Full Text Journal Articles by
Author Carlo Giaquinto

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Acute infectious osteomyelitis in children: new treatment strategies for an old enemy.

Sabrina Congedi, Chiara Minotti, Carlo Giaquinto, Liviana Da Dalt, Daniele Donà,

BACKGROUND:Acute osteomyelitis still represents a significant clinical challenge, with an increasing incidence in paediatric population. A careful assessment and a rapid diagnosis with proper timing and choice of empirical antimicrobial therapy are necessary to avoid sequelae. The initial treatment should consist of empirical antibiotic therapy, to cover the major responsible ... Read more >>

World J Pediatr (World journal of pediatrics : WJP)
[2020, :]

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Clinical Outcomes of a Zika Virus Mother-Child Pair Cohort in Spain.

Antoni Soriano-Arandes, Marie Antoinette Frick, Milagros García López-Hortelano, Elena Sulleiro, Carlota Rodó, María Paz Sánchez-Seco, Marta Cabrera-Lafuente, Anna Suy, María De la Calle, Mar Santos, Eugenia Antolin, María Del Carmen Viñuela, María Espiau, Ainara Salazar, Borja Guarch-Ibáñez, Ana Vázquez, Juan Navarro-Morón, José-Tomás Ramos-Amador, Andrea Martin-Nalda, Eva Dueñas, Daniel Blázquez-Gamero, Resurrección Reques-Cosme, Iciar Olabarrieta, Luis Prieto, Fernando De Ory, Claire Thorne, Thomas Byrne, Anthony E Ades, Elisa Ruiz-Burga, Carlo Giaquinto, María José Mellado-Peña, Alfredo García-Alix, Elena Carreras, Pere Soler-Palacín,

BACKGROUND:Zika virus (ZIKV) infection has been associated with congenital microcephaly and other neurodevelopmental abnormalities. There is little published research on the effect of maternal ZIKV infection in a non-endemic European region. We aimed to describe the outcomes of pregnant travelers diagnosed as ZIKV-infected in Spain, and their exposed children. METHODS:This ... Read more >>

Pathogens (Pathogens (Basel, Switzerland))
[2020, 9(5):]

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Use of Machine Learning Techniques for Case-Detection of Varicella Zoster Using Routinely Collected Textual Ambulatory Records: Pilot Observational Study.

Corrado Lanera, Paola Berchialla, Ileana Baldi, Giulia Lorenzoni, Lara Tramontan, Antonio Scamarcia, Luigi Cantarutti, Carlo Giaquinto, Dario Gregori,

BACKGROUND:The detection of infectious diseases through the analysis of free text on electronic health reports (EHRs) can provide prompt and accurate background information for the implementation of preventative measures, such as advertising and monitoring the effectiveness of vaccination campaigns. OBJECTIVE:The purpose of this paper is to compare machine learning techniques ... Read more >>

JMIR Med Inform (JMIR medical informatics)
[2020, 8(5):e14330]

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How is immunosuppressive status affecting children and adults in SARS-CoV-2 infection? A systematic review.

Chiara Minotti, Francesca Tirelli, Elisa Barbieri, Carlo Giaquinto, Daniele Donà,

OBJECTIVES:SARS-CoV-2 infection has now a global resonance. Data on how COVID-19 is affecting immunocompromised patients are however few. With our study we aimed to systematically review the current knowledge on SARS-CoV-2 cases in children and adults with immunosuppression, to evaluate outcomes in this special population. METHODS:A systematic review of literature ... Read more >>

J. Infect. (The Journal of Infection)
[2020, :]

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An optimised dosing regimen versus a standard dosing regimen of vancomycin for the treatment of late onset sepsis due to Gram-positive microorganisms in neonates and infants aged less than 90 days (NeoVanc): study protocol for a randomised controlled trial.

Louise F Hill, Mark A Turner, Irja Lutsar, Paul T Heath, Pollyanna Hardy, Louise Linsell, Evelyne Jacqz-Aigrain, Emmanuel Roilides, Mike Sharland, ,

BACKGROUND:Vancomycin has been used in clinical practice for over 50 years; however, validated, pharmacokinetic (PK) data relating clinical outcomes to different dosing regimens in neonates are lacking. Coagulase negative staphylococci (CoNS) are the most commonly isolated organisms in neonatal, late-onset sepsis (LOS). Optimised use to maximise efficacy while minimising toxicity ... Read more >>

Trials (Trials)
[2020, 21(1):329]

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FECAL-ORAL TRANSMISSION OF SARS-COV-2 IN CHILDREN: IS IT TIME TO CHANGE OUR APPROACH?

