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Author Carmine Musto

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COVID-19, Acute Myocardial Injury and Infarction

Armando Del Prete, Francesca Conway, Domenico Giovanni Della Rocca, Giuseppe Biondi-Zoccai, Francesco De Felice, Carmine Musto, Marco Picichè, Eugenio Martuscelli, Andrea Natale, Francesco Versaci,

Synopsis SARS-CoV-2 can affect the cardiovascular system yielding a wide range of complications, including acute myocardial injury. The myocardium can be damaged by direct viral invasion or indirect mechanisms, sustained by systemic inflammation, immune-mediated response and dysregulation of the renin-angiotensin system. Myocardial injury affects about one-quarter of patients with COVID-19, ... Read more >>

Card Electrophysiol Clin (Cardiac electrophysiology clinics)
[2021, :]

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Gender Differences after Transcatheter Aortic Valve Replacement (TAVR): Insights from the Italian Clinical Service Project.

Andrea Denegri, Michele Romano, Anna Sonia Petronio, Marco Angelillis, Cristina Giannini, Claudia Fiorina, Luca Branca, Marco Barbanti, Giuliano Costa, Nedy Brambilla, Valentina Mantovani, Matteo Montorfano, Luca Ferri, Giuseppe Bruschi, Bruno Merlanti, Bernhard Reimers, Carlo Pivato, Arnaldo Poli, Carmine Musto, Massimo Fineschi, Diego Maffeo, Carlo Trani, Flavio Airoldi, Corrado Lettieri,

<h4>Background</h4>TAVR is a safe alternative to surgical aortic valve replacement (SAVR); however, sex-related differences are still debated. This research aimed to examine gender differences in a real-world transcatheter aortic valve replacement (TAVR) cohort.<h4>Methods</h4>All-comer aortic stenosis (AS) patients undergoing TAVR with a Medtronic valve across 19 Italian sites were prospectively included ... Read more >>

J Cardiovasc Dev Dis (Journal of cardiovascular development and disease)
[2021, 8(9):]

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A Comparison Between Gore Cardioform and Amplatzer Septal Occluder for Percutaneous Closure of Patent Foramen Ovale Associated With Atrial Septal Aneurysm: Clinical and Echocardiographic Outcomes.

Carmine Musto, Alberta Cifarelli, Francesco Dipasquale, Diana Chin, Marco Stefano Nazzaro, Rocco Edoardo Stio, Mauro Pennacchi, Francesco De Felice,

<h4>Objectives</h4>To evaluate the short- and long-term clinical and echocardiographic outcomes of the percutaneous closure of the patent foramen ovale (PFO) with an atrial septal aneurysm (ASA) using 2 different devices.<h4>Methods</h4>We enrolled 100 patients with PFO and ASA. Fifty consecutive patients had transcatheter closure of the PFO with the Gore Cardioform ... Read more >>

J Invasive Cardiol (The Journal of invasive cardiology)
[2021, 33(11):E857-E862]

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Platypnea and orthodeoxia syndrome as an uncommon clinical indication for a challenging percutaneous patent foramen ovale closure: a case report.

Francesco Dipasquale, Carmine Musto, Mauro Pennacchi, Francesco De Felice,

<h4>Background</h4>Platypnea and Orthodeoxia Syndrome (POS) is a rare clinical condition characterized by positional dyspnoea and arterial desaturation. Various mechanisms are related to this syndrome. The simultaneous presence of abnormal anatomical findings [aortic root dilatation, atrial septal aneurysm (ASA), Lipomatous septum, and patent foramen ovale (PFO)] and an occurring ventilation/perfusion mismatch ... Read more >>

Eur Heart J Case Rep (European heart journal. Case reports)
[2021, 5(4):ytab029]

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Instantaneous wave-free ratio-guided revascularization of non-culprit lesion in patients with ST-segment elevation myocardial infarction and multivessel coronary disease: design and rationale of the WAVE Registry.

