Full Text Journal Articles by
Author Celalettin Semih Kunak

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Xenobiotic/drug metabolizing enzyme and TP53 polymorphisms and clinical outcome in advanced nonsmall cell lung cancer patients.

Volkan Karacaoğlan, Ahmet Oğuz Ada, Serdar Bilgen, Guzide Tuğba Çetinkaya, Emre Soydaş, Celalettin Semih Kunak, Sibel Meryem Alpar, Meral Gülhan, Mümtaz Işcan,

<h4>Background/aim</h4>The association between polymorphisms of xenobiotic/drug metabolizing enzymes and TP53 and response to chemotherapy and survival of patients with nonsmall cell lung cancer (NSCLC) are limited and inconclusive. In this study, CYP2E1*5B, CYP2E1*6, CYP2E1*7B, GSTO1 (A140D), and TP53 (Arg72Pro) polymorphisms and response to platinum-based chemotherapy and survival in 137 advanced ... Read more >>

Turk J Med Sci (Turkish journal of medical sciences)
[2017, 47(2):554-562]

Cited: 2 times

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Association between the TP53 and CYP2E1*5B gene polymorphisms and non-small cell lung cancer.

Ahmet Oguz Ada, Serdar Bilgen, Volkan Karacaoglan, Celalettin Semih Kunak, Emre Soydas, Sibel Alpar, Meral Gulhan, Mumtaz Iscan,

Non-small cell lung cancer (NSCLC) is the most common form of lung cancer. Genetic polymorphisms in tumour suppressor genes and genes encoding xenobiotic metabolising enzymes alter the activity of their corresponding enzymes and are important individual susceptibility factors for NSCLC. Because of the lack of information in literature, the aim ... Read more >>

Arh Hig Rada Toksikol (Arhiv za higijenu rada i toksikologiju)
[2016, 67(4):311-316]

Cited: 1 time

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The Effect of Etoricoxib on Hepatic Ischemia-Reperfusion Injury in Rats.

Celalettin Semih Kunak, Osman Kukula, Emre Mutlu, Fatma Genç, Gülçer Güleç Peker, Ufuk Kuyrukluyıldız, Orhan Binici, Durdu Altuner, Hamit Hakan Alp,

<h4>Unlabelled</h4>Ischemia-reperfusion (I/R) damage is known to be a pathological process which continues with the increase of oxidants and expands with the inflammatory response. There is not any study about protective effect of etoricoxib on the liver I/R damage in literature.<h4>Objective</h4>This study investigates the effect of etoricoxib on oxidative stress induced ... Read more >>

Oxid Med Cell Longev (Oxidative medicine and cellular longevity)
[2015, 2015:598162]

Cited: 7 times

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Does bosentan protect diabetic brain alterations in rats? The role of endothelin-1 in the diabetic brain.

Recep Demir, Elif Cadirci, Erol Akpinar, Yasemin Cayir, Hasan Tarik Atmaca, Harun Un, Celalettin Semih Kunak, Muhammed Yayla, Zafer Bayraktutan, Ilknur Demir,

Diabetes mellitus (DM) is a major problem all over the world, affecting more people in recent years. Individuals with diabetes are more prone to disease than non-diabetics, especially vascular complications. The aim of this study was to examine the roles of the endothelin (ET)-1 in brain damage formed in a ... Read more >>

Basic Clin Pharmacol Toxicol (Basic & clinical pharmacology & toxicology)
[2015, 116(3):236-243]

Cited: 3 times

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High serum HTATIP2/TIP30 level in serous ovarian cancer as prognostic or diagnostic marker.

Yakup Kumtepe, Zekai Halici, Ozlem Sengul, Celalettin Semih Kunak, Yasin Bayir, Nergiz Kilic, Elif Cadirci, Alparslan Pulur, Zafer Bayraktutan,

<h4>Background</h4>Human HIV-1 TAT interactive protein 2 (HTATIP2/TIP30) is an evolutionarily conserved gene that is expressed ubiquitously in human tissues and some tumor tissues. This protein has been found to be associated with some gynecological cancers; as such, this study aimed to investigate blood HTATIP2/TIP30 levels in patients with ovarian cancer.<h4>Methods</h4>Twenty-three ... Read more >>

Eur J Med Res (European journal of medical research)
[2013, 18:18]

Cited: 6 times

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