Daniele Donà, Chiara Minotti, Paola Costenaro, Liviana Da Dalt, Carlo Giaquinto,

Starting from 2 pediatric cases of COVID-19, with confirmation at nasopharyngeal and rectal swabs, we considered the lesson learnt from previous Coronavirus epidemics and reviewed evidence on the current outbreak. Surveillance with rectal swabs might be extended to infants and children, for the implications for household contacts and isolation timing. ... Read more >>

Pediatr. Infect. Dis. J. (The Pediatric infectious disease journal)
[2020, :]

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High proportion of unknown HIV exposure status among children aged less than 2 years: An analytical study using the 2015 National AIDS Indicator Survey in Mozambique.

Maria Grazia Lain, Sergio Chicumbe, Aleny Couto, Esmeralda Karajeanes, Carlo Giaquinto, Paula Vaz,

Determination of the human immunodeficiency virus (HIV) exposure status in infants and young children is required to guarantee timely diagnosis and access to appropriate care. HIV prevalence among Mozambican women aged 15-49 years is 15%, and vertical transmission rate is still high. The study investigated HIV exposure in children aged ... Read more >>

PLoS ONE (PloS one)
[2020, 15(4):e0231143]

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Multinational cohort study of mortality in patients with asthma and severe asthma.

Marjolein Engelkes, Maria Aj de Ridder, Elisabeth Svensson, Klara Berencsi, Daniel Prieto-Alhambra, Francesco Lapi, Carlo Giaquinto, Gino Picelli, Nada Boudiaf, Frank C Albers, Sarah M Cockle, Eric S Bradford, Robert Y Suruki, Guy Go Brusselle, Peter R Rijnbeek, Miriam Cjm Sturkenboom, Katia Mc Verhamme,

BACKGROUND:Data on the risk of death following an asthma exacerbation are scarce. With this multinational cohort study, we assessed all-cause mortality rates, mortality rates following an exacerbation, and patient characteristics associated with all-cause mortality in asthma. METHODS:Asthma patients aged ≥18 years and with ≥1 year of follow-up were identified in ... Read more >>

Respir Med (Respiratory medicine)
[2020, 165:105919]

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Immunological and Inflammatory Biomarkers of Susceptibility and Severity in Adult Respiratory Syncytial Virus Infections.

Dexter J Wiseman, Ryan S Thwaites, Simon B Drysdale, Sophie Janet, Gavin C Donaldson, Jadwiga A Wedzicha, Peter J Openshaw, ,

BACKGROUND:. Respiratory syncytial virus (RSV) is the most common cause of bronchiolitis in young infants. However, it is also a significant pathogen in older adults. Validated biomarkers of RSV disease severity would benefit diagnostics, treatment decisions, and prophylactic interventions. This review summarizes knowledge of biomarkers for RSV disease in adults. ... Read more >>

J. Infect. Dis. (The Journal of infectious diseases)
[2020, :]

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Low Sensitivity of BinaxNOW RSV in Infants.

Roy P Zuurbier, Louis J Bont, Annefleur C Langedijk, Mirjam Hamer, Koos Korsten, Simon B Drysdale, Matthew D Snape, Hannah Robinson, Andrew J Pollard, Federico Martinón-Torres, Carmen Rodríguez-Tenreiro Sánchez, Alberto Gómez-Carballa, Ana Isabel Dacosta-Urbieta, Terho Heikkinen, Steve Cunningham, Marlies A van Houten, Joanne G Wildenbeest, ,

BACKGROUND:Respiratory syncytial virus (RSV) is a major cause of hospitalization in infants. Early detection of RSV can optimize clinical management and minimize use of antibiotics. BinaxNOW RSV (BN) is a rapid antigen detection test that is widely used. We aimed to validate the sensitivity of BN in hospitalized and nonhospitalized ... Read more >>

J. Infect. Dis. (The Journal of infectious diseases)
[2020, :]

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Cost of Respiratory Syncytial Virus-Associated Acute Lower Respiratory Infection Management in Young Children at the Regional and Global Level: A Systematic Review and Meta-Analysis.

