related to increased oxidative stress in multicellular organisms. We tested the effectiveness of several of these compounds in substituting for authentic SOD ... Read more >>

J Inorg Biochem (Journal of inorganic biochemistry)
[2007, 101(11-12):1875-1882]

Cited: 29 times

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Manganous ion supplementation accelerates wild type development, enhances stress resistance, and rescues the life span of a short-lived Caenorhabditis elegans mutant.

Yi-Ting Lin, Hanh Hoang, Scott I Hsieh, Natalie Rangel, Amanda L Foster, James N Sampayo, Gordon J Lithgow, Chandra Srinivasan,

Relative to iron and copper we know very little about the cellular roles of manganese. Some studies claim that manganese acts as a radical scavenger in unicellular organisms, while there have been other reports that manganese causes Parkinson's disease-like syndrome, DNA fragmentation, and interferes with cellular energy production. The goal ... Read more >>

Free Radic. Biol. Med. (Free radical biology & medicine)
[2006, 40(7):1185-1193]

Cited: 30 times

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Exogenous manganous ion at millimolar levels rescues all known dioxygen-sensitive phenotypes of yeast lacking CuZnSOD.

Raylene J Sanchez, Chandra Srinivasan, William H Munroe, Matthew Alan Wallace, Jacob Martins, Tina Y Kao, Kate Le, Edith Butler Gralla, Joan Selverstone Valentine,

Yeasts lacking copper-zinc superoxide dismutase (sod1Delta) exhibit a broad range of phenotypes, many of which can be rescued by growth in the presence of high levels of ionic manganese. We undertook a comprehensive survey of the effects of manganese on wild-type and sod1Delta yeasts and found that 5 mM Mn2+ ... Read more >>

J. Biol. Inorg. Chem. (Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry)
[2005, 10(8):913-923]

Cited: 35 times

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Mutations in Saccharomyces cerevisiae iron-sulfur cluster assembly genes and oxidative stress relevant to Cu,Zn superoxide dismutase.

Laran T Jensen, Raylene J Sanchez, Chandra Srinivasan, Joan Selverstone Valentine, Valeria Cizewski Culotta,

Saccharomyces cerevisiae lacking Cu,Zn superoxide dismutase (SOD1) show several metabolic defects including aerobic blockages in methionine and lysine biosynthesis. We have previously shown that mutations in genes implicated in the formation of iron-sulfur clusters, designated seo (suppressors of endogenous oxidation), reverse the oxygen-dependent methionine and lysine auxotrophies of a sod1Delta ... Read more >>

J. Biol. Chem. (The Journal of biological chemistry)
[2004, 279(29):29938-29943]

Cited: 17 times

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Competition between lithium and magnesium ions for the G-protein transducin in the guanosine 5'-diphosphate bound conformation.

Chandra Srinivasan, Jason Toon, Louis Amari, Abde M Abukhdeir, Heidi Hamm, Carlos F G C Geraldes, Yee-Kin Ho, Duarte Mota de Freitas,

Li(+) is the most effective drug used to treat bipolar disorder; however, its exact mechanism of action has yet to be elucidated. One hypothesis is that Li(+) competes with Mg2+ for the Mg2+ binding sites on guanine-nucleotide binding proteins (G-proteins). Using 7Li T1 relaxation measurements and fluorescence spectroscopy with the ... Read more >>

J. Inorg. Biochem. (Journal of inorganic biochemistry)
[2004, 98(5):691-701]

Cited: 10 times

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Measurement of "free" or electron paramagnetic resonance-detectable iron in whole yeast cells as indicator of superoxide stress.

Chandra Srinivasan, Edith Butler Gralla,

Meth. Enzymol. (Methods in enzymology)
[2002, 349:173-180]

Cited: 6 times

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A dual role for zinc fingers in both DNA binding and zinc sensing by the Zap1 transcriptional activator.

A J Bird, H Zhao, H Luo, L T Jensen, C Srinivasan, M Evans-Galea, D R Winge, D J Eide,

The Zap1 transcriptional activator of Saccharomyces cerevisiae controls zinc homeostasis. Zap1 induces target gene expression in zinc-limited cells and is repressed by high zinc. One such target gene is ZAP1 itself. In this report, we examine how zinc regulates Zap1 function. First, we show that transcriptional autoregulation of Zap1 is ... Read more >>

EMBO J (The EMBO journal)
[2000, 19(14):3704-3713]

Cited: 46 times

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