Full Text Journal Articles by
Author Carlo Caffarelli

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COVID-19 and food allergy in children.

Enza D'Auria, Caterina Anania, Barbara Cuomo, Fabio Decimo, Giovanni Cosimo Indirli, Violetta Mastrorilli, Angelica Santoro, Marco U A Sartorio, Elisabetta Veronelli, Carlo Caffarelli, Gian Luigi Marseglia, Mauro Calvani, The Italian Society Of Pediatric Allergy And Immunology Siaip Food Allergy Study Group,

In children with food allergy the visits should be limited to those that are unequivocally needed on clinical basis. Food challenge can be performed in selected situations, taking a more detailed history to make sure that patients provide whatever information we need. The maintenance of a safe diet can be ... Read more >>

Acta Biomed (Acta bio-medica : Atenei Parmensis)
[2020, 91(2):204-206]

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Preschool Wheezing: Trajectories and Long-Term Treatment.

Valentina Fainardi, Angelica Santoro, Carlo Caffarelli,

Wheezing is very common in infancy affecting one in three children during the first 3 years of life. Several wheeze phenotypes have been identified and most rely on temporal pattern of symptoms. Assessing the risk of asthma development is difficult. Factors predisposing to onset and persistence of wheezing such as ... Read more >>

Front Pediatr (Frontiers in pediatrics)
[2020, 8:240]

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COVID19: potential cardiovascular issues in pediatric patients.

Deborah Bertoncelli, Marta Guidarini, Anna Della Greca, Chiara Ratti, Francesca Falcinella, Brunella Iovane, Mauro Luigi Dutto, Carlo Caffarelli, Bertrand Tchana,

The novel severe acute respiratory syndrome coronavirus 2 (SARS-COV 2) has rapidly spread worldwide with increasing hospitalization and mortality rate. Ongoing studies and accumulated data are de- tailing the features and the effects of the new coronavirus disease 19 (COVID 19) in the adult population, and cardiovascular involvement is emerging ... Read more >>

Acta Biomed (Acta bio-medica : Atenei Parmensis)
[2020, 91(2):177-183]

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Preschool Wheezing: Trajectories and Long-Term Treatment.

Valentina Fainardi, Angelica Santoro, Carlo Caffarelli,

Wheezing is very common in infancy affecting one in three children during the first 3 years of life. Several wheeze phenotypes have been identified and most rely on temporal pattern of symptoms. Assessing the risk of asthma development is difficult. Factors predisposing to onset and persistence of wheezing such as ... Read more >>

Front Pediatr (Frontiers in pediatrics)
[2020, 8:]

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Hypersensitivity Reactions to Monoclonal Antibodies in Children.

Francesca Mori, Francesca Saretta, Annamaria Bianchi, Giuseppe Crisafulli, Silvia Caimmi, Lucia Liotti, Paolo Bottau, Fabrizio Franceschini, Claudia Paglialunga, Giampaolo Ricci, Angelica Santoro, Carlo Caffarelli,

Biologic drugs are widely used in pediatric medicine. Monoclonal antibodies (mAbs) in particular are a therapeutic option for rheumatic, autoinflammatory and oncologic diseases. Adverse drug reactions and hypersensitivity reactions (HSR) to mAbs may occur in children. Clinical presentation of HSRs to mAbs can be classified according to phenotypes in infusion-related ... Read more >>

Medicina (Kaunas) (Medicina (Kaunas, Lithuania))
[2020, 56(5):]

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An unusual cause of Steven-Johnson Syndrome.

Claudia De Guido, Adriana Calderaro, Maria Beatrice Ruozi, Valentina Maffini, Margherita Varini, Irene Lapetina, Monica Rubini, Sara Montecchini, Carlo Caffarelli, Icilio Dodi,

SJS is a rare mucocutaneous syndrome characterized by skin and mucous detachment. The main etiological factors are drugs and infections; sometimes the cause remains unknown. In the prodromal phase we observed non-specific symptoms, followed by mucocutaneous manifestation. Due to risk of complications and mortality a multidisciplinary approach is needed.  We ... Read more >>

Acta Biomed (Acta bio-medica : Atenei Parmensis)
[2020, 91(1):128-131]

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Point-of-care ultrasound (POCUS) in a remote area of Sierra Leone: impact on patient management and training program for community health officers.

