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Author Celso Arango

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Trends in utilisation of hypnotics among Scandinavian young people.

Celso Arango, Laura Pina-Camacho,

Acta Psychiatr Scand (Acta psychiatrica Scandinavica)
[2021, 144(2):97-99]

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Imputing the Number of Responders from the Mean and Standard Deviation of CGI-Improvement in Clinical Trials Investigating Medications for Autism Spectrum Disorder

Spyridon Siafis, Alessandro Rodolico, Oğulcan Çıray, Declan G. Murphy, Mara Parellada, Celso Arango, Stefan Leucht,

Introduction: Response to treatment, according to Clinical Global Impression-Improvement (CGI-I) scale, is an easily interpretable outcome in clinical trials of autism spectrum disorder (ASD). Yet, the CGI-I rating is sometimes reported as a continuous outcome, and converting it to dichotomous would allow meta-analysis to incorporate more evidence. Methods: Clinical trials ... Read more >>

Brain Sci (Brain sciences)
[2021, 11(7):]

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Sex Differences in Lifespan Trajectories and Variability of Human Sulcal and Gyral Morphology.

Covadonga M Díaz-Caneja, Clara Alloza, Pedro M Gordaliza, Alberto Fernández-Pena, Lucía de Hoyos, Javier Santonja, Elizabeth E L Buimer, Neeltje E M van Haren, Wiepke Cahn, Celso Arango, René S Kahn, Hilleke E Hulshoff Pol, Hugo G Schnack, Joost Janssen,

Sex differences in the development and aging of human sulcal morphology have been understudied. We charted sex differences in trajectories and inter-individual variability of global sulcal depth, width, and length, pial surface area, exposed (hull) gyral surface area, unexposed sulcal surface area, cortical thickness, gyral span, and cortex volume across ... Read more >>

Cereb Cortex (Cerebral cortex (New York, N.Y. : 1991))
[2021, :]

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Mental health services during the first wave of the COVID-19 pandemic in Europe: Results from the EPA Ambassadors Survey and implications for clinical practice.

Martina Rojnic Kuzman, Simavi Vahip, Andrea Fiorillo, Julian Beezhold, Mariana Pinto da Costa, Oleg Skugarevsky, Geert Dom, Izet Pajevic, Alma Mihaljevic Peles, Pavel Mohr, Anne Kleinberg, Eka Chkonia, Judit Balazs, William Flannery, Ramune Mazaliauskiene, Jana Chihai, Jerzy Samochowiec, Doina Cozman, Goran Mihajlovic, Lubomira Izakova, Celso Arango, Philip Goorwod,

<h4>Background</h4>The COVID-19 pandemic caused an unprecedented worldwide crisis affecting several sectors, including health, social care, economy and society at large. The World Health Organisation has emphasized that mental health care should be considered as one of the core sectors within the overall COVID-19 health response. By March 2020, recommendations for ... Read more >>

Eur Psychiatry (European psychiatry : the journal of the Association of European Psychiatrists)
[2021, 64(1):e41]

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Affective symptom dimensions in early-onset psychosis over time: a principal component factor analysis of the Young Mania Rating Scale and the Hamilton Depression Rating Scale.

Gonzalo Salazar de Pablo, Dolores Moreno, Ana Gonzalez-Pinto, Beatriz Paya, Josefina Castro-Fonieles, Inmaculada Baeza, Montserrat Graell, Celso Arango, Marta Rapado-Castro, Carmen Moreno,

Early-onset psychosis (EOP) is a complex disorder characterized by a wide range of symptoms, including affective symptoms. Our aim was to (1) examine the dimensional structure of affective symptoms in EOP, (2) evaluate the predominance of the clinical dimensions and (3) assess the progression of the clinical dimensions over a ... Read more >>

Eur Child Adolesc Psychiatry (European child & adolescent psychiatry)
[2021, :]

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Drug development for Autism Spectrum Disorder (ASD): Progress, challenges, and future directions.

