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Author Carlo Lavalle

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Prevalence and Clinical Implications of COVID-19 Myocarditis

Cristina Chimenti, Michele Magnocavallo, Federico Ballatore, Federico Bernardini, Maria Alfarano, Domenico Giovanni Della Rocca, Paolo Severino, Carlo Lavalle, Fedele Francesco, Andrea Frustaci,

Synopsis The clinical manifestations of COVID-19 are widely variable and may involve several districts. Although the clinical course is mostly characterized by respiratory involvement, up to 30% of hospitalized patients have evidence of myocardial injury due to acute coronary syndrome, cardiac arrhythmias, myocarditis, and cardiogenic shock. In particular, myocarditis is ... Read more >>

Card Electrophysiol Clin (Cardiac electrophysiology clinics)
[2021, :]

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Dual pathway inhibition in atherothrombosis prevention: yes, now we can!

Francesco Summaria, Giuseppe Biondi-Zoccai, Enrico Romagnoli, Mamas A Mamas, Francesco Franchi, Paolo Severino, Carlo Lavalle, Francesco Versaci, Achille Gaspardone, Deepak L Bhatt,

Despite ongoing developments, prevention and treatment of atherothrombotic cardiovascular disease remains a common challenge. Antithrombotic options for cardiocerebrovascular disease prevention involves a choice between dual antiplatelet therapy (DAPT) and dual pathway inhibition (DPI), which includes an antiplatelet agent and a reduced dose anticoagulant agent. In selected patients at high risk ... Read more >>

Minerva Cardiol Angiol (Minerva cardiology and angiology)
[2021, :]

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ECG evaluation in 11 949 Italian teenagers: results of screening in secondary school.

Massimo Mancone, Viviana Maestrini, Antonio Fusto, Francesco Adamo, Paola Scarparo, Alessandra D'Ambrosi, Alessandra Cinque, Maria Chiara Gatto, Nicolò Salvi, Gianluca Agnes, Mariateresa Pucci, Lucia Ilaria Birtolo, Laura Marruncheddu, Igino Genuini, Claudio De Lazzari, Paolo Severino, Giuseppe Giunta, Carlo Lavalle, Danilo Alunni Fegatelli, Annarita Vestri, Francesco Fedele, ,

<h4>Background</h4>There is lack of evidence regarding the screening role of ECG for sudden cardiac death (SCD) prevention.<h4>Objective</h4>To evaluate the prevalence of ECG abnormalities among teenagers according to sport participation and competitive status.<h4>Methods</h4>Eleven thousand nine hundred and forty-nine Italian pupils from 179 secondary schools (13-19 years) were consecutively enrolled. ECG abnormalities were ... Read more >>

J Cardiovasc Med (Hagerstown) (Journal of cardiovascular medicine (Hagerstown, Md.))
[2021, :]

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Sodium-glucose cotransporter 2 inhibitors and heart failure: the best timing for the right patient.

Paolo Severino, Andrea D'Amato, Silvia Prosperi, Bettina Costi, Danilo Angotti, Lucia Ilaria Birtolo, Cristina Chimenti, Carlo Lavalle, Viviana Maestrini, Massimo Mancone, Francesco Fedele,

Sodium-glucose cotransporter 2 inhibitors (SGLT2i), initially born as anti-diabetic drugs, have shown many beneficial effects on the cardiovascular system, in particular against heart failure (HF). HF is a complex and multifaceted disease that requires a comprehensive approach. It should not be considered as a simplistic cardiac disease, but a systemic ... Read more >>

Heart Fail Rev (Heart failure reviews)
[2021, :]

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Half-Dose Direct Oral Anticoagulation Versus Standard Antithrombotic Therapy After Left Atrial Appendage Occlusion.