Vittorio Sabatino, Maria Rosaria Caramia, Antonietta Curatola, Francesca Vassallo, Andrea Deidda, Bianca Cinicola, Francesco Iodice, Carlo Caffarelli, Nicola Sverzellati, Danilo Buonsenso,

PURPOSE:Point-of-care ultrasound (POCUS) has been shown to have unique potential in low-income countries. Physicians and other healthcare providers can perform effective scans after a short period of training. This study aimed to evaluate indications and utility of ultrasonography as the main imaging service in a poor rural sub-Saharan region of ... Read more >>

J Ultrasound (Journal of ultrasound)
[2020, :]

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Report on advances for pediatricians in 2018: allergy, cardiology, critical care, endocrinology, hereditary metabolic diseases, gastroenterology, infectious diseases, neonatology, nutrition, respiratory tract disorders and surgery.

Carlo Caffarelli, Francesca Santamaria, Carla Mastrorilli, Angelica Santoro, Brunella Iovane, Maddalena Petraroli, Valeria Gaeta, Rosita Di Pinto, Melissa Borrelli, Sergio Bernasconi, Giovanni Corsello,

This review reported notable advances in pediatrics that have been published in 2018. We have highlighted progresses in allergy, cardiology, critical care, endocrinology, hereditary metabolic diseases, gastroenterology, infectious diseases, neonatology, nutrition, respiratory tract disorders and surgery. Many studies have informed on epidemiologic observations. Promising outcomes in prevention, diagnosis and treatment ... Read more >>

Ital J Pediatr (Italian journal of pediatrics)
[2019, 45(1):126]

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Allergen-specific Immunotherapy for Inhalant Allergens in Children

Carlo Caffarelli, Jessica Cangemi, Carla Mastrorilli, Arianna Giannetti, Giampaolo Ricci,

Allergen-specific immunotherapy (AIT) for aeroallergens consists of the administration of standardized allergen extracts to patients with respiratory IgE-mediated diseases to the same allergen in order to achieve immune tolerance to the allergen and prevent the onset of symptoms. AIT is usually delivered by sublingual (SLIT), subcutaneous (SCIT) route. AIT with one or multiple allergens ... Read more >>

Curr Pediatr Rev (Current pediatric reviews)
[2019, :]

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Pollen-Food Allergy Syndrome: A not so Rare Disease in Childhood.

Carla Mastrorilli, Fabio Cardinale, Arianna Giannetti, Carlo Caffarelli,

Seasonal allergic rhinoconjunctivitis (SAR) affects millions of people worldwide, particularly in childhood and adolescence. Pollen food allergy syndrome (PFAS) is a common adverse reaction occurring few minutes after the consumption of vegetable foods in patients with pollen-induced SAR. PFAS has rarely been investigated in the pediatric population, as it has ... Read more >>

Medicina (Kaunas) (Medicina (Kaunas, Lithuania))
[2019, 55(10):]

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Hazardous Medications in Children with Egg, Red Meat, Gelatin, Fish, and Cow's Milk Allergy.

Sule Caglayan-Sozmen, Angelica Santoro, Francesca Cipriani, Carla Mastrorilli, Giampaolo Ricci, Carlo Caffarelli,

Childhood food allergies are a growing public health problem. Once the offending food allergens have been identified, a strict elimination diet is necessary in treatment or prevention of most of the allergic reactions. Accidental food ingestion can lead to severe anaphylaxis. Food- derived substances can be used in medications at ... Read more >>

Medicina (Kaunas) (Medicina (Kaunas, Lithuania))
[2019, 55(8):]

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The practical clinical relevance of rhinitis classification in children with asthma: outcomes of the "ControL'Asma" study.

Maria Angela Tosca, Marzia Duse, Gianluigi Marseglia, Giorgio Ciprandi, ,

Ann. Allergy Asthma Immunol. (Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology)
[2019, 123(5):516-519]

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Influence of Atopic Dermatitis on Cow's Milk Allergy in Children.

Arianna Giannetti, Francesca Cipriani, Valentina Indio, Marcella Gallucci, Carlo Caffarelli, Giampaolo Ricci,

Background and Objectives: Cow's milk protein allergy (CMA) is the most common allergy in children. The natural history of CMA is generally favorable and the majority of children reach tolerance during childhood, even if studies show variable results. Atopic dermatitis (AD) is a complex disease from an immunological point of ... Read more >>

Medicina (Kaunas) (Medicina (Kaunas, Lithuania))
[2019, 55(8):]

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Wheat Allergy in Children: A Comprehensive Update.

