Full Text Journal Articles by
Author Cai Ping Du

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Neuronal activity-induced SUMOylation of Akt1 by PIAS3 is required for long-term potentiation of synaptic transmission.

Li Meng, Cai-Ping Du, Chun-Yuan Lu, Kun Zhang, Lin Li, Jing-Zhi Yan, Xiao-Yu Hou,

Neuronal activity regulates spatial distribution of the SUMOylation system in cytosolic and dendritic sites, which has been implicated in learning, memory, and underlying synaptic structural and functional remodeling in the hippocampus. However, the functional target proteins for activated small ubiquitin-like modifiers (SUMOs) and downstream molecular consequences behind long-term potentiation (LTP) ... Read more >>

FASEB J (FASEB journal : official publication of the Federation of American Societies for Experimental Biology)
[2021, 35(8):e21769]

Cited: 0 times

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Activity-Induced SUMOylation of Neuronal Nitric Oxide Synthase Is Associated with Plasticity of Synaptic Transmission and Extracellular Signal-Regulated Kinase 1/2 Signaling.

Cai-Ping Du, Mei Wang, Chi Geng, Bin Hu, Li Meng, Yan Xu, Bao Cheng, Nan Wang, Qiu-Ju Zhu, Xiao-Yu Hou,

Aims: Neuronal nitric oxide synthase (nNOS) and nitric oxide (NO) signaling have been implicated in learning, memory, and underlying long-lasting synaptic plasticity. In this study, we aimed at detecting whether nNOS is a target protein of SUMOylation in the hippocampus and its contributions to hippocampal long-term potentiation (LTP) of synaptic ... Read more >>

Antioxid Redox Signal (Antioxidants & redox signaling)
[2020, 32(1):18-34]

Cited: 4 times

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Tyrosine phosphorylation of GluK2 up-regulates kainate receptor-mediated responses and downstream signaling after brain ischemia.

Qiu-Ju Zhu, Fan-Shu Kong, Hao Xu, Yi Wang, Cai-Ping Du, Chang-Cheng Sun, Yong Liu, Ting Li, Xiao-Yu Hou,

Although kainate receptors play important roles in ischemic stroke, the molecular mechanisms underlying postischemic regulation of kainate receptors remain unclear. In this study we demonstrate that Src family kinases contribute to the potentiation of kainate receptor function. Brain ischemia and reperfusion induce rapid and sustained phosphorylation of the kainate receptor ... Read more >>

Proc Natl Acad Sci U S A (Proceedings of the National Academy of Sciences of the United States of America)
[2014, 111(38):13990-13995]

Cited: 4 times

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The upregulation of NR2A-containing N-methyl-D-aspartate receptor function by tyrosine phosphorylation of postsynaptic density 95 via facilitating Src/proline-rich tyrosine kinase 2 activation.

Chao Zhao, Cai-Ping Du, Yan Peng, Zhen Xu, Chang-Cheng Sun, Yong Liu, Xiao-Yu Hou,

The activation of postsynaptic N-methyl-D-aspartate (NMDA) receptors is required for long-term potentiation (LTP) of synaptic transmission. Postsynaptic density 95 (PSD-95) serves as a scaffold protein that tethers NMDA receptor subunits, kinases, and signal molecules. Our previous study proves that PSD-95 is a substrate of Src/Fyn and identifies Y523 on PSD-95 ... Read more >>

Mol Neurobiol (Molecular neurobiology)
[2015, 51(2):500-511]

Cited: 8 times

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SUMOylation of the kainate receptor subunit GluK2 contributes to the activation of the MLK3-JNK3 pathway following kainate stimulation.

Qiu-Ju Zhu, Yan Xu, Cai-Ping Du, Xiao-Yu Hou,

Protein SUMOylation has been implicated in the pathogenesis of ischemic stroke. However, the underlying mechanisms remain unclear. Here, we found that global brain ischemia evokes a sustained elevation of GluK2 SUMOylation in the rat hippocampal CA1 region. Over-expression of wild-type GluK2, but not SUMOylation-deficient mutant, significantly increased the activity of ... Read more >>

FEBS Lett (FEBS letters)
[2012, 586(9):1259-1264]

Cited: 12 times

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Fyn kinases play a critical role in neuronal apoptosis induced by oxygen and glucose deprivation or amyloid-β peptide treatment.

Cai-Ping Du, Ran Tan, Xiao-Yu Hou,

<h4>Aims</h4>Src family protein tyrosine kinases (SrcPTKs) have been implicated in the pathogenesis of brain ischemia and Alzheimer's disease (AD). In this study, we investigated whether Src and Fyn kinases, two major members of SrcPTKs in the brain, have distinct roles in the oxygen and glucose deprivation (OGD) and amyloid-β peptide ... Read more >>

CNS Neurosci Ther (CNS neuroscience & therapeutics)
[2012, 18(9):754-761]

Cited: 22 times

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Increased tyrosine phosphorylation of PSD-95 by Src family kinases after brain ischaemia.

Cai-Ping Du, Jin Gao, Jian-Min Tai, Yong Liu, Jing Qi, Wei Wang, Xiao-Yu Hou,

PSD (postsynaptic density)-95, a scaffold protein that tethers NMDA (N-methyl-D-aspartate) receptors to signal molecules, is implicated in pathological events resulting from excitotoxicity. The present study demonstrates that brain ischaemia and reperfusion increase the tyrosine phosphorylation of PSD-95 in the rat hippocampus. PP2, a specific inhibitor of SrcPTKs (Src family protein ... Read more >>

Biochem J (The Biochemical journal)
[2009, 417(1):277-285]

Cited: 24 times

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