Domenico G Della Rocca, Michele Magnocavallo, Luigi Di Biase, Sanghamitra Mohanty, Chintan Trivedi, Nicola Tarantino, Carola Gianni, Carlo Lavalle, Christoffel Johannes Van Niekerk, Jorge Romero, David F Briceño, Mohamed Bassiouny, Amin Al-Ahmad, J David Burkhardt, Veronica N Natale, G Joseph Gallinghouse, Armando Del Prete, Giovanni B Forleo, Javier Sanchez, Dhanunjaya Lakkireddy, Rodney P Horton, Douglas N Gibson, Andrea Natale,

<h4>Objectives</h4>This study evaluated the long-term efficacy of a standard antithrombotic strategy versus half-dose direct oral anticoagulation (DOAC) after Watchman implantation.<h4>Background</h4>No consensus currently exists on the selection of the most effective antithrombotic strategy to prevent device-related thrombosis (DRT) in patients undergoing endocardial left atrial appendage closure.<h4>Methods</h4>After successful left atrial appendage closure, ... Read more >>

JACC Cardiovasc Interv (JACC. Cardiovascular interventions)
[2021, 14(21):2353-2364]

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The Practice of Deep Sedation in Electrophysiology and Cardiac Pacing Laboratories: Results of an Italian Survey Promoted by the AIAC (Italian Association of Arrhythmology and Cardiac Pacing).

Pietro Palmisano, Matteo Ziacchi, Andrea Angeletti, Federico Guerra, Giovanni Battista Forleo, Matteo Bertini, Pasquale Notarstefano, Michele Accogli, Carlo Lavalle, Giovanni Bisignani, Maurizio Landolina, Gabriele Zanotto, Antonio D'Onofrio, Renato Pietro Ricci, Roberto De Ponti, Giuseppe Boriani,

The aim of this survey, which was open to all Italian cardiologists involved in arrhythmia, was to assess common practice regarding sedation and analgesia in interventional electrophysiology procedures in Italy. The survey consisted of 28 questions regarding the approach to sedation used for elective direct-current cardioversion (DCC), subcutaneous implantable cardioverter-defibrillator ... Read more >>

J Clin Med (Journal of clinical medicine)
[2021, 10(21):]

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The Practice of Deep Sedation in Electrophysiology and Cardiac Pacing Laboratories: Results of an Italian Survey Promoted by the AIAC (Italian Association of Arrhythmology and Cardiac Pacing)

Pietro Palmisano, Matteo Ziacchi, Andrea Angeletti, Federico Guerra, Giovanni Battista Forleo, Matteo Bertini, Pasquale Notarstefano, Michele Accogli, Carlo Lavalle, Giovanni Bisignani, Maurizio Landolina, Gabriele Zanotto, Antonio D’Onofrio, Renato Pietro Ricci, Roberto De Ponti, Giuseppe Boriani,

The aim of this survey, which was open to all Italian cardiologists involved in arrhythmia, was to assess common practice regarding sedation and analgesia in interventional electrophysiology procedures in Italy. The survey consisted of 28 questions regarding the approach to sedation used for elective direct-current cardioversion (DCC), subcutaneous implantable cardioverter-defibrillator ... Read more >>

J Clin Med (Journal of clinical medicine)
[2021, 10(21):]

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Role of cardiac imaging in patients undergoing catheter ablation of ventricular tachycardia.

Daniele Muser, Carlo Lavalle, Fabrizio Guarracini, Biagio Sassone, Edoardo Conte, Silvia Magnani, Pasquale Notarstefano, Gaetano Barbato, Giuseppe Sgarito, Giuseppe Grandinetti, Gaetano Nucifora, Renato P Ricci, Giuseppe Boriani, Roberto De Ponti, Michela Casella, ,

Ventricular tachycardia is a major health issue in patients with structural heart disease (SHD). Implantable cardioverter defibrillator (ICD) therapy has significantly reduced the risk of sudden cardiac death (SCD) in such patients, but on the other hand, it has led to frequent ICD shocks as an emerging problem, being associated ... Read more >>

J Cardiovasc Med (Hagerstown) (Journal of cardiovascular medicine (Hagerstown, Md.))
[2021, 22(10):727-737]

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Impact of COVID-19 Pandemic on Cardiac Electronic Device Management and Role of Remote Monitoring

Michele Magnocavallo, Giampaolo Vetta, Alessia Bernardini, Agostino Piro, Maria Chiara Mei, Martina Di Iorio, Marco Valerio Mariani, Domenico G. Della Rocca, Paolo Severino, Raffaele Quaglione, Giuseppe Giunta, Cristina Chimenti, Fabio Miraldi, Carmine Dario Vizza, Francesco Fedele, Carlo Lavalle,

Synopsis During the Coronavirus Disease 2019 (COVID-19) worldwide pandemic, patients with cardiac implantable electronic device (CIED) refused scheduled follow-up visits due to the risk of infection. In this scenario, different telemedicine strategies have been implemented to ensure continuity of care to CIED patients. Patients can be monitored through dedicated apps, ... Read more >>

Card Electrophysiol Clin (Cardiac electrophysiology clinics)
[2021, :]

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New evidence of direct oral anticoagulation therapy on cardiac valve calcifications, renal preservation and inflammatory modulation.

