Full Text Journal Articles by
Author Carlos J Rodriguez Ortiz

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Generation of a humanized Aβ expressing mouse demonstrating aspects of Alzheimer's disease-like pathology.

David Baglietto-Vargas, Stefania Forner, Lena Cai, Alessandra C Martini, Laura Trujillo-Estrada, Vivek Swarup, Marie Minh Thu Nguyen, Kelly Do Huynh, Dominic I Javonillo, Kristine Minh Tran, Jimmy Phan, Shan Jiang, Enikö A Kramár, Cristina Nuñez-Diaz, Gabriela Balderrama-Gutierrez, Franklin Garcia, Jessica Childs, Carlos J Rodriguez-Ortiz, Juan Antonio Garcia-Leon, Masashi Kitazawa, Mohammad Shahnawaz, Dina P Matheos, Xinyi Ma, Celia Da Cunha, Ken C Walls, Rahasson R Ager, Claudio Soto, Antonia Gutierrez, Ines Moreno-Gonzalez, Ali Mortazavi, Andrea J Tenner, Grant R MacGregor, Marcelo Wood, Kim N Green, Frank M LaFerla,

The majority of Alzheimer's disease (AD) cases are late-onset and occur sporadically, however most mouse models of the disease harbor pathogenic mutations, rendering them better representations of familial autosomal-dominant forms of the disease. Here, we generated knock-in mice that express wildtype human Aβ under control of the mouse App locus. ... Read more >>

Nat Commun (Nature communications)
[2021, 12(1):2421]

Cited: 0 times

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Inflammatory Cytokine IL-1β Downregulates Endothelial LRP1 via MicroRNA-mediated Gene Silencing.

Heng-Wei Hsu, Carlos J Rodriguez-Ortiz, Joannee Zumkehr, Masashi Kitazawa,

Effective clearance of neurotoxic amyloid-beta (Aβ) from the brain is a critical process to prevent Alzheimer's disease (AD). One major clearance mechanism is Aβ transcytosis mediated by low-density lipoprotein receptor-related protein 1 (LRP1) in capillary endothelial cells. A marked loss of endothelial LRP1 is found in AD brains and is ... Read more >>

Neuroscience (Neuroscience)
[2021, 453:69-80]

Cited: 0 times

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Chronic copper exposure directs microglia towards degenerative expression signatures in wild-type and J20 mouse model of Alzheimer's disease.

Siok Lam Lim, Carlos J Rodriguez-Ortiz, Heng-Wei Hsu, Jie Wu, Joannee Zumkehr, Jason Kilian, Janielle Vidal, Pinar Ayata, Masashi Kitazawa,

<h4>Background</h4>Copper (Cu) is an essential metal mediating a variety of vital biological reactions with its redox property. Its dyshomeostasis has been associated with accelerated cognitive decline and neurodegenerative disorders, such as Alzheimer's disease (AD). However, underlying neurotoxic mechanisms elicited by dysregulated Cu remain largely elusive. We and others previously demonstrated ... Read more >>

J Trace Elem Med Biol (Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS))
[2020, 62:126578]

Cited: 1 time

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Genetic Ablation of Hematopoietic Cell Kinase Accelerates Alzheimer's Disease-Like Neuropathology in Tg2576 Mice.

Siok Lam Lim, Diana Nguyen Tran, Zanett Kieu, Christine Chen, Emmanuel Villanueva, Sagar Ghiaar, Victoria Gallup, Joannee Zumkehr, David H Cribbs, Carlos J Rodriguez-Ortiz, Masashi Kitazawa,

Microglial dysregulation, pertaining to impairment in phagocytosis, clearance and containment of amyloid-β (Aβ), and activation of neuroinflammation, has been posited to contribute to the pathogenesis of Alzheimer's disease (AD). Detailed cellular mechanisms that are disrupted during the disease course to display such impairment in microglia, however, remain largely undetermined. We ... Read more >>

Mol Neurobiol (Molecular neurobiology)
[2020, 57(5):2447-2460]

Cited: 2 times

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Copper-Induced Upregulation of MicroRNAs Directs the Suppression of Endothelial LRP1 in Alzheimer's Disease Model.