Shanshan Zhang, Lily Zainal Akmar, Freddie Bailey, Barbara A Rath, Maren Alchikh, Brunhilde Schweiger, Marilla G Lucero, Leilani T Nillos, Moe H Kyaw, Alexia Kieffer, Sabine Tong, Harry Campbell, Philippe Beutels, Harish Nair, ,

BACKGROUND:Respiratory syncytial virus (RSV) is a major cause of acute lower respiratory infection (ALRI) in young children aged <5 years. METHODS:We aimed to identify the global inpatient and outpatient cost of management of RSV-ALRI in young children to assist health policy makers in making decisions related to resource allocation for ... Read more >>

J. Infect. Dis. (The Journal of infectious diseases)
[2020, :]

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Outcomes of second-line antiretroviral therapy among children living with HIV: a global cohort analysis.

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INTRODUCTION:Limited data describe outcomes on second-line antiretroviral therapy (ART) among children globally. Our objective was to contribute data on outcomes among children living with HIV after initiation of second-line ART in the context of routine care within a large global cohort collaboration. METHODS:Patient-level data from 1993 through 2015 from 11 ... Read more >>

J Int AIDS Soc (Journal of the International AIDS Society)
[2020, 23(4):e25477]

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Meropenem vs standard of care for treatment of neonatal late onset sepsis (NeoMero1): A randomised controlled trial.

Irja Lutsar, Corine Chazallon, Ursula Trafojer, Vincent Meiffredy de Cabre, Cinzia Auriti, Chiara Bertaina, Francesca Ippolita Calo Carducci, Fuat Emre Canpolat, Susanna Esposito, Isabelle Fournier, Maarja Hallik, Paul T Heath, Mari-Liis Ilmoja, Elias Iosifidis, Jelena Kuznetsova, Laurence Meyer, Tuuli Metsvaht, George Mitsiakos, Zoi Dorothea Pana, Fabio Mosca, Lorenza Pugni, Emmanuel Roilides, Paolo Rossi, Kosmas Sarafidis, Laura Sanchez, Michael Sharland, Vytautas Usonis, Adilia Warris, Jean-Pierre Aboulker, Carlo Giaquinto, ,

BACKGROUND:The early use of broad-spectrum antibiotics remains the cornerstone for the treatment of neonatal late onset sepsis (LOS). However, which antibiotics should be used is still debatable, as relevant studies were conducted more than 20 years ago, recruited in single centres or countries, evaluated antibiotics not in clinical use anymore ... Read more >>

PLoS ONE (PloS one)
[2020, 15(3):e0229380]

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Incidence, risk factors and re-exacerbation rate of severe asthma exacerbations in a multinational, multidatabase pediatric cohort study.

Marjolein Engelkes, Esme J Baan, Maria A J de Ridder, Elisabeth Svensson, Daniel Prieto-Alhambra, Francesco Lapi, Carlo Giaquinto, Gino Picelli, Nada Boudiaf, Frank Albers, Lee A Evitt, Sarah Cockle, Eric Bradford, Melissa K Van Dyke, Robert Suruki, Peter Rijnbeek, Miriam C J M Sturkenboom, Hettie M Janssens, Katia M C Verhamme,

BACKGROUND:There are sparse real-world data on severe asthma exacerbations (SAE) in children. This multinational cohort study assessed the incidence of and risk factors for SAE and the incidence of asthma-related rehospitalization in children with asthma. METHODS:Asthma patients 5-17 years old with ≥1 year of follow-up were identified in six European electronic databases ... Read more >>

Pediatr Allergy Immunol (Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology)
[2020, :]

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Researching Zika in pregnancy: lessons for global preparedness.

A E Ades, Claire Thorne, Antoni Soriano-Arandes, Catherine S Peckham, David W Brown, Daniel Lang, J Glenn Morris, Celia D C Christie, Carlo Giaquinto,

Our understanding of congenital infections is based on prospective studies of women infected during pregnancy. The EU has funded three consortia to study Zika virus, each including a prospective study of pregnant women. Another multi-centre study has been funded by the US National Institutes of Health. This Personal View describes ... Read more >>

Lancet Infect Dis (The Lancet. Infectious diseases)
[2020, 20(4):e61-e68]

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Preventing recurrent acute otitis media with Streptococcus salivarius 24SMB and Streptococcus oralis 89a five months intermittent treatment: An observational prospective cohort study.