Luca Di Lullo, Carlo Lavalle, Michele Magnocavallo, Marco Valerio Mariani, Domenico Giovanni Della Rocca, Paolo Severino, Biagio Raffaele Di Iorio, Domenico Russo, Francesco Summaria, Giovanni Battista Forleo, Claudio Ronco, Massimo Mancone, Cristina Chimenti, Fabio Miraldi, Andrea Natale, Antonio Bellasi,

<h4>Background</h4>Rivaroxaban is a direct inhibitor of activated Factor X (FXa), an anti-inflammatory protein exerting a protective effect on the cardiac valve and vascular endothelium. We compare the effect of Warfarin and Rivaroxaban on inflammation biomarkers and their contribution to heart valve calcification progression and renal preservation in a population of ... Read more >>

Int J Cardiol (International journal of cardiology)
[2021, 345:90-97]

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Direct Oral Anticoagulants in Patients with Obesity and Atrial Fibrillation: Position Paper of Italian National Association of Hospital Cardiologists (ANMCO).

David Mocini, Stefania Angela Di Fusco, Edoardo Mocini, Lorenzo Maria Donini, Carlo Lavalle, Andrea Di Lenarda, Carmine Riccio, Pasquale Caldarola, Leonardo De Luca, Michele Massimo Gulizia, Fabrizio Oliva, Domenico Gabrielli, Furio Colivicchi,

The use of the direct oral anticoagulants dabigatran, rivaroxaban, apixaban and edoxaban (DOACs) offers some major advantages over warfarin and other vitamin K antagonists (VKAs). One advantage is the possibility to use a fixed dose in normal-weight patients, overweight patients and patients with obesity. However, the "one size fits all" ... Read more >>

J Clin Med (Journal of clinical medicine)
[2021, 10(18):]

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Reply to the Editor-High subthreshold pacing impedance from device-lead connection issues.

Carlo Pignalberi, Marco Valerio Mariani, Antonello Castro, Agostino Piro, Barbara Magris, Bruno Albano, Stefano Aquilani, Michele Magnocavallo, Furio Colivicchi, Francesco Fedele, Carlo Lavalle,

Heart Rhythm (Heart rhythm)
[2021, 18(12):2225-2226]

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Targeting non-pulmonary vein triggers in persistent atrial fibrillation: results from a prospective, multicentre, observational registry.

Domenico G Della Rocca, Luigi Di Biase, Sanghamitra Mohanty, Chintan Trivedi, Carola Gianni, Jorge Romero, Nicola Tarantino, Michele Magnocavallo, Mohamed Bassiouny, Veronica N Natale, Angel Quintero Mayedo, Bryan Macdonald, Carlo Lavalle, Ghulam Murtaza, Krishna Akella, Giovanni B Forleo, Amin Al-Ahmad, John David Burkhardt, Gerald Joseph Gallinghouse, Javier E Sanchez, Rodney P Horton, Juan F Viles-Gonzalez, Dhanunjaya Lakkireddy, Andrea Natale,

<h4>Aims</h4>We evaluated the efficacy of an ablation strategy empirically targeting pulmonary veins (PVs) and posterior wall (PW) and the prevalence and clinical impact of extrapulmonary trigger inducibility and ablation in a large cohort of patients with persistent atrial fibrillation (PerAF).<h4>Methods and results</h4>A total of 1803 PerAF patients were prospectively enrolled. ... Read more >>

Europace (Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology)
[2021, :]

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Potential Role of eNOS Genetic Variants in Ischemic Heart Disease Susceptibility and Clinical Presentation.