Heng-Wei Hsu, Carlos J Rodriguez-Ortiz, Siok Lam Lim, Joannee Zumkehr, Jason G Kilian, Janielle Vidal, Masashi Kitazawa,

Chronic exposure to copper and its dyshomeostasis have been linked to accelerated cognitive decline and potentially increasing risk for Alzheimer's disease (AD). We and others have previously demonstrated that exposure to copper through drinking water significantly increased parenchymal amyloid-beta (Aβ) plaques and decreased endothelial low-density lipoprotein receptor-related protein 1 (LRP1) ... Read more >>

Toxicol Sci (Toxicological sciences : an official journal of the Society of Toxicology)
[2019, 170(1):144-156]

Cited: 4 times

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Impaired AMPA signaling and cytoskeletal alterations induce early synaptic dysfunction in a mouse model of Alzheimer's disease.

David Baglietto-Vargas, Gilberto Aleph Prieto, Agenor Limon, Stefania Forner, Carlos J Rodriguez-Ortiz, Kenji Ikemura, Rahasson R Ager, Rodrigo Medeiros, Laura Trujillo-Estrada, Alessandra C Martini, Masashi Kitazawa, Jose C Davila, Carl W Cotman, Antonia Gutierrez, Frank M LaFerla,

Alzheimer's disease (AD) is a devastating neurodegenerative disorder that impairs memory and causes cognitive and psychiatric deficits. New evidences indicate that AD is conceptualized as a disease of synaptic failure, although the molecular and cellular mechanisms underlying these defects remain to be elucidated. Determining the timing and nature of the ... Read more >>

Aging Cell (Aging cell)
[2018, 17(4):e12791]

Cited: 20 times

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Inflammatory Cytokine, IL-1β, Regulates Glial Glutamate Transporter via microRNA-181a in vitro.

Joannee Zumkehr, Carlos J Rodriguez-Ortiz, Rodrigo Medeiros, Masashi Kitazawa,

Glutamate overload triggers synaptic and neuronal loss that potentially contributes to neurodegenerative diseases including Alzheimer's disease (AD). Glutamate clearance and regulation at synaptic clefts is primarily mediated by glial glutamate transporter 1 (GLT-1). We determined that inflammatory cytokines significantly upregulated GLT-1 through microRNA-181a-mediated post-transcriptional modifications. Unveiling the key underlying mechanisms ... Read more >>

J Alzheimers Dis (Journal of Alzheimer's disease : JAD)
[2018, 63(3):965-975]

Cited: 3 times

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Determinants to trigger memory reconsolidation: The role of retrieval and updating information.

Carlos J Rodriguez-Ortiz, Federico Bermúdez-Rattoni,

Long-term memories can undergo destabilization/restabilization processes, collectively called reconsolidation. However, the parameters that trigger memory reconsolidation are poorly understood and are a matter of intense investigation. Particularly, memory retrieval is widely held as requisite to initiate reconsolidation. This assumption makes sense since only relevant cues will induce reconsolidation of a ... Read more >>

Neurobiol Learn Mem (Neurobiology of learning and memory)
[2017, 142(Pt A):4-12]

Cited: 5 times

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The Myoblast C2C12 Transfected with Mutant Valosin-Containing Protein Exhibits Delayed Stress Granule Resolution on Oxidative Stress.