Anna Cantarutti, Federico Rea, Daniele Donà, Luigi Cantarutti, Andrea Passarella, Antonio Scamarcia, Rebecca Lundin, Valerio Damiani, Carlo Giaquinto, Giovanni Corrao,

INTRODUCTION:Acute otitis media (AOM) is the most common childhood disease leading to antibiotic use. More than 80% of children under three years of age experience at least one episode, and about one-third of these report significant recurrence of episodes. In recent years, several studies reported that normal nasopharyngeal flora inhibits ... Read more >>

Int. J. Pediatr. Otorhinolaryngol. (International journal of pediatric otorhinolaryngology)
[2020, 132:109921]

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Prevalence and Clinical Outcomes of Poor Immune Response Despite Virologically Suppressive Antiretroviral Therapy Among Children and Adolescents With Human Immunodeficiency Virus in Europe and Thailand: Cohort Study.

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BACKGROUND:In human immunodeficiency virus (HIV)-positive adults, low CD4 cell counts despite fully suppressed HIV-1 RNA on antiretroviral therapy (ART) have been associated with increased risk of morbidity and mortality. We assessed the prevalence and outcomes of poor immune response (PIR) in children receiving suppressive ART. METHODS:Sixteen cohorts from the European ... Read more >>

Clin. Infect. Dis. (Clinical infectious diseases : an official publication of the Infectious Diseases Society of America)
[2020, 70(3):404-415]

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Standardising neonatal and paediatric antibiotic clinical trial design and conduct: the PENTA-ID network view.

Laura Folgori, Irja Lutsar, Joseph F Standing, A Sarah Walker, Emmanuel Roilides, Theoklis E Zaoutis, Hasan Jafri, Carlo Giaquinto, Mark A Turner, Mike Sharland,

Antimicrobial development for children remains challenging due to multiple barriers to conducting randomised clinical trials (CTs). There is currently considerable heterogeneity in the design and conduct of paediatric antibiotic studies, hampering comparison and meta-analytic approaches. The board of the European networks for paediatric research at the European Medicines Agency (EMA), ... Read more >>

BMJ Open (BMJ open)
[2019, 9(12):e032592]

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Respiratory Syncytial Virus-Associated Acute Lower Respiratory Infections in Children With Bronchopulmonary Dysplasia: Systematic Review and Meta-Analysis.

Pa Saidou Chaw, Lei Hua, Steve Cunningham, Harry Campbell, Rafael Mikolajczyk, Harish Nair, ,

BACKGROUND:Respiratory syncytial virus (RSV) is among the most important causes of acute lower respiratory tract infection (ALRI) in young children. We assessed the severity of RSV-ALRI in children less than 5 years old with bronchopulmonary dysplasia (BPD). METHODS:We searched for studies using EMBASE, Global Health, and MEDLINE. We assessed hospitalization ... Read more >>

J. Infect. Dis. (The Journal of infectious diseases)
[2019, :]

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Reduced Time to Suppression Among Neonates With HIV Initiating Antiretroviral Therapy Within 7 Days After Birth.

Sara Domínguez-Rodríguez, Alfredo Tagarro, Paolo Palma, Caroline Foster, Thanyawee Puthanakit, Thidarat Jupimai, Nicola Cotugno, Jintanat Ananworanich, Paola Zangari, Eleni Nastouli, María Ángeles Muñoz-Fernández, María Luisa Navarro, Carlo Giaquinto, Paolo Rossi, Louise Kuhn, Pablo Rojo,

There are limited data on infants with HIV starting antiretroviral therapy (ART) in the neonatal period. We investigated the association between the timing of ART initiation and time-to-suppression among infants who tested HIV-positive and initiated ART within the first 28 days of life. The effect was estimated using cumulative probability ... Read more >>

J. Acquir. Immune Defic. Syndr. (Journal of acquired immune deficiency syndromes (1999))
[2019, 82(5):483-490]

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Human Immunodeficiency Virus (HIV)-Antibody Repertoire Estimates Reservoir Size and Time of Antiretroviral Therapy Initiation in Virally Suppressed Perinatally HIV-Infected Children.

