Full Text Journal Articles by
Author Caitlyn McNaughton

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Anticancer Therapy at the End of Life: Lessons From a Community Cancer Institute.

Shanthi Sivendran, Selah Lynch, Caitlyn McNaughton, Riley Wong, Sarah Svetec, Jason H Moore, Rachel Holliday, Randall A Oyer, Kristina Newport,

INTRODUCTION:Studies have shown aggressive cancer care at the end of life is associated with decreased quality of life, decreased median survival, and increased cost of care. This study describes the patients most likely to receive systemic anticancer therapy at the end of life in a community cancer institute. MATERIALS AND ... Read more >>

J Palliat Care (Journal of palliative care)
[2019, :825859719851484]

Cited: 0 times

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Patterns of Support Service, Emergency Department, and Hospital Utilization in Patients with Advanced Cancer: A Descriptive Study.

Caitlyn H McNaughton, Michael Horst, Emily Gehron, Shanthi Sivendran, Julie Nguyen, Rachel Holliday, Kristina Newport,

CONTEXT:Palliative care in oncology provides multiple benefits, however access to specialty palliative clinicians is limited in community cancer centers. Individual support services are more often available, but little is known on the utilization and impact of these services. OBJECTIVES:To describe the utilization of outpatient support services in the advanced cancer ... Read more >>

J Palliat Care (Journal of palliative care)
[2019, :825859719851492]

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Methylphenidate restores novel object recognition in DARPP-32 knockout mice.

Charles J Heyser, Caitlyn H McNaughton, Donna Vishnevetsky, Allen A Fienberg,

Previously, we have shown that Dopamine- and cAMP-regulated phosphoprotein of 32kDa (DARPP-32) knockout mice required significantly more trials to reach criterion than wild-type mice in an operant reversal-learning task. The present study was conducted to examine adult male and female DARPP-32 knockout mice and wild-type controls in a novel object ... Read more >>

Behav. Brain Res. (Behavioural brain research)
[2013, 253:266-273]

Cited: 5 times

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MK-801 produces a deficit in sucrose preference that is reversed by clozapine, D-serine, and the metabotropic glutamate 5 receptor positive allosteric modulator CDPPB: relevance to negative symptoms associated with schizophrenia?

Joshua D Vardigan, Sarah L Huszar, Caitlyn H McNaughton, Peter H Hutson, Jason M Uslaner,

Currently prescribed antipsychotics attenuate the positive symptoms of schizophrenia but fail or only mildly improve negative symptoms. The present study aimed to establish an animal model of negative symptoms by examining the effects of the NMDA receptor antagonist MK-801 on sucrose preference. We sought to validate the model by examining ... Read more >>

Pharmacol. Biochem. Behav. (Pharmacology, biochemistry, and behavior)
[2010, 95(2):223-229]

Cited: 32 times

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The behavioral and neurochemical effects of a novel D-amino acid oxidase inhibitor compound 8 [4H-thieno [3,2-b]pyrrole-5-carboxylic acid] and D-serine.

Sean M Smith, Jason M Uslaner, Lihang Yao, Chadwick M Mullins, Nathan O Surles, Sarah L Huszar, Caitlyn H McNaughton, Danette M Pascarella, Monika Kandebo, Richard M Hinchliffe, Tim Sparey, Nicholas J Brandon, Brian Jones, Shankar Venkatraman, Mary Beth Young, Nancy Sachs, Marlene A Jacobson, Peter H Hutson,

Multiple studies indicate that N-methyl-D-aspartate (NMDA) receptor hypofunction underlies some of the deficits associated with schizophrenia. One approach for improving NMDA receptor function is to enhance occupancy of the glycine modulatory site on the NMDA receptor by increasing the availability of the endogenous coagonists D-serine. Here, we characterized a novel ... Read more >>

J. Pharmacol. Exp. Ther. (The Journal of pharmacology and experimental therapeutics)
[2009, 328(3):921-930]

Cited: 47 times

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Dose-dependent effect of CDPPB, the mGluR5 positive allosteric modulator, on recognition memory is associated with GluR1 and CREB phosphorylation in the prefrontal cortex and hippocampus.

Jason M Uslaner, Sophie Parmentier-Batteur, Rosemarie B Flick, Nathaniel O Surles, June S H Lam, Caitlyn H McNaughton, Marlene A Jacobson, Pete H Hutson,

In the search for strategies to treat schizophrenia, attention has focused on enhancing NMDA receptor function. In vitro experiments show that metabotropic glutamate 5 receptor (mGluR5) activation enhances NMDA receptor activity, and in vivo experiments indicate that mGluR5 positive allosteric modulators (PAMs) are effective in preclinical assays measuring antipsychotic potential ... Read more >>

Neuropharmacology (Neuropharmacology)
[2009, 57(5-6):531-538]

Cited: 78 times

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Evidence for social anxiety and impaired social cognition in a mouse model of fragile X syndrome.

Caitlyn H McNaughton, Jisook Moon, Myla S Strawderman, Kenneth N Maclean, Jeffrey Evans, Barbara J Strupp,

This study assessed social behavior in a mouse model of Fragile X syndrome (FXS), the Fmr1 (tm1Cgr) or Fmr1 "knockout" (KO) mouse. Both the KO and wild-type (WT) mice preferred to be near a novel conspecific than to be alone. However, during the initial interaction with a novel conspecific, (1) ... Read more >>

Behav. Neurosci. (Behavioral neuroscience)
[2008, 122(2):293-300]

Cited: 93 times

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