Full Text Journal Articles by
Author Caiyun G Li

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ALDH1A3 Coordinates Metabolism With Gene Regulation in Pulmonary Arterial Hypertension.

Dan Li, Ning-Yi Shao, Jan-Renier Moonen, Zhixin Zhao, Minyi Shi, Shoichiro Otsuki, Lingli Wang, Tiffany Nguyen, Elaine Yan, David P Marciano, Kévin Contrepois, Caiyun G Li, Joseph C Wu, Michael P Snyder, Marlene Rabinovitch,

<h4>Background</h4>Metabolic alterations provide substrates that influence chromatin structure to regulate gene expression that determines cell function in health and disease. Heightened proliferation of smooth muscle cells (SMC) leading to the formation of a neointima is a feature of pulmonary arterial hypertension (PAH) and systemic vascular disease. Increased glycolysis is linked ... Read more >>

Circulation (Circulation)
[2021, 143(21):2074-2090]

Cited: 0 times

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Eliminating hypoxic tumor cells improves response to PARP inhibitors in homologous recombination-deficient cancer models.

Manal Mehibel, Yu Xu, Caiyun G Li, Eui Jung Moon, Kaushik N Thakkar, Anh N Diep, Ryan K Kim, Joshua D Bloomstein, Yiren Xiao, Julien Bacal, Joshua C Saldivar, Quynh-Thu Le, Karlene A Cimprich, Erinn B Rankin, Amato J Giaccia,

Hypoxia, a hallmark feature of the tumor microenvironment, causes resistance to conventional chemotherapy, but was recently reported to synergize with poly(ADP-ribose) polymerase inhibitors (PARPis) in homologous recombination-proficient (HR-proficient) cells through suppression of HR. While this synergistic killing occurs under severe hypoxia (<0.5% oxygen), our study shows that moderate hypoxia (2% ... Read more >>

J Clin Invest (The Journal of clinical investigation)
[2021, 131(11):]

Cited: 0 times

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PPARγ-p53-Mediated Vasculoregenerative Program to Reverse Pulmonary Hypertension.

Jan K Hennigs, Aiqin Cao, Caiyun G Li, Minyi Shi, Julia Mienert, Kazuya Miyagawa, Jakob Körbelin, David P Marciano, Pin-I Chen, Matthew Roughley, Matthew V Elliott, Rebecca L Harper, Matthew A Bill, James Chappell, Jan-Renier Moonen, Isabel Diebold, Lingli Wang, Michael P Snyder, Marlene Rabinovitch,

<h4>Rationale</h4>In pulmonary arterial hypertension (PAH), endothelial dysfunction and obliterative vascular disease are associated with DNA damage and impaired signaling of BMPR2 (bone morphogenetic protein type 2 receptor) via two downstream transcription factors, PPARγ (peroxisome proliferator-activated receptor gamma), and p53.<h4>Objective</h4>We investigated the vasculoprotective and regenerative potential of a newly identified PPARγ-p53 ... Read more >>

Circ Res (Circulation research)
[2021, 128(3):401-418]

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Smooth Muscle Contact Drives Endothelial Regeneration by BMPR2-Notch1-Mediated Metabolic and Epigenetic Changes.

Kazuya Miyagawa, Minyi Shi, Pin-I Chen, Jan K Hennigs, Zhixin Zhao, Mouer Wang, Caiyun G Li, Toshie Saito, Shalina Taylor, Silin Sa, Aiqin Cao, Lingli Wang, Michael P Snyder, Marlene Rabinovitch,

<h4>Rationale</h4>Maintaining endothelial cells (EC) as a monolayer in the vessel wall depends on their metabolic state and gene expression profile, features influenced by contact with neighboring cells such as pericytes and smooth muscle cells (SMC). Failure to regenerate a normal EC monolayer in response to injury can result in occlusive ... Read more >>

Circ Res (Circulation research)
[2019, 124(2):211-224]

Cited: 16 times

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PPARγ Interaction with UBR5/ATMIN Promotes DNA Repair to Maintain Endothelial Homeostasis.

Caiyun G Li, Cathal Mahon, Nathaly M Sweeney, Erik Verschueren, Vivek Kantamani, Dan Li, Jan K Hennigs, David P Marciano, Isabel Diebold, Ossama Abu-Halawa, Matthew Elliott, Silin Sa, Feng Guo, Lingli Wang, Aiqin Cao, Christophe Guignabert, Julie Sollier, Nils P Nickel, Mark Kaschwich, Karlene A Cimprich, Marlene Rabinovitch,

Using proteomic approaches, we uncovered a DNA damage response (DDR) function for peroxisome proliferator activated receptor γ (PPARγ) through its interaction with the DNA damage sensor MRE11-RAD50-NBS1 (MRN) and the E3 ubiquitin ligase UBR5. We show that PPARγ promotes ATM signaling and is essential for UBR5 activity targeting ATM interactor ... Read more >>

Cell Rep (Cell reports)
[2019, 26(5):1333-1343.e7]

Cited: 10 times

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Upregulation of Human Endogenous Retrovirus-K Is Linked to Immunity and Inflammation in Pulmonary Arterial Hypertension.