Paolo Severino, Andrea D'Amato, Silvia Prosperi, Michele Magnocavallo, Marco Valerio Mariani, Lucrezia Netti, Lucia Ilaria Birtolo, Paolo De Orchi, Cristina Chimenti, Viviana Maestrini, Fabio Miraldi, Carlo Lavalle, Viviana Caputo, Raffaele Palmirotta, Massimo Mancone, Francesco Fedele,

<b>Background:</b> IHD is determined by an inadequate coronary blood supply to the myocardium, and endothelial dysfunction may represent one of the main pathophysiological mechanisms involved. Genetic predisposition to endothelial dysfunction has been associated with IHD and its clinical manifestation. However, studies are often confounding and inconclusive for several reasons, such ... Read more >>

J Cardiovasc Dev Dis (Journal of cardiovascular development and disease)
[2021, 8(9):]

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Flecainide in Ventricular Arrhythmias: From Old Myths to New Perspectives.

Carlo Lavalle, Sara Trivigno, Giampaolo Vetta, Michele Magnocavallo, Marco Valerio Mariani, Luca Santini, Giovanni Battista Forleo, Massimo Grimaldi, Roberto Badagliacca, Luigi Lanata, Renato Pietro Ricci,

Flecainide is an IC antiarrhythmic drug (AAD) that received in 1984 Food and Drug Administration approval for the treatment of sustained ventricular tachycardia (VT) and subsequently for rhythm control of atrial fibrillation (AF). Currently, flecainide is mainly employed for sinus rhythm maintenance in AF and the treatment of idiopathic ventricular ... Read more >>

J Clin Med (Journal of clinical medicine)
[2021, 10(16):]

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Clinical presentation, diagnosis, and treatment of atrioesophageal fistula resulting from atrial fibrillation ablation.

Domenico G Della Rocca, Michele Magnocavallo, Veronica N Natale, Carola Gianni, Sanghamitra Mohanty, Chintan Trivedi, Carlo Lavalle, Giovanni B Forleo, Nicola Tarantino, Jorge Romero, Xiadong Zhang, Mohamed Bassiouny, Amin Al-Ahmad, David J Burkhardt, Joseph G Gallinghouse, Javier E Sanchez, Rodney P Horton, Luigi Di Biase, Andrea Natale,

<h4>Background</h4>Atrioesophageal fistula (AEF) is a worrisome complication of atrial fibrillation (AF) ablation. Its clinical manifestations and time course are unpredictable and may contribute to diagnostic and treatment delays. We conducted a systematic review of all available cases of AEF, aiming at characterizing clinical presentation, time course, diagnostic pitfalls, and outcomes.<h4>Methods</h4>The ... Read more >>

J Cardiovasc Electrophysiol (Journal of cardiovascular electrophysiology)
[2021, 32(9):2441-2450]

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Clinical management of electrical storm: a current overview.

Fabrizio Guarracini, Michela Casella, Daniele Muser, Gaetano Barbato, Pasquale Notarstefano, Giuseppe Sgarito, Massimiliano Marini, Giuseppe Grandinetti, Marco V Mariani, Giuseppe Boriani, Renato P Ricci, Roberto De Ponti, Carlo Lavalle, ,

The number of patients affected by electrical storm has been continuously increasing in emergency departments. Patients are often affected by multiple comorbidities requiring multidisciplinary interventions to achieve a clinical stability. Careful reprogramming of cardiac devices, correction of electrolyte imbalance, knowledge of underlying heart disease and antiarrhythmic drugs in the acute ... Read more >>

J Cardiovasc Med (Hagerstown) (Journal of cardiovascular medicine (Hagerstown, Md.))
[2021, 22(9):669-679]

Cited: 1 time

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Direct oral anticoagulants and chronic kidney disease: it is time to be brave.

Marco Valerio Mariani, Luca Di Lullo, Carlo Lavalle,

J Nephrol (Journal of nephrology)
[2021, 34(5):1419-1420]

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Myocardial Tissue Characterization in Heart Failure with Preserved Ejection Fraction: From Histopathology and Cardiac Magnetic Resonance Findings to Therapeutic Targets.

