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Author Camelia Radulescu

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A Machine-learning Signature Performs as Well as Experts' Consensus to Diagnose Pelvic Lymph Node Involvement in Bladder Cancer on [18F]-FDG PET/CT: A Pathology-controlled Study

Antoine GIRARD, Laurent DERCLE, Helena VILA-REYES, Lawrence SCHWARTZ, Astrid GIRMA, Marc BERTAUX, Camelia RADULESCU, Thierry LEBRET, Olivier DELCROIX, Mathieu ROUANNE,

<h4>Purpose: </h4> To develop and validate an objective machine-learning-based signature for the diagnosis of pelvic lymph node (LN) involvement based on [ 18 F]-FDG PET/CT before radical cystectomy in patients with muscle-invasive bladder cancer (MIBC). <h4>Methods: </h4> Between 2010-2017, consecutive patients with localized MIBC were retrospectively and randomly assigned to ... Read more >>

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Artificial intelligence to improve cytology performances in bladder carcinoma detection: results of the VisioCyt test.

Thierry Lebret, Geraldine Pignot, Marc Colombel, Laurent Guy, Xavier Rebillard, Laurent Savareux, Mathieu Roumigue, Sebastien Nivet, Monique Coutade Saidi, Eric Piaton, Camelia Radulescu,

<h4>Objective</h4>To explore the utility of artificial intelligence (AI) using the VisioCyt® test (VitaDX International, Rennes, France) to improve diagnosis of bladder carcinoma using voided urine cytology.<h4>Patients and methods</h4>A national prospective multicentre trial (14 centres) was conducted on 1360 patients, divided in two groups. The first group included bladder carcinoma diagnosis ... Read more >>

BJU Int (BJU international)
[2021, :]

Cited: 1 time

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Immunodynamics of explanted human tumors for immuno-oncology.

Agathe Dubuisson, Jean-Eudes Fahrner, Anne-Gaëlle Goubet, Safae Terrisse, Nicolas Voisin, Charles Bayard, Sebastien Lofek, Damien Drubay, Delphine Bredel, Séverine Mouraud, Sandrine Susini, Alexandria Cogdill, Lucas Rebuffet, Elise Ballot, Nicolas Jacquelot, Vincent Thomas de Montpreville, Odile Casiraghi, Camélia Radulescu, Sophie Ferlicot, David J Figueroa, Sapna Yadavilli, Jeremy D Waight, Marc Ballas, Axel Hoos, Thomas Condamine, Bastien Parier, Christophe Gaudillat, Bertrand Routy, François Ghiringhelli, Lisa Derosa, Ingrid Breuskin, Mathieu Rouanne, Fabrice André, Cédric Lebacle, Hervé Baumert, Marie Wislez, Elie Fadel, Isabelle Cremer, Laurence Albiges, Birgit Geoerger, Jean-Yves Scoazec, Yohann Loriot, Guido Kroemer, Aurélien Marabelle, Mélodie Bonvalet, Laurence Zitvogel,

Decision making in immuno-oncology is pivotal to adapt therapy to the tumor microenvironment (TME) of the patient among the numerous options of monoclonal antibodies or small molecules. Predicting the best combinatorial regimen remains an unmet medical need. Here, we report a multiplex functional and dynamic immuno-assay based on the capacity ... Read more >>

EMBO Mol Med (EMBO molecular medicine)
[2021, 13(1):e12850]

Cited: 1 time

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PD-L1 testing in urothelial bladder cancer: essentials of clinical practice.

Mathieu Rouanne, Camélia Radulescu, Julien Adam, Yves Allory,

<h4>Purpose</h4>While immunotherapy has become an increasingly attractive strategy in patients with urothelial bladder cancer, the need for a biomarker to identify patients whose cancer is the most likely to respond has never been more crucial. This review systematically evaluates evidence regarding PD-L1 as a predictive biomarker of response to anti-PD(L)1 ... Read more >>

World J Urol (World journal of urology)
[2021, 39(5):1345-1355]

Cited: 2 times

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Prognostic Impact of pT3 Subclassification in a Multicentre Cohort of Patients with Urothelial Carcinoma of the Renal Pelvicalyceal System Undergoing Radical Nephroureterectomy: A Propensity Score-weighted Analysis After Central Pathology Review.

