Full Text Journal Articles by
Author Catia Giovannini

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Hepatic Cancer Stem Cells: Molecular Mechanisms, Therapeutic Implications, and Circulating Biomarkers.

Laura Gramantieri, Catia Giovannini, Fabrizia Suzzi, Ilaria Leoni, Francesca Fornari,

Hepatocellular carcinoma (HCC) is one of the deadliest cancers. HCC is associated with multiple risk factors and is characterized by a marked tumor heterogeneity that makes its molecular classification difficult to apply in the clinics. The lack of circulating biomarkers for the diagnosis, prognosis, and prediction of response to treatments ... Read more >>

Cancers (Basel) (Cancers)
[2021, 13(18):]

Cited: 0 times

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Elucidating the Molecular Basis of Sorafenib Resistance in HCC: Current Findings and Future Directions.

Francesca Fornari, Catia Giovannini, Fabio Piscaglia, Laura Gramantieri,

Hepatocellular carcinoma (HCC) is the second leading cause of cancer-related mortality worldwide. Sorafenib is the first multi-tyrosine kinase inhibitor approved for HCC and it has represented the standard of care for advanced HCC for almost 10 years, offering a survival benefit when compared to placebo. However, this benefit is limited, ... Read more >>

J Hepatocell Carcinoma (Journal of hepatocellular carcinoma)
[2021, 8:741-757]

Cited: 3 times

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MicroRNAs as Modulators of Tumor Metabolism, Microenvironment, and Immune Response in Hepatocellular Carcinoma.

Laura Gramantieri, Catia Giovannini, Fabio Piscaglia, Francesca Fornari,

Hepatocellular carcinoma (HCC) is the second leading cause of cancer-related mortality. Molecular heterogeneity and absence of biomarkers helping patient allocation to the best therapeutic option contribute to poor prognosis in advanced stages. MicroRNAs' (miRNAs) deregulated expression contributes to tumor development and progression and influences drug resistance in HCC. Accordingly, miRNAs ... Read more >>

J Hepatocell Carcinoma (Journal of hepatocellular carcinoma)
[2021, 8:369-385]

Cited: 1 time

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Molecules Present in Plant Essential Oils for Prevention and Treatment of Colorectal Cancer (CRC).

Giovannamaria Petrocelli, Fulvia Farabegoli, Maria Chiara Valerii, Catia Giovannini, Alberto Sardo, Enzo Spisni,

Essential oils (EOs) are a complex mixture of hydrophobic and volatile compounds synthesized from aromatic plants, commonly present in the human diet. In recent years, many in vitro studies have suggested possible anticancer properties of single EO compounds, on colorectal cancer (CRC) cells. However, the majority of these studies did ... Read more >>

Molecules (Molecules (Basel, Switzerland))
[2021, 26(4):]

Cited: 0 times

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MiR-30e-3p Influences Tumor Phenotype through MDM2/TP53 Axis and Predicts Sorafenib Resistance in Hepatocellular Carcinoma.

Laura Gramantieri, Daniela Pollutri, Martina Gagliardi, Catia Giovannini, Santina Quarta, Manuela Ferracin, Andrea Casadei-Gardini, Elisa Callegari, Sabrina De Carolis, Sara Marinelli, Francesca Benevento, Francesco Vasuri, Matteo Ravaioli, Matteo Cescon, Fabio Piscaglia, Massimo Negrini, Luigi Bolondi, Francesca Fornari,

The molecular background of hepatocellular carcinoma (HCC) is highly heterogeneous, and biomarkers predicting response to treatments are an unmet clinical need. We investigated miR-30e-3p contribution to HCC phenotype and response to sorafenib, as well as the mutual modulation of <i>TP53/MDM2</i> pathway, in HCC tissues and preclinical models. MiR-30e-3p was downregulated ... Read more >>

Cancer Res (Cancer research)
[2020, 80(8):1720-1734]

Cited: 14 times

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LncRNAs as novel players in hepatocellular carcinoma recurrence.