Giampaolo Ricci, Laura Andreozzi, Francesca Cipriani, Arianna Giannetti, Marcella Gallucci, Carlo Caffarelli,

Gluten-related disorders are very common in pediatric patients. Wheat allergy is triggered by an immunoglobulin E (IgE)-dependent mechanism; its prevalence varies according to the age and region, and in Europe has been estimated to be lower than 1%. Many studies investigated the potential role of several external factors that can ... Read more >>

Medicina (Kaunas) (Medicina (Kaunas, Lithuania))
[2019, 55(7):]

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Early molecular biomarkers predicting the evolution of allergic rhinitis and its comorbidities: A longitudinal multicenter study of a patient cohort.

Francesca Cipriani, Salvatore Tripodi, Valentina Panetta, Serena Perna, Ekaterina Potapova, Arianna Dondi, Roberto Bernardini, Carlo Caffarelli, Antonella Casani, Rosa Cervone, Loredana Chini, Pasquale Comberiati, Giovanna De Castro, Michele Miraglia Del Giudice, Iride Dello Iacono, Andrea Di Rienzo Businco, Marcella Gallucci, Arianna Giannetti, Carla Mastrorilli, Viviana Moschese, Simone Pelosi, Ifigenia Sfika, Elena Varin, Valeria Villella, Anna Maria Zicari, Giulia Brindisi, Giampaolo Ricci, Paolo Maria Matricardi, ,

BACKGROUND:Pollen-related seasonal allergic rhinoconjunctivitis (SAR) is a very frequent pediatric disease in Westernized countries. Risk factors and disease phenotypes have been thoroughly examined in several cross-sectional studies. By contrast, only a few studies have examined disease evolution in patient cohorts. We investigated predictive biomarkers of disease evolution in a large ... Read more >>

Pediatr Allergy Immunol (Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology)
[2019, 30(3):325-334]

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Pediatric drug hypersensitivity: which diagnostic tests?

Francesca Saretta, Francesca Mori, Fabio Cardinale, Lucia Liotti, Fabrizio Franceschini, Giuseppe Crisafulli, Silvia Caimmi, Paolo Bottau, Roberto Bernardini, Carlo Caffarelli,

Along with the anamnesis and clinical evaluation, diagnostic tests are one of the mainstream key points in the evaluation and management of drug hypersensitivity reactions (DHR). A wide knowledge gap, both in diagnosis and management of pediatric DHR, must be filled.  Only a few published studies evaluated sensitivity and specificity ... Read more >>

Acta Biomed (Acta bio-medica : Atenei Parmensis)
[2019, 90(3-S):94-107]

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Clinical features, outcomes and treatment in children with drug induced Stevens-Johnson syndrome and toxic epidermal necrolysis.

Lucia Liotti, Silvia Caimmi, Paolo Bottau, Roberto Bernardini, Fabio Cardinale, Francesca Saretta, Francesca Mori, Giuseppe Crisafulli, Fabrizio Franceschini, Carlo Caffarelli,

Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN), which can be considered a late-onset allergic reaction, can cause serious long-term sequelae. SJS/TEN are considered a spectrum of life-threatening adverse drug reactions. They have the same clinical manifestations and the only difference is in the extent of epidermal detachment. These conditions ... Read more >>

Acta Biomed (Acta bio-medica : Atenei Parmensis)
[2019, 90(3-S):52-60]

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A practical management of children with antibiotic allergy.

Elisabetta Calamelli, Carlo Caffarelli, Fabrizio Franceschini, Francesca Saretta, Fabio Cardinale, Roberto Bernardini, Lucia Liotti, Francesca Mori, Giuseppe Crisafulli, Silvia Caimmi, Paolo Bottau,

About 10% of the parents reported that their children are allergic to one drug and the betalactam antibiotics are the most frequently suspected. Even if most of the adverse events following antibiotic prescriptions to children are considered allergic, after a full allergy work-up only a few of the suspected reactions ... Read more >>

Acta Biomed (Acta bio-medica : Atenei Parmensis)
[2019, 90(3-S):11-19]

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Chronic urticaria and drug hypersensitivity in children.

Carlo Mastrorilli, Roberto Bernardini, Lucia Liotti, Fabrizio Franceschini, Giuseppe Crisafulli, Silvia Caimmi, Paolo Bottau, Francesca Mori, Fabio Cardinale, Francesca Saretta, Giovanni Simeone, Marcello Bergamini, Carlo Caffarelli,

The cause of chronic urticaria remains often elusive. The association between chronic urticaria and intake of medications have been reported in children. However, the causative role of drugs has been rarely ascertained by onset of symptoms on drug provocation test. Chronic urticaria can be mediated by immunologic and nonimmunologic mechanisms. ... Read more >>

Acta Biomed (Acta bio-medica : Atenei Parmensis)
[2019, 90(3-S):61-65]

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Drug desensitization in allergic children.