Carmine Musto, Annunziata Nusca, Giuseppe Biondi-Zoccai, Francesco DE Felice, Massimiliano Scappaticci, Marco S Nazzaro, Michele M Viscusi, Andrea Ceccacci, Francesco Versaci,

<h4>Background</h4>The optimal management of patients with ST-elevation acute coronary syndromes and multivessel coronary artery disease is challenging. There is a growing body of evidence supporting invasive functional evaluation of multivessel disease with FFR or iFR, which it has been added to the literature. In this regard, the WAVE Study recently ... Read more >>

Minerva Cardiol Angiol (Minerva cardiology and angiology)
[2021, 69(3):291-298]

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339 Interplay between COVID-19, pollution, and weather features on changes in the incidence of acute coronary syndromes in early 2020

Simone Griffo, Achille Gaspardone, Alessandro Danesi, Fabio Ferranti, Enrica Mariano, Francesco Rotolo, Carmine Musto, Alessandro Di Giosa, Giada Marchegiani, Giuseppe Biondi Zoccai, Francesco Versaci,

Abstract <h4>Aims</h4> Coronavirus disease 2019 (COVID-19) has caused an unprecedented change in the apparent epidemiology of acute coronary syndromes (ACS). However, the interplay between this disease, changes in pollution, climate, and aversion to activation of emergency medical services represents a challenging conundrum. We aimed at appraising the impact of COVID-19, ... Read more >>

Eur Heart J Suppl (European heart journal supplements : journal of the European Society of Cardiology)
[2020, 22(Suppl N):N17-N18]

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Hutchinson-Gilford Progeria Syndrome and Severe Aortic Stenosis: A New Hope for Treatment.

Francesco Musumeci, Antonio Giovanni Cammardella, Antonio Lio, Carmine Musto, Vincenzo Polizzi, Vitaliano Buffa, Andrea Montalto, Marina Comisso, Federico Ranocchi, Mauro Cassese,

Hutchinson-Gilford progeria syndrome is an autosomal dominant, rare, fatal pediatric segmental premature aging disease. Cardiovascular and cerebrovascular diseases constitute the major cause of morbidity and mortality. Patients with the syndrome and severe aortic valve stenosis have been described in the literature, and for all of them a strategy of conservative ... Read more >>

Ann Thorac Surg (The Annals of thoracic surgery)
[2020, 110(5):e365-e367]

Cited: 1 time

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Evaluation and Management of Nonculprit Lesions in STEMI.

Troels Thim, Nina W van der Hoeven, Carmine Musto, Robin Nijveldt, Matthias Götberg, Thomas Engstrøm, Pieter C Smits, Keith G Oldroyd, Anthony H Gershlick, Javier Escaned, Sergio Bravo Baptista, Luis Raposo, Niels van Royen, Michael Maeng,

Nonculprit lesions are frequently observed in patients with ST-segment elevation myocardial infarction. Results from recent randomized clinical trials suggest that complete revascularization after ST-segment elevation myocardial infarction improves outcomes. In this state-of-the-art paper, the authors review these trials and consider how best to determine which nonculprit lesions require revascularization and ... Read more >>

JACC Cardiovasc Interv (JACC. Cardiovascular interventions)
[2020, 13(10):1145-1154]

Cited: 2 times

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Long-term clinical outcome and performance of transcatheter aortic valve replacement with a self-expandable bioprosthesis.

Luca Testa, Azeem Latib, Nedy Brambilla, Federico De Marco, Claudia Fiorina, Marianna Adamo, Cristina Giannini, Marco Angelillis, Marco Barbanti, Carmelo Sgroi, Arnaldo Poli, Erica Ferrara, Giuseppe Bruschi, Claudio Francesco Russo, Montorfano Matteo, Francesco De Felice, Carmine Musto, Salvatore Curello, Antonio Colombo, Corrado Tamburino, Anna Sonia Petronio, Francesco Bedogni,

<h4>Aims</h4>In the last decade, transcatheter aortic valve (TAV) replacement determined a paradigm shift in the treatment of patients with severe symptomatic aortic stenosis. Data on long-term TAV performance are still limited. We sought to evaluate the clinical and haemodynamic outcomes of the CoreValve self-expandable valve up to 8-year follow-up (FU).<h4>Methods ... Read more >>

Eur Heart J (European heart journal)
[2020, 41(20):1876-1886]

Cited: 3 times

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Five-year clinical outcome of multicenter randomized trial comparing amphilimus - with paclitaxel-eluting stents in de novo native coronary artery lesions.

Didier Carrié, Jacques Berland, Stefan Verheye, Karl Eugen Hauptmann, Mathias Vrolix, Carmine Musto, Sergio Berti, Alain Dibié, Eric Maupas, David Antoniucci, Joachim Schofer,

<h4>Objectives</h4>Long-term data from randomized studies on polymer-free stents are scarce. Long-term data of Cre8 amphilimus eluting stent are still not available. We sought to investigate contribution of a polymer-free design versus a permanent-polymer one on the long-term.<h4>Methods and results</h4>Patients undergoing percutaneous coronary intervention for de novo lesions were randomized 1:1 ... Read more >>

Int J Cardiol (International journal of cardiology)
[2020, 301:50-55]

Cited: 1 time

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Efficacy and Safety of Stents in ST-Segment Elevation Myocardial Infarction.

