Full Text Journal Articles by
Author Cagman Tan

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A Patient With AIRE Mutation Who Presented With Severe Diarrhea and Lung Abscess.

Elif Soyak Aytekin, Oguzhan Serin, Deniz Cagdas, Cagman Tan, Tekin Aksu, Yagmur Unsal, Selma Yeni, Diclehan Orhan, Zeynep Alev Ozon, Ilhan Tezcan,

Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED) (polyglandular endocrinopathy type 1) is a rare autosomal recessive disorder caused by mutations in the autoimmune regulator gene (AIRE). The major clinical features of APECED are hypoparathyroidism, adrenal insufficiency (Addison disease), and chronic mucocutaneous candidiasis. This disease is also associated with multiple other and uncommon autoimmune ... Read more >>

Pediatr Infect Dis J (The Pediatric infectious disease journal)
[2021, 40(1):66-69]

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Correction to: Evaluation of periodontal status and cytokine/chemokine profile of GCF in patients with severe congenital neutropenia.

Buket Acar, Deniz Cagdas, Çağman Tan, Begüm Özbek, İsmail Yaz, Yağmur Deniz Yıldırım, Cansu Özşin-Özler, Betül Karaatmaca, Pınar Gür-Çetinkaya, Elif Soyak, Erdem Karabulut, İlhan Tezcan, Ezel Berker,

Odontology (Odontology)
[2020, :]

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Evaluation of periodontal status and cytokine/chemokine profile of GCF in patients with severe congenital neutropenia.

Buket Acar, Deniz Cagdas, Çağman Tan, Begüm Özbek, İsmail Yaz, Yağmur Deniz Yıldırım, Cansu Özşin-Özler, Betül Karaatmaca, Pınar Gür-Çetinkaya, Elif Soyak, Erdem Karabulut, İlhan Tezcan, Ezel Berker,

Severe congenital neutropenia (SCN) is a primary immunodeficiency characterized by defect in neutrophil count. Increased risk of infections in addition to periodontal problems, such as ulcerations of oral mucosa, gingival inflammation, and rapid loss of attachment are common in the course of the disease. The aim of the present study ... Read more >>

Odontology (Odontology)
[2020, :]

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Frequency of HLA Class I and Class II Alleles in Patients with CVID from Turkey.

Begum Ozbek, Cagman Tan, Ismail Yaz, Can Kosukcu, Saliha Esenboga, Pınar Gur Cetinkaya, Deniz Cagdas, Ilhan Tezcan,

BACKGROUND:Common variable immunodeficiency (CVID) is the most common symptomatic primary immunodeficiency. Certain gene loci are pointed out in several studies in CVID patients. Until now, monogenic defects have been identified in only 2-10% of CVID patients; therefore, association of the disease with HLA alleles may be important for elucidating immunological ... Read more >>

Immunol Invest (Immunological investigations)
[2020, :1-9]

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Impact of mannose-binding lectin 2 gene polymorphisms on disease severity in noncystic fibrosis bronchiectasis in children.

Deniz Dogru, Sanem E Polat, Çağman Tan, İlhan Tezcan, Sıddıka S Yalçın, Eda Utine, Berna Oğuz, İsmail Yaz, Nagehan Emiralioğlu, Mina Hızal, Ebru Yalçın, Uğur Özçelik, Deniz Çağdaş, Nural Kiper,

BACKGROUND:Mannose-binding lectin (MBL) is a complement protein involved in the innate immune system, and is associated with some chronic respiratory diseases including noncystic fibrosis (non-CF) bronchiectasis in adults. The aim of this study was to investigate the frequency of MBL2 gene polymorphisms in children with non-CF bronchiectasis, and the effect ... Read more >>

Pediatr Pulmonol (Pediatric pulmonology)
[2020, 55(5):1190-1198]

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Elevated Interleukin-17A expression in amlodipine-induced gingival overgrowth.

Siddika Selva Sume, Ezel Berker, Yagmur Ilarslan, Ozlem Ozer Yucel, Cagman Tan, Samir Goyushov, Sibel E Gultekin, Ilhan Tezcan,

<h4>Background and objectives</h4>Amlodipine, a calcium channel blocker derivative, is frequently used by patients with high blood pressure. Studies reported that it can induce gingival overgrowth. However, the underlying mechanism is not fully described yet. Interleukin-17A (IL-17A) is known as a proinflammatory cytokine, but current studies indicate that it has a ... Read more >>

J Periodontal Res (Journal of periodontal research)
[2020, 55(5):613-621]

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Autoinflammation in addition to combined immunodeficiency: SLC29A3 gene defect.