James T McCracken, Evdokia Anagnostou, Celso Arango, Geraldine Dawson, Tiffany Farchione, Valentina Mantua, James McPartland, Declan Murphy, Gahan Pandina, Jeremy Veenstra-VanderWeele, ,

In 2017, facing lack of progress and failures encountered in targeted drug development for Autism Spectrum Disorder (ASD) and related neurodevelopmental disorders, the ISCTM with the ECNP created the ASD Working Group charged to identify barriers to progress and recommending research strategies for the field to gain traction. Working Group ... Read more >>

Eur Neuropsychopharmacol (European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology)
[2021, 48:3-31]

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The Role of Premorbid IQ and Age of Onset as Useful Predictors of Clinical, Functional Outcomes, and Recovery of Individuals with a First Episode of Psychosis.

Mariola Molina-García, David Fraguas, Ángel Del Rey-Mejías, Gisela Mezquida, Ana M Sánchez-Torres, Silvia Amoretti, Antonio Lobo, Ana González-Pinto, Álvaro Andreu-Bernabeu, Iluminada Corripio, Eduard Vieta, Inmaculada Baeza, Anna Mané, Manuel Cuesta, Elena de la Serna, Beatriz Payá, Iñaki Zorrilla, Celso Arango, Miquel Bernardo, Marta Rapado-Castro, Mara Parellada,

<h4>Background</h4>premorbid IQ (pIQ) and age of onset are predictors of clinical severity and long-term functioning after a first episode of psychosis. However, the additive influence of these variables on clinical, functional, and recovery rates outcomes is largely unknown.<h4>Methods</h4>we characterized 255 individuals who have experienced a first episode of psychosis in ... Read more >>

J Clin Med (Journal of clinical medicine)
[2021, 10(11):]

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Methodologic and Reporting Issues in Published Meta-analysis-Reply.

David Fraguas, Covadonga M Díaz-Caneja, Celso Arango,

JAMA Pediatr (JAMA pediatrics)
[2021, 175(6):644-645]

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Longitudinal outcome of attenuated positive symptoms, negative symptoms, functioning and remission in people at clinical high risk for psychosis: a meta-analysis.

Gonzalo Salazar de Pablo, Filippo Besana, Vincenzo Arienti, Ana Catalan, Julio Vaquerizo-Serrano, Anna Cabras, Joana Pereira, Livia Soardo, Francesco Coronelli, Simi Kaur, Josette da Silva, Dominic Oliver, Natalia Petros, Carmen Moreno, Ana Gonzalez-Pinto, Covadonga M Díaz-Caneja, Jae Il Shin, Pierluigi Politi, Marco Solmi, Renato Borgatti, Martina Maria Mensi, Celso Arango, Christoph U Correll, Philip McGuire, Paolo Fusar-Poli,

<h4>Background</h4>Little is known about clinical outcomes other than transition to psychosis in people at Clinical High-Risk for psychosis (CHR-P). Our aim was to comprehensively meta-analytically evaluate for the first time a wide range of clinical and functional outcomes beyond transition to psychosis in CHR-P individuals.<h4>Methods</h4>PubMed and Web of Science were ... Read more >>

EClinicalMedicine (EClinicalMedicine)
[2021, 36:100909]

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Genetic underpinnings of sociability in the general population.

Janita Bralten, Nina R Mota, Cornelius J H M Klemann, Ward De Witte, Emma Laing, David A Collier, Hilde de Kluiver, Stephanie E E C Bauduin, Celso Arango, Jose L Ayuso-Mateos, Chiara Fabbri, Martien J Kas, Nic van der Wee, Brenda W J H Penninx, Alessandro Serretti, Barbara Franke, Geert Poelmans,

Levels of sociability are continuously distributed in the general population, and decreased sociability represents an early manifestation of several brain disorders. Here, we investigated the genetic underpinnings of sociability in the population. We performed a genome-wide association study (GWAS) of a sociability score based on four social functioning-related self-report questions ... Read more >>

Neuropsychopharmacology (Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology)
[2021, 46(9):1627-1634]

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The Independent Effects of Psychosocial Stressors on Subclinical Psychosis: Findings From the Multinational EU-GEI Study.

