Full Text Journal Articles by
Author Carlo Sacdalan

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Brief Report: Syphilis Incidence and Effect on Viral Load, CD4, and CD4/CD8 Ratio in a Thai Cohort of Predominantly Men Who Have Sex With Men Living With HIV.

Camilla Muccini, Trevor A Crowell, Suteeraporn Pinyakorn, Eugène Kroon, Carlo Sacdalan, Jintanat Ananworanich, Sandhya Vasan, Nittaya Phanuphak, Donn J Colby, ,

<h4>Background</h4>Syphilis has been increasing in the past years, especially among men who have sex with men (MSM). The aim of the study was to assess syphilis prevalence and incidence and changes in CD4 count and viremia in the RV254 cohort of persons living with HIV who initiated antiretroviral therapy during ... Read more >>

J Acquir Immune Defic Syndr (Journal of acquired immune deficiency syndromes (1999))
[2021, 86(2):219-223]

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Minimal detection of cerebrospinal fluid escape after initiation of antiretroviral therapy in acute HIV-1 infection.

Ryan Handoko, Phillip Chan, Linda Jagodzinski, Suteeraporn Pinyakorn, Sasiwimol Ubolyam, Nittaya Phanuphak, Carlo Sacdalan, Eugene Kroon, Netsiri Dumrongpisutikul, Robert Paul, Victor Valcour, Jintanat Ananworanich, Sandhya Vasan, Serena Spudich, ,

<h4>Objective</h4>Despite suppression of HIV-1 replication in the periphery by antiretroviral therapy (ART), up to 10% of treated individuals have quantifiable HIV-1 in the CSF, termed CSF escape. CSF escape may be asymptomatic but has also been linked to progressive neurological disease, and may indicate persistence of HIV in the central ... Read more >>

AIDS (AIDS (London, England))
[2020, :]

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Central nervous system safety during brief analytic treatment interruption of antiretroviral therapy within four HIV remission trials: an observational study in acutely treated people living with HIV.

Joanna Hellmuth, Camilla Muccini, Donn J Colby, Eugène Kroon, Mark de Souza, Trevor A Crowell, Phillip Chan, Carlo Sacdalan, Jintana Intasan, Khunthalee Benjapornpong, Somporn Tipsuk, Suwanna Puttamaswin, Nitiya Chomchey, Victor Valcour, Michal Sarnecki, Frank Tomaka, Shelly J Krebs, Bonnie M Slike, Linda L Jagodzinski, Netsiri Dumrongpisutikul, Napapon Sailasuta, Vishal Samboju, Nelson L Michael, Merlin L Robb, Sandhya Vasan, Jintanat Ananworanich, Praphan Phanuphak, Nittaya Phanuphak, Robert Paul, Serena Spudich,

<h4>Background</h4>The central nervous system (CNS) is a likely reservoir of HIV, vulnerable to viral rebound, inflammation, and clinical changes upon stopping antiretroviral therapy (ART). It is critical to evaluate the CNS safety of studies using analytic treatment interruption (ATI) to assess HIV remission.<h4>Methods</h4>Thirty participants who started ART during acute HIV ... Read more >>

Clin Infect Dis (Clinical infectious diseases : an official publication of the Infectious Diseases Society of America)
[2020, :]

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Brief Report: Group Sex and Methamphetamine Use Fuel an Explosive Epidemic of Hepatitis C Among HIV-Infected Men Who Have Sex With Men in Bangkok, Thailand.

Tanyaporn Wansom, Suteeraporn Pinyakorn, Christy J Kolsteeg, Eugene Kroon, Carlo P Sacdalan, Nitiya Chomchey, Jintanat Ananworanich, Sandhya Vasan, Nittaya Phanuphak, Donn J Colby,

BACKGROUND:Increased rates of hepatitis C virus (HCV) infection among HIV-infected men who have sex with men (MSM) and who deny injecting drugs have been reported in resource-rich settings. SETTING:We measured HCV prevalence and incidence in a predominantly MSM cohort with acute HIV infection in Bangkok, Thailand. METHODS:In 2009-2018, participants with ... Read more >>

J Acquir Immune Defic Syndr (Journal of acquired immune deficiency syndromes (1999))
[2020, 84(4):331-335]

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Plasmacytoid dendritic cells sense HIV replication before detectable viremia following treatment interruption.