Carlos J Rodriguez-Ortiz, Julio C Flores, Joanna A Valenzuela, Gema J Rodriguez, Joannee Zumkehr, Diana N Tran, Virginia E Kimonis, Masashi Kitazawa,

Valosin-containing protein (VCP) mutations cause inclusion body myopathy with Paget disease and frontotemporal dementia. However, the mechanisms by which mutant VCP triggers degeneration remain unknown. Here, we investigated the role of VCP in cellular stress and found that the oxidative stressor arsenite and heat shock-activated stress responses evident by T-intracellular ... Read more >>

Am J Pathol (The American journal of pathology)
[2016, 186(6):1623-1634]

Cited: 3 times

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Short-term modern life-like stress exacerbates Aβ-pathology and synapse loss in 3xTg-AD mice.

David Baglietto-Vargas, Yuncai Chen, Dongjin Suh, Rahasson R Ager, Carlos J Rodriguez-Ortiz, Rodrigo Medeiros, Kristoffer Myczek, Kim N Green, Tallie Z Baram, Frank M LaFerla,

Alzheimer's disease (AD) is a progressive neurological disorder that impairs memory and other cognitive functions in the elderly. The social and financial impacts of AD are overwhelming and are escalating exponentially as a result of population aging. Therefore, identifying AD-related risk factors and the development of more efficacious therapeutic approaches ... Read more >>

J Neurochem (Journal of neurochemistry)
[2015, 134(5):915-926]

Cited: 44 times

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Repeated cognitive stimulation alleviates memory impairments in an Alzheimer's disease mouse model.

Hilda Martinez-Coria, Stephen T Yeung, Rahasson R Ager, Carlos J Rodriguez-Ortiz, David Baglietto-Vargas, Frank M LaFerla,

Alzheimer's disease is a neurodegenerative disease associated with progressive memory and cognitive decline. Previous studies have identified the benefits of cognitive enrichment on reducing disease pathology. Additionally, epidemiological and clinical data suggest that repeated exercise, and cognitive and social enrichment, can improve and/or delay the cognitive deficiencies associated with aging ... Read more >>

Brain Res Bull (Brain research bulletin)
[2015, 117:10-15]

Cited: 6 times

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Infection, systemic inflammation, and Alzheimer's disease.

Siok Lam Lim, Carlos J Rodriguez-Ortiz, Masashi Kitazawa,

Alzheimer's disease (AD) is a leading cause of dementia among elderly. Yet, its etiology remains largely unclear. In this review, we summarize studies that associate systemic infection and neuroinflammation with AD, while highlighting that early-life or life-long exposure to infectious agents predisposes one to develop AD at a later age. ... Read more >>

Microbes Infect (Microbes and infection)
[2015, 17(8):549-556]

Cited: 43 times

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Ceftriaxone ameliorates tau pathology and cognitive decline via restoration of glial glutamate transporter in a mouse model of Alzheimer's disease.

Joannee Zumkehr, Carlos J Rodriguez-Ortiz, David Cheng, Zanett Kieu, Thin Wai, Charlesice Hawkins, Jason Kilian, Siok Lam Lim, Rodrigo Medeiros, Masashi Kitazawa,

Glial glutamate transporter, GLT-1, is the major Na(+)-driven glutamate transporter to control glutamate levels in synapses and prevent glutamate-induced excitotoxicity implicated in neurodegenerative disorders including Alzheimer's disease (AD). Significant functional loss of GLT-1 has been reported to correlate well with synaptic degeneration and severity of cognitive impairment among AD patients, ... Read more >>

Neurobiol Aging (Neurobiology of aging)
[2015, 36(7):2260-2271]

Cited: 52 times

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Retrieval is not necessary to trigger reconsolidation of object recognition memory in the perirhinal cortex.

Marianela Santoyo-Zedillo, Carlos J Rodriguez-Ortiz, Gianfranco Chavez-Marchetta, Federico Bermudez-Rattoni, Israela Balderas,

Memory retrieval has been considered as requisite to initiate memory reconsolidation; however, some studies indicate that blocking retrieval does not prevent memory from undergoing reconsolidation. Since N-methyl-D-aspartate (NMDA) and α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) glutamate receptors in the perirhinal cortex have been involved in object recognition memory formation, the present study evaluated ... Read more >>

Learn Mem (Learning & memory (Cold Spring Harbor, N.Y.))
[2014, 21(9):452-456]

Cited: 13 times

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Consolidation and reconsolidation of object recognition memory.