Ply Chichareon, Rodrigo Modolo, Carlos Collet, Erhan Tenekecioglu, Maarten A Vink, Pyung Chun Oh, Jung-Min Ahn, Carmine Musto, Luis S Díaz de la Llera, Young-Seok Cho, Roberto Violini, Seung-Jung Park, Harry Suryapranata, Jan J Piek, Robbert J de Winter, Joanna J Wykrzykowska, Christian Spaulding, Woong Chol Kang, Ton Slagboom, Sjoerd H Hofma, Inge F Wijnbergen, Emilio Di Lorenzo, Nico H Pijls, Lorenz Räber, Salvatore Brugaletta, Manel Sabaté, Hans-Peter Stoll, Gregg W Stone, Stephan Windecker, Yoshinobu Onuma, Patrick W Serruys,

BACKGROUND:To date, no specific drug-eluting stent (DES) has fully proven its superiority over others in patients with ST-segment elevation myocardial infarction (STEMI) undergoing percutaneous coronary intervention. OBJECTIVES:The purpose of this study was to compare the safety and efficacy of coronary artery stents in STEMI patients in a patient-level network meta-analysis. ... Read more >>

J Am Coll Cardiol (Journal of the American College of Cardiology)
[2019, 74(21):2572-2584]

Cited: 1 time

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Percutaneous Aortic Valve Closure in Patient With Left Ventricular Assist Device and Dilated Aortic Annulus.

Francesca Nicolò, Andrea Montalto, Carmine Musto, Marina Comisso, Antonio Lio, Francesco Musumeci,

Percutaneous transcatheter intervention for aortic regurgitation secondary to implantation of a continuous-flow left ventricular assist device remains challenging, because of the minimal global experience with these procedures. Two treatment options are available: transcatheter aortic valve replacement, which is not always feasible when a dilated aortic annulus is present, and percutaneous ... Read more >>

Ann Thorac Surg (The Annals of thoracic surgery)
[2020, 109(1):e25-e27]

Cited: 0 times

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Instantaneous wave-free ratio and fractional flow reserve for the assessment of nonculprit lesions during the index procedure in patients with ST-segment elevation myocardial infarction: The WAVE study.

Carmine Musto, Francesco De Felice, Stefano Rigattieri, Diana Chin, Andrea Marra, Marco Stefano Nazzaro, Alberta Cifarelli, Roberto Violini,

<h4>Background</h4>Functional assessment of non-infarct-related artery lesions during primary percutaneous coronary intervention (PCI) might be useful to avoid revascularization of nonsignificant stenosis and staged procedures, thus reducing hospital stay. We aimed to assess the diagnostic performance of instantaneous wave-free ratio (iFR) as compared with fractional flow reserve (FFR) in this setting.<h4>Methods</h4>In ... Read more >>

Am Heart J (American heart journal)
[2017, 193:63-69]

Cited: 6 times

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RARE CO-EXISTENCE OF CORONARY ANOMALIES: ANOMALY OF ORIGIN AND DISTRIBUTION TOGETHER WITH ANOMALY OF INTRINSIC CORONARY ARTERY ANOMALY.

Abraha Hailu, Diana Chin, Carmine Musto, Rosario Fiorilli, Roberto Violini,

We describe a 63 year old Romanian female patient admitted to our institution with complaints of typical angina and a diagnosis of non ST-elevation myocardial infarction. Coronary arteriography unveiled anomalous origin of a left circumflex coronary artery from the right coronary sinus of Valsalva near the right coronary ostium and a hyperdominant left ... Read more >>

Ethiop Med J (Ethiopian medical journal)
[2017, 55(1):73-76]

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"Life hanging by a thread".

Marzia Cottini, Amedeo Pergolini, Marco Picichè, Carmine Musto, Francesco Musumeci,

Kardiol Pol (Kardiologia polska)
[2016, 74(10):1188]

Cited: 0 times

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Noncompaction and embolic myocardial infarction: the importance of oral anticoagulation.