Silvia Caimmi, Carlo Caffarelli, Francesca Saretta, Lucia Liotti, Giuseppe Crisafulli, Fabio Cardinale, Paolo Bottau, Francesca Mori, Fabrizio Franceschini, Roberto Bernardini, Gian Luigi Marseglia,

Drug allergy is an increasing problem worldwide, affecting all populations and races, children and adults, and for which diagnosis and treatment are not well standardized yet. Besides classical treatments, new drugs have been developed, especially for patients suffering from malignancies and chronic inflammatory diseases, that specifically target the cause of ... Read more >>

Acta Biomed (Acta bio-medica : Atenei Parmensis)
[2019, 90(3-S):20-29]

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Allergic reactions to cow's milk proteins in medications in childhood.

Angelica Santoro, Laura Andreozzi, Giampaolo Ricci, Carla Mastrorilli, Carlo Caffarelli,

INTRODUCTION:Cow's milk is a frequent trigger of allergic reactions in childhood. Cow's milk proteins can be present in pharmaceutical excipients. METHODS:We have analyzed paediatric literature on allergic reactions to cow's milk proteins in medication, focusing on the different routes of administration (inhaled, parental and oral). RESULTS:Dry-powder inhalers may contain lactose ... Read more >>

Acta Biomed (Acta bio-medica : Atenei Parmensis)
[2019, 90(3-S):91-93]

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Mechanisms of hypersensitivity reactions induced by drugs.

Fabrizio Franceschini, Paolo Bottau, Silvia Caimmi, Fabio Cardinale, Giuseppe Crisafulli, Lucia Liotti, Francesca Saretta, Roberto Bernardini, Francesca Mori, Carlo Caffarelli,

Adverse drug reactions include drug hypersensitivity reactions (DHRs), which can be immunologically mediated or non-immunologically mediated. The high number of DHRs unconfirmed and/or self-reported is a frequent problem in daily clinical practice, with considerable impact on future prescription choices and patient health. It is important to distinguish between hypersensitivity and ... Read more >>

Acta Biomed (Acta bio-medica : Atenei Parmensis)
[2019, 90(3-S):44-51]

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Drug-induced anaphylaxis in children.

Fabio Cardinale, Doriana Amato, Maria Felicia Mastrototaro, Carlo Caffarelli, Giuseppe Crisafulli, Fabrizio Franceschini, Lucia Liotti, Silvia Caimmi, Paolo Bottau, Francesca Saretta, Francesca Mori, Roberto Bernardini,

Anaphylaxis represents one of the most frequent medical emergencies in childhood. However, as compared to adults, drugs are less common triggers of anaphylaxis in children, with a frequency which is increasing  from infancy to adolescence. Deaths seldom occur, maybe because of the paucity of comorbidities in children.  Antibiotics and non-steroidal ... Read more >>

Acta Biomed (Acta bio-medica : Atenei Parmensis)
[2019, 90(3-S):30-35]

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Drug reaction with eosinophilia and systemic symptoms (DRESS) in children.

Francesca Mori, Carlo Caffarelli, Silvia Caimmi, Paolo Bottau, Lucia Liotti, Fabrizio Franceschini, Fabio Cardinale, Roberto Bernardini, Giuseppe Crisafulli, Francesca Saretta, Elio Novembre,

Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS) is a severe reaction to drugs. Incidence of DRESS in children is not well known and the mortality rate seems to be lower than 10%. Anticonvulsants are the main drugs involved both in adults and in children. The treatment of choice is ... Read more >>

Acta Biomed (Acta bio-medica : Atenei Parmensis)
[2019, 90(3-S):66-79]

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Hypersensitivity reactions to food and drug additives: problem or myth?

Laura Andreozzi, Arianna Giannetti, Francesca Cipriani, Carlo Caffarelli, Carla Mastrorilli, Giampaolo Ricci,

BACKGROUND AND AIM OF THE WORK:The possibility of an allergic reaction or an intolerance to additives is frequently suspected by parents, especially for chronic illness with frequent exacerbations such as atopic dermatitis or chronic urticaria. For more than 50 years, potential adverse reactions to additives have been suggested, but to ... Read more >>

Acta Biomed (Acta bio-medica : Atenei Parmensis)
[2019, 90(3-S):80-90]

Cited: 1 time

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