Baptiste Pignon, Mohamed Lajnef, James B Kirkbride, Hugo Peyre, Aziz Ferchiou, Jean-Romain Richard, Grégoire Baudin, Sarah Tosato, Hannah Jongsma, Lieuwe de Haan, Ilaria Tarricone, Miguel Bernardo, Eva Velthorst, Mauro Braca, Celso Arango, Manuel Arrojo, Julio Bobes, Cristina Marta Del-Ben, Marta Di Forti, Charlotte Gayer-Anderson, Peter B Jones, Caterina La Cascia, Antonio Lasalvia, Paulo Rossi Menezes, Diego Quattrone, Julio Sanjuán, Jean-Paul Selten, Andrea Tortelli, Pierre-Michel Llorca, Jim van Os, Bart P F Rutten, Robin M Murray, Craig Morgan, Marion Leboyer, Andrei Szöke, Franck Schürhoff,

The influence of psychosocial stressors on psychosis risk has usually been studied in isolation and after the onset of the disorder, potentially ignoring important confounding relationships or the fact that some stressors that may be the consequence of the disorder rather than preexisting. The study of subclinical psychosis could help ... Read more >>

Schizophr Bull (Schizophrenia bulletin)
[2021, :]

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Preventive psychiatry: a blueprint for improving the mental health of young people.

Paolo Fusar-Poli, Christoph U Correll, Celso Arango, Michael Berk, Vikram Patel, John P A Ioannidis,

Preventive approaches have latterly gained traction for improving mental health in young people. In this paper, we first appraise the conceptual foundations of preventive psychiatry, encompassing the public health, Gordon's, US Institute of Medicine, World Health Organization, and good mental health frameworks, and neurodevelopmentally-sensitive clinical staging models. We then review ... Read more >>

World Psychiatry (World psychiatry : official journal of the World Psychiatric Association (WPA))
[2021, 20(2):200-221]

Cited: 2 times

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Subtly altered topological asymmetry of brain structural covariance networks in autism spectrum disorder across 43 datasets from the ENIGMA consortium

Zhiqiang Sha, Daan van Rooij, Evdokia Anagnostou, Celso Arango, Guillaume Auzias, Marlene Behrmann, Boris Bernhardt, Sven Bolte, Geraldo Busatto, Sara Calderoni, Rosa Calvo, Eileen Daly, Christine Deruelle, Meiyu Duan, Fabio Luis Souza Duran, Sarah Durston, Christine Ecker, Stefan Ehrlich, Damien Fair, Jennifer Fedor, Jacqueline Fitzgerald, Dorothea Floris, Barbara Franke, Christine Freitag, Louise Gallagher, David Glahn, Shlomi Haar, Liesbeth Hoekstra, Neda Jahanshad, Maria Jalbrzikowski, Joost Janssen, Joseph King, Luisa Lazaro, Beatriz Luna, Jane McGrath, Sarah Medland, Ciara Molloy, Filippo Muratori, Declan G.M. Murphy, Janina Neufeld, Kirsten O’Hearn, Bob Oranje, Mara Parellada, Jose Pariente, Merel Postema, Karl Lundin Remnelius, Alessandra Retico, Pedro Gomes Penteado Rosa, Katya Rubia, Devon Shook, Kristiina Tammimies, Margot Taylor, Michela Tosetti, Gregory Wallace, Fengfeng Zhou, Paul Thompson, Simon Fisher, Jan Buitelaar, Clyde Francks,

Small average differences in the left-right asymmetry of cerebral cortical thickness have been reported in individuals with autism spectrum disorder (ASD) compared to typically developing controls. Although these alterations affect multiple and widespread cortical regional asymmetries, the extent to which specific structural networks might be affected remains unknown. Inter-regional morphological ... Read more >>

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Duration of Untreated Psychosis in First-Episode Psychosis is not Associated With Common Genetic Variants for Major Psychiatric Conditions: Results From the Multi-Center EU-GEI Study.