Giovanni Pulignano, Maria Denitza Tinti, Stefano Tolone, Carmine Musto, Lucia De Lio, Paolo Giuseppe Pino, Giovanni Minardi, Roberto Violini, Massimo Uguccioni,

Left ventricular noncompaction (LVNC) is characterized by left ventricular (LV) hypertrabeculations and is associated with heart failure, arrhythmias and embolism. We report the case of a 67-year-old LVNC patient, under oral anticoagulation (OAC) therapy for apical thrombosis. After she discontinued OAC, the thrombus involved almost the whole of the left ... Read more >>

Rev Port Cardiol (Revista portuguesa de cardiologia : orgao oficial da Sociedade Portuguesa de Cardiologia = Portuguese journal of cardiology : an official journal of the Portuguese Society of Cardiology)
[2015, 34(7-8):497.e1-4]

Cited: 4 times

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Effect of Abciximab Therapy in Patients Undergoing Coronary Angioplasty for Acute ST-Elevation Myocardial Infarction Complicated by Cardiogenic Shock.

Francesco De Felice, Francesco Tomassini, Rosario Fiorilli, Andrea Gagnor, Antonio Parma, Enrico Cerrato, Carmine Musto, Marco Stefano Nazzaro, Ferdinando Varbella, Roberto Violini,

<h4>Background</h4>The effect of abciximab on survival in patients with ST-elevation myocardial infarction (STEMI) complicated by cardiogenic shock (CS) undergoing primary percutaneous coronary intervention (PCI) is not clear. METHODS AND RESULTS: We evaluated outcome in 410 consecutive patients with STEMI and CS who underwent PCI treated without (n=123) or with (n=287) abciximab. The ... Read more >>

Circ J (Circulation journal : official journal of the Japanese Circulation Society)
[2015, 79(7):1568-1574]

Cited: 2 times

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Impact of hypertension on clinical outcome in STEMI patients undergoing primary angioplasty with BMS or DES: insights from the DESERT cooperation.

Giuseppe De Luca, Maurits T Dirksen, Christian Spaulding, Henning Kelbæk, Martin Schalij, Leif Thuesen, Bas van der Hoeven, Marteen A Vink, Christoph Kaiser, Carmine Musto, Tania Chechi, Gaia Spaziani, Luis Salvador Diaz de la Llera, Vincenzo Pasceri, Emilio Di Lorenzo, Roberto Violini, Harry Suryapranata, Gregg W Stone, ,

<h4>Background</h4>Hypertension is a well known risk factor for atherosclerosis. However, data on the prognostic impact of hypertension in patients with ST elevation myocardial infarction (STEMI) are inconsistent and mainly related to studies performed in the thrombolytic era, with very few data in patients undergoing primary angioplasty. Therefore, the aim of ... Read more >>

Int J Cardiol (International journal of cardiology)
[2014, 175(1):50-54]

Cited: 8 times

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Drug-eluting stents in patients with anterior STEMI undergoing primary angioplasty: a substudy of the DESERT cooperation.

Giuseppe De Luca, Maurits T Dirksen, Christian Spaulding, Henning Kelbæk, Martin Schalij, Leif Thuesen, Bas van der Hoeven, Marteen A Vink, Christoph Kaiser, Carmine Musto, Tania Chechi, Gaia Spaziani, Luis Salvador Diaz de la Llera, Vincenzo Pasceri, Emilio Di Lorenzo, Roberto Violini, Harry Suryapranata, Gregg W Stone,

<h4>Background</h4>Several concerns have emerged on the higher risk of in-stent thrombosis after drug-eluting stent (DES) implantation, especially in the setting of STEMI patients. Few data have even been reported in high-risk patients, such as those with anterior MI. Therefore this represents the aim of the current study.<h4>Methods</h4>The literature was scanned ... Read more >>

Clin Res Cardiol (Clinical research in cardiology : official journal of the German Cardiac Society)
[2014, 103(9):685-699]

Cited: 3 times

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One-year clinical outcome of elderly patients undergoing angioplasty for ST-elevation myocardial infarction complicated by cardiogenic shock: the importance of 3-vessel disease and final TIMI-3 flow grade.

Francesco De Felice, Elena Guerra, Rosario Fiorilli, Antonio Parma, Carmine Musto, Marco Stefano Nazzaro, Roberto Violini,

<h4>Background</h4>The influence of age on clinical results of primary percutaneous coronary intervention (PCI) in patients with ST-elevation myocardial infarctions (STEMI) complicated by cardiogenic shock (CS) is poorly investigated.<h4>Methods</h4>In this study, we evaluated the outcome of 216 consecutive all-comer patients with STEMI and CS undergoing PCI who were divided into 2 ... Read more >>

J Invasive Cardiol (The Journal of invasive cardiology)
[2014, 26(3):114-118]

Cited: 5 times

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Gender-related differences in outcome after BMS or DES implantation in patients with ST-segment elevation myocardial infarction treated by primary angioplasty: insights from the DESERT cooperation.