Julie L Mitchell, Hiroshi Takata, Roshell Muir, Donn J Colby, Eugène Kroon, Trevor A Crowell, Carlo Sacdalan, Suteeraporn Pinyakorn, Suwanna Puttamaswin, Khunthalee Benjapornpong, Rapee Trichavaroj, Randall L Tressler, Lawrence Fox, Victoria R Polonis, Diane L Bolton, Frank Maldarelli, Sharon R Lewin, Elias K Haddad, Praphan Phanuphak, Merlin L Robb, Nelson L Michael, Mark de Souza, Nittaya Phanuphak, Jintanat Ananworanich, Lydie Trautmann, ,

Plasmacytoid dendritic cells (pDCs) are robust producers of IFNα and one of the first immune cells to respond to SIV infection. To elucidate responses to early HIV-1 replication, we studied blood pDCs in 29 HIV-infected participants who initiated antiretroviral therapy during acute infection and underwent analytic treatment interruption (ATI). We ... Read more >>

J Clin Invest (The Journal of clinical investigation)
[2020, 130(6):2845-2858]

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Neutralizing antibody VRC01 failed to select for HIV-1 mutations upon viral rebound.

Evan M Cale, Hongjun Bai, Meera Bose, Michael A Messina, Donn J Colby, Eric Sanders-Buell, Bethany Dearlove, Yifan Li, Emily Engeman, Daniel Silas, Anne Marie O'Sullivan, Brendan Mann, Suteeraporn Pinyakorn, Jintana Intasan, Khunthalee Benjapornpong, Carlo Sacdalan, Eugène Kroon, Nittaya Phanuphak, Robert Gramzinski, Sandhya Vasan, Merlin L Robb, Nelson L Michael, Rebecca M Lynch, Robert T Bailer, Amélie Pagliuzza, Nicolas Chomont, Amarendra Pegu, Nicole A Doria-Rose, Lydie Trautmann, Trevor A Crowell, John R Mascola, Jintanat Ananworanich, Sodsai Tovanabutra, Morgane Rolland, ,

Infusion of the broadly neutralizing antibody VRC01 has been evaluated in individuals chronically infected with HIV-1. Here, we studied how VRC01 infusions affected viral rebound after cessation of antiretroviral therapy (ART) in 18 acutely treated and durably suppressed individuals. Viral rebound occurred in all individuals, yet VRC01 infusions modestly delayed ... Read more >>

J Clin Invest (The Journal of clinical investigation)
[2020, 130(6):3299-3304]

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Safety and immunogenicity of Ad26 and MVA vaccines in acutely treated HIV and effect on viral rebound after antiretroviral therapy interruption.

Donn J Colby, Michal Sarnecki, Dan H Barouch, Somporn Tipsuk, Daniel J Stieh, Eugène Kroon, Alexandra Schuetz, Jintana Intasan, Carlo Sacdalan, Suteeraporn Pinyakorn, Pornsuk Grandin, Hongshuo Song, Sodsai Tovanabutra, Zhanna Shubin, Dohoon Kim, Dominic Paquin-Proulx, Michael A Eller, Rasmi Thomas, Mark de Souza, Lindsay Wieczorek, Victoria R Polonis, Amélie Pagliuzza, Nicolas Chomont, Lauren Peter, Joseph P Nkolola, Johan Vingerhoets, Carla Truyers, Maria G Pau, Hanneke Schuitemaker, Nittaya Phanuphak, Nelson Michael, Merlin L Robb, Frank L Tomaka, Jintanat Ananworanich,

We administered Ad26, modified vaccinia Ankara vectors containing mosaic HIV-1 antigens or placebo in 26 individuals who initiated antiretroviral therapy during acute human immunodeficiency virus infection as an exploratory study to determine the safety and duration of viremic control after treatment interruption. The vaccine was safe and generated robust immune ... Read more >>

Nat Med (Nature medicine)
[2020, 26(4):498-501]

Cited: 1 time

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Feasibility and safety of research sigmoid colon biopsy in a cohort of Thai men who have sex with men with acute HIV-1.