Laura Gramantieri, Michele Baglioni, Francesca Fornari, Maria Antonella Laginestra, Manuela Ferracin, Valentina Indio, Matteo Ravaioli, Matteo Cescon, Vanessa De Pace, Simona Leoni, Camelia Alexandra Coadă, Massimo Negrini, Luigi Bolondi, Catia Giovannini,

Long non-coding RNAs (lncRNAs) are ncRNAs more than 200 nucleotides long that participate to a wide range of biological functions. However, their role in cancer is poorly known. By using an NGS-based approach we analyzed the intragenic and poliA-lncRNAs in hepatocellular carcinoma (HCC) and we assayed the relationships between their ... Read more >>

Oncotarget (Oncotarget)
[2018, 9(80):35085-35099]

Cited: 14 times

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Tacripyrimidines, the first tacrine-dihydropyrimidine hybrids, as multi-target-directed ligands for Alzheimer's disease.

Mourad Chioua, Eleonora Buzzi, Ignacio Moraleda, Isabel Iriepa, Maciej Maj, Artur Wnorowski, Catia Giovannini, Anna Tramarin, Federica Portali, Lhassane Ismaili, Pilar López-Alvarado, Maria Laura Bolognesi, Krzysztof Jóźwiak, J Carlos Menéndez, José Marco-Contelles, Manuela Bartolini,

Notwithstanding the combination of cholinesterase (ChE) inhibition and calcium channel blockade within a multitarget therapeutic approach is envisaged as potentially beneficial to confront Alzheimer's disease (AD), this strategy has been scarcely investigated. To explore this promising line, a series of 5-amino-4-aryl-3,4,6,7,8,9-hexahydropyrimido [4,5-b]quinoline-2(1H)-thiones (tacripyrimidines) (4a-l) were designed by juxtaposition of tacrine, ... Read more >>

Eur J Med Chem (European journal of medicinal chemistry)
[2018, 155:839-846]

Cited: 9 times

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MiR-199-3p replacement affects E-cadherin expression through Notch1 targeting in hepatocellular carcinoma.

Catia Giovannini, Francesca Fornari, Rossella Dallo, Martina Gagliardi, Elisa Nipoti, Francesco Vasuri, Camelia Alexandra Coadă, Matteo Ravaioli, Luigi Bolondi, Laura Gramantieri,

Hepatocellular carcinoma (HCC) represents the second cause of cancer-related mortality worldwide and is associated with poor prognosis, due to a high recurrence rate after curative treatments and a drug resistance phenotype. In this scenario, the identification of innovative and effective therapeutic strategies is an unmet clinical need. The safety and ... Read more >>

Acta Histochem (Acta histochemica)
[2018, 120(2):95-102]

Cited: 10 times

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The epigenetically regulated miR-494 associates with stem-cell phenotype and induces sorafenib resistance in hepatocellular carcinoma.

Daniela Pollutri, Clarissa Patrizi, Sara Marinelli, Catia Giovannini, Elena Trombetta, Ferdinando A Giannone, Maurizio Baldassarre, Santina Quarta, Y P Vandewynckel, A Vandierendonck, H Van Vlierberghe, Laura Porretti, Massimo Negrini, Luigi Bolondi, Laura Gramantieri, Francesca Fornari,

Hepatocellular carcinoma (HCC) represents the second cause of cancer-related mortality worldwide and is associated with poor prognosis, especially in patients not amenable for curative treatments. The multi-kinase inhibitor sorafenib represents the first-line treatment option for advanced HCC; nevertheless, its effectiveness is limited due to tumor heterogeneity as well as innate ... Read more >>

Cell Death Dis (Cell death & disease)
[2018, 9(1):4]

Cited: 27 times

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Corrigendum: Vidatox 30 CH has tumor activating effect in hepatocellular carcinoma.