Olesya Ajnakina, Victoria Rodriguez, Diego Quattrone, Marta di Forti, Evangelos Vassos, Celso Arango, Domenico Berardi, Miguel Bernardo, Julio Bobes, Lieuwe de Haan, Cristina Marta Del-Ben, Charlotte Gayer-Anderson, Hannah E Jongsma, Antonio Lasalvia, Sarah Tosato, Pierre-Michel Llorca, Paulo Rossi Menezes, Bart P Rutten, Jose Luis Santos, Julio Sanjuán, Jean-Paul Selten, Andrei Szöke, Ilaria Tarricone, Giuseppe D'Andrea, Alexander Richards, Andrea Tortelli, Eva Velthorst, Peter B Jones, Manuel Arrojo Romero, Caterina La Cascia, James B Kirkbride, Jim van Os, Mick O'Donovan, Robin M Murray, ,

Duration of untreated psychosis (DUP) is associated with clinical outcomes in people with a diagnosis of first-episode psychosis (FEP), but factors associated with length of DUP are still poorly understood. Aiming to obtain insights into the possible biological impact on DUP, we report genetic analyses of a large multi-center phenotypically ... Read more >>

Schizophr Bull (Schizophrenia bulletin)
[2021, :]

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Efficacy of a Web-Enabled, School-Based, Preventative Intervention to Reduce Bullying and Improve Mental Health in Children and Adolescents: Study Protocol for a Cluster Randomized Controlled Trial.

Covadonga M Díaz-Caneja, Javier Martín-Babarro, Renzo Abregú-Crespo, Miguel Á Huete-Diego, Marta Giménez-Dasí, Isabel Serrano-Marugán, Celso Arango,

<b>Introduction:</b> Bullying is a major preventable risk factor for mental disorders. Available evidence suggests school-based interventions reduce bullying prevalence rates. This study aims to test the efficacy of a web-enabled, school-based, multicomponent anti-bullying intervention to prevent school bullying and to assess its effects on mental health and quality of life. ... Read more >>

Front Pediatr (Frontiers in pediatrics)
[2021, 9:628984]

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Universal and Selective Interventions to Prevent Poor Mental Health Outcomes in Young People: Systematic Review and Meta-analysis.

Gonzalo Salazar de Pablo, Andrea De Micheli, Marco Solmi, Dominic Oliver, Ana Catalan, Valeria Verdino, Lucia Di Maggio, Ilaria Bonoldi, Joaquim Radua, Ottone Baccaredda Boy, Umberto Provenzani, Francesca Ruzzi, Federica Calorio, Guido Nosari, Benedetto Di Marco, Irene Famularo, Iriana Montealegre, Lorenzo Signorini, Silvia Molteni, Eleonora Filosi, Martina Mensi, Umberto Balottin, Pierluigi Politi, Jae Il Shin, Christoph U Correll, Celso Arango, Paolo Fusar-Poli,

<h4>Background</h4>Much is not known about the efficacy of interventions to prevent poor mental health outcomes in young people by targeting either the general population (universal prevention) or asymptomatic individuals with high risk of developing a mental disorder (selective prevention).<h4>Methods</h4>We conducted a PRISMA/MOOSE-compliant systematic review and meta-analysis of Web of Science ... Read more >>

Harv Rev Psychiatry (Harvard review of psychiatry)
[2021, 29(3):196-215]

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The pediatric psychopharmacology of autism spectrum disorder: A systematic review - Part I: The past and the present.

