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COMPERA 2.0: A refined 4-strata risk assessment model for pulmonary arterial hypertension.

Marius M Hoeper, Christine Pausch, Karen M Olsson, Doerte Huscher, David Pittrow, Ekkehard Grünig, Gerd Staehler, Carmine Dario Vizza, Henning Gall, Oliver Distler, Christian Opitz, J Simon R Gibbs, Marion Delcroix, H Ardeschir Ghofrani, Da-Hee Park, Ralf Ewert, Harald Kaemmerer, Hans-Joachim Kabitz, Dirk Skowasch, Juergen Behr, Katrin Milger, Michael Halank, Heinrike Wilkens, Hans-Jürgen Seyfarth, Matthias Held, Daniel Dumitrescu, Iraklis Tsangaris, Anton Vonk-Noordegraaf, Silvia Ulrich, Hans Klose, Martin Claussen, Tobias J Lange, Stephan Rosenkranz,

<h4>Background</h4>Risk stratification plays an essential role in the management of patients with pulmonary arterial hypertension (PAH). The current European guidelines propose a 3-strata model to categorise risk as low, intermediate, or high, based on the expected 1-year mortality. However, with this model, most patients are categorised as intermediate risk. We ... Read more >>

Eur Respir J (The European respiratory journal)
[2021, :]

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Impact of COVID-19 Pandemic on Cardiac Electronic Device Management and Role of Remote Monitoring

Michele Magnocavallo, Giampaolo Vetta, Alessia Bernardini, Agostino Piro, Maria Chiara Mei, Martina Di Iorio, Marco Valerio Mariani, Domenico G. Della Rocca, Paolo Severino, Raffaele Quaglione, Giuseppe Giunta, Cristina Chimenti, Fabio Miraldi, Carmine Dario Vizza, Francesco Fedele, Carlo Lavalle,

Synopsis During the Coronavirus Disease 2019 (COVID-19) worldwide pandemic, patients with cardiac implantable electronic device (CIED) refused scheduled follow-up visits due to the risk of infection. In this scenario, different telemedicine strategies have been implemented to ensure continuity of care to CIED patients. Patients can be monitored through dedicated apps, ... Read more >>

Card Electrophysiol Clin (Cardiac electrophysiology clinics)
[2021, :]

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Temporal trends in pulmonary arterial hypertension: Results from the COMPERA registry.

Marius M Hoeper, Christine Pausch, Ekkehard Grünig, Gerd Staehler, Doerte Huscher, David Pittrow, Karen M Olsson, Carmine Dario Vizza, Henning Gall, Oliver Distler, Christian Opitz, J Simon R Gibbs, Marion Delcroix, H Ardeschir Ghofrani, Stephan Rosenkranz, Da-Hee Park, Ralf Ewert, Harald Kaemmerer, Tobias J Lange, Hans-Joachim Kabitz, Dirk Skowasch, Andris Skride, Martin Claussen, Juergen Behr, Katrin Milger, Michael Halank, Heinrike Wilkens, Hans-Jürgen Seyfarth, Matthias Held, Daniel Dumitrescu, Iraklis Tsangaris, Anton Vonk-Noordegraaf, Silvia Ulrich, Hans Klose,

<h4>Background</h4>Since 2015, the European pulmonary hypertension guidelines recommend the use of combination therapy in most patients with pulmonary arterial hypertension (PAH). However, it is unclear to what extend this treatment strategy is adopted in clinical practice and if it is associated with improved long-term survival.<h4>Methods</h4>We analysed data from COMPERA, a ... Read more >>

Eur Respir J (The European respiratory journal)
[2021, :]

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The Authors Reply.

Roberto Badagliacca, Beatrice Pezzuto, Silvia Papa, Robert Naeije, Carmine Dario Vizza,

JACC Cardiovasc Imaging (JACC. Cardiovascular imaging)
[2021, 14(7):1488-1489]

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Peripheral Arterial Stiffness in Acute Pulmonary Embolism and Pulmonary Hypertension at Short-Term Follow-Up.