Thomas Seisen, Andrea Mari, Riccardo Campi, Benoit Peyronnet, Karim Bensalah, Nathalie Rioux-Leclercq, Christian Pfister, Françoise Gobet, Alexandre De La Taille, Yves Allory, Evanguelos Xylinas, Yann Neuzillet, Camelia Radulescu, Jean-Luc Descotes, Géraldine Saada-Sebag, Jacques Irani, Céline Delpech-Debiais, Pierre Bigot, Caroline Eymerit, Sebastien Crouzet, Florence Mege-Lechevallier, Alain Ruffion, Myriam Decaussin-Petrucci, Stéphane Droupy, Pascal Roger, Xavier Durand, Philippe Camparo, Olivier Cussenot, Eva Compérat, Morgan Rouprêt,

<h4>Background</h4>The current pathological tumour-node-metastasis (pTNM) classification for upper tract urothelial carcinoma (UTUC) does not include any risk stratification of pT3 renal pelvicalyceal tumours.<h4>Objective</h4>To assess the prognostic impact of pT3 subclassification in a multicentre cohort of patients with UTUC of the renal pelvicalyceal system undergoing radical nephroureterectomy (RNU).<h4>Design, setting, and participants</h4>Data ... Read more >>

Eur Urol Focus (European urology focus)
[2020, :]

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A comparative study of peptide-based imaging agents [68Ga]Ga-PSMA-11, [68Ga]Ga-AMBA, [68Ga]Ga-NODAGA-RGD and [68Ga]Ga-DOTA-NT-20.3 in preclinical prostate tumour models.

Jules Zhang-Yin, Claire Provost, Géraldine Cancel-Tassin, Timofei Rusu, Mallaurie Penent, Camelia Radulescu, Eva Comperat, Olivier Cussenot, Françoise Montravers, Raphaële Renard-Penna, Jean-Noël Talbot, Aurélie Prignon,

<h4>Introduction</h4>Peptide-based imaging agents targeting prostate-specific membrane antigen (PSMA) have revolutionized the evaluation of biochemical recurrence of prostate cancer (PCa) but lacks sensitivity at very low serum prostate specific antigen (PSA) levels. Once recurrence is suspected, other positron emission tomography (PET) radiotracers could be of interest to discriminate between local and ... Read more >>

Nucl Med Biol (Nuclear medicine and biology)
[2020, 84-85:88-95]

Cited: 3 times

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Neuroendocrine Carcinoma of the Urinary Bladder: A Large, Retrospective Study From the French Genito-Urinary Tumor Group.

Marine Sroussi, Reza Elaidi, Aude Fléchon, Marianne Lorcet, Delphine Borchiellini, Magalie P Tardy, Gwenaelle Gravis, Mathilde Guérin, Brigitte Laguerre, Florian Estrade, Rémi Delva, Phillipe Barthélémy, Yohann Loriot, Pernelle Lavaud, Thierry Lebret, Yann Neuzillet, Nicolas Penel, Nadine Houede, Damien Pouessel, Benoit Rousseau, Elodie Mussat, Marine Gross-Goupil, Stéphane Culine, Hélène Gauthier, Aurélien Gobert, Morgan Roupret, Olivier Huillard, Sophie Tartas, Camélia Radulescu, Yves Allory, Stéphane Oudard,

<h4>Background</h4>Neuroendocrine carcinoma of the urinary bladder (NCUB) is rare, accounting for < 1% of bladder cancer cases, with scarce reported data available.<h4>Materials and methods</h4>We retrospectively reviewed the data from patients with NCUB treated at French institutions. The objectives were to describe the patient characteristics, treatments received, and outcomes (ie, disease-free survival ... Read more >>

Clin Genitourin Cancer (Clinical genitourinary cancer)
[2020, 18(4):295-303.e3]

Cited: 2 times

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Author Correction: c-Met activation leads to the establishment of a TGFβ-receptor regulatory network in bladder cancer progression.