Antonio M Persico, Arianna Ricciardello, Marco Lamberti, Laura Turriziani, Francesca Cucinotta, Claudia Brogna, Benedetto Vitiello, Celso Arango,

Autism Spectrum Disorder (ASD) is a severe and lifelong neurodevelopmental disorder, with high social costs and a dramatic burden on the quality of life of patients and family members. Despite its high prevalence, reaching 1/54 children and 1/45 adults in the United States, no pharmacological treatment is still directed to ... Read more >>

Prog Neuropsychopharmacol Biol Psychiatry (Progress in neuro-psychopharmacology & biological psychiatry)
[2021, 110:110326]

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The role of depression in the prediction of a "late" remission in first-episode psychosis: An analysis of the OPTiMiSE study.

David Fraguas, Covadonga M Díaz-Caneja, Laura Pina-Camacho, Inge Winter van Rossum, Lone Baandrup, Iris E Sommer, Birte Glenthøj, René S Kahn, Stefan Leucht, Celso Arango,

<h4>Objective</h4>The identification of predictors of psychosis remission could guide early clinical decision-making for treatment of first-episode schizophrenia (FES).<h4>Methods</h4>We analyzed two non-independent subsamples of patients with FES ages 18-40 years from the OPTiMiSE study dataset to investigate the demographic and clinical factors that might help to differentiate "late" remitters (i.e., not ... Read more >>

Schizophr Res (Schizophrenia research)
[2021, 231:100-107]

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Drug development in ASD, an ISCTM-ECNP joint adventure.

Celso Arango,

Eur Neuropsychopharmacol (European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology)
[2021, 48:1-2]

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Use of multiple Polygenic Risk Scores for distinguishing Schizophrenia-spectrum disorder and Affective psychosis categories; the EUGEI study

Victoria Rodriguez, Luis Alameda, Diego Quattrone, Giada Tripoli, Charlotte Gayer-Anderson, Edoardo Spinazzola, Giulia Trotta, Hannah Jongsma, Simona Stilo, Caterina La Cascia, Laura Ferraro, Daniele La Barbera, Antonio Lasalvia, Sarah Tosato, Ilaria Tarricone, Elena Bonora, Stéphane Jamain, Jean-Paul Selten, Eva Velthorst, Lieuwe de Haan, Pierre-Michel Llorca, Manuel Arrojo, Julio Bobes, Miguel Bernardo, Celso Arango, James Kirkbride, Peter Jones, Bart Rutten, Alexander Richards, Pak Sham, Michael O’Donovan, Jim Van Os, Craig Morgan, Marta Di Forti, Robin Murray, Evangelos Vassos,

<h4>ABSTRACT</h4> Schizophrenia (SZ), Bipolar Disorder (BD) and Depression (D) run in families. This susceptibility is partly due to hundreds or thousands of common genetic variants, each conferring a fractional risk. The cumulative effects of the associated variants can be summarised as a polygenic risk score (PRS). Using data from the ... Read more >>

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Examining the association between exposome score for schizophrenia and functioning in schizophrenia, siblings, and healthy controls: Results from the EUGEI study.

Gamze Erzin, Lotta-Katrin Pries, Jim van Os, Laura Fusar-Poli, Philippe Delespaul, Gunter Kenis, Jurjen J Luykx, Bochao D Lin, Alexander L Richards, Berna Akdede, Tolga Binbay, Vesile Altınyazar, Berna Yalınçetin, Güvem Gümüş-Akay, Burçin Cihan, Haldun Soygür, Halis Ulaş, Eylem Şahin Cankurtaran, Semra Ulusoy Kaymak, Marina M Mihaljevic, Sanja Andric-Petrovic, Tijana Mirjanic, Miguel Bernardo, Gisela Mezquida, Silvia Amoretti, Julio Bobes, Pilar A Saiz, Maria Paz García-Portilla, Julio Sanjuan, Eduardo J Aguilar, Jose Luis Santos, Estela Jiménez-López, Manuel Arrojo, Angel Carracedo, Gonzalo López, Javier González-Peñas, Mara Parellada, Nadja P Maric, Cem Atbaşoğlu, Alp Ucok, Köksal Alptekin, Meram Can Saka, , Celso Arango, Micheal C O'Donovan, Bart P F Rutten, Sinan Guloksuz,

