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Activation of lateral hypothalamic group III metabotropic glutamate receptors suppresses cocaine-seeking following abstinence and normalizes drug-associated increases in excitatory drive to orexin/hypocretin cells.

Jiann W Yeoh, Morgan H James, Cameron D Adams, Jaideep S Bains, Takeshi Sakurai, Gary Aston-Jones, Brett A Graham, Christopher V Dayas,

The perifornical/lateral hypothalamic area (LHA) orexin (hypocretin) system is involved in drug-seeking behavior elicited by drug-associated stimuli. Cocaine exposure is associated with presynaptic plasticity at LHA orexin cells such that excitatory input to orexin cells is enhanced acutely and into withdrawal. These changes may augment orexin cell reactivity to drug-related ... Read more >>

Neuropharmacology (Neuropharmacology)
[2019, 154:22-33]

Cited: 0 times

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Increased DNA methylation of SLFN12 in CD4+ and CD8+ T cells from multiple sclerosis patients.

Brooke Rhead, Ina S Brorson, Tone Berge, Cameron Adams, Hong Quach, Stine Marit Moen, Pål Berg-Hansen, Elisabeth Gulowsen Celius, Dipen P Sangurdekar, Paola G Bronson, Rodney A Lea, Sean Burnard, Vicki E Maltby, Rodney J Scott, Jeannette Lechner-Scott, Hanne F Harbo, Steffan D Bos, Lisa F Barcellos,

DNA methylation is an epigenetic mark that is influenced by environmental factors and is associated with changes to gene expression and phenotypes. It may link environmental exposures to disease etiology or indicate important gene pathways involved in disease pathogenesis. We identified genomic regions that are differentially methylated in T cells ... Read more >>

PLoS ONE (PloS one)
[2018, 13(10):e0206511]

Cited: 4 times

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Activation of lateral hypothalamic group III mGluRs suppresses drug-seeking following abstinence and cocaine-associated increases in excitatory drive to orexin/hypocretin cells

Jiann Yeoh, Morgan James, Cameron Adams, Jaideep Bains, Takeshi Sakurai, Gary Aston-Jones, Brett Graham, Christopher Dayas,

Abstract The perifornical/lateral hypothalamic area (LHA) orexin (hypocretin) system is involved in drug-seeking behavior elicited by drug-associated stimuli. Cocaine exposure is associated with presynaptic plasticity at LHA orexin cells such that excitatory input to orexin cells is enhanced, both acutely and into withdrawal. These changes may augment orexin cell reactivity ... Read more >>

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Psychosocial stress increases craving for alcohol in social drinkers: Effects of risk-taking.

James M Clay, Cameron Adams, Peter Archer, Mark English, Abbey Hyde, Lorenzo D Stafford, Matthew O Parker,

BACKGROUND:Exposure to stress and trait impulsivity are independent predictors of relapse in recovering alcoholics, but potential mechanisms that link these two risk-factors in terms of their putative additive or interactive contributions to relapse are not known. The aim of this study was to use a model of stress-induced relapse to ... Read more >>

Drug Alcohol Depend (Drug and alcohol dependence)
[2018, 185:192-197]

Cited: 2 times

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Chemogenetic activation of the lateral hypothalamus reverses early life stress-induced deficits in motivational drive.

Erin J Campbell, Caitlin S Mitchell, Cameron D Adams, Jiann Wei Yeoh, Deborah M Hodgson, Brett A Graham, Christopher V Dayas,

Altered motivated behaviour is a cardinal feature of several neuropsychiatric conditions including mood disorders. One well-characterized antecedent to the development of mood disorders is exposure to early life stress (ELS). A key brain substrate controlling motivated behaviour is the lateral hypothalamus (LH). Here, we examined the effect of ELS on ... Read more >>

Eur. J. Neurosci. (The European journal of neuroscience)
[2017, 46(7):2285-2296]

Cited: 3 times

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Correction: Targeted Isolation of Antibodies Directed against Major Sites of SIV Env Vulnerability.

Rosemarie D Mason, Hugh C Welles, Cameron Adams, Bimal K Chakrabarti, Jason Gorman, Tongqing Zhou, Richard Nguyen, Sijy O'Dell, Sabrina Lusvarghi, Carole A Bewley, Hui Li, George M Shaw, Zizhang Sheng, Lawrence Shapiro, Richard Wyatt, Peter D Kwong, John R Mascola, Mario Roederer,

[This corrects the article DOI: 10.1371/journal.ppat.1005537.]. ... Read more >>

PLoS Pathog. (PLoS pathogens)
[2016, 12(5):e1005674]

Cited: 0 times

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Targeted Isolation of Antibodies Directed against Major Sites of SIV Env Vulnerability.

Rosemarie D Mason, Hugh C Welles, Cameron Adams, Bimal K Chakrabarti, Jason Gorman, Tongqing Zhou, Richard Nguyen, Sijy O'Dell, Sabrina Lusvarghi, Carole A Bewley, Hui Li, George M Shaw, Zizhang Sheng, Lawrence Shapiro, Richard Wyatt, Peter D Kwong, John R Mascola, Mario Roederer,

The simian immunodeficiency virus (SIV) challenge model of lentiviral infection is often used as a model to human immunodeficiency virus type 1 (HIV-1) for studying vaccine mediated and immune correlates of protection. However, knowledge of the structure of the SIV envelope (Env) glycoprotein is limited, as is knowledge of binding ... Read more >>

PLoS Pathog. (PLoS pathogens)
[2016, 12(4):e1005537]

Cited: 13 times

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Potent SIV-specific Antibodies Targeting the Cyanovirin Binding Site.