Deniz Çağdaş, Naz Sürücü, Çağman Tan, Başak Kayaoğlu, Rıza Köksal Özgül, Yeliz Z Akkaya-Ulum, Ayşe Tülay Aydınoğlu, Selin Aytaç, Fatma Gümrük, Burcu Balci-Hayta, Banu Balci-Peynircioğlu, Seza Özen, Mayda Gürsel, İlhan Tezcan,

INTRODUCTION:H Syndrome is an autosomal recessive (AR) disease caused by defects in SLCA29A3 gene. This gene encodes the equilibrative nucleoside transporter, the protein which is highly expressed in spleen, lymph node and bone marrow. Autoinflammation and autoimmunity accompanies H Syndrome (HS). AIM:The aim was to further elucidate the mechanisms of ... Read more >>

Mol Immunol (Molecular immunology)
[2020, 121:28-37]

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A rare form of congenital neutropenia: VPS45 deficiency.

Betül Karaatmaca, Deniz Cagdas, Çağman Tan, Selin Aytaç, Begüm Özbek, Ayşegül Üner, Fatma Gümrük, İlhan Tezcan,

Scand J Immunol (Scandinavian journal of immunology)
[2020, 91(5):e12871]

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Lymphocyte Subgroups and KREC Numbers in Common Variable Immunodeficiency: A Single Center Study.

Ismail Yaz, Begum Ozbek, Yuk Yin Ng, Pinar Gur Cetinkaya, Sevil Oskay Halacli, Cagman Tan, Merve Kasikci, Can Kosukcu, Ilhan Tezcan, Deniz Cagdas,

Common variable immunodeficiency (CVID) results in defective B cell differentiation and impaired antibody production and is the most common symptomatic primary immunodeficiency. Our aim was to evaluate the correlation among B cell subgroups, κ-deleting recombination excision circle (KREC) copy numbers, and clinical and immunological data of the patients with CVID, ... Read more >>

J Clin Immunol (Journal of clinical immunology)
[2020, 40(3):494-502]

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In case of recurrent wheezing and bronchiolitis: Think again, it may be a primary immunodeficiency.

Begum Ozbek, Deniz Çağdaş Ayvaz, Saliha Esenboga, Sevil Oskay Halaçlι, Elif Soyak Aytekin, Ismail Yaz, Çağman Tan, Ilhan Tezcan,

BACKGROUND:Wheezing, starting early in life, is a heterogeneous medical condition caused by airway obstruction due to different underlying mechanisms. Primary immunodeficiencies are also among the risk factors that cause wheezing and recurrent bronchiolitis. ADA deficiency is a primary immunodeficiency, also a rare metabolic disease associated with multisystemic clinical findings. OBJECTIVE:This ... Read more >>

Asian Pac J Allergy Immunol (Asian Pacific journal of allergy and immunology)
[2019, :]

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Levels of pro- and anti-inflammatory cytokines in cystic fibrosis patients with or without gingivitis.

Onurcem Duruel, Ezel Berker, Cansu Özşin-Özler, Mina Gharibzadeh-Hızal, Öznur Gürpınar, Sanem Eryılmaz-Polat, Emel Tuğba Ataman-Duruel, Çağman Tan, Erdem Karabulut, Meryem Tekçiçek, Özgen Köseoğlu Eser, Nural Kiper, İlhan Tezcan,

BACKGROUND:Inflammatory periodontal diseases are caused by interaction between gram negative, anaerobic bacteria and host response. Persistent infection of Pseudomonas aeruginosa in cystic fibrosis (CF) patients also cause increased pro-inflammatory response and the imbalance of pro- and anti-inflammatory response in brochoalveolar lavage fluid which leads to destruction of lungs. The aim ... Read more >>

Cytokine (Cytokine)
[2020, 127:154987]

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Recurrent Demyelinating Episodes as Sole Manifestation of Inherited CD59 Deficiency.

Ismail Solmaz, Elif Soyak Aytekin, Deniz Çağdaş, Cagman Tan, Ilhan Tezcan, Rahsan Gocmen, Goknur Haliloglu, Banu Anlar,

Defects in the regulatory components of the complement system can lead to inflammatory diseases. We present a patient who had four episodes of demyelination in the central nervous system as the only manifestation of inherited CD59 deficiency. Relapsing encephalopathy partially responsive to intravenous immunoglobulin and steroid treatments on the background ... Read more >>

Neuropediatrics (Neuropediatrics)
[2020, 51(3):206-210]

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A Spectrum of Clinical Findings from ALPS to CVID: Several Novel LRBA Defects.

Deniz Cagdas, Sevil Oskay Halaçlı, Çağman Tan, Bernice Lo, Pınar Gür Çetinkaya, Saliha Esenboğa, Betül Karaatmaca, Helen Matthews, Burcu Balcı-Hayta, Tuba Arıkoğlu, Fatih Ezgü, Elifcan Aladağ, İnci N Saltık-Temizel, Hülya Demir, Barış Kuşkonmaz, Visal Okur, Fatma Gümrük, Hakan Göker, Duygu Çetinkaya, Kaan Boztuğ, Michael Lenardo, Özden Sanal, İlhan Tezcan,

<h4>Introduction</h4>Autosomal recessively inherited lipopolysaccharide-responsive beige-like anchor (LRBA) protein deficiency was shown to be responsible for different types of inborn errors of immunity, such as common variable immunodeficiency (CVID) and autoimmune lymphoproliferative syndrome (ALPS). The aim of this study was to compare patients with LRBA-related ALPS and LRBA-related CVID, to describe ... Read more >>

J Clin Immunol (Journal of clinical immunology)
[2019, 39(7):726-738]

Cited: 2 times

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Evaluation of Long-Term Silicone Hydrogel Use on Ocular Surface Inflammation and Tear Function in Patients With and Without Meibomian Gland Dysfunction.