Toshie Saito, Kazuya Miyagawa, Shih-Yu Chen, Rasa Tamosiuniene, Lingli Wang, Orr Sharpe, Erik Samayoa, Daisuke Harada, Jan-Renier A J Moonen, Aiqin Cao, Pin-I Chen, Jan K Hennigs, Mingxia Gu, Caiyun G Li, Ryan D Leib, Dan Li, Christopher M Adams, Patricia A Del Rosario, Matthew Bill, Francois Haddad, Jose G Montoya, William H Robinson, Wendy J Fantl, Garry P Nolan, Roham T Zamanian, Mark R Nicolls, Charles Y Chiu, Maria E Ariza, Marlene Rabinovitch,

<h4>Background</h4>Immune dysregulation has been linked to occlusive vascular remodeling in pulmonary arterial hypertension (PAH) that is hereditary, idiopathic, or associated with other conditions. Circulating autoantibodies, lung perivascular lymphoid tissue, and elevated cytokines have been related to PAH pathogenesis but without a clear understanding of how these abnormalities are initiated, perpetuated, ... Read more >>

Circulation (Circulation)
[2017, 136(20):1920-1935]

Cited: 16 times

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Induced Pluripotent Stem Cell Model of Pulmonary Arterial Hypertension Reveals Novel Gene Expression and Patient Specificity.

Silin Sa, Mingxia Gu, James Chappell, Ning-Yi Shao, Mohamed Ameen, Kathryn A T Elliott, Dan Li, Fabian Grubert, Caiyun G Li, Shalina Taylor, Aiqin Cao, Yu Ma, Ryan Fong, Long Nguyen, Joseph C Wu, Michael P Snyder, Marlene Rabinovitch,

<h4>Rationale</h4>Idiopathic or heritable pulmonary arterial hypertension is characterized by loss and obliteration of lung vasculature. Endothelial cell dysfunction is pivotal to the pathophysiology, but different causal mechanisms may reflect a need for patient-tailored therapies.<h4>Objectives</h4>Endothelial cells differentiated from induced pluripotent stem cells were compared with pulmonary arterial endothelial cells from the ... Read more >>

Am J Respir Crit Care Med (American journal of respiratory and critical care medicine)
[2017, 195(7):930-941]

Cited: 35 times

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Amphetamines promote mitochondrial dysfunction and DNA damage in pulmonary hypertension.

Pin-I Chen, Aiqin Cao, Kazuya Miyagawa, Nancy F Tojais, Jan K Hennigs, Caiyun G Li, Nathaly M Sweeney, Audrey S Inglis, Lingli Wang, Dan Li, Matthew Ye, Brian J Feldman, Marlene Rabinovitch,

Amphetamine (AMPH) or methamphetamine (METH) abuse can cause oxidative damage and is a risk factor for diseases including pulmonary arterial hypertension (PAH). Pulmonary artery endothelial cells (PAECs) from AMPH-associated-PAH patients show DNA damage as judged by γH2AX foci and DNA comet tails. We therefore hypothesized that AMPH induces DNA damage ... Read more >>

JCI Insight (JCI insight)
[2017, 2(2):e90427]

Cited: 25 times

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RNA Sequencing Analysis Detection of a Novel Pathway of Endothelial Dysfunction in Pulmonary Arterial Hypertension.

Christopher J Rhodes, Hogune Im, Aiqin Cao, Jan K Hennigs, Lingli Wang, Silin Sa, Pin-I Chen, Nils P Nickel, Kazuya Miyagawa, Rachel K Hopper, Nancy F Tojais, Caiyun G Li, Mingxia Gu, Edda Spiekerkoetter, Zhaoying Xian, Rui Chen, Mingming Zhao, Mark Kaschwich, Patricia A Del Rosario, Daniel Bernstein, Roham T Zamanian, Joseph C Wu, Michael P Snyder, Marlene Rabinovitch,

RATIONALE:Pulmonary arterial hypertension is characterized by endothelial dysregulation, but global changes in gene expression have not been related to perturbations in function. OBJECTIVES:RNA sequencing was used to discriminate changes in transcriptomes of endothelial cells cultured from lungs of patients with idiopathic pulmonary arterial hypertension versus control subjects and to assess ... Read more >>

Am J Respir Crit Care Med (American journal of respiratory and critical care medicine)
[2015, 192(3):356-366]

Cited: 40 times

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Elafin Reverses Pulmonary Hypertension via Caveolin-1-Dependent Bone Morphogenetic Protein Signaling.