Catia Giovannini, Michele Baglioni, Marco Baron Toaldo, Matteo Cescon, Luigi Bolondi, Laura Gramantieri,

This corrects the article DOI: 10.1038/srep44685. ... Read more >>

Sci Rep (Scientific reports)
[2017, 7:46920]

Cited: 1 time

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Targeting Notch3 in Hepatocellular Carcinoma: Molecular Mechanisms and Therapeutic Perspectives.

Catia Giovannini, Luigi Bolondi, Laura Gramantieri,

The Notch signaling pathway is a very conserved system that controls embryonic cell fate decisions and the maintenance of adult stem cells through cell to cell communication. Accumulating evidence support the relevance of Notch signaling in different human diseases and it is one of the most commonly activated signaling pathways ... Read more >>

Int J Mol Sci (International journal of molecular sciences)
[2016, 18(1):]

Cited: 12 times

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In Hepatocellular Carcinoma miR-221 Modulates Sorafenib Resistance through Inhibition of Caspase-3-Mediated Apoptosis.

Francesca Fornari, Daniela Pollutri, Clarissa Patrizi, Tiziana La Bella, Sara Marinelli, Andrea Casadei Gardini, Giorgia Marisi, Marco Baron Toaldo, Michele Baglioni, Veronica Salvatore, Elisa Callegari, Maurizio Baldassarre, Marzia Galassi, Catia Giovannini, Matteo Cescon, Matteo Ravaioli, Massimo Negrini, Luigi Bolondi, Laura Gramantieri,

<b>Purpose:</b> The aberrant expression of miR-221 is a hallmark of human cancers, including hepatocellular carcinoma (HCC), and its involvement in drug resistance, together with a proved <i>in vivo</i> efficacy of anti-miR-221 molecules, strengthen its role as an attractive target candidate in the oncologic field. The discovery of biomarkers predicting the ... Read more >>

Clin Cancer Res (Clinical cancer research : an official journal of the American Association for Cancer Research)
[2017, 23(14):3953-3965]

Cited: 61 times

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Vidatox 30 CH has tumor activating effect in hepatocellular carcinoma.

Catia Giovannini, Michele Baglioni, Marco Baron Toaldo, Matteo Cescon, Luigi Bolondi, Laura Gramantieri,

Complementary and alternative medicine (CAM) is the term used to describe many kinds of products, practices, and systems that are not part of conventional medicine. Cancer patients usually do everything they can to combat the disease, manage its symptoms, and cope with the side effects of treatment. Unfortunately, patients who ... Read more >>

Sci Rep (Scientific reports)
[2017, 7:44685]

Cited: 3 times

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Suppression of p53 by Notch3 is mediated by Cyclin G1 and sustained by MDM2 and miR-221 axis in hepatocellular carcinoma.

Catia Giovannini, Manuela Minguzzi, Michele Baglioni, Francesca Fornari, Ferdinando Giannone, Matteo Ravaioli, Matteo Cescon, Pasquale Chieco, Luigi Bolondi, Laura Gramantieri,

To successfully target Notch receptors as part of a multidrug anticancer strategy, it will be essential to fully characterize the factors that are modulated by Notch signaling. We recently reported that Notch3 silencing in HCC results in p53 up-regulation in vitro and, therefore, we focused on the mechanisms that associate ... Read more >>

Oncotarget (Oncotarget)
[2014, 5(21):10607-10620]

Cited: 26 times

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Notch3 inhibition enhances sorafenib cytotoxic efficacy by promoting GSK3b phosphorylation and p21 down-regulation in hepatocellular carcinoma.

Catia Giovannini, Michele Baglioni, Marco Baron Toaldo, Cristiano Ventrucci, Stefania D'Adamo, Mario Cipone, Pasquale Chieco, Laura Gramantieri, Luigi Bolondi,

Sorafenib (Nexavar), a multiple kinase inhibitor, is the only clinically approved drug for patients with advanced HCC. However, its therapeutic success is limited by the emergence of drug resistance. Here we found that p21 and pGSK3βSer9 are major players in the resistance to sorafenib. We recently reported that aberrant Notch3 ... Read more >>

Oncotarget (Oncotarget)
[2013, 4(10):1618-1631]

Cited: 27 times

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CDKN1C/P57 is regulated by the Notch target gene Hes1 and induces senescence in human hepatocellular carcinoma.