Burcu Yucekul, Mehmet C Mocan, Sibel Kocabeyoglu, Cagman Tan, Murat Irkec,

<h4>Objectives</h4>To determine whether silicone hydrogel (SH) contact lens (CL) use, with or without meibomian gland dysfunction (MGD), promotes ocular surface inflammation.<h4>Methods</h4>Subjects wearing SH-CL for at least 6 months who also had coexisting MGD (group 1, n=20), SH-CL users who did not have MGD (group 2, n=20), patients who had MGD ... Read more >>

Eye Contact Lens (Eye & contact lens)
[2019, 45(1):61-66]

Cited: 1 time

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Effects of oral prophylaxis including tongue cleaning on halitosis and gingival inflammation in gingivitis patients-a randomized controlled clinical trial.

Buket Acar, Ezel Berker, Çağman Tan, Yağmur D İlarslan, Meryem Tekçiçek, İlhan Tezcan,

<h4>Objective</h4>The objective of this study was to assess the effect of oral prophylaxis including tongue scraping on level of halitosis, clinical periodontal parameters and local cytokine response in gingivitis patients.<h4>Materials and methods</h4>In this randomized controlled clinical trial, 36 gingivitis patients were randomly assigned into two subgroups after scaling and polishing. ... Read more >>

Clin Oral Investig (Clinical oral investigations)
[2019, 23(4):1829-1836]

Cited: 3 times

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ADA Deficiency: Evaluation of the Clinical and Laboratory Features and the Outcome.

Deniz Cagdas, Pınar Gur Cetinkaya, Betül Karaatmaca, Saliha Esenboga, Cagman Tan, Togay Yılmaz, Ersin Gümüş, Safa Barış, Barış Kuşkonmaz, Tuba Turul Ozgur, Pawan Bali, Ines Santisteban, Diclehan Orhan, Aysel Yüce, Duygu Cetinkaya, Kaan Boztug, Michael Hershfield, Ozden Sanal, İlhan Tezcan,

INTRODUCTION:Adenosine deaminase (ADA) deficiency is an autosomal recessive primary immunodeficiency. It results in the intracellular accumulation of toxic metabolites which have effects particularly on lymphocytes and the brain. The aim of this study was to evaluate the outcome of 13 ADA-deficient patients. We planned to evaluate their clinical and laboratory ... Read more >>

J Clin Immunol (Journal of clinical immunology)
[2018, 38(4):484-493]

Cited: 1 time

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Tumor necrosis factor α-308 G/A and interleukin 1 β-511 C/T gene polymorphisms in patients with scarring acne.

Gulsen Akoglu, Cagman Tan, Deniz Cagdas Ayvaz, Ilhan Tezcan,

BACKGROUND:Acne is a chronic inflammatory skin disorder which may heal with scarring. Tumor necrosis factor alpha (TNF α) and interleukin 1 β (IL-1β) are considered as the main responsible proinflammatory mediators of acne pathogenesis. Oversecretion of these cytokines was found to be associated with TNF α-308 G>A and IL-1β-511 C<T polymorphisms. ... Read more >>

J Cosmet Dermatol (Journal of cosmetic dermatology)
[2019, 18(1):395-400]

Cited: 0 times

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Clinical and genetic features of IL12Rb1 deficiency: Single center experience of 18 patients.

Çağman Tan, Deniz Çağdaş-Ayvaz, Ayşe Metin, Özlem Keskin, İlhan Tezcan, Özden Sanal,

Mendelian susceptibility to mycobacterial disease (MSMD) is characterized by infections with weakly virulent mycobacteria (BCG and environmental mycobacteria), M. tuberculosis, Salmonella, candida and some other intracellular microorganisms. Nine different genetic defects have been defined to cause MSMD and IL-12Rβ1 deficiency is the most common form. We present here the clinical ... Read more >>

Turk J Pediatr (The Turkish journal of pediatrics)
[2016, 58(4):356-361]

Cited: 2 times

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Polymorphisms in FAS and CASP8 genes may contribute to the development of ALPS phenotype: a study in 25 patients with probable ALPS.

Çağman Tan, Rıza Köksal Özgül, Deniz Çağdaş Ayvaz, İlhan Tezcan, Özden Sanal,

Defects in genes that have role in apoptotic pathways result in development of Autoimmune Lymphoproliferative Syndrome (ALPS) and ALPS related disorders. Germline and somatic FAS mutations, FASL and CASP10 mutations constitute other genetic defects in ALPS. Patients who fulfill ALPS diagnostic criteria and do not have any identified known disease ... Read more >>

Turk J Pediatr (The Turkish journal of pediatrics)
[2015, 57(2):141-145]

Cited: 0 times

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C1q deficiency: