Full Text Journal Articles by
Author Carolina Chavez

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COVID-19 and Multisystem Inflammatory Syndrome in Latin American Children: A Multinational Study.

Omar Yassef Antúnez-Montes, Maria Isabel Escamilla, Augusto Flavio Figueroa-Uribe, Erick Arteaga-Menchaca, Manuel Lavariega-Saráchaga, Perla Salcedo-Lozada, Priscilla Melchior, Rodrigo Beréa de Oliveira, Juan Carlos Tirado Caballero, Hernando Pinzon Redondo, Laura Vanessa Montes Fontalvo, Roger Hernandez, Carolina Chavez, Francisco Campos, Fadia Uribe, Olguita Del Aguila, Jorge Alberto Rios Aida, Andrea Parra Buitrago, Lina Maria Betancur Londoño, León Felipe Mendoza Vega, Carolina Almeida Hernández, Michela Sali, Julian Esteban Higuita Palacio, Jessica Gomez-Vargas, Adriana Yock-Corrales, Danilo Buonsenso,

<h4>Background</h4>To date, there are no comprehensive data on pediatric COVID-19 from Latin America. This study aims to assess COVID-19 and Multisystem Inflammatory Syndrome (MIS-C) in Latin American children, to appropriately plan and allocate resources to face the pandemic on a local and international level.<h4>Methods</h4>Ambispective multicenter cohort study from 5 Latin ... Read more >>

Pediatr Infect Dis J (The Pediatric infectious disease journal)
[2021, 40(1):e1-e6]

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COVID-19 and Multisystem Inflammatory Syndrome in Latin American children: a multinational study

Omar Yassef Antunez-Montes, Maria Isabel Escamilla, Augusto Flavio Figueroa-Uribe, Erick Arteaga-Menchaca, Manuel Lavariega-Sarachaga, Perla Salcedo-Lozada, Priscilla Melchior, Rodrigo Berea de Oliveira, Juan Carlos Tirado Caballero, Hernando Pinzon Redondo, Laura Vanessa Montes Fontalvo, Roger Hernandez, Carolin Chavez, Francisco Eduardo Campos, Fadia Uribe, Olguita del Aguila, JORGE ALBERTO RIOS AIDA, Andrea Parra Buitrago, Lina Maria Betancur Londono, Leon Felipe Mendoza Vega, Carolina Almeida Hernandez, Michela Sali, JULIAN HIGUITA PALACIO, Jessica Gomez-Vargas, Adriana Yock Corrales, Danilo Buonsenso,

<h4>Background: </h4> To date, there are no comprehensive data on pediatric COVID19 from Latin America. This study aims to assess COVID-19 and Multisystem Inflammatory Syndrome (MIS C) in Latin American children, in order to appropriately plan and allocate resources to face the pandemic on a local and International lever ... Read more >>

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The Opening of Connexin 43 Hemichannels Alters Hippocampal Astrocyte Function and Neuronal Survival in Prenatally LPS-Exposed Adult Offspring.

Carolina E Chávez, Juan E Oyarzún, Beatriz C Avendaño, Luis A Mellado, Carla A Inostroza, Tanhia F Alvear, Juan A Orellana,

Clinical evidence has revealed that children born from mothers exposed to viral and bacterial pathogens during pregnancy are more likely to suffer various neurological disorders including schizophrenia, autism bipolar disorder, major depression, epilepsy, and cerebral palsy. Despite that most research has centered on the impact of prenatal inflammation in neurons ... Read more >>

Front Cell Neurosci (Frontiers in cellular neuroscience)
[2019, 13:460]

Cited: 1 time

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The effect of angiotensin AT1A inactivation on innate and learned fear responses in mice and its relationship to blood pressure.

Kwok H C Choy, Carolina A Chavez, Jing Yu, Dmitry N Mayorov,

Angiotensin AT<sub>1</sub> receptors are implicated in behavioral and physiological processes associated with fear and stress. However, the precise role of AT<sub>1</sub> receptors in modulating fear-related behavior and its relation to their physiological effects remains unclear. Here, we examined innate and learned fear responses and their relationship to cardiovascular arousal in ... Read more >>

Psychoneuroendocrinology (Psychoneuroendocrinology)
[2019, 107:208-216]

Cited: 0 times

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ANRIL Promoter DNA Methylation: A Perinatal Marker for Later Adiposity.

Karen Lillycrop, Robert Murray, Clara Cheong, Ai Ling Teh, Rebecca Clarke-Harris, Sheila Barton, Paula Costello, Emma Garratt, Eloise Cook, Philip Titcombe, Bhuvaneshwari Shunmuganathan, Samantha J Liew, Yong-Cai Chua, Xinyi Lin, Yonghui Wu, Graham C Burdge, Cyrus Cooper, Hazel M Inskip, Neerja Karnani, James C Hopkins, Caroline E Childs, Carolina Paras Chavez, Philip C Calder, Fabian Yap, Yung Seng Lee, Yap Seng Chong, Philip E Melton, Lawrie Beilin, Rae-Chi Huang, Peter D Gluckman, Nick Harvey, Mark A Hanson, Joanna D Holbrook, , Keith M Godfrey,

Experimental studies show a substantial contribution of early life environment to obesity risk through epigenetic processes. We examined inter-individual DNA methylation differences in human birth tissues associated with child's adiposity. We identified a novel association between the level of CpG methylation at birth within the promoter of the long non-coding ... Read more >>

EBioMedicine (EBioMedicine)
[2017, 19:60-72]

Cited: 20 times

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Botulinum neurotoxin type B uses a distinct entry pathway mediated by CDC42 into intestinal cells versus neuronal cells.

Chloé Connan, Marie Voillequin, Carolina Varela Chavez, Christelle Mazuet, Christian Leveque, Sandrine Vitry, Alain Vandewalle, Michel R Popoff,

Botulinum neurotoxins (BoNTs) are responsible for severe flaccid paralysis by inhibiting the release of acetylcholine at the neuromuscular junctions. BoNT type B (BoNT/B) most often induces mild forms of botulism with predominant dysautonomic symptoms. In food borne botulism and botulism by intestinal colonisation such as infant botulism, which are the ... Read more >>

Cell Microbiol (Cellular microbiology)
[2017, 19(8):]

Cited: 3 times

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Prenatal exposure to inflammatory conditions increases Cx43 and Panx1 unopposed channel opening and activation of astrocytes in the offspring effect on neuronal survival.

Beatriz C Avendaño, Trinidad D Montero, Carolina E Chávez, Rommy von Bernhardi, Juan A Orellana,

Several epidemiological studies indicate that children born from mothers exposed to infections during gestation, have an increased risk to develop neurological disorders, including schizophrenia, autism and cerebral palsy. Given that it is unknown if astrocytes and their crosstalk with neurons participate in the above mentioned brain pathologies, the aim of ... Read more >>

Glia (Glia)
[2015, 63(11):2058-2072]

Cited: 21 times

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Perioperative immunonutrition in patients undergoing liver transplantation: a randomized double-blind trial.

Lindsay D Plank, Sachin Mathur, Edward J Gane, Sze-Lin Peng, Lyn K Gillanders, Kerry McIlroy, Carolina Paras Chavez, Philip C Calder, John L McCall,

<h4>Unlabelled</h4>Preliminary work suggested that perioperative immunonutrition (IMN) enriched in n-3 fatty acids, arginine, and nucleotides may improve preoperative nutritional status, enhance postoperative recovery, and reduce postoperative infectious complications in patients undergoing liver transplantation (LT). The current study examined these outcomes in a double-blind, randomized, controlled trial. Patients wait-listed for LT ... Read more >>

Hepatology (Hepatology (Baltimore, Md.))
[2015, 61(2):639-647]

Cited: 17 times

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Nitric oxide participates in the toxicity of Bacillus thuringiensis Cry1Ab toxin to kill Manduca sexta larvae.

Carolina Chavez, Benito Recio-Tótoro, Biviana Flores-Escobar, Humberto Lanz-Mendoza, Jorge Sanchez, Mario Soberón, Alejandra Bravo,

Nitric oxide (NO) produced by the nitric oxide synthase (NOS) enzyme is a reactive oxygen molecule widely considered as important participant in the immune system of different organisms to confront microbial infections. In insects the NO molecule has also been implicated in immune response against microbial pathogens. Bacillus thuringiensis (Bt) ... Read more >>

Peptides (Peptides)
[2015, 68:134-139]

Cited: 0 times

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Psychometric properties of the Cardiac Depression Scale: a systematic review.

Carolina A Chavez, Chantal F Ski, David R Thompson,

BACKGROUND: The prevalence of depression is high in cardiac patients. Depression has a significant impact on quality of life, adherence to therapy, and an independent effect on prognosis. The Cardiac Depression Scale (CDS) is the only instrument designed to measure depression in cardiac patients. This study systematically reviewed the psychometric ... Read more >>

Heart Lung Circ (Heart, lung & circulation)
[2014, 23(7):610-618]

Cited: 3 times

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Depression and coronary heart disease: apprehending the elusive black dog.

Carolina A Chavez, Chantal F Ski, David R Thompson,

Depression is the third leading cause of disease burden worldwide and is predicted to be the leading cause by 2030. Importantly, depression has been identified as an independent risk factor for coronary heart disease (CHD) and both share significant physiological overlap. Identification of depression is complex. Consequently, accurate diagnosis of ... Read more >>

Int J Cardiol (International journal of cardiology)
[2012, 158(3):335-336]

Cited: 1 time

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Differential effect of amphetamine on c-fos expression in female aromatase knockout (ArKO) mice compared to wildtype controls.

Carolina Chavez, Andrea Gogos, Rachel Hill, Michelle Van Sinderen, Evan Simpson, Wah Chin Boon, Maarten van den Buuse,

Estrogen may be involved in psychosis by an interaction with central dopaminergic activity. Aromatase knockout mice are unable to produce estrogen and have been shown to display altered behavioural responses and effects of the dopamine releaser, amphetamine. This study investigates the effect of gonadal status on amphetamine-induced c-fos expression in ... Read more >>

Psychoneuroendocrinology (Psychoneuroendocrinology)
[2011, 36(5):761-768]

Cited: 3 times

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The cyclomodulin Cif of Photorhabdus luminescens inhibits insect cell proliferation and triggers host cell death by apoptosis.

Carolina Varela Chavez, Grégory Jubelin, Gabriel Courties, Aurélie Gomard, Nadège Ginibre, Sylvie Pages, Frédéric Taïeb, Pierre-Alain Girard, Eric Oswald, Alain Givaudan, Robert Zumbihl, Jean-Michel Escoubas,

Cycle inhibiting factors (Cif) constitute a broad family of cyclomodulins present in bacterial pathogens of invertebrates and mammals. Cif proteins are thought to be type III effectors capable of arresting the cell cycle at G(2)/M phase transition in human cell lines. We report here the first direct functional analysis of ... Read more >>

Microbes Infect (Microbes and infection)
[2010, 12(14-15):1208-1218]

Cited: 6 times

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Role of angiotensin II Type 1A receptors in cardiovascular reactivity and neuronal activation after aversive stress in mice.

Pamela J Davern, Daian Chen, Geoffrey A Head, Carolina A Chavez, Thomas Walther, Dmitry N Mayorov,

We determined whether genetic deficiency of angiotensin II Type 1A (AT(1A)) receptors in mice results in altered neuronal responsiveness and reduced cardiovascular reactivity to stress. Telemetry devices were used to measure mean arterial pressure, heart rate, and activity. Before stress, lower resting mean arterial pressure was recorded in AT(1A)(-/-) (85+/-2 ... Read more >>

Hypertension (Hypertension (Dallas, Tex. : 1979))
[2009, 54(6):1262-1268]

Cited: 33 times

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Initial human transmission dynamics of the pandemic (H1N1) 2009 virus in North America.

Babak Pourbohloul, Armando Ahued, Bahman Davoudi, Rafael Meza, Lauren A Meyers, Danuta M Skowronski, Ignacio Villaseñor, Fernando Galván, Patricia Cravioto, David J D Earn, Jonathan Dushoff, David Fisman, W John Edmunds, Nathaniel Hupert, Samuel V Scarpino, Jesús Trujillo, Miguel Lutzow, Jorge Morales, Ada Contreras, Carolina Chávez, David M Patrick, Robert C Brunham,

<h4>Background</h4>Between 5 and 25 April 2009, pandemic (H1N1) 2009 caused a substantial, severe outbreak in Mexico, and subsequently developed into the first global pandemic in 41 years. We determined the reproduction number of pandemic (H1N1) 2009 by analyzing the dynamics of the complete case series in Mexico City during this ... Read more >>

Influenza Other Respir Viruses (Influenza and other respiratory viruses)
[2009, 3(5):215-222]

Cited: 61 times

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The effect of estrogen on dopamine and serotonin receptor and transporter levels in the brain: an autoradiography study.

Carolina Chavez, Marianne Hollaus, Elizabeth Scarr, Geoff Pavey, Andrea Gogos, Maarten van den Buuse,

The aim of the present study was to elucidate the effect of estrogen on dopaminergic and serotonergic regulation of prepulse inhibition (PPI) by measuring its effects on the density of dopamine transporters (DAT), dopamine D(1) and D(2) receptors, serotonin transporters (SERT), serotonin-1A (5-HT(1A)) and 5-HT(2A) receptors using radioligand binding autoradiography. ... Read more >>

Brain Res (Brain research)
[2010, 1321:51-59]

Cited: 56 times

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Estrogen treatment blocks 8-hydroxy-2-dipropylaminotetralin- and apomorphine-induced disruptions of prepulse inhibition: involvement of dopamine D1 or D2 or serotonin 5-HT1A, 5-HT2A, or 5-HT7 receptors.

