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Validation of Cardiovascular Risk Prediction by the arriba Instrument-an Analysis Based on Data From the Study of Health in Pomerania.

Aniela Angelow, Christine Klötzer, Norbert Donner-Banzhoff, Jörg Haasenritter, Carsten Oliver Schmidt, Marcus Dörr, Jean-François Chenot,

<h4>Background</h4>It is recommended in cardiovascular prevention guidelines that treatment should be based on overall cardiovascular risk. The arriba instrument has been widely used for this purpose in Germany. The aim of this study is to validate risk prediction by arriba with the aid of morbidity and mortality data from the ... Read more >>

Dtsch Arztebl Int (Deutsches Arzteblatt international)
[2022, (Forthcoming):arztebl.m2022.0220]

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Multi-ancestry genome-wide association study improves resolution of genes, pathways and pleiotropy for lung function and chronic obstructive pulmonary disease

Nick Shrine, Abril Izquierdo, Jing Chen, Richard Packer, Robert Hall, Anna Guyatt, Chiara Batini, Rebecca Thompson, Chandan Pavuluri, Vidhi Malik, Brian Hobbs, Matthew Moll, Wonji Kim, Ruth Tal-Singer, Per Bakke, Katherine Fawcett, Catherine John, Kayesha Coley, Noemi Nicole Piga, Alfred Pozarickij, Kuang Lin, Iona Millwood, Zhengming Chen, Liming Li, Sara RA Wielscher, Lies Lahousse, Guy Brusselle, Andre Uitterlinden, Ani Manichaikul, Elizabeth Oelsner, Stephen Rich, Graham Barr, Shona Kerr, Veronique Vitart, Michael Brown, Matthias Wielscher, Medea Imboden, Ayoung Jeong, Traci Bartz, Sina Gharib, Claudia Flexeder, Stefan Karrasch, Christian Gieger, Annette Peters, Beate Stubbe, Xiaowei Hu, Victor Ortega, Deborah Meyers, Eugene Bleecker, Stacey Gabriel, Namrata Gupta, Albert Vernon Smith, Jian’an Luan, Jing-Hua Zhao, Ailin Hansen, Arnulf Langhammer, Cristen Willer, Laxmi Bhatta, David Porteous, Blair Smith, Archie Campbell, Tamar Sofer, Jiwon Lee, Martha Daviglus, Bing Yu, Elise Lim, Hanfei Xu, George O’Connor, Gaurav Thareja, Omar E, Hamdi Mbarek, Karsten Suhre, Raquel Granell, Tariq Faquih, Pieter Hiemstra, Annelies Slats, Benjamin Mullin, Jennie Hui, Alan James, John Beilby, Karina Patasova, Pirro Hysi, Jukka Koskela, Annah Wyss, Jianping Jin, Sinjini Sikdar, Mikyeong Lee, Sebastian May-Wilson, Nicola Pirastu, Katherine Kentistou, Peter Joshi, Paul RHJ Timmers, Alexander Williams, Robert Free, Xueyang Wang, John Morrison, Frank Gilliland, Zhanghua Chen, Carol Wang, Rachel Foong, Sarah Harris, Adele Taylor, Paul Redmond, James Cook, Anubha Mahajan, Lars Lind, Teemu Palviainen, Terho Lehtimäki, Olli Raitakari, Jaakko Kaprio, Taina Rantanen, Kirsi Pietiläinen, Simon Cox, Craig Pennell, Graham Hall, James Gauderman, Chris Brightling, James Wilson, Tuula Vasankari, Tarja Laitinen, Veikko Salomaa, Dennis Mook-Kanamori, Nicholas Timpson, Eleftheria Zeggini, Josée Dupuis, Caroline Hayward, Ben Brumpton, Claudia Langenberg, Stefan Weiss, Georg Homuth, Carsten Oliver Schmidt, Nicole Probst-Hensch, Marjo-Riitta Jarvelin, Alanna Morrison, Ozren Polasek, Igor Rudan, Joo-Hyeon Lee, Ian Sayers, Emma Rawlins, Frank Dudbridge, Edwin Silverman, David Strachan, Robin Walters, Andrew Morris, Stephanie London, Michael Cho, Louise Wain, Ian Hall, Martin Tobin,

Lung function impairment underlies chronic obstructive pulmonary disease (COPD) and predicts mortality. In the largest multi-ancestry GWAS meta-analysis of lung function to date, comprising 580,869 participants, 1020 independent association signals identified 559 genes supported by ≥2 criteria from a systematic variant-to-gene mapping framework. These genes were enriched in 29 pathways. ... Read more >>

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