Silvia Papa, Cristiano Miotti, Giovanna Manzi, Gianmarco Scoccia, Federico Luongo, Federica Toto, Claudia Malerba, Nadia Cedrone, Elena Sofia Canuti, Annalisa Caputo, Giulia Manguso, Serena Valentini, Susanna Sciomer, Francesco Ciciarello, Giulia Benedetti, Francesco Fedele, Carmine Dario Vizza, Roberto Badagliacca,

Chronic thromboembolic pulmonary hypertension (CTEPH) is a severe and under-recognized complication of acute pulmonary embolism (PE). Forty consecutive patients with acute PE (Group 1), predominantly female (22, 55%) with a mean age of 69 ± 15 years, were matched for demographic data with 40 healthy subjects (Group 2), 40 systemic ... Read more >>

J Clin Med (Journal of clinical medicine)
[2021, 10(14):]

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Incidence and long-term outcomes of pregnant women complicated with pulmonary arterial hypertension during different pregnancies: A prospective cohort study from China.

Cristiano Miotti, Silvia Papa, Giovanna Manzi, Federico Luongo, Gianmarco Scoccia, Carmine Dario Vizza, Roberto Badagliacca,

Int J Cardiol (International journal of cardiology)
[2021, 332:193-194]

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ECMO Assistance during Mechanical Ventilation: Effects Induced on Energetic and Haemodynamic Variables.

Beatrice De Lazzari, Attilio Iacovoni, Khosrow Mottaghy, Massimo Capoccia, Roberto Badagliacca, Carmine Dario Vizza, Claudio De Lazzari,

<h4>Background and objective</h4>Simulation in cardiovascular medicine may help clinicians understand the important events occurring during mechanical ventilation and circulatory support. During the COVID-19 pandemic, a significant number of patients have required hospital admission to tertiary referral centres for concomitant mechanical ventilation and extracorporeal membrane oxygenation (ECMO). Nevertheless, the management of ... Read more >>

Comput Methods Programs Biomed (Computer methods and programs in biomedicine)
[2021, 202:106003]

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Switching to riociguat versus maintenance therapy with phosphodiesterase-5 inhibitors in patients with pulmonary arterial hypertension (REPLACE): a multicentre, open-label, randomised controlled trial.

Marius M Hoeper, Hikmet Al-Hiti, Raymond L Benza, Sung-A Chang, Paul A Corris, J Simon R Gibbs, Ekkehard Grünig, Pavel Jansa, James R Klinger, David Langleben, Vallerie V McLaughlin, Gisela M B Meyer, Jaquelina Ota-Arakaki, Andrew J Peacock, Tomás Pulido, Stephan Rosenkranz, Carmine Dario Vizza, Anton Vonk-Noordegraaf, R James White, Mikyung Chang, Frank Kleinjung, Christian Meier, Karen Paraschin, Hossein Ardeschir Ghofrani, Gérald Simonneau, ,

<h4>Background</h4>Riociguat and phosphodiesterase-5 inhibitors (PDE5i), approved for the treatment of pulmonary arterial hypertension (PAH), act on the same pathway via different mechanisms. Riociguat might be an alternative option for patients with PAH who do not respond sufficiently to treatment with PDE5i, but comparisons of the potential benefits of riociguat and ... Read more >>

Lancet Respir Med (The Lancet. Respiratory medicine)
[2021, 9(6):573-584]

Cited: 1 time

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Right ventricular assessment matters for precision medicine. Reply to "Identifying parameters associated with response to switching from a PDE5i to riociguat in RESPITE".

Giovanna Manzi, Silvia Papa, Carmine Dario Vizza, Roberto Badagliacca,

Int J Cardiol (International journal of cardiology)
[2021, 333:210]

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Pulmonary Hypertension in Patients With COPD: Results From the Comparative, Prospective Registry of Newly Initiated Therapies for Pulmonary Hypertension (COMPERA).