Andrea Gogos, Perrin Kwek, Carolina Chavez, Maarten van den Buuse,

Prepulse inhibition (PPI) is a measure of sensorimotor gating and an endophenotype of schizophrenia. We have shown previously in rats that estrogen treatment prevents disruption of PPI by the 5-HT(1A)/5-HT(7) receptor agonist 8-hydroxy-2-dipropylaminotetralin (8-OH-DPAT). The aim of the present study was to examine the role of dopamine D(1) and D(2) ... Read more >>

J Pharmacol Exp Ther (The Journal of pharmacology and experimental therapeutics)
[2010, 333(1):218-227]

Cited: 36 times

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Cycle inhibiting factors (CIFs) are a growing family of functional cyclomodulins present in invertebrate and mammal bacterial pathogens.

Grégory Jubelin, Carolina Varela Chavez, Frédéric Taieb, Mark J Banfield, Ascel Samba-Louaka, Rika Nobe, Jean-Philippe Nougayrède, Robert Zumbihl, Alain Givaudan, Jean-Michel Escoubas, Eric Oswald,

The cycle inhibiting factor (Cif) produced by enteropathogenic and enterohemorrhagic Escherichia coli was the first cyclomodulin to be identified that is injected into host cells via the type III secretion machinery. Cif provokes cytopathic effects characterized by G(1) and G(2) cell cycle arrests, accumulation of the cyclin-dependent kinase inhibitors (CKIs) ... Read more >>

PLoS One (PloS one)
[2009, 4(3):e4855]

Cited: 33 times

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Recent insight into the pathogenicity mechanisms of the emergent pathogen Photorhabdus asymbiotica.

Sónia C P Costa, Carolina Varela Chavez, Grégory Jubelin, Alain Givaudan, Jean-Michel Escoubas, Michel Brehélin, Robert Zumbihl,

Photorhabdus asymbiotica is unique among the entomopathogenic bacteria of this genus in also being able to infect humans, leading to its isolation from some clinical samples. Recent comparative genomics data and the results of studies of interactions between bacteria and cells provide insight into the adaptation of this bacterium to ... Read more >>

Microbes Infect (Microbes and infection)
[2010, 12(3):182-189]

Cited: 11 times

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Psychotropic drug-induced locomotor hyperactivity and prepulse inhibition regulation in male and female aromatase knockout (ArKO) mice: role of dopamine D1 and D2 receptors and dopamine transporters.

Carolina Chavez, Andrea Gogos, Margaret E Jones, Maarten van den Buuse,

<h4>Rationale and objectives</h4>The aim of the present study was to investigate the possible role of oestrogen in schizophrenia by comparing aromatase knockout (ArKO) mice, which are unable to produce oestrogen, with wild-type controls using two behavioural animal models with relevance to the illness, psychotropic drug-induced locomotor hyperactivity and prepulse inhibition ... Read more >>

Psychopharmacology (Berl) (Psychopharmacology)
[2009, 206(2):267-279]

Cited: 19 times

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Effect of adrenalectomy and corticosterone replacement on prepulse inhibition and locomotor activity in mice.

Maarten van den Buuse, Margaret Morris, Carolina Chavez, Sally Martin, JianHong Wang,

1 Stress is a risk factor in psychiatric illnesses such as schizophrenia. The aim of the present study was to investigate the effect of different circulating levels of the adrenal steroid corticosterone (CORT) on locomotor hyperactivity and prepulse inhibition of acoustic startle, two behavioural animal models of aspects of schizophrenia. ... Read more >>

Br J Pharmacol (British journal of pharmacology)
[2004, 142(3):543-550]

Cited: 23 times

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The effect of low estrogen state on serotonin transporter function in mouse hippocampus: a behavioral and electrochemical study.

Paul P Bertrand, Udeni T Paranavitane, Carolina Chavez, Andrea Gogos, Margaret Jones, Maarten van den Buuse,

Defects in serotonergic transmission, including serotonin transporter (SERT) function, have been implicated in depression, anxiety disorders and some aspects of schizophrenia. The sex steroid hormone estrogen is known to modulate functional SERT activity, but whether it is up- or down-regulated is unclear. The aim of the present study was to ... Read more >>

Brain Res (Brain research)
[2005, 1064(1-2):10-20]

Cited: 29 times

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Microbiological contamination of enteral feeding solutions used in Costa Rican hospitals.

Maria Laura Arias, Rafael Monge, Carolina Chávez,

Enteral feeding is the most common and preferred modality for providing nutritional support to hospital patients with a functional gastrointestinal tract that can not satisfy their nutritional requirements. Nevertheless, enteral feeding may be an important cause of bacterial infection. The aim of this study was to evaluate the microbial contamination ... Read more >>

Arch Latinoam Nutr (Archivos latinoamericanos de nutricion)
[2003, 53(3):277-281]

Cited: 2 times

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