Catia Giovannini, Laura Gramantieri, Manuela Minguzzi, Francesca Fornari, Pasquale Chieco, Gian Luca Grazi, Luigi Bolondi,

CDKN1C/P57 is a cyclin-dependent kinase inhibitor implicated in different human cancers, including hepatocellular carcinoma (HCC); however, little is known regarding the role of CDKN1C/P57 and its regulation in HCC. In this study, we show that the down-regulation of Notch1 and Notch3 in two HCC cell lines resulted in Hes1 down-regulation, ... Read more >>

Am J Pathol (The American journal of pathology)
[2012, 181(2):413-422]

Cited: 37 times

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MiR-122/cyclin G1 interaction modulates p53 activity and affects doxorubicin sensitivity of human hepatocarcinoma cells.

Francesca Fornari, Laura Gramantieri, Catia Giovannini, Angelo Veronese, Manuela Ferracin, Silvia Sabbioni, George Adrian Calin, Gian Luca Grazi, Carlo Maria Croce, Simona Tavolari, Pasquale Chieco, Massimo Negrini, Luigi Bolondi,

The identification of target genes is a key step for assessing the role of aberrantly expressed microRNAs (miRNA) in human cancer and for the further development of miRNA-based gene therapy. MiR-122 is a liver-specific miRNA accounting for 70% of the total miRNA population. Its down-regulation is a common feature of ... Read more >>

Cancer Res (Cancer research)
[2009, 69(14):5761-5767]

Cited: 230 times

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Aberrant Notch3 and Notch4 expression in human hepatocellular carcinoma.

Laura Gramantieri, Catia Giovannini, Arianna Lanzi, Pasquale Chieco, Matteo Ravaioli, Annamaria Venturi, Gian Luca Grazi, Luigi Bolondi,

<h4>Background</h4>Notch signalling is altered in several solid tumours and it plays a role in growth inhibition and apoptosis of hepatocellular carcinoma (HCC)-derived cell lines, bile duct development and hepatocyte regeneration.<h4>Aims</h4>This study aims to analyse the expression of Notch3, Notch4 and HES1 and HES6 as Notch-target genes in HCC, matched non-neoplastic ... Read more >>

Liver Int (Liver international : official journal of the International Association for the Study of the Liver)
[2007, 27(7):997-1007]

Cited: 65 times

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Selective ablation of Notch3 in HCC enhances doxorubicin's death promoting effect by a p53 dependent mechanism.

Catia Giovannini, Laura Gramantieri, Pasquale Chieco, Manuela Minguzzi, Federica Lago, Simona Pianetti, Eric Ramazzotti, Kenneth B Marcu, Luigi Bolondi,

<h4>Background/aims</h4>The functional roles of endogenous Notch3 and Notch1 for protecting human hepatocellular carcinoma (HCC) lines against doxorubicin-induced death have been investigated. We previously reported aberrant Notch3 and Notch4 up-regulation in HCC and we have extended these observations to include Notch1.<h4>Methods</h4>Notch1 expression was assessed by immunohistochemistry and immunoblotting. Notch3 and Notch1 ... Read more >>

J Hepatol (Journal of hepatology)
[2009, 50(5):969-979]

Cited: 53 times

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IL-6 triggers malignant features in mammospheres from human ductal breast carcinoma and normal mammary gland.

Pasquale Sansone, Gianluca Storci, Simona Tavolari, Tiziana Guarnieri, Catia Giovannini, Mario Taffurelli, Claudio Ceccarelli, Donatella Santini, Paola Paterini, Kenneth B Marcu, Pasquale Chieco, Massimiliano Bonafè,

High serum levels of IL-6 correlate with poor outcome in breast cancer patients. However, no data are available on the relationship between IL-6 and mammary stem/progenitor cells, which may fuel the genesis of breast cancer in vivo. Herein, we address this issue in the MCF-7 breast cancer cell line and ... Read more >>

J Clin Invest (The Journal of clinical investigation)
[2007, 117(12):3988-4002]

Cited: 447 times

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Human hepatocellular carcinoma expresses specific PCNA isoforms: an in vivo and in vitro evaluation.