Nils P Nickel, Edda Spiekerkoetter, Mingxia Gu, Caiyun G Li, Hai Li, Mark Kaschwich, Isabel Diebold, Jan K Hennigs, Ki-Yoon Kim, Kazuya Miyagawa, Lingli Wang, Aiqin Cao, Silin Sa, Xinguo Jiang, Raymond W Stockstill, Mark R Nicolls, Roham T Zamanian, Richard D Bland, Marlene Rabinovitch,

<h4>Rationale</h4>Pulmonary arterial hypertension is characterized by endothelial dysfunction, impaired bone morphogenetic protein receptor 2 (BMPR2) signaling, and increased elastase activity. Synthetic elastase inhibitors reverse experimental pulmonary hypertension but cause hepatotoxicity in clinical studies. The endogenous elastase inhibitor elafin attenuates hypoxic pulmonary hypertension in mice, but its potential to improve endothelial ... Read more >>

Am J Respir Crit Care Med (American journal of respiratory and critical care medicine)
[2015, 191(11):1273-1286]

Cited: 67 times

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BMPR2 preserves mitochondrial function and DNA during reoxygenation to promote endothelial cell survival and reverse pulmonary hypertension.

Isabel Diebold, Jan K Hennigs, Kazuya Miyagawa, Caiyun G Li, Nils P Nickel, Mark Kaschwich, Aiqin Cao, Lingli Wang, Sushma Reddy, Pin-I Chen, Kiichi Nakahira, Miguel A Alejandre Alcazar, Rachel K Hopper, Lijuan Ji, Brian J Feldman, Marlene Rabinovitch,

Mitochondrial dysfunction, inflammation, and mutant bone morphogenetic protein receptor 2 (BMPR2) are associated with pulmonary arterial hypertension (PAH), an incurable disease characterized by pulmonary arterial (PA) endothelial cell (EC) apoptosis, decreased microvessels, and occlusive vascular remodeling. We hypothesized that reduced BMPR2 induces PAEC mitochondrial dysfunction, promoting a pro-inflammatory or pro-apoptotic ... Read more >>

Cell Metab (Cell metabolism)
[2015, 21(4):596-608]

Cited: 76 times

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FK506 activates BMPR2, rescues endothelial dysfunction, and reverses pulmonary hypertension.

Edda Spiekerkoetter, Xuefei Tian, Jie Cai, Rachel K Hopper, Deepti Sudheendra, Caiyun G Li, Nesrine El-Bizri, Hirofumi Sawada, Roxanna Haghighat, Roshelle Chan, Leila Haghighat, Vinicio de Jesus Perez, Lingli Wang, Sushma Reddy, Mingming Zhao, Daniel Bernstein, David E Solow-Cordero, Philip A Beachy, Thomas J Wandless, Peter Ten Dijke, Marlene Rabinovitch,

Dysfunctional bone morphogenetic protein receptor-2 (BMPR2) signaling is implicated in the pathogenesis of pulmonary arterial hypertension (PAH). We used a transcriptional high-throughput luciferase reporter assay to screen 3,756 FDA-approved drugs and bioactive compounds for induction of BMPR2 signaling. The best response was achieved with FK506 (tacrolimus), via a dual mechanism ... Read more >>

J Clin Invest (The Journal of clinical investigation)
[2013, 123(8):3600-3613]

Cited: 175 times

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PAX Genes in Cancer; Friends or Foes?

Caiyun G Li, Michael R Eccles,

PAX genes have been shown to be critically required for the development of specific tissues and organs during embryogenesis. In addition, PAX genes are expressed in a handful of adult tissues where they are thought to play important roles, usually different from those in embryogenesis. A common theme in adult ... Read more >>

Front Genet (Frontiers in genetics)
[2012, 3:6]

Cited: 31 times

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PAX3 knockdown in metastatic melanoma cell lines does not reduce MITF expression.

Shujie He, Caiyun G Li, Lynn Slobbe, Amy Glover, Elaine Marshall, Bruce C Baguley, Michael R Eccles,

PAX3 and MITF are important transcriptional activators in the melanocyte lineage and PAX3 is thought to control MITF expression during normal melanocyte differentiation. However, it is not clear whether this is still true in melanoma and whether the effects of knockdown of PAX3 on the inhibition of melanoma growth or ... Read more >>

Melanoma Res (Melanoma research)
[2011, 21(1):24-34]

Cited: 10 times

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