Salvatore Rocca, Paola Zangari, Nicola Cotugno, Anita De Rossi, Bridget Ferns, Davide Petricone, Stefano Rinaldi, Carlo Giaquinto, Stefania Bernardi, Pablo Rojo, Paolo Rossi, Savita Pahwa, Eleni Nastouli, Paolo Palma, ,

BACKGROUND:Assays to estimate human immunodeficiency virus (HIV) reservoir size require large amounts of blood, which represents a drawback especially in pediatric settings. We investigated whether HIV-antibody repertoire could estimate the viral reservoir size. Moreover, we assessed the magnitude of HIV-antibody response as a predictor of time of antiretroviral therapy (ART) ... Read more >>

J Pediatric Infect Dis Soc (Journal of the Pediatric Infectious Diseases Society)
[2019, 8(5):433-438]

Cited: 2 times

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Association Between Respiratory Syncytial Virus-Associated Acute Lower Respiratory Infection in Early Life and Recurrent Wheeze and Asthma in Later Childhood.

Ting Shi, Yujing Ooi, Ei Mon Zaw, Natasa Utjesanovic, Harry Campbell, Steve Cunningham, Louis Bont, Harish Nair, ,

BACKGROUND:Recurrent wheeze and asthma in childhood are commons causes of chronic respiratory morbidity globally. We aimed to explore the association between respiratory syncytial virus (RSV) infection in early life and subsequent respiratory sequelae up to age 12 years. METHODS:We estimated the strength of association by 3 control groups and 3 ... Read more >>

J. Infect. Dis. (The Journal of infectious diseases)
[2019, :]

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The challenge of the laboratory diagnosis in a confirmed congenital Zika virus syndrome in utero: A case report.

Elena Sulleiro, Marie Antoinette Frick, Carlota Rodó, Mateu Espasa, Claire Thorne, María Espiau, Andrea Martín-Nalda, Anna Suy, Carlo Giaquinto, Susana Melendo, Ariadna Rando, Ana Alarcón, Federico Martinón-Torres, Tomás Pumarola, Pere Soler-Palacín, Antoni Soriano-Arandes,

INTRODUCTION:Zika virus (ZIKV) has caused one of the most challenging global infectious epidemics in recent years because of its causal association with severe microcephaly and other congenital malformations. The diagnosis of viral infections usually relies on the detection of virus proteins or genetic material in clinical samples as well as ... Read more >>

Medicine (Baltimore) (Medicine)
[2019, 98(20):e15532]

Cited: 1 time

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Treatment and monitoring of children with chronic hepatitis C in the Pre-DAA era: A European survey of 38 paediatric specialists.

Giuseppe Indolfi, Heather Bailey, Daniele Serranti, Carlo Giaquinto, Claire Thorne, ,

The burden of paediatric Hepatitis C virus (HCV) infection across Europe is unknown, as are current policies regarding monitoring and treatment. This collaborative study aimed to collect aggregate data to characterise the population of ≤18-year-olds with HCV infection in specialist follow up in a 12-month period (2016) across the PENTAHep ... Read more >>

J. Viral Hepat. (Journal of viral hepatitis)
[2019, 26(8):961-968]

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Hepatitis C virus infection in children and adolescents.

Giuseppe Indolfi, Philippa Easterbrook, Geoffrey Dusheiko, Manal H El-Sayed, Maureen M Jonas, Claire Thorne, Marc Bulterys, George Siberry, Nick Walsh, Mei-Hwei Chang, Tammy Meyers, Carlo Giaquinto, Stefan Wirth, Po-Lin Chan, Martina Penazzato,

Hepatitis C virus (HCV) infection is a major cause of chronic liver disease and associated morbidity and mortality worldwide. Short-course, oral, curative, direct-acting antiviral regimens have transformed treatment for HCV infection. Since the 2016 launch of the first global strategy towards elimination of viral hepatitis as a public health threat ... Read more >>

Lancet Gastroenterol Hepatol (The lancet. Gastroenterology & hepatology)
[2019, 4(6):477-487]

Cited: 1 time

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