Michelle Chintanaphol, Carlo Sacdalan, Suteeraporn Pinyakorn, Rungsun Rerknimitr, Wiriyaporn Ridtitid, Piyapan Prueksapanich, Irini Sereti, Alexandra Schuetz, Trevor A Crowell, Donn J Colby, Merlin L Robb, Nittaya Phanuphak, Jintanat Ananworanich, Serena S Spudich, Eugène Kroon,

Background:The gut-associated lymphoid tissue (GALT) is a major reservoir of HIV-1 established early in acute HIV-1 infection (AHI). Sampling tissue from GALT can provide information about viral reservoirs and immune responses but may be complicated during AHI for reasons such as high viral replication, CD4 T cell depletion and immune ... Read more >>

J Virus Erad (Journal of virus eradication)
[2020, 6(1):7-10]

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Very Early Initiation of Antiretroviral Therapy During Acute HIV Infection Is Associated With Normalized Levels of Immune Activation Markers in Cerebrospinal Fluid but Not in Plasma.

Joanna Hellmuth, Bonnie M Slike, Carlo Sacdalan, John Best, Eugene Kroon, Nittaya Phanuphak, James L K Fletcher, Peeriya Prueksakaew, Linda L Jagodzinski, Victor Valcour, Merlin Robb, Jintanat Ananworanich, Isabel E Allen, Shelly J Krebs, Serena Spudich,

<h4>Background</h4>Chronic immune activation in the blood and central nervous system is a consequence of human immunodeficiency virus (HIV) infection that contributes to disease morbidity and can occur despite virally suppressive antiretroviral therapy (ART). The trajectory of HIV-related inflammation may vary with the timing of ART initiation. We examined immune activation ... Read more >>

J Infect Dis (The Journal of infectious diseases)
[2019, 220(12):1885-1891]

Cited: 3 times

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Neuropsychiatric outcomes before and after switching to dolutegravir-based therapy in an acute HIV cohort.

Phillip Chan, Orlanda Goh, Eugène Kroon, Donn Colby, Carlo Sacdalan, Suteeraporn Pinyakorn, Peeriya Prueksakaew, Peter Reiss, Jintanat Ananworanich, Victor Valcour, Serena Spudich, Robert Paul, ,

<h4>Introduction</h4>Dolutegravir (DTG)-based antiretroviral therapy (ART) is currently the first-line treatment for people living with HIV. Neuropsychiatric adverse events (NP-AEs) have been reported with DTG but neuropsychiatric symptoms have not been systemically quantified using structured scales. This study examined mood and cognitive parameters before and after a planned transition from non-DTG ... Read more >>

AIDS Res Ther (AIDS research and therapy)
[2020, 17(1):1]

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Liver function test abnormalities in a longitudinal cohort of Thai individuals treated since acute HIV infection.

Michael J Peluso, Donn J Colby, Suteeraporn Pinyakorn, Sasiwimol Ubolyam, Jintana Intasan, Rapee Trichavaroj, Nitiya Chomchey, Peeriya Prueksakaew, Bonnie M Slike, Shelly J Krebs, Ningbo Jian, Merlin L Robb, Praphan Phanuphak, Nittaya Phanuphak, Serena Spudich, Jintanat Ananworanich, Eugène Kroon, ,

<h4>Introduction</h4>Liver disease is a common cause of non-AIDS morbidity and mortality in people living with HIV (PLHIV), but the prevalence and significance of liver function test (LFT) abnormalities in early HIV infection is unknown. This study aimed to characterize LFTs in a large cohort of participants with acute HIV infection ... Read more >>

J Int AIDS Soc (Journal of the International AIDS Society)
[2020, 23(1):e25444]

Cited: 1 time

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Deep Sequencing Reveals Central Nervous System Compartmentalization in Multiple Transmitted/Founder Virus Acute HIV-1 Infection.