Paolo Severino, Andrea D'Amato, Silvia Prosperi, Francesca Fanisio, Lucia Ilaria Birtolo, Bettina Costi, Lucrezia Netti, Cristina Chimenti, Carlo Lavalle, Viviana Maestrini, Massimo Mancone, Francesco Fedele,

Heart failure with preserved ejection fraction (HFpEF) is a complex clinical syndrome responsible for high mortality and morbidity rates. It has an ever growing social and economic impact and a deeper knowledge of molecular and pathophysiological basis is essential for the ideal management of HFpEF patients. The association between HFpEF ... Read more >>

Int J Mol Sci (International journal of molecular sciences)
[2021, 22(14):]

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Long-term complications in patients implanted with subcutaneous implantable cardioverter-defibrillators: Real-world data from the extended ELISIR experience.

Alessio Gasperetti, Marco Schiavone, Matteo Ziacchi, Julia Vogler, Alexander Breitenstein, Mikael Laredo, Pietro Palmisano, Danilo Ricciardi, Gianfranco Mitacchione, Paolo Compagnucci, Antonio Bisignani, Andrea Angeletti, Michela Casella, Francesco Picarelli, Thomas Fink, Lukas Kaiser, Samer Hakmi, Leonardò Calò, Carlo Pignalberi, Luca Santini, Carlo Lavalle, Ennio Pisanò, Iacopo Olivotto, Claudio Tondo, Antonio Curnis, Antonio Dello Russo, Nicolas Badenco, Jan Steffel, Charles J Love, Roland Tilz, Giovanni Forleo, Mauro Biffi,

<h4>Background</h4>Recently, the Food and Drug Administration issued a recall for the subcutaneous implantable cardioverter-defibrillator (S-ICD) because of the possibility of lead ruptures and accelerated battery depletion.<h4>Objective</h4>The aim of this study was to evaluate device-related complications over time in a large real-world multicenter S-ICD cohort.<h4>Methods</h4>Patients implanted with an S-ICD from January ... Read more >>

Heart Rhythm (Heart rhythm)
[2021, 18(12):2050-2058]

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Cardiac involvement in consecutive unselected hospitalized COVID-19 population: In-hospital evaluation and one-year follow-up.

Viviana Maestrini, Lucia Ilaria Birtolo, Marco Francone, Gioacchino Galardo, Nicola Galea, Paolo Severino, Francesco Alessandri, Maria Chiara Colaiacomo, Giulia Cundari, Cristina Chimenti, Carlo Lavalle, Maria Ciardi, Paolo Palange, Alberto Deales, Gabriella d'Ettorre, Claudio M Mastroianni, Carlo Catalano, Franco Ruberto, Francesco Pugliese, Giulia d'Amati, Francesco Fedele, Massimo Mancone, ,

<h4>Background</h4>Cardiovascular disease (CVD) can occur in COVID-19 and has impact on clinical course. Data on CVD prevalence in hospitalized COVID-19 patients and sequelae in survivors is limited. Aim of this prospective study carried out on consecutive unselected COVID-19 population, was to assess: 1) CVD occurrence among hospitalized COVID-19 patients, 2) ... Read more >>

Int J Cardiol (International journal of cardiology)
[2021, 339:235-242]

Cited: 3 times

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Incidence of Device-Related Thrombosis in Watchman Patients Undergoing a Genotype-Guided Antithrombotic Strategy.

Domenico G Della Rocca, Rodney P Horton, Luigi Di Biase, Carola Gianni, Chintan Trivedi, Sanghamitra Mohanty, Alisara Anannab, Michele Magnocavallo, Qiong Chen, Nicola Tarantino, Mohamed Bassiouny, Carlo Lavalle, Veronica N Natale, Giovanni B Forleo, Armando Del Prete, Christoffel Johannes Van Niekerk, Amin Al-Ahmad, J David Burkhardt, G Joseph Gallinghouse, Javier E Sanchez, Dhanunjaya Lakkireddy, Douglas N Gibson, Andrea Natale,

<h4>Objectives</h4>This study sought to report the incidence of device-related thrombosis (DRT) and thromboembolic (TE) events when an alternative to clopidogrel is prescribed in loss-of-function (LOF) allele carriers of the cytochrome P450 2C19 (CYP2C19) gene.<h4>Background</h4>LOF polymorphisms of the CYP2C19 gene are associated with reduced hepatic bioactivation of clopidogrel.<h4>Methods</h4>One thousand two Watchman ... Read more >>

JACC Clin Electrophysiol (JACC. Clinical electrophysiology)
[2021, :]

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Subcutaneous implantable cardioverter-defibrillator and defibrillation testing: A propensity-matched pilot study.

