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Author Carlo Caffarelli

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Safety, Efficacy, and Preventive Role of Subcutaneous and Sublingual Allergen Immunotherapy for the Treatment of Pediatric Asthma.

Arianna Giannetti, Giampaolo Ricci, Michela Procaccianti, Angelica Santoro, Carlo Caffarelli,

Allergen-specific immunotherapy is currently the only treatment with the potential to modify and prevent progression of allergic asthma in children. In clinical practice, it is available in two forms: subcutaneous immunotherapy and sublingual immunotherapy. Trials and meta-analyses showed both the safety and the short- and long-term benefits of allergen-specific immunotherapy ... Read more >>

J Asthma Allergy (Journal of asthma and allergy)
[2020, 13:575-587]

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Hypersensitivity reactions to proton pump inhibitors in childhood.

Francesca Mori, Fabrizio Franceschini, Francesca Saretta, Annamaria Bianchi, Paolo Bottau, Silvia Caimmi, Giuseppe Crisafulli, Lucia Liotti, Claudia Paglialunga, Carlo Caffarelli,

Hypersensitivity reactions (HRs) to proton pump inhibitors (PPIs) are mainly described in adults. Anyway, increased use of PPIs in childhood has been observed in recent years. In the literature, only case reports are published on children. Most of the PPI HRs are IgE-mediated. Skin test concentrations and allergy workup protocols ... Read more >>

Pediatr Allergy Immunol (Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology)
[2020, 31 Suppl 26:29-32]

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ControL'Asma Project: new insights.

Maria Angela Tosca, Amelia Licari, Angela Pistorio, Gian Luigi Marseglia, Giorgio Ciprandi, ,

The Italian Society of Paediatric Allergy and Immunology has developed the project "ControL'Asma," a nationwide study involved ten third-level pediatric allergy clinics across Italy. The first findings of the "ControL'Asma" project showed that asthma was more frequent in males, had an early onset and allergic phenotype with very frequent rhinitis ... Read more >>

Pediatr Allergy Immunol (Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology)
[2020, 31 Suppl 26:23-25]

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Use of Sublingual Immunotherapy for Aeroallergens in Children with Asthma.

Carlo Caffarelli, Carla Mastrorilli, Michela Procaccianti, Angelica Santoro,

Asthma is a heterogeneous disease that in children is often allergen-driven with a type 2 inflammation. Sublingual immunotherapy represents an important progress in the use of personalized medicine in children with allergic asthma. It is a viable option for house dust mite-driven asthma and in subjects with the asthma associated ... Read more >>

J Clin Med (Journal of clinical medicine)
[2020, 9(10):]

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Food allergy: an updated review on pathogenesis, diagnosis, prevention and management.

Mauro Calvani, Caterina Anania, Carlo Caffarelli, Alberto Martelli, Michele Miraglia Del Giudice, Claudio Cravidi, Marzia Duse, Sara Manti, Maria Angela Tosca, Fabio Cardinale, Elena Chiappini, Francesca Olivero, Gian Luigi Marseglia,

Food allergy (FA) is an adverse immunologic response triggered by normally innocuous food protein antigens.  FA can be broadly classified into those that are IgE mediated, those that are mediated by both IgE-dependent and IgE-independent pathways (mixed), and those that are not IgE mediated  Immunoglobulin E. (IgE)-mediated reaction is characterized ... Read more >>

Acta Biomed (Acta bio-medica : Atenei Parmensis)
[2020, 91(11-S):e2020012]

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Allergic rhinoconjunctivitis.

Michele Miraglia Del Giudice, Annalisa Allegorico, Gian Luigi Marseglia, Alberto Martelli, Mauro Calvani, Fabio Cardinale, Marzia Duse, Elena Chiappini, Sara Manti, Claudio Cravidi, Maria Angela Tosca, Carlo Caffarelli,

Allergic rhinitis (AR) is induced by an IgE-mediated immune reaction after allergen exposure. The typical symptoms are itching, nasal discharge, sneezing and nasal obstruction. The diagnosis is based on the concordance between allergic symptoms and diagnostic tests. The skin prick test (SPT) is recommended as the "gold standard" method. First ... Read more >>

Acta Biomed (Acta bio-medica : Atenei Parmensis)
[2020, 91(11-S):e2020007]

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Asthma in children and adolescents: the ControL'Asma project.