Sodsai Tovanabutra, Rujipas Sirijatuphat, Phuc T Pham, Lydia Bonar, Elizabeth A Harbolick, Meera Bose, Hongshuo Song, David Chang, Celina Oropeza, Anne Marie O'Sullivan, Joyce Balinang, Eugene Kroon, Donn J Colby, Carlo Sacdalan, Joanna Hellmuth, Phillip Chan, Peeriya Prueksakaew, Suteeraporn Pinyakorn, Linda L Jagodzinski, Duanghathai Sutthichom, Suwanna Pattamaswin, Mark de Souza, Robert A Gramzinski, Jerome H Kim, Nelson L Michael, Merlin L Robb, Nittaya Phanuphak, Jintanat Ananworanich, Victor Valcour, Gustavo H Kijak, Eric Sanders-Buell, Serena Spudich, , ,

HIV-1 disseminates to a broad range of tissue compartments during acute HIV-1 infection (AHI). The central nervous system (CNS) can serve as an early and persistent site of viral replication, which poses a potential challenge for HIV-1 remission strategies that target the HIV reservoir. CNS compartmentalization is a key feature ... Read more >>

Cells (Cells)
[2019, 8(8):]

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Neurosyphilis During Acute HIV Infection: A CNS Immunologic and Virologic Characterization.

Phillip Chan, Netsiri Dumrongpisutikul, Caroline Subra, Donn J Colby, Eugène Kroon, James Fletcher, Carlo Sacdalan, Nittaya Phanuphak, Victor Valcour, Jintanat Ananworanich, Lydie Trautmann, Serena Spudich,

J Acquir Immune Defic Syndr (Journal of acquired immune deficiency syndromes (1999))
[2019, 82(2):e34-e37]

Cited: 0 times

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Safety and efficacy of VRC01 broadly neutralising antibodies in adults with acutely treated HIV (RV397): a phase 2, randomised, double-blind, placebo-controlled trial.

Trevor A Crowell, Donn J Colby, Suteeraporn Pinyakorn, Carlo Sacdalan, Amélie Pagliuzza, Jintana Intasan, Khunthalee Benjapornpong, Kamonkan Tangnaree, Nitiya Chomchey, Eugène Kroon, Mark S de Souza, Sodsai Tovanabutra, Morgane Rolland, Michael A Eller, Dominic Paquin-Proulx, Diane L Bolton, Andrey Tokarev, Rasmi Thomas, Hiroshi Takata, Lydie Trautmann, Shelly J Krebs, Kayvon Modjarrad, Adrian B McDermott, Robert T Bailer, Nicole Doria-Rose, Bijal Patel, Robert J Gorelick, Brandie A Fullmer, Alexandra Schuetz, Pornsuk V Grandin, Robert J O'Connell, Julie E Ledgerwood, Barney S Graham, Randall Tressler, John R Mascola, Nicolas Chomont, Nelson L Michael, Merlin L Robb, Nittaya Phanuphak, Jintanat Ananworanich, ,

<h4>Background</h4>HIV-1-specific broadly neutralising antibodies such as VRC01 could promote HIV remission by halting viral replication and clearing infected cells. We investigated whether VRC01 could promote sustained viral control off antiretroviral therapy (ART) in adults who initiated ART during acute HIV infection.<h4>Methods</h4>We did a randomised, double-blind, placebo-controlled trial at the Thai ... Read more >>

Lancet HIV (The lancet. HIV)
[2019, 6(5):e297-e306]

Cited: 12 times

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Normalization of Soluble CD163 Levels After Institution of Antiretroviral Therapy During Acute HIV Infection Tracks with Fewer Neurological Abnormalities.