Wen Jing Sim, Prasanna Vasudevan Iyengar, Dilraj Lama, Sarah Kit Leng Lui, Hsien Chun Ng, Lior Haviv-Shapira, Eytan Domany, Dennis Kappei, Tuan Zea Tan, Azad Saei, Patrick William Jaynes, Chandra Shekhar Verma, Alan Prem Kumar, Mathieu Rouanne, Hong Koo Ha, Camelia Radulescu, Peter Ten Dijke, Pieter Johan Adam Eichhorn, Jean Paul Thiery,

An amendment to this paper has been published and can be accessed via a link at the top of the paper. ... Read more >>

Nat Commun (Nature communications)
[2019, 10(1):5148]

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Multiple recurrences and risk of disease progression in patients with primary low-grade (TaG1) non-muscle-invasive bladder cancer and with low and intermediate EORTC-risk score.

Marie Simon, Pierre-Olivier Bosset, Mathieu Rouanne, Simone Benhamou, Camelia Radulescu, Vincent Molinié, Yann Neuzillet, Xavier Paoletti, Thierry Lebret,

AIM:To assess the prognostic value of multiple recurrences on the risk of progression in a large cohort of TaG1 bladder cancer of low and intermediate risk based on the EORTC score and to evaluate prognostic factors of multiple recurrences. MATERIALS AND METHODS:We retrospectively analyzed a French cohort of 470 patients ... Read more >>

PLoS One (PloS one)
[2019, 14(2):e0211721]

Cited: 4 times

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Integrated analysis of 18F-FDG PET/CT improves preoperative lymph node staging for patients with invasive bladder cancer.

Antoine Girard, Mathieu Rouanne, Sarah Taconet, Camélia Radulescu, Yann Neuzillet, Astrid Girma, Aurélie Beaufrere, Thierry Lebret, Elise Le Stanc, Jean-François Grellier,

<h4>Objectives</h4>Preoperative <sup>18</sup>F-fluoro-2-deoxy-D-glucose (<sup>18</sup>F-FDG) positron emission tomography/computed tomography (PET/CT) is controversial to assess lymph node (LN) staging in patients with invasive bladder cancer. We proposed to use the maximum standardized uptake value (SUV<sub>max</sub>) associated with axial-based LN size to improve the detection of regional LN metastasis.<h4>Methods</h4>From May 2015 to May 2017, ... Read more >>

Eur Radiol (European radiology)
[2019, 29(8):4286-4293]

Cited: 4 times

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Stromal lymphocyte infiltration is associated with tumour invasion depth but is not prognostic in high-grade T1 bladder cancer.

Mathieu Rouanne, Reem Betari, Camélia Radulescu, Aïcha Goubar, Nicolas Signolle, Yann Neuzillet, Yves Allory, Aurélien Marabelle, Julien Adam, Thierry Lebret,

<h4>Introduction</h4>Assessment of tumour-infiltrating lymphocytes (TILs) can provide important prognostic information in various cancers and may be of value in predicting response to immunotherapy. The objective of the present study was to investigate the association of stromal lymphocytic infiltration with clinicopathological parameters and their correlation with outcomes in patients with high-grade pT1 ... Read more >>

Eur J Cancer (European journal of cancer (Oxford, England : 1990))
[2019, 108:111-119]

Cited: 4 times

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[Testicular germ cell tumors: Histopathological and molecular features].