Giuseppe De Luca, Monica Verdoia, Maurits T Dirksen, Christian Spaulding, Henning Kelbæk, Martin Schalij, Leif Thuesen, Bas van der Hoeven, Marteen A Vink, Christoph Kaiser, Carmine Musto, Tania Chechi, Gaia Spaziani, Luis Salvador Diaz de la Llera, Vincenzo Pasceri, Emilio Di Lorenzo, Roberto Violini, Harry Suryapranata, Gregg W Stone, ,

<h4>Background</h4>Several studies have found that among patients with ST-segment elevation myocardial infarction (STEMI) treated by thrombolysis, female sex is associated with a worse outcome. However, still controversial is the prognostic impact of gender in primary angioplasty, especially in the era of drug-eluting stents (DES). Therefore, the aim of this study ... Read more >>

Atherosclerosis (Atherosclerosis)
[2013, 230(1):12-16]

Cited: 7 times

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Comparison between the new Gore septal and Amplatzer devices for transcatheter closure of patent foramen ovale. Short- and mid-term clinical and echocardiographic outcomes.

Carmine Musto, Alberta Cifarelli, Rosario Fiorilli, Francesco De Felice, Antonio Parma, Marco Stefano Nazzaro, Elena Guerra, Francesca Fiorilli, Roberto Violini,

<h4>Background</h4>The ideal device for percutaneous patent foramen ovale (PFO) occlusion should provide effective closure with long-term biocompatibility and it should have a low profile without interfering with adjacent cardiac structures. Long-term data regarding safety and efficacy of the GORE Septal Occluder (GSO) are lacking. The aim of this study was ... Read more >>

Circ J (Circulation journal : official journal of the Japanese Circulation Society)
[2013, 77(12):2922-2927]

Cited: 7 times

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Impact of age on long-term outcome after primary angioplasty with bare-metal or drug-eluting stent (from the DESERT cooperation).

Giuseppe De Luca, Maurits T Dirksen, Christian Spaulding, Henning Kelbæk, Martin Schalij, Leif Thuesen, Bas van der Hoeven, Marteen A Vink, Christoph Kaiser, Carmine Musto, Tania Chechi, Gaia Spaziani, Luis Salvador Diaz de la Llera, Vincenzo Pasceri, Emilio Di Lorenzo, Roberto Violini, Harry Suryapranata, Gregg W Stone, ,

Despite mechanical reperfusion, elderly patients with ST-segment elevation myocardial infarction (STEMI) still experience unsatisfactory outcomes. Drug-eluting stents (DES) have significantly reduced target-vessel revascularization (TVR), but concerns have emerged about the higher risk of late stent thrombosis, which may be more pronounced in elderly patients. Therefore, the aim of this study ... Read more >>

Am J Cardiol (The American journal of cardiology)
[2013, 112(2):181-186]

Cited: 11 times

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Response letter to "Quality of evidence for multivariate analysis to keep stable estimates".

Francesco De Felice, Antonio Parma, Rosario Fiorilli, Carmine Musto, Roberto Violini,

Int J Cardiol (International journal of cardiology)
[2013, 168(4):4266]

Cited: 0 times

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Time course, predictors and clinical implications of stent thrombosis following primary angioplasty. Insights from the DESERT cooperation.

Giuseppe De Luca, Maurits T Dirksen, Christian Spaulding, Henning Kelbæk, Martin Schalij, Leif Thuesen, Bas van der Hoeven, Marteen A Vink, Christoph Kaiser, Carmine Musto, Tania Chechi, Gaia Spaziani, Luis Salvador Diaz de la Llera, Vincenzo Pasceri, Emilio Di Lorenzo, Roberto Violini, Harry Suryapranata, Gregg W Stone, ,

Primary percutaneous coronary intervention (pPCI) has improved survival as compared to thrombolysis. Concerns still remain regarding the risk of stent thrombosis in the setting of STEMI, especially after drug-eluting stent (DES) implantation. Therefore, the aim of this study was to report on the timing of stent thrombosis (ST) with both ... Read more >>

Thromb Haemost (Thrombosis and haemostasis)
[2013, 110(4):826-833]

Cited: 31 times

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