Michelle L D'Antoni, Mary Margaret Byron, Phillip Chan, Napapon Sailasuta, Carlo Sacdalan, Pasiri Sithinamsuwan, Somporn Tipsuk, Suteeraporn Pinyakorn, Eugene Kroon, Bonnie M Slike, Shelly J Krebs, Vedbar S Khadka, Thep Chalermchai, Kalpana J Kallianpur, Merlin Robb, Serena Spudich, Victor Valcour, Jintanat Ananworanich, Lishomwa C Ndhlovu, ,

<h4>Background</h4>Myeloid activation contributes to cognitive impairment in chronic human immunodeficiency virus (HIV) infection. We explored whether combination antiretroviral therapy (cART) initiation during acute HIV infection impacts CD163 shedding, a myeloid activation marker, and in turn, implications on the central nervous system (CNS).<h4>Methods</h4>We measured soluble CD163 (sCD163) levels in plasma and ... Read more >>

J Infect Dis (The Journal of infectious diseases)
[2018, 218(9):1453-1463]

Cited: 8 times

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Brief Report: Safety and Tolerability of Inguinal Lymph Node Biopsy in Individuals With Acute HIV Infection in Thailand.

Michelle Chintanaphol, Carlo Sacdalan, Suthat Chottanapund, Suteeraporn Pinyakorn, Supranee Buranapraditkun, Trevor A Crowell, Eugene Kroon, Sopark Manasnayakorn, Jeffrey G Chipman, Timothy W Schacker, Nelson Michael, Nittaya Phanuphak, Serena S Spudich, Donn J Colby, Jintanat Ananworanich,

<h4>Introduction</h4>Latent HIV reservoirs are rapidly established in lymphoid tissues during acute HIV infection (AHI). Sampling these tissues provides important information about HIV pathogenesis. This period is associated with viral replication and immune activation that may affect procedure-related adverse events (AEs). We examined the safety and tolerability of inguinal lymph node ... Read more >>

J Acquir Immune Defic Syndr (Journal of acquired immune deficiency syndromes (1999))
[2018, 79(2):244-248]

Cited: 3 times

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Acquisition of Multidrug-Resistant Human Immunodeficiency Virus Type 1 Infection in a Patient Taking Preexposure Prophylaxis.

Donn J Colby, Eugene Kroon, Carlo Sacdalan, Monica Gandhi, Robert M Grant, Praphan Phanuphak, Jintanat Ananworanich, Merlin L Robb, Nittaya Phanuphak,

We report a case indicating that acquisition of multidrug-resistant human immunodeficiency (HIV) virus type 1 during preexposure prophylaxis with combination tenofovir disoproxil fumarate and emtricitabine or evolution of resistance after HIV seroconversion remains a risk. ... Read more >>

Clin Infect Dis (Clinical infectious diseases : an official publication of the Infectious Diseases Society of America)
[2018, 67(6):962-964]

Cited: 3 times

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Distribution of Human Immunodeficiency Virus (HIV) Ribonucleic Acid in Cerebrospinal Fluid and Blood Is Linked to CD4/CD8 Ratio During Acute HIV.

Phillip Chan, Payal Patel, Joanna Hellmuth, Donn J Colby, Eugène Kroon, Carlo Sacdalan, Suteeraporn Pinyakorn, Linda Jagodzinski, Shelly Krebs, Jintanat Ananworanich, Victor Valcour, Serena Spudich, ,

Background:Human immunodeficiency virus (HIV) ribonucleic acid (RNA) levels in the plasma and cerebrospinal fluid (CSF) are correlated in chronic HIV infection, but their dynamics have not been characterized during acute infection. Methods:This study analyzed predictors of CSF HIV RNA and relative degree of CNS viral transmigration expressed as plasma minus ... Read more >>

J Infect Dis (The Journal of infectious diseases)
[2018, 218(6):937-945]

Cited: 1 time

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Acute Retroviral Syndrome Is Associated With High Viral Burden, CD4 Depletion, and Immune Activation in Systemic and Tissue Compartments.

Trevor A Crowell, Donn J Colby, Suteeraporn Pinyakorn, James L K Fletcher, Eugène Kroon, Alexandra Schuetz, Shelly J Krebs, Bonnie M Slike, Louise Leyre, Nicolas Chomont, Linda L Jagodzinski, Irini Sereti, Netanya S Utay, Robin Dewar, Rungsun Rerknimitr, Nitiya Chomchey, Rapee Trichavaroj, Victor G Valcour, Serena Spudich, Nelson L Michael, Merlin L Robb, Nittaya Phanuphak, Jintanat Ananworanich, ,

Background:Many individuals with acute human immunodeficiency virus infection (AHI) experience acute retroviral syndrome (ARS), which is associated with adverse long-term clinical outcomes. Methods:Participants presenting for voluntary human immunodeficiency virus (HIV) testing were enrolled during AHI in Bangkok, Thailand. ARS was defined by ≥3 qualifying signs/symptoms. HIV burden, immunophenotypes, and biomarkers ... Read more >>

Clin Infect Dis (Clinical infectious diseases : an official publication of the Infectious Diseases Society of America)
[2018, 66(10):1540-1549]

Cited: 5 times

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Safety of lumbar puncture procedure in an international research setting during acute HIV infection.

Phillip Chan, Joanna Hellmuth, Donn Colby, Eugene Kroon, Carlo Sacdalan, James Fletcher, Payal Patel, Suteera Pinyakorn, Victor Valcour, Jintanat Ananworanich, Serena Spudich,

<b>Background:</b> Cerebrospinal fluid (CSF) sampling at the time of acute HIV infection (AHI) is crucial in understanding NeuroAIDS pathogenesis. Here, we report on the safety of performing a lumbar puncture (LP) during untreated AHI and follow-up after initiation of combination antiretroviral therapy (cART). <b>Methods:</b> We reviewed clinical records of participants who took ... Read more >>

J Virus Erad (Journal of virus eradication)
[2018, 4(1):16-20]

Cited: 1 time

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Brief Report: Safety of Frequent Blood Sampling in Research Participants in an Acute HIV Infection Cohort in Thailand.

Carlo Sacdalan, Trevor Crowell, Donn Colby, Eugène Kroon, Phillip Chan, Suteeraporn Pinyakorn, Nitiya Chomchey, Peeriya Prueksakaew, Suwanna Puttamaswin, Michelle Chintanaphol, Theresa Cheng, Nittaya Phanuphak, Jintanat Ananworanich,

<h4>Introduction</h4>Anemia is a potential adverse effect of phlebotomy during participation in research. Clinical studies of acute HIV infection (AHI) require frequent phlebotomy to maximize scientific yield, but this participant population may also be at increased risk for anemia and other adverse events.<h4>Objective</h4>The objective of this study was to describe baseline ... Read more >>

J Acquir Immune Defic Syndr (Journal of acquired immune deficiency syndromes (1999))
[2017, 76(1):98-101]

Cited: 1 time

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Virological and immunological characteristics of HIV-infected individuals at the earliest stage of infection.

Jintanat Ananworanich, Carlo P Sacdalan, Suteeraporn Pinyakorn, Nicolas Chomont, Mark de Souza, Tassanee Luekasemsuk, Alexandra Schuetz, Shelly J Krebs, Robin Dewar, Linda Jagodzinski, Sasiwimol Ubolyam, Rapee Trichavaroj, Sodsai Tovanabutra, Serena Spudich, Victor Valcour, Irini Sereti, Nelson Michael, Merlin Robb, Praphan Phanuphak, Jerome H Kim, Nittaya Phanuphak,

<h4>Background</h4>The challenges of identifying acute HIV infection (AHI) have resulted in a lack of critical information on early AHI that constrains the development of therapeutics that are designed to eradicate HIV from the infected host.<h4>Methods</h4>AHI participants were recruited from the Thai Red Cross Anonymous Clinic in Bangkok, Thailand into the ... Read more >>

J Virus Erad (Journal of virus eradication)
[2016, 2:43-48]

Cited: 34 times

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