Morgan Tourne, Camelia Radulescu, Yves Allory,

In 2016, the WHO classification of testicular germ cell tumors was revised considering advances in the understanding of their tumorigenesis and molecular features. This restructuring led to a division into two major groups with, on one hand, prepubertal-type tumors, not derived from germ cell neoplasia in situ (GCNIS), and on ... Read more >>

Bull Cancer (Bulletin du cancer)
[2019, 106(4):328-341]

Cited: 1 time

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Sex steroids in serum and prostatic tissue of human cancerous prostate (STERKPROSER trial).

Matthias E Meunier, Yann Neuzillet, Jean-Pierre Raynaud, Camelia Radulescu, Tarek Ghoneim, Jean Fiet, Franck Giton, Mathieu Rouanne, Jean-François Dreyfus, Thierry Lebret, Henry Botto,

<h4>Background</h4>Currently, there is no consensus regarding the expected concentration levels of intra-prostatic sex steroids in patients with Prostate Cancer (PCa). Our objective was to assess the concentration levels of sex steroids in prostatic tissue and serum, in two cohorts of patients with localized PCa or benign prostatic hyperplasia (BPH).<h4>Methods</h4>Between September ... Read more >>

Prostate (The Prostate)
[2019, 79(3):272-280]

Cited: 1 time

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Aggressiveness of Localized Prostate Cancer: the Key Value of Testosterone Deficiency Evaluated by Both Total and Bioavailable Testosterone: AndroCan Study Results.

Yann Neuzillet, Jean-Pierre Raynaud, Jean-François Dreyfus, Camélia Radulescu, Mathieu Rouanne, Marc Schneider, Sylvie Krish, Morgan Rouprêt, Sarah J Drouin, Eva Comperat, Marc Galiano, Xavier Cathelineau, Pierre Validire, Vincent Molinié, Jean Fiet, Franck Giton, Thierry Lebret, Henry Botto,

Failure rates after first-line treatment of localized prostate cancer (PCa) treatment remain high. Improvements to patient selection and identification of at-risk patients are central to reducing mortality. We aimed to determine if cancer aggressiveness correlates with androgen levels in patients undergoing radical prostatectomy for localized PCa. We performed a prospective, ... Read more >>

Horm Cancer (Hormones & cancer)
[2019, 10(1):36-44]

Cited: 6 times

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[Tim-3: a novel biomarker and therapeutic target in oncology].

Clémence Granier, Alain Gey, Charles Dariane, Arnaud Mejean, Marc-Olivier Timsit, Charlotte Blanc, Virginie Verkarre, Camélia Radulescu, Elisabeth Fabre, Yann Vano, Stéphane Oudard, Cécile Badoual, Éric Tartour,

T cells harboring multiple co-inhibitory molecules lose their anti-tumoral functionality. PD-1 is a clinically approved target in cancer therapy, but its expression alone does not mean dysfunctionality. The expression of Tim-3 on numerous cell types (T cell, Treg, dendritic cell, myeloid cells) favors tumor escape to immune cells. Within many ... Read more >>

Med Sci (Paris) (Medecine sciences : M/S)
[2018, 34(3):231-237]

Cited: 1 time

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From arterial stiffness to kidney graft microvasculature: Mortality and graft survival within a cohort of 220 kidney transplant recipients.

Lynda Cheddani, Camélia Radulescu, Michel Chaignon, Alexandre Karras, Yann Neuzillet, Jean-Paul Duong, Nahid Tabibzadeh, Emmanuel Letavernier, Michel Delahousse, Jean-Philippe Haymann,

<h4>Background</h4>Aortic stiffness assessed by carotid-femoral pulse wave velocity (CF-PWV) is a predictor of mortality in several populations. However, little is known in kidney transplant recipients. Our objectives were to evaluate the ability of CF-PWV measured 3 months following transplantation to predict mortality, graft loss and its potential links to measured ... Read more >>

PLoS One (PloS one)
[2018, 13(5):e0195928]

Cited: 3 times

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Re: Differential Expression of PD-L1 in High Grade T1 vs Muscle Invasive Bladder Carcinoma and its Prognostic Implications: S. A. M. Wankowicz, L. Werner, A. Orsola, J. Novak, M. Bowden, T. K. Choueiri, I. de Torres, J. Morote, G. J. Freeman, S. Signoretti and J. Bellmunt J Urol 2017;198:817-823.