Amelia Licari, Giorgio Ciprandi, Gian Luigi Marseglia, Michela Silvestri, Maria Angela Tosca, Elisa Anastasio, Ilaria Brambilla, Carlo Caffarelli, Riccardo Castagnoli, Loredana Chini, Riccardo Ciprandi, Valentina De Vittori, Marzia Duse, Maria Elisa Di Cicco, Luciana Indinnimeo, Ahmad Kantar, Maddalena Leone, Guido Marinelli, Viviana Moschese, Roberta Olcese, Diego G Peroni, Angela Pistorio, Claudia Salmaso, Anna Maria Zicari,

The control of asthma is the objective of asthma management. However, it is difficult to obtain in clinical practice. The Italian Society of Allergy and Clinical Immunology promoted the nationwide project "ControL'Asma" to investigate the real situation in a group of children and adolescents with asthma. The preliminary outcomes demonstrated ... Read more >>

Acta Biomed (Acta bio-medica : Atenei Parmensis)
[2020, 91(11-S):e2020002]

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Urticaria in childhood.

Carlo Caffarelli, Marzia Duse, Alberto Martelli, Mauro Calvani, Fabio Cardinale, Elena Chiappini, Gian Luigi Marseglia, Michele Miraglia Del Giudice, Maria Angela Tosca, Riccardo Castagnoli, Ilaria Brambilla, Angelica Santoro, Michela Procaccianti, Arianna Giannetti, Giampaolo Ricci, Domenico Minasi,

Histaminergic urticaria-angiodema is a common complaint in children. According to clinical criteria, it is classified as acute and chronic urticaria. A further clinical classification relies on triggering factors. We focus on diagnosis and therapeutic strategies. We report the main progresses in the field and issues that remain to be understood. ... Read more >>

Acta Biomed (Acta bio-medica : Atenei Parmensis)
[2020, 91(11-S):e2020013]

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Drug Allergy in children: focus on beta-lactams and NSAIDs.

Claudio Cravidi, Silvia Caimmi, Maria De Filippo, Alberto Martelli, Carlo Caffarelli, Michele Miraglia Del Giudice, Mauro Calvani, Maria Angela Tosca, Fabio Cardinale, Gian Luigi Marseglia, Sara Manti, Elena Chiappini, Davide Caimmi,

Drug hypersensitivity reactions (DHRs) are adverse reactions to a drug. In children, most common drugs inducing such reactions include beta-lactams (BLs) and non-steroidal anti-inflammatory drugs (NSAIDs). The aim of the present work was to provide current knowledge on the management of DHRs in the pediatric population, focusing on BLs and ... Read more >>

Acta Biomed (Acta bio-medica : Atenei Parmensis)
[2020, 91(11-S):e2020008]

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SARS-CoV-2 infection in pediatric population.

Sara Manti, Amelia Licari, Lorenza Montagna, Martina Votto, Salvatore Leonardi, Ilaria Brambilla, Riccardo Castagnoli, Thomas Foiadelli, Gian Luigi Marseglia, Fabio Cardinale, Carlo Caffarelli, Maria Angela Tosca, Claudio Cravidi, Marzia Duse, Elena Chiappini,

n December 2019, in Wuhan (Hubei, China), the first COVID-19 cases due to SARS-COV-2 had been reported. On July 1st 2020, more than 10.268.839 million people had developed the disease, with at least 506.064 deaths. At present, Italy is the third country considering the number of cases (n=240.760), after Spain, ... Read more >>

Acta Biomed (Acta bio-medica : Atenei Parmensis)
[2020, 91(11-S):e2020003]

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Atopic dermatitis.

Elena Galli, Bianca Cinicola, Rossella Carello, Silvia Caimmi, Giulia Brindisi, Giovanna De Castro, Anna Maria Zicari, Maria Angela Tosca, Sara Manti, Alberto Martelli, Mauro Calvani, Claudio Cravidi, Gian Luigi Marseglia, Fabio Cardinale, Michele Miraglia Del Giudice, Carlo Caffarelli, Marzia Duse,

Atopic dermatitis (AD) is a common inflammatory skin disease, clinically characterized by recurrent eczematous lesions and intense itching, leading to excoriations and susceptibility to cutaneous infections. Although it is considered a pediatric disorder, mainly starting in infancy, it is also very common in adults. Etiology of AD is complex and ... Read more >>

Acta Biomed (Acta bio-medica : Atenei Parmensis)
[2020, 91(11-S):e2020011]

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Allergen immunotherapy in children and adolescents with respiratory diseases.

Maria Angela Tosca, Amelia Licari, Roberta Olcese, Riccardo Castagnoli, Alessia Marseglia, Gian Luigi Marseglia, Michele Miraglia Del Giudice, Alberto Martelli, Mauro Calvani, Carlo Caffarelli, Marzia Duse, Claudio Cravidi, Fabio Cardinale, Giorgio Ciprandi,

To date, the only disease-modifying treatment strategy for allergic rhinitis and asthma is allergen immunotherapy (AIT). There is evidence that AIT improves allergic rhinitis and asthma, such as reducing symptom severity and medication use and improving of quality of life, with a long-lasting effect after the end of the course. ... Read more >>

Acta Biomed (Acta bio-medica : Atenei Parmensis)
[2020, 91(11-S):e2020006]

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Foreword.