Carmine Dario Vizza, Marius M Hoeper, Doerte Huscher, David Pittrow, Nicola Benjamin, Karen M Olsson, H Ardeschir Ghofrani, Matthias Held, Hans Klose, Tobias Lange, Stephan Rosenkranz, Daniel Dumitrescu, Roberto Badagliacca, Martin Claussen, Michael Halank, Anton Vonk-Noordegraaf, Dirk Skowasch, Ralf Ewert, J Simon R Gibbs, Marion Delcroix, Andris Skride, Gerry Coghlan, Silvia Ulrich, Christian Opitz, Harald Kaemmerer, Oliver Distler, Ekkehard Grünig,

<h4>Background</h4>Pulmonary hypertension (PH) in COPD is a poorly investigated clinical condition.<h4>Research question</h4>Which factors determine the outcome of PH in COPD?<h4>Study design and methods</h4>We analyzed the characteristics and outcome of patients enrolled in the Comparative, Prospective Registry of Newly Initiated Therapies for Pulmonary Hypertension (COMPERA) with moderate or severe PH in ... Read more >>

Chest (Chest)
[2021, 160(2):678-689]

Cited: 1 time

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The Growing Role of Echocardiography in Pulmonary Arterial Hypertension Risk Stratification: The Missing Piece.

Cristiano Miotti, Silvia Papa, Giovanna Manzi, Gianmarco Scoccia, Federico Luongo, Federica Toto, Claudia Malerba, Nadia Cedrone, Susanna Sciomer, Francesco Ciciarello, Francesco Fedele, Carmine Dario Vizza, Roberto Badagliacca,

Pulmonary arterial hypertension (PAH) is a rare, progressive disease with a poor prognosis. The pathophysiologic model is mainly characterized by an afterload mismatch in which an increased right ventricle afterload, driven by increased pulmonary vascular resistance (PVR), leads to right heart failure. International guidelines recommend optimization of treatment based on ... Read more >>

J Clin Med (Journal of clinical medicine)
[2021, 10(4):]

Cited: 2 times

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Reply to Weatherald et al.: Pulmonary Vascular Resistance in Pulmonary Arterial Hypertension: La Pièce de Résistance?

Roberto Badagliacca, Michele D'Alto, Stefano Ghio, Carmine Dario Vizza, Robert Naeije,

Am J Respir Crit Care Med (American journal of respiratory and critical care medicine)
[2021, 203(4):525-526]

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Risk Reduction and Hemodynamics with Initial Combination Therapy in Pulmonary Arterial Hypertension.

Roberto Badagliacca, Michele D'Alto, Stefano Ghio, Paola Argiento, Vincenzo Bellomo, Natale Daniele Brunetti, Gavino Casu, Marco Confalonieri, Marco Corda, Michele Correale, Carlo D'Agostino, Lucrezia De Michele, Giuseppe Galgano, Alessandra Greco, Carlo Lombardi, Giovanna Manzi, Valentina Mercurio, Massimiliano Mulè, Giuseppe Paciocco, Silvia Papa, Emanuele Romeo, Laura Scelsi, Davide Stolfo, Patrizio Vitulo, Robert Naeije, Carmine Dario Vizza,

<b>Rationale:</b> An initial oral combination of drugs is being recommended in pulmonary arterial hypertension (PAH), but the effects of this approach on risk reduction and pulmonary vascular resistance (PVR) are not known.<b>Objectives:</b> To test the hypothesis that a low-risk status would be determined by the reduction of PVR in patients ... Read more >>

Am J Respir Crit Care Med (American journal of respiratory and critical care medicine)
[2021, 203(4):484-492]

Cited: 6 times

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Riociguat treatment in patients with pulmonary arterial hypertension: Final safety data from the EXPERT registry.

Marius M Hoeper, Miguel-Angel Gomez Sanchez, Marc Humbert, David Pittrow, Gérald Simonneau, Henning Gall, Ekkehard Grünig, Hans Klose, Michael Halank, David Langleben, Repke J Snijder, Pilar Escribano Subias, Lisa M Mielniczuk, Tobias J Lange, Jean-Luc Vachiéry, Hubert Wirtz, Douglas S Helmersen, Iraklis Tsangaris, Joan A Barberà, Joanna Pepke-Zaba, Anco Boonstra, Stephan Rosenkranz, Silvia Ulrich, Regina Steringer-Mascherbauer, Marion Delcroix, Pavel Jansa, Iveta Šimková, George Giannakoulas, Jens Klotsche, Evgenia Williams, Christian Meier, Hossein-Ardeschir Ghofrani, ,

<h4>Objective</h4>The soluble guanylate cyclase stimulator riociguat is approved for the treatment of adult patients with pulmonary arterial hypertension (PAH) and inoperable or persistent/recurrent chronic thromboembolic pulmonary hypertension following Phase 3 randomized trials. The EXPosurE Registry RiociguaT in patients with pulmonary hypertension (EXPERT) study was designed to monitor the long-term safety ... Read more >>

Respir Med (Respiratory medicine)
[2020, 177:106241]

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Riociguat treatment in patients with chronic thromboembolic pulmonary hypertension: Final safety data from the EXPERT registry.