Mathieu Rouanne, Thierry Lebret, Camélia Radulescu, Julien Adam,

J Urol (The Journal of urology)
[2018, 199(3):854-856]

Cited: 0 times

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Sexual steroids in serum and prostatic tissue of human non-cancerous prostate (STERPROSER trial).

Yann Neuzillet, Jean-Pierre Raynaud, Camélia Radulescu, Jean Fiet, Franck Giton, Jean-François Dreyfus, Tarek P Ghoneim, Thierry Lebret, Henry Botto,

<h4>Background</h4>The specific involvement of the sex steroids in the growth of the prostatic tissue remains unclear. Sex steroid concentrations in plasma and in fresh surgical samples of benign central prostate were correlated to prostate volume.<h4>Methods</h4>Monocentric prospective study performed between September 2014 and January 2017. Age, obesity parameters, and both serum ... Read more >>

Prostate (The Prostate)
[2017, 77(15):1512-1519]

Cited: 5 times

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Gleason Score within Prostate Abnormal Areas Defined by Multiparametric Magnetic Resonance Imaging Did Not Vary According to the PIRADS Score.

Hakim Slaoui, Yann Neuzillet, Tarek Ghoneim, Mathieu Rouanne, Abdelali Abdou, Pierre Marie Lugagne-Delpon, Antoine Scherrer, Camelia Radulescu, Christian Delancourt, Vincent Molinié, Thierry Lebret,

<h4>Background</h4>We aim to correlate multiparametric magnetic resonance imaging (mpMRI) of the prostate reporting (Prostate Imaging Reporting and Data System [PI-RADS] version 2) with the Gleason score into both radical prostatectomy (RP) specimen and MRI fusion-targeted biopsies (FTB).<h4>Methods</h4>mpMRI of 74 patients who underwent an RP after FTB were retrospectively reviewed. The ... Read more >>

Urol Int (Urologia internationalis)
[2017, 99(2):156-161]

Cited: 5 times

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Tim-3 Expression on Tumor-Infiltrating PD-1+CD8+ T Cells Correlates with Poor Clinical Outcome in Renal Cell Carcinoma.

Clémence Granier, Charles Dariane, Pierre Combe, Virginie Verkarre, Saïk Urien, Cécile Badoual, Hélène Roussel, Marion Mandavit, Patrice Ravel, Mathilde Sibony, Lucie Biard, Camélia Radulescu, Emeline Vinatier, Nadine Benhamouda, Michael Peyromaure, Stéphane Oudard, Arnaud Méjean, Marc-Olivier Timsit, Alain Gey, Eric Tartour,

Inhibitory receptors expressed by T cells mediate tolerance to tumor antigens, with coexpression of these receptors exacerbating this dysfunctional state. Using the VectraR automated multiparametric immunofluorescence technique, we quantified intratumoral CD8<sup>+</sup> T cells coexpressing the inhibitory receptors PD-1 and Tim-3 from patients with renal cell carcinoma (RCC). A second validation ... Read more >>

Cancer Res (Cancer research)
[2017, 77(5):1075-1082]

Cited: 62 times

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Positive surgical margins after radical prostatectomy: What should we care about?