Carlo Caffarelli, Mauro Calvani, Fabio Cardinale, Elena Chiappini, Giorgio Ciprandi, Claudio Cravidi, Marzia Duse, Elena Galli, Amelia Licari, Sara Manti, Alberto Martelli, Domenico Minasi, Michele Miraglia Del Giudice, Giovanni Battista Pajno, Giampaolo Ricci, Maria Angela Tosca, Gian Luigi Marseglia,

The management of chronic diseases are paramount in health care in these days. Among them, there has been an expansion of allergic and immunologic diseases, especially in children. Thanks to the action of the Italian Society of Pediatric Allergy and Immunology (SIAIP), the quality level of care has progressively grown. ... Read more >>

Acta Biomed (Acta bio-medica : Atenei Parmensis)
[2020, 91(11-S):e2020001]

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Update in Primary Immunodeficiencies.

Lucia Leonardi, Beatrice Rivalta, Caterina Cancrini, Elena Chiappini, Claudio Cravidi, Carlo Caffarelli, Sara Manti, Mauro Calvani, Alberto Martelli, Michele Miraglia Del Giudice, Marzia Duse, Gian Luigi Marseglia, Fabio Cardinale,

Primary immunodeficiencies (PIDs) are inherited disorders classically characterized by increased susceptibility to infections. Nevertheless, in the last two decades, genomic analysis (such as NGS) coupled with biochemical and cellular studies led to a more accurate definition for a growing number of novel genetic disorders associated with PIDs. This revealed new ... Read more >>

Acta Biomed (Acta bio-medica : Atenei Parmensis)
[2020, 91(11-S):e2020010]

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What is new in anaphylaxis?

Alberto Martelli, Rosario Ippolito, Martina Votto, Maria De Filippo, Ilaria Brambilla, Mauro Calvani, Fabio Cardinale, Elena Chiappini, Marzia Duse, Sara Manti, Gian Luigi Marseglia, Carlo Caffarelli, Claudio Cravidi, Michele Miraglia Del Giudice, Maria Angela Tosca,

Available information suggests that anaphylaxis must be promptly recognized keeping in mind the airway patency, breathing (ventilation and respiration), circulation and mental status and treated. The first treatment is adrenaline. After successful treatment of an anaphylactic episode, attention must be paid to the prevention of early recurrences (biphasic anaphylaxis) and ... Read more >>

Acta Biomed (Acta bio-medica : Atenei Parmensis)
[2020, 91(11-S):e2020005]

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Tuberculosis and TNF-α inhibitors in children: how to manage a fine balance.

Sara Parigi, Amelia Licari, Sara Manti, Gian Luigi Marseglia, Maria Angela Tosca, Michele Miraglia Del Giudice, Carlo Caffarelli, Mauro Calvani, Alberto Martelli, Fabio Cardinale, Claudio Cravidi, Marzia Duse, Elena Chiappini,

Since the introduction of biologic response modifiers (BRMs) in the management of children affected by the immune-mediated inflammatory disease, these patients substantially improved their quality of life. BRMs are generally well tolerated and effective in most children and adolescents refractory to conventional immunosuppressive therapy. On the other hand, patients receiving ... Read more >>

Acta Biomed (Acta bio-medica : Atenei Parmensis)
[2020, 91(11-S):e2020009]

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Primary Prevention of Allergic Diseases: The Role of Early Exposure to Cow's Milk Formula.

Carla Mastrorilli, Angelica Santoro, Carlo Caffarelli,

The burden of atopic disorders is continuously worsening worldwide, especially in childhood. Therefore, risk factors and preventive measures have been called into question. The age when infants introduce complementary foods, varies greatly according to traditional habits, clinical practice recommendations, and breastfeeding duration. It is still debated the impact of early ... Read more >>

Front Pediatr (Frontiers in pediatrics)
[2020, 8:420]

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New insights into food protein-induced enterocolitis in children.

Carla Mastrorilli, Angelica Santoro, Michela Procaccianti, Giuseppe Pagliaro, Carlo Caffarelli,

Food protein-induced enterocolitis syndrome (FPIES) represents a non-IgE-mediated food allergic disorder with delayed gastrointestinal symptoms that may evolve in a medical emergency. Clinically, FPIES can be distinguished into acute and chronic phenotypes. FPIES is mainly diagnosed in infancy however the onset at older ages is being progressively described. The pathogenetic ... Read more >>

Minerva Pediatr (Minerva pediatrica)
[2020, 72(5):416-423]

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Advances in paediatrics in 2019: current practices and challenges in allergy, endocrinology, gastroenterology, public health, neonatology, nutrition, nephrology, neurology, respiratory diseases and rheumatic diseases.