Rosemarie Mason, Cameron Adams, Carole Bewley, John Mascola, Mario Roederer,

AIDS Res. Hum. Retroviruses (AIDS research and human retroviruses)
[2014, 30(Suppl 1):A211-A212]

Cited: 0 times

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Effectiveness and safety of recombinant human bone morphogenetic protein-2 versus local bone graft in primary lumbar interbody fusions.

Cameron Louis Adams, Kathryn Ogden, Iain Kilpatrick Robertson, Stephen Broadhurst, David Edis,

STUDY DESIGN: Retrospective cohort study. OBJECTIVE: To compare clinical outcomes, fusion rates, and rates of complications in posterior lumbar interbody fusions (PLIFs) and transforaminal lumbar interbody fusion procedures with either recombinant human bone morphogenetic protein-2 (rhBMP-2) and local bone graft (LBG) or LBG alone used as graft material. SUMMARY OF ... Read more >>

Spine (Spine)
[2014, 39(2):164-171]

Cited: 10 times

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University of Tasmania student's foray into surgical research (Re: ANZ J. Surg. 2011; 81: 851-2).

Cameron Louis Adams,

ANZ J Surg (ANZ journal of surgery)
[2012, 82(4):284]

Cited: 0 times

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Combined antagonism of glutamate mGlu5 and adenosine A2A receptors interact to regulate alcohol-seeking in rats.

Cameron L Adams, Michael S Cowen, Jennifer L Short, Andrew J Lawrence,

Adenosine and glutamate have been implicated as mediators involved in the self-administration of alcohol. In the present study we sought to determine whether adenosine receptors could interact with metabotropic glutamate receptors to regulate operant responding for alcohol and also the integration of the salience of alcohol-paired cues. Alcohol-preferring (iP) rats ... Read more >>

Int. J. Neuropsychopharmacol. (The international journal of neuropsychopharmacology)
[2008, 11(2):229-241]

Cited: 43 times

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SeqVis: visualization of compositional heterogeneity in large alignments of nucleotides.

Joshua W K Ho, Cameron E Adams, Jie Bin Lew, Timothy J Matthews, Chiu Chin Ng, Arash Shahabi-Sirjani, Leng Hong Tan, Yu Zhao, Simon Easteal, Susan R Wilson, Lars S Jermiin,

UNLABELLED: Most phylogenetic methods assume that the sequences evolved under homogeneous, stationary and reversible conditions. Compositional heterogeneity in data intended for studies of phylogeny suggests that the data did not evolve under these conditions. SeqVis, a Java application for analysis of nucleotide content, reads sequence alignments in several formats and ... Read more >>

Bioinformatics (Bioinformatics (Oxford, England))
[2006, 22(17):2162-2163]

Cited: 22 times

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Pure-culture growth of fermentative bacteria, facilitated by H2 removal: bioenergetics and H2 production.

Cameron J Adams, Molly C Redmond, David L Valentine,

We used an H2-purging culture vessel to replace an H2-consuming syntrophic partner, allowing the growth of pure cultures of Syntrophothermus lipocalidus on butyrate and Aminobacterium colombiense on alanine. By decoupling the syntrophic association, it was possible to manipulate and monitor the single organism's growth environment and determine the change in ... Read more >>

Appl. Environ. Microbiol. (Applied and environmental microbiology)
[2006, 72(2):1079-1085]

Cited: 19 times

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The acute anti-craving effect of acamprosate in alcohol-preferring rats is associated with modulation of the mesolimbic dopamine system.

Michael S Cowen, Cameron Adams, Tracey Kraehenbuehl, Valentina Vengeliene, Andrew J Lawrence,

Acamprosate (Campral) is a drug used clinically for the treatment of alcoholism. In order to examine further the time-course and mechanism of action of acamprosate, the effect of acute and repeated acamprosate administration was examined on (i) operant ethanol self-administration and (ii) voluntary home cage ethanol consumption by alcohol-preferring Fawn-Hooded, ... Read more >>

Addict Biol (Addiction biology)
[2005, 10(3):233-242]

Cited: 41 times

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Bethlem myopathy in a black creole pedigree.

Cameron R Adams, Karla P Figueroa, Lan Zu, Thomas L Anderson, Michael C Graves, Carlos A Garcia, Stefan-M Pulst,

OBJECTIVES: To analyze the clinical and molecular features of a distinctive muscular dystrophy in a family of black Creole descent. METHODS: We clinically characterized a four-generation pedigree and performed linkage analysis for all relevant autosomal-dominant muscular dystrophies. RESULTS: Affected family members had minor neurologic dissimilarities from previously reported Bethlem myopathy ... Read more >>

J Clin Neuromuscul Dis (Journal of clinical neuromuscular disease)
[2002, 4(1):7-10]

Cited: 1 time

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