Hossein-Ardeschir Ghofrani, Miguel-Angel Gomez Sanchez, Marc Humbert, David Pittrow, Gérald Simonneau, Henning Gall, Ekkehard Grünig, Hans Klose, Michael Halank, David Langleben, Repke J Snijder, Pilar Escribano Subias, Lisa M Mielniczuk, Tobias J Lange, Jean-Luc Vachiéry, Hubert Wirtz, Douglas S Helmersen, Iraklis Tsangaris, Joan A Barberá, Joanna Pepke-Zaba, Anco Boonstra, Stephan Rosenkranz, Silvia Ulrich, Regina Steringer-Mascherbauer, Marion Delcroix, Pavel Jansa, Iveta Šimková, George Giannakoulas, Jens Klotsche, Evgenia Williams, Christian Meier, Marius M Hoeper, ,

<h4>Objective</h4>The soluble guanylate cyclase stimulator riociguat is approved for the treatment of adult patients with pulmonary arterial hypertension (PAH) and inoperable or persistent/recurrent chronic thromboembolic pulmonary hypertension (CTEPH) following Phase 3 randomized trials. The EXPosurE Registry RiociguaT in patients with pulmonary hypertension (EXPERT) study was designed to monitor the long-term ... Read more >>

Respir Med (Respiratory medicine)
[2021, 178:106220]

Cited: 1 time

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Right Ventricular Strain Curve Morphology and Outcome in Idiopathic Pulmonary Arterial Hypertension.

Roberto Badagliacca, Beatrice Pezzuto, Silvia Papa, Roberto Poscia, Giovanna Manzi, Antonella Pascaretta, Cristiano Miotti, Federico Luongo, Gianmarco Scoccia, Francesco Ciciarello, Gavino Casu, Susanna Sciomer, Francesco Fedele, Robert Naeije, Carmine Dario Vizza,

<h4>Objectives</h4>The purpose of this study was to explore speckle tracking echocardiographic right ventricular (RV) post-systolic strain patterns and their clinical relevance in idiopathic pulmonary arterial hypertension (PAH).<h4>Background</h4>The imaging of RV diastolic function in PAH remains incompletely understood.<h4>Methods</h4>Speckle tracking echocardiography of RV post-systolic strain recordings were examined in 108 consecutive idiopathic ... Read more >>

JACC Cardiovasc Imaging (JACC. Cardiovascular imaging)
[2021, 14(1):162-172]

Cited: 5 times

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Idiopathic pulmonary arterial hypertension phenotypes determined by cluster analysis from the COMPERA registry.

Marius M Hoeper, Christine Pausch, Ekkehard Grünig, Hans Klose, Gerd Staehler, Doerte Huscher, David Pittrow, Karen M Olsson, Carmine Dario Vizza, Henning Gall, Nicola Benjamin, Oliver Distler, Christian Opitz, J Simon R Gibbs, Marion Delcroix, H Ardeschir Ghofrani, Stephan Rosenkranz, Ralf Ewert, Harald Kaemmerer, Tobias J Lange, Hans-Joachim Kabitz, Dirk Skowasch, Andris Skride, Elena Jureviciene, Egle Paleviciute, Skaidrius Miliauskas, Martin Claussen, Juergen Behr, Katrin Milger, Michael Halank, Heinrike Wilkens, Hubert Wirtz, Elena Pfeuffer-Jovic, Lars Harbaum, Werner Scholtz, Daniel Dumitrescu, Leonhard Bruch, Gerry Coghlan, Claus Neurohr, Iraklis Tsangaris, Matthias Gorenflo, Laura Scelsi, Anton Vonk-Noordegraaf, Silvia Ulrich, Matthias Held,

The term idiopathic pulmonary arterial hypertension (IPAH) is used to categorize patients with pre-capillary pulmonary hypertension of unknown origin. There is considerable variability in the clinical presentation of these patients. Using data from the Comparative, Prospective Registry of Newly Initiated Therapies for Pulmonary Hypertension, we performed a cluster analysis of ... Read more >>

J Heart Lung Transplant (The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation)
[2020, 39(12):1435-1444]

Cited: 3 times

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Imaging risk in pulmonary arterial hypertension.