Israela Balderas, Carlos J Rodriguez-Ortiz, Federico Bermudez-Rattoni,

In the first part of this review, we will present evidence showing a functional double dissociation between different structures of the medial temporal lobe in the consolidation of object and object-in-context recognition memory. In addition, we will provide evidence to support this differential participation through protein synthesis inhibitors and neurotransmitters ... Read more >>

Behav Brain Res (Behavioural brain research)
[2015, 285:213-222]

Cited: 17 times

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Upregulation of miR-181 decreases c-Fos and SIRT-1 in the hippocampus of 3xTg-AD mice.

Carlos J Rodriguez-Ortiz, David Baglietto-Vargas, Hilda Martinez-Coria, Frank M LaFerla, Masashi Kitazawa,

MicroRNAs are a group of small RNAs that regulate diverse cellular processes including neuronal function. Recent studies have shown that dysregulation of specific microRNAs is critically involved in the development of Alzheimer's disease (AD). Most of these reports have focused on microRNAs implicated in alterations of amyloid-β and tau. However, ... Read more >>

J Alzheimers Dis (Journal of Alzheimer's disease : JAD)
[2014, 42(4):1229-1238]

Cited: 34 times

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Genetic ablation of tau mitigates cognitive impairment induced by type 1 diabetes.

Serena Abbondante, David Baglietto-Vargas, Carlos J Rodriguez-Ortiz, Tatiana Estrada-Hernandez, Rodrigo Medeiros, Frank M Laferla,

Patients affected by diabetes show an increased risk of developing Alzheimer disease (AD). Similarly, patients with AD show impaired insulin function and glucose metabolism. However, the underlying molecular mechanisms connecting these two disorders are still not well understood. Herein, we investigated the microtubule-associated protein tau as a new link between ... Read more >>

Am J Pathol (The American journal of pathology)
[2014, 184(3):819-826]

Cited: 19 times

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Endogenous murine tau promotes neurofibrillary tangles in 3xTg-AD mice without affecting cognition.

David Baglietto-Vargas, Masashi Kitazawa, Elaine J Le, Tatiana Estrada-Hernandez, Carlos J Rodriguez-Ortiz, Rodrigo Medeiros, Kim N Green, Frank M LaFerla,

Recent studies on tauopathy animal models suggest that the concomitant expression of the endogenous murine tau delays the pathological accumulation of human tau, and interferes with the disease progression. To elucidate the role of endogenous murine tau in a model with both plaques and tangles, we developed a novel transgenic ... Read more >>

Neurobiol Dis (Neurobiology of disease)
[2014, 62:407-415]

Cited: 12 times

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Neuronal-specific overexpression of a mutant valosin-containing protein associated with IBMPFD promotes aberrant ubiquitin and TDP-43 accumulation and cognitive dysfunction in transgenic mice.

Carlos J Rodriguez-Ortiz, Hitomi Hoshino, David Cheng, Liqun Liu-Yescevitz, Mathew Blurton-Jones, Benjamin Wolozin, Frank M LaFerla, Masashi Kitazawa,

Mutations in valosin-containing protein (VCP) cause a rare, autosomal dominant disease called inclusion body myopathy associated with Paget disease of bone and frontotemporal dementia (IBMPFD). One-third of patients with IBMPFD develop frontotemporal dementia, characterized by an extensive neurodegeneration in the frontal and temporal lobes. Neuropathologic hallmarks include nuclear and cytosolic ... Read more >>

Am J Pathol (The American journal of pathology)
[2013, 183(2):504-515]

Cited: 18 times

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Taste aversion memory reconsolidation is independent of its retrieval.