Annamaria Venturi, Fabrizio Dal Piaz, Catia Giovannini, Laura Gramantieri, Pasquale Chieco, Luigi Bolondi,

Proliferating cell nuclear antigen (PCNA) is a 36 kDa protein involved in several cellular mechanisms, including DNA synthesis and repair, cell cycle regulation and apoptosis. An alteration in PCNA structure might contribute to DNA-damage accumulation in cancer cells. This study was aimed to evaluate the PCNA pattern of expression, in ... Read more >>

Lab Invest (Laboratory investigation; a journal of technical methods and pathology)
[2008, 88(9):995-1007]

Cited: 12 times

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Neuroendocrine carcinoma of the urinary bladder: case report and review of the literature.

Alessandro Bertaccini, Debora Marchiori, Antonia Cricca, Marco Garofalo, Catia Giovannini, Fabio Manferrari, Tiziana Gemma Gerace, Remigio Pernetti, Giuseppe Martorana,

Small and large cell neuroendocrine carcinomas of the urinary bladder are rare and usually coexist with urothelial carcinoma in elderly patients. Here we report the clinical case of a young smoker who was referred to our institution for a primary pure neuroendocrine carcinoma of the bladder, and review the existing ... Read more >>

Anticancer Res (Anticancer research)
[2008, 28(2B):1369-1372]

Cited: 14 times

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p66Shc/Notch-3 interplay controls self-renewal and hypoxia survival in human stem/progenitor cells of the mammary gland expanded in vitro as mammospheres.

Pasquale Sansone, Gianluca Storci, Catia Giovannini, Silvia Pandolfi, Simona Pianetti, Mario Taffurelli, Donatella Santini, Claudio Ceccarelli, Pasquale Chieco, Massimiliano Bonafé,

The comprehension of the basic biology of stem cells is expected to provide a useful insight into the pathogenesis of cancer. In particular, there is evidence that hypoxia promotes stem cell renewal in vitro as well as in vivo. It therefore seems reasonable that stem cell survival and hypoxia response ... Read more >>

Stem Cells (Stem cells (Dayton, Ohio))
[2007, 25(3):807-815]

Cited: 112 times

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Cyclin G1 is a target of miR-122a, a microRNA frequently down-regulated in human hepatocellular carcinoma.

Laura Gramantieri, Manuela Ferracin, Francesca Fornari, Angelo Veronese, Silvia Sabbioni, Chang-Gong Liu, George A Calin, Catia Giovannini, Eros Ferrazzi, Gian Luca Grazi, Carlo M Croce, Luigi Bolondi, Massimo Negrini,

We investigated the role of microRNAs (miRNAs) in the pathogenesis of human hepatocellular carcinoma (HCC). A genome-wide miRNA microarray was used to identify differentially expressed miRNAs in HCCs arisen on cirrhotic livers. Thirty-five miRNAs were identified. Several of these miRNAs were previously found deregulated in other human cancers, such as ... Read more >>

Cancer Res (Cancer research)
[2007, 67(13):6092-6099]

Cited: 511 times

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Notch3 intracellular domain accumulates in HepG2 cell line.

Catia Giovannini, Michela Lacchini, Laura Gramantieri, Pasquale Chieco, Luigi Bolondi,

<h4>Background</h4>By mediating local cell-cell interactions, the Notch signaling pathway seems to control a variety of processes from cell fate decisions during development, to stem cell renewal and to differentiation in many adult tissues. Hence, perturbed Notch signaling may be involved both in the development and the spread of cancer. The ... Read more >>

Anticancer Res (Anticancer research)
[2006, 26(3A):2123-2127]

Cited: 25 times

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