Full Text Journal Articles by
Author Celia Da Cunha

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Systematic Phenotyping and Characterization of the 5xFAD mouse model of Alzheimer’s Disease

Stefania Forner, Shimako Kawauchi, Gabriela Balderrama-Gutierrez, Enikö Kramár, Dina Matheos, Jimmy Phan, Dominic Javonillo, Kristine Minh Tran, Edna Hingco, Celia da Cunha, Narges Rezaie, Joshua Andrei Alcantara, David Baglietto-Vargas, Camden Jansen, Jonathan Neumann, Marcelo Wood, Grant MacGregor, Ali Mortazavi, Andrea Tenner, Frank LaFerla, Kim Green,

Mouse models of human diseases are invaluable tools for studying pathogenic mechanisms and testing interventions and therapeutics. For disorders such as Alzheimer’s disease in which numerous models are being generated, a challenging first step is to identify the most appropriate model and age to effectively evaluate new therapeutic approaches. Here ... Read more >>

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Generation of a humanized Aβ expressing mouse demonstrating aspects of Alzheimer's disease-like pathology.

David Baglietto-Vargas, Stefania Forner, Lena Cai, Alessandra C Martini, Laura Trujillo-Estrada, Vivek Swarup, Marie Minh Thu Nguyen, Kelly Do Huynh, Dominic I Javonillo, Kristine Minh Tran, Jimmy Phan, Shan Jiang, Enikö A Kramár, Cristina Nuñez-Diaz, Gabriela Balderrama-Gutierrez, Franklin Garcia, Jessica Childs, Carlos J Rodriguez-Ortiz, Juan Antonio Garcia-Leon, Masashi Kitazawa, Mohammad Shahnawaz, Dina P Matheos, Xinyi Ma, Celia Da Cunha, Ken C Walls, Rahasson R Ager, Claudio Soto, Antonia Gutierrez, Ines Moreno-Gonzalez, Ali Mortazavi, Andrea J Tenner, Grant R MacGregor, Marcelo Wood, Kim N Green, Frank M LaFerla,

The majority of Alzheimer's disease (AD) cases are late-onset and occur sporadically, however most mouse models of the disease harbor pathogenic mutations, rendering them better representations of familial autosomal-dominant forms of the disease. Here, we generated knock-in mice that express wildtype human Aβ under control of the mouse App locus. ... Read more >>

Nat Commun (Nature communications)
[2021, 12(1):2421]

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Tau underlies synaptic and cognitive deficits for type 1, but not type 2 diabetes mouse models.

Laura Trujillo-Estrada, Cassidy Nguyen, Celia da Cunha, Lena Cai, Stefania Forner, Alessandra C Martini, Rahasson R Ager, Gilberto Aleph Prieto, Carl W Cotman, David Baglietto-Vargas, Frank M LaFerla,

Diabetes mellitus (DM) is one of the most devastating diseases that currently affects the aging population. Recent evidence indicates that DM is a risk factor for many brain disorders, due to its direct effects on cognition. New findings have shown that the microtubule-associated protein tau is pathologically processed in DM; ... Read more >>

Aging Cell (Aging cell)
[2019, 18(3):e12919]

Cited: 4 times

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