Carlo Caffarelli, Francesca Santamaria, Virginia Mirra, Ermanno Bacchini, Angelica Santoro, Sergio Bernasconi, Giovanni Corsello,

We highlight the main developments that have been published during the first semester of the last year in the Italian Journal of Pediatrics. We have carefully chosen information from numerous exciting progresses issued in the Journal in the field of allergy, endocrinology, gastroenterology, neonatology, nutrition, nephrology, neurology, public health, respiratory ... Read more >>

Ital J Pediatr (Italian journal of pediatrics)
[2020, 46(1):89]

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COVID-19 and food allergy in children.

Enza D'Auria, Caterina Anania, Barbara Cuomo, Fabio Decimo, Giovanni Cosimo Indirli, Violetta Mastrorilli, Angelica Santoro, Marco U A Sartorio, Elisabetta Veronelli, Carlo Caffarelli, Gian Luigi Marseglia, Mauro Calvani, The Italian Society Of Pediatric Allergy And Immunology Siaip Food Allergy Study Group,

In children with food allergy the visits should be limited to those that are unequivocally needed on clinical basis. Food challenge can be performed in selected situations, taking a more detailed history to make sure that patients provide whatever information we need. The maintenance of a safe diet can be ... Read more >>

Acta Biomed (Acta bio-medica : Atenei Parmensis)
[2020, 91(2):204-206]

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Preschool Wheezing: Trajectories and Long-Term Treatment.

Valentina Fainardi, Angelica Santoro, Carlo Caffarelli,

Wheezing is very common in infancy affecting one in three children during the first 3 years of life. Several wheeze phenotypes have been identified and most rely on temporal pattern of symptoms. Assessing the risk of asthma development is difficult. Factors predisposing to onset and persistence of wheezing such as ... Read more >>

Front Pediatr (Frontiers in pediatrics)
[2020, 8:240]

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COVID19: potential cardiovascular issues in pediatric patients.

Deborah Bertoncelli, Marta Guidarini, Anna Della Greca, Chiara Ratti, Francesca Falcinella, Brunella Iovane, Mauro Luigi Dutto, Carlo Caffarelli, Bertrand Tchana,

The novel severe acute respiratory syndrome coronavirus 2 (SARS-COV 2) has rapidly spread worldwide with increasing hospitalization and mortality rate. Ongoing studies and accumulated data are de- tailing the features and the effects of the new coronavirus disease 19 (COVID 19) in the adult population, and cardiovascular involvement is emerging ... Read more >>

Acta Biomed (Acta bio-medica : Atenei Parmensis)
[2020, 91(2):177-183]

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Hypersensitivity Reactions to Monoclonal Antibodies in Children.

Francesca Mori, Francesca Saretta, Annamaria Bianchi, Giuseppe Crisafulli, Silvia Caimmi, Lucia Liotti, Paolo Bottau, Fabrizio Franceschini, Claudia Paglialunga, Giampaolo Ricci, Angelica Santoro, Carlo Caffarelli,

Biologic drugs are widely used in pediatric medicine. Monoclonal antibodies (mAbs) in particular are a therapeutic option for rheumatic, autoinflammatory and oncologic diseases. Adverse drug reactions and hypersensitivity reactions (HSR) to mAbs may occur in children. Clinical presentation of HSRs to mAbs can be classified according to phenotypes in infusion-related ... Read more >>

Medicina (Kaunas) (Medicina (Kaunas, Lithuania))
[2020, 56(5):]

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Point-of-care ultrasound (POCUS) in a remote area of Sierra Leone: impact on patient management and training program for community health officers.

Vittorio Sabatino, Maria Rosaria Caramia, Antonietta Curatola, Francesca Vassallo, Andrea Deidda, Bianca Cinicola, Francesco Iodice, Carlo Caffarelli, Nicola Sverzellati, Danilo Buonsenso,

PURPOSE:Point-of-care ultrasound (POCUS) has been shown to have unique potential in low-income countries. Physicians and other healthcare providers can perform effective scans after a short period of training. This study aimed to evaluate indications and utility of ultrasonography as the main imaging service in a poor rural sub-Saharan region of ... Read more >>

J Ultrasound (Journal of ultrasound)
[2020, 23(4):521-527]

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Allergen-specific Immunotherapy for Inhalant Allergens in Children.

Carlo Caffarelli, Jessica Cangemi, Carla Mastrorilli, Arianna Giannetti, Giampaolo Ricci,

Allergen-specific immunotherapy (AIT) for aeroallergens consists of the administration of standardized allergen extracts to patients with respiratory IgE-mediated diseases to the same allergen in order to achieve immune tolerance to the allergen and prevent the onset of symptoms. AIT is usually delivered by sublingual (SLIT), subcutaneous (SCIT) route. AIT with ... Read more >>

Curr Pediatr Rev (Current pediatric reviews)
[2020, 16(2):129-139]

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