Full Text Journal Articles by
Author Chandler B Sy

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Basophils prime group 2 innate lymphoid cells for neuropeptide-mediated inhibition.

Juan M Inclan-Rico, John J Ponessa, Nuriban Valero-Pacheco, Christina M Hernandez, Chandler B Sy, Alexander D Lemenze, Aimee M Beaulieu, Mark C Siracusa,

Type 2 cytokine responses promote parasitic immunity and initiate tissue repair; however, they can also result in immunopathologies when not properly restricted. Although basophilia is recognized as a common feature of type 2 inflammation, the roles basophils play in regulating these responses are unknown. Here, we demonstrate that helminth-induced group ... Read more >>

Nat Immunol (Nature immunology)
[2020, 21(10):1181-1193]

Cited: 6 times

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Trichinella spiralis-induced mastocytosis and erythropoiesis are simultaneously supported by a bipotent mast cell/erythrocyte precursor cell.

Juan M Inclan-Rico, Christina M Hernandez, Everett K Henry, Hannah G Federman, Chandler B Sy, John J Ponessa, Alexander D Lemenze, Nathanael Joseph, Patricia Soteropoulos, Aimee M Beaulieu, George S Yap, Mark C Siracusa,

Anti-helminth responses require robust type 2 cytokine production that simultaneously promotes worm expulsion and initiates the resolution of helminth-induced wounds and hemorrhaging. However, how infection-induced changes in hematopoiesis contribute to these seemingly distinct processes remains unknown. Recent studies have suggested the existence of a hematopoietic progenitor with dual mast cell-erythrocyte ... Read more >>

PLoS Pathog (PLoS pathogens)
[2020, 16(5):e1008579]

Cited: 2 times

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The Therapeutic Potential of Targeting Cytokine Alarmins to Treat Allergic Airway Inflammation.

Chandler B Sy, Mark C Siracusa,

Asthma is a heterogeneous disorder that results in recurrent attacks of breathlessness, coughing, and wheezing that affects millions of people worldwide. Although the precise causes of asthma are unclear, studies suggest that a combination of genetic predisposition and environmental exposure to various allergens and pathogens contribute to its development. Currently, ... Read more >>

Front Physiol (Frontiers in physiology)
[2016, 7:214]

Cited: 6 times

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