<h4>Background</h4>A cumulative environmental exposure score for schizophrenia (exposome score for schizophrenia [ES-SCZ]) may provide potential utility for risk stratification and outcome prediction. Here, we investigated whether ES-SCZ was associated with functioning in patients with schizophrenia spectrum disorder, unaffected siblings, and healthy controls.<h4>Methods</h4>This cross-sectional sample consisted of 1,261 patients, 1,282 unaffected ... Read more >>

Eur Psychiatry (European psychiatry : the journal of the Association of European Psychiatrists)
[2021, 64(1):e25]

Cited: 1 time

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Longitudinal allometry of sulcal morphology in health and schizophrenia

Joost Janssen, Clara Alloza, Covadonga Díaz-Caneja, Javier Santonja, Laura Pina-Camacho, Pedro Gordaliza, Alberto Fernández-Pena, Noemi González Lois, Elizabeth E.L. Buimer, Neeltje E.M. van Haren, Wiepke Cahn, Eduardo Vieta, Josefina Castro-Fornieles, Miquel Bernardo, Mara Parellada, Celso Arango, René Kahn, Hilleke Hulshoff Pol, Hugo Schnack,

Scaling between subcomponents of cortical folding and total brain volume (TBV) in healthy individuals (HI) is allometric, i.e. non-linear. It is unclear whether this is also true in individuals with schizophrenia (SZ) or first-episode psychosis (FEP). The current study first confirmed normative allometric scaling norms in HI using discovery and ... Read more >>

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Calling for the integration of children's mental health and protection into COVID-19 responses.

Mireia Solerdelcoll, Celso Arango, Gisela Sugranyes,

Rev Psiquiatr Salud Ment (Revista de psiquiatria y salud mental)
[2021, 14(2):113-116]

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Calling for the integration of children's mental health and protection into COVID-19 responses.

Mireia Solerdelcoll, Celso Arango, Gisela Sugranyes,

Rev Psiquiatr Salud Ment (Revista de psiquiatria y salud mental)
[2021, 14(2):113-116]

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Perceived major experiences of discrimination, ethnic group, and risk of psychosis in a six-country case-control study.

Supriya Misra, Bizu Gelaye, David R Williams, Karestan C Koenen, Christina P C Borba, Diego Quattrone, Marta Di Forti, Giada Tripoli, Caterina La Cascia, Daniele La Barbera, Laura Ferraro, Ilaria Tarricone, Domenico Berardi, Antonio Lasalvia, Sarah Tosato, Andrei Szöke, Pierre-Michel Llorca, Celso Arango, Andrea Tortelli, Lieuwe de Haan, Eva Velthorst, Julio Bobes, Miguel Bernardo, Julio Sanjuán, Jose Luis Santos, Manuel Arrojo, Cristina Marta Del-Ben, Paulo Rossi Menezes, Jean-Paul Selten, Peter B Jones, Hannah E Jongsma, James B Kirkbride, Bart P F Rutten, Jim van Os, Robin M Murray, Charlotte Gayer-Anderson, Craig Morgan,

<h4>Background</h4>Perceived discrimination is associated with worse mental health. Few studies have assessed whether perceived discrimination (i) is associated with the risk of psychotic disorders and (ii) contributes to an increased risk among minority ethnic groups relative to the ethnic majority.<h4>Methods</h4>We used data from the European Network of National Schizophrenia Networks ... Read more >>

Psychol Med (Psychological medicine)
[2021, :1-9]

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