Roberto Badagliacca, Carmine Dario Vizza,

Eur Respir J (The European respiratory journal)
[2020, 56(3):]

Cited: 1 time

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Hemodynamics and risk assessment 2 years after the initiation of upfront ambrisentan‒tadalafil in pulmonary arterial hypertension.

Michele D'Alto, Roberto Badagliacca, Francesco Lo Giudice, Paola Argiento, Gavino Casu, Marco Corda, Michele Correale, Stefano Ghio, Alessandra Greco, Mariangela Lattanzio, Valentina Mercurio, Giuseppe Paciocco, Silvia Papa, Renato Prediletto, Emanuele Romeo, Maria Giovanna Russo, Alessandro Tayar, Patrizio Vitulo, Carmine Dario Vizza, Paolo Golino, Robert Naeije,

<h4>Background</h4>Upfront combination therapy with ambrisentan and tadalafil has been reported to improve the condition of patients with pulmonary arterial hypertension (PAH) more than with either drug alone. However, little is known about the long-term associated changes in hemodynamics and risk assessment scores.<h4>Methods</h4>This was a multicenter, retrospective analysis of clinical data ... Read more >>

J Heart Lung Transplant (The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation)
[2020, 39(12):1389-1397]

Cited: 1 time

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Pulmonary Hypertension in Adults with Congenital Heart Disease: Real-World Data from the International COMPERA-CHD Registry.

Harald Kaemmerer, Matthias Gorenflo, Dörte Huscher, David Pittrow, Christian Apitz, Helmut Baumgartner, Felix Berger, Leonhard Bruch, Eva Brunnemer, Werner Budts, Martin Claussen, Gerry Coghlan, Ingo Dähnert, Michele D'Alto, Marion Delcroix, Oliver Distler, Sven Dittrich, Daniel Dumitrescu, Ralf Ewert, Martin Faehling, Ingo Germund, Hossein Ardeschir Ghofrani, Christian Grohé, Karsten Grossekreymborg, Michael Halank, Georg Hansmann, Dominik Harzheim, Attila Nemes, Kalman Havasi, Matthias Held, Marius M Hoeper, Michael Hofbeck, Wolfgang Hohenfrost-Schmidt, Elena Jurevičienė, Lina Gumbienè, Hans-Joachim Kabitz, Hans Klose, Thomas Köhler, Stavros Konstantinides, Martin Köestenberger, Rainer Kozlik-Feldmann, Hans-Heiner Kramer, Cornelia Kropf-Sanchen, Astrid Lammers, Tobias Lange, Philipp Meyn, Oliver Miera, Katrin Milger-Kneidinger, Rhoia Neidenbach, Claus Neurohr, Christian Opitz, Christian Perings, Bjoern Andrew Remppis, Gabriele Riemekasten, Laura Scelsi, Werner Scholtz, Iveta Simkova, Dirk Skowasch, Andris Skride, Gerd Stähler, Brigitte Stiller, Iraklis Tsangaris, Carmine Dario Vizza, Anton Vonk Noordegraaf, Heinrike Wilkens, Hubert Wirtz, Gerhard-Paul Diller, Ekkehard Grünig, Stephan Rosenkranz,

INTRODUCTION:Pulmonary hypertension (PH) is a common complication in patients with congenital heart disease (CHD), aggravating the natural, post-operative, or post-interventional course of the underlying anomaly. The various CHDs differ substantially in characteristics, functionality, and clinical outcomes among each other and compared with other diseases with pulmonary hypertension. OBJECTIVE:To describe current ... Read more >>

J Clin Med (Journal of clinical medicine)
[2020, 9(5):]

Cited: 0 times

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Usefulness of Adding Echocardiography of the Right Heart to Risk-Assessment Scores in Prostanoid-Treated Pulmonary Arterial Hypertension.

Roberto Badagliacca, Silvia Papa, Giovanna Manzi, Cristiano Miotti, Federico Luongo, Susanna Sciomer, Nadia Cedrone, Francesco Fedele, Robert Naeije, Carmine Dario Vizza,

JACC Cardiovasc Imaging (JACC. Cardiovascular imaging)
[2020, 13(9):2054-2056]

Cited: 2 times

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Interleukin-32 in systemic sclerosis, a potential new biomarker for pulmonary arterial hypertension.

Paola Di Benedetto, Giuliana Guggino, Giovanna Manzi, Piero Ruscitti, Onorina Berardicurti, Noemi Panzera, Nicolò Grazia, Roberto Badagliacca, Valeria Riccieri, Carmine Dario Vizza, Ganna Radchenko, Vasiliki Liakouli, Francesco Ciccia, Paola Cipriani, Roberto Giacomelli,

<h4>Background</h4>Pulmonary arterial hypertension (PAH) is a severe complication of systemic sclerosis (SSc), associated with a progressive elevation in pulmonary vascular resistance and subsequent right heart failure and death. Due to unspecific symptoms, the diagnosis of PAH is often delayed. On this basis, it is of great value to improve current ... Read more >>

Arthritis Res Ther (Arthritis research & therapy)
[2020, 22(1):127]

Cited: 4 times

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Intra-aortic balloon counterpulsation timing: A new numerical model for programming and training in the clinical environment.

Claudio De Lazzari, Beatrice De Lazzari, Attilio Iacovoni, Silvia Marconi, Silvia Papa, Massimo Capoccia, Roberto Badagliacca, Carmine Dario Vizza,

<h4>Background and objective</h4>The intra-aortic balloon pump (IABP) is the most widely available device for short-term mechanical circulatory support, often used to wean off cardiopulmonary bypass or combined with extra-corporeal membrane oxygenation support or as a bridge to a left ventricular assist device. Although based on a relatively simple principle, its ... Read more >>

Comput Methods Programs Biomed (Computer methods and programs in biomedicine)
[2020, 194:105537]

Cited: 0 times

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Combination Therapy with Oral Treprostinil for Pulmonary Arterial Hypertension. A Double-Blind Placebo-controlled Clinical Trial.

R James White, Carlos Jerjes-Sanchez, Gisela Martina Bohns Meyer, Tomas Pulido, Pablo Sepulveda, Kuo Yang Wang, Ekkehard Grünig, Shirish Hiremath, Zaixin Yu, Zhang Gangcheng, Wei Luen James Yip, Shuyang Zhang, Akram Khan, C Q Deng, Rob Grover, Victor F Tapson, ,

Rationale: Oral treprostinil improves exercise capacity in patients with pulmonary arterial hypertension (PAH), but the effect on clinical outcomes was unknown.Objectives: To evaluate the effect of oral treprostinil compared with placebo on time to first adjudicated clinical worsening event in participants with PAH who recently began approved oral monotherapy.Methods: In ... Read more >>

Am J Respir Crit Care Med (American journal of respiratory and critical care medicine)
[2020, 201(6):707-717]

Cited: 14 times

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Clinical implications of idiopathic pulmonary arterial hypertension phenotypes defined by cluster analysis.

Roberto Badagliacca, Franz Rischard, Silvia Papa, Saad Kubba, Rebecca Vanderpool, Jason X-J Yuan, Joe G N Garcia, Sophia Airhart, Roberto Poscia, Beatrice Pezzuto, Giovanna Manzi, Cristiano Miotti, Federico Luongo, Gianmarco Scoccia, Susanna Sciomer, Roberto Torre, Francesco Fedele, Carmine Dario Vizza,

<h4>Background</h4>>Despite advances in drug development, life expectancy in idiopathic pulmonary arterial hypertension (IPAH) remains unacceptable. Contemporary IPAH characterization is based on criteria that may not adequately capture disease heterogeneity and may be proposed as a possible explanation for why patient outcome is still unfavorable. The aim of this study was ... Read more >>

J Heart Lung Transplant (The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation)
[2020, 39(4):310-320]

Cited: 4 times

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