Caroline Pettenati, Yann Neuzillet, Camelia Radulescu, Jean-Marie Hervé, Vincent Molinié, Thierry Lebret,

<h4>Purpose</h4>Positive surgical margins (PSMs) after radical prostatectomy (RP) are a known factor associated with biochemical recurrence (BCR) and raise the issue of adjuvant treatment by radiotherapy versus salvage treatment at recurrence. To help this choice, our study aimed to analyze BCR-free survival and factors associated with BCR in patients with ... Read more >>

World J Urol (World journal of urology)
[2015, 33(12):1973-1978]

Cited: 9 times

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Obesity and hypogonadism are associated with an increased risk of predominant Gleason 4 pattern on radical prostatectomy specimen.

Yann Neuzillet, Jean-Pierre Raynaud, Thierry Lebret, Audrey Pichon, Camelia Radulescu, Vincent Molinie, Henry Botto,

<h4>Purpose</h4>To compare histological features of prostate cancer according to both obesity, defined by a body mass index (BMI) ≥30 kg/m2, and androgenic status in patients who underwent radical prostatectomy.<h4>Materials and methods</h4>Between March 2007 and September 2013, clinical, pathological and biological data were prospectively collected for patients referred for radical prostatectomy ... Read more >>

Horm Mol Biol Clin Investig (Hormone molecular biology and clinical investigation)
[2015, 22(3):101-109]

Cited: 3 times

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A 16-gene assay to predict recurrence after surgery in localised renal cell carcinoma: development and validation studies.

Brian Rini, Audrey Goddard, Dejan Knezevic, Tara Maddala, Ming Zhou, Hakan Aydin, Steven Campbell, Paul Elson, Serge Koscielny, Margarita Lopatin, Christer Svedman, Jean-Francois Martini, J Andrew Williams, Virginie Verkarre, Camelia Radulescu, Yann Neuzillet, Isabelle Hemmerlé, Marc Olivier Timsit, Athanasios C Tsiatis, Michael Bonham, Thierry Lebret, Arnaud Mejean, Bernard Escudier,

<h4>Background</h4>The likelihood of tumour recurrence after nephrectomy in localised clear cell renal cell carcinoma is well characterised by clinical and pathological parameters. However, these assessments can be improved and personalised by the addition of molecular characteristics of each patient's tumour. We aimed to develop and validate a prognostic multigene signature ... Read more >>

Lancet Oncol (The Lancet. Oncology)
[2015, 16(6):676-685]

Cited: 96 times

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Assessment of diagnostic gain with hexaminolevulinate (HAL) in the setting of newly diagnosed non-muscle-invasive bladder cancer with positive results on urine cytology.

Yann Neuzillet, Charlotte Methorst, Marc Schneider, Thierry Lebret, Mathieu Rouanne, Camelia Radulescu, Vincent Molinie, Jean-François Dreyfus, Veronique Pelcat, Henry Botto,

<h4>Objective</h4>In accordance with the European Association of Urology guidelines, a second transurethral resection of the bladder (TURB) is recommended for high-grade or T1-category tumors. This practice brings into question the benefit of photodynamic diagnosis (PDD) in reducing the residual disease after TURB in patients with positive results on urine cytology ... Read more >>

Urol Oncol (Urologic oncology)
[2014, 32(8):1135-1140]

Cited: 7 times

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The value of urinary prostate cancer gene 3 (PCA3) scores in predicting pathological features at radical prostatectomy.

Xavier Durand, Evanguelos Xylinas, Camelia Radulescu, Rachel Haus-Cheymol, Stephane Moutereau, Gillaume Ploussard, Aurelien Forgues, Grégoire Robert, Francis Vacherot, Sylvain Loric, Yves Allory, Alain Ruffion, Alexandre de la Taille,

<h4>Unlabelled</h4>Study Type - Diagnostic (exploratory cohort) Level of Evidence 2b What's known on the subject? and What does the study add? PCA3 scores correlate to numerous histoprognostic factors, specifically tumour volume and positive surgical margins. These results may have a clinical impact in the near future on the selection of ... Read more >>

BJU Int (BJU international)
[2012, 110(1):43-49]

Cited: 33 times

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