Giovanni B Forleo, Alessio Gasperetti, Alexander Breitenstein, Mikael Laredo, Marco Schiavone, Matteo Ziacchi, Julia Vogler, Danilo Ricciardi, Pietro Palmisano, Agostino Piro, Paolo Compagnucci, Xavier Waintraub, Gianfranco Mitacchione, Gianmarco Carrassa, Giulia Russo, Silvana De Bonis, Andrea Angeletti, Antonio Bisignani, Francesco Picarelli, Michela Casella, Edoardo Bressi, Giovanni Rovaris, Leonardo Calò, Luca Santini, Carlo Pignalberi, Carlo Lavalle, Maurizio Viecca, Ennio Pisanò, Iacopo Olivotto, Antonio Curnis, Antonio Dello Russo, Claudio Tondo, Charles J Love, Luigi Di Biase, Jan Steffel, Roland Tilz, Nicolas Badenco, Mauro Biffi,

<h4>Background</h4>To date, only a few comparisons between subcutaneous implantable cardioverter-defibrillator (S-ICD) patients undergoing and those not undergoing defibrillation testing (DT) at implantation (DT+ vs DT-) have been reported.<h4>Objective</h4>The purpose of this study was to compare long-term clinical outcomes of 2 propensity-matched cohorts of DT+ and DT- patients.<h4>Methods</h4>Among consecutive S-ICD patients ... Read more >>

Heart Rhythm (Heart rhythm)
[2021, 18(12):2072-2079]

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Radiofrequency Energy Applications Targeting Significant Residual Leaks After Watchman Implantation: A Prospective, Multicenter Experience.

Domenico G Della Rocca, Ghulam Murtaza, Luigi Di Biase, Krishna Akella, Subramaniam C Krishnan, Michele Magnocavallo, Sanghamitra Mohanty, Carola Gianni, Chintan Trivedi, Carlo Lavalle, Giovanni B Forleo, Veronica N Natale, Nicola Tarantino, Jorge Romero, Rakesh Gopinathannair, Philip J Patel, Mohamed Bassiouny, Armando Del Prete, Amin Al-Ahmad, J David Burkhardt, G Joseph Gallinghouse, Javier E Sanchez, Shephal K Doshi, Rodney P Horton, Dhanunjaya Lakkireddy, Andrea Natale,

<h4>Objectives</h4>The aim of this study was to evaluate the efficacy of radiofrequency (RF) energy applications targeting the atrial side of a significant residual leak in patients with acute and chronic evidence of incomplete percutaneous left atrial appendage (LAA) occlusion.<h4>Background</h4>RF applications have been proved to prevent recanalization of intracranial aneurysms after ... Read more >>

JACC Clin Electrophysiol (JACC. Clinical electrophysiology)
[2021, :]

Cited: 1 time

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Home delivery of the communicator for remote monitoring of cardiac implantable devices: A multicenter experience during the covid-19 lockdown.

Michele Magnocavallo, Alessia Bernardini, Marco Valerio Mariani, Agostino Piro, Massimiliano Marini, Antonino Nicosia, Carmen Adduci, Antonio Rapacciuolo, Davide Saporito, Stefano Grossi, Giuseppe Santarpia, Paola Vaccaro, Roberto Rordorf, Francesco Pentimalli, Giuseppe Giunta, Monica Campari, Sergio Valsecchi, Carlo Lavalle,

<h4>Background</h4>During the COVID-19 pandemic in-person visits for patients with cardiac implantable electronic devices should be replaced by remote monitoring (RM), in order to prevent viral transmission. A direct home-delivery service of the RM communicator has been implemented at 49 Italian arrhythmia centers.<h4>Methods</h4>According to individual patient preference or the organizational decision ... Read more >>

Pacing Clin Electrophysiol (Pacing and clinical electrophysiology : PACE)
[2021, 44(6):995-1003]

Cited: 3 times

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