Carlos J Rodriguez-Ortiz, Israela Balderas, Paola Garcia-DeLaTorre, Federico Bermudez-Rattoni,

Reconsolidation refers to the destabilization/re-stabilization memory process upon its activation. However, the conditions needed to undergo reconsolidation, as well as its functional significance is quite unclear and a matter of intense investigation. Even so, memory retrieval is held as requisite to initiate reconsolidation. Therefore, in the present work we examined ... Read more >>

Neurobiol Learn Mem (Neurobiology of learning and memory)
[2012, 98(3):215-219]

Cited: 27 times

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Muscarinic receptors activity in the perirhinal cortex and hippocampus has differential involvement in the formation of recognition memory.

Israela Balderas, Jean-Pascal Morin, Carlos J Rodriguez-Ortiz, Federico Bermudez-Rattoni,

In this work we probed the effects of post-trial infusions of the muscarinic receptor antagonist scopolamine on object recognition memory formation. Scopolamine was infused bilaterally immediately after the sample phase in the perirhinal cortex or dorsal hippocampus and animals were tested for short-term (90 min) or long-term (24 h) memory. ... Read more >>

Neurobiol Learn Mem (Neurobiology of learning and memory)
[2012, 97(4):418-424]

Cited: 10 times

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Long-term aversive taste memory requires insular and amygdala protein degradation.

Carlos J Rodriguez-Ortiz, Israela Balderas, Fernando Saucedo-Alquicira, Paulina Cruz-Castañeda, Federico Bermudez-Rattoni,

Some reports have shown that the ubiquitin-proteasome system (UPS) is necessary to degrade repressor factors to produce new proteins essential to memory consolidation. Furthermore, recent evidence suggests that memory updating also relies on protein degradation through the UPS. To evaluate whether degradation of proteins is part of the cellular events ... Read more >>

Neurobiol Learn Mem (Neurobiology of learning and memory)
[2011, 95(3):311-315]

Cited: 17 times

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Differential participation of temporal structures in the consolidation and reconsolidation of taste aversion extinction.

Paola Garcia-Delatorre, Carlos J Rodríguez-Ortiz, Israela Balderas, Federico Bermúdez-Rattoni,

The extinction process has been described as the decline in the frequency or intensity of the conditioned response following the withdrawal of reinforcement. Hence, experimental extinction does not reflect loss of the original memory, but rather reflects new learning, which in turn requires consolidation in order to be maintained in ... Read more >>

Eur J Neurosci (The European journal of neuroscience)
[2010, 32(6):1018-1023]

Cited: 20 times

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Simultaneous but not independent anisomycin infusions in insular cortex and amygdala hinder stabilization of taste memory when updated.

Paola García-DeLaTorre, Carlos J Rodriguez-Ortiz, Jose L Arreguin-Martinez, Paulina Cruz-Castañeda, Federico Bermúdez-Rattoni,

Reconsolidation has been described as a process where a consolidated memory returns to a labile state when retrieved. Growing evidence suggests that reconsolidation is, in fact, a destabilization/stabilization process that incorporates updated information to a previously consolidated memory. We used the conditioned taste aversion (CTA) task in order to test ... Read more >>

Learn Mem (Learning & memory (Cold Spring Harbor, N.Y.))
[2009, 16(9):514-519]

Cited: 21 times

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Medial temporal lobe structures participate differentially in consolidation of safe and aversive taste memories.

Vanesa De la Cruz, Carlos J Rodriguez-Ortiz, Israela Balderas, Federico Bermudez-Rattoni,

Taste memories are amongst the most important kinds of memories, as adequate identification of safe and toxic edibles will determine the subject's survival. Despite the well-established role that the medial temporal lobe plays in consolidation of memory, specific contributions of the different regions of the temporal lobe to taste memory ... Read more >>

Eur J Neurosci (The European journal of neuroscience)
[2008, 28(7):1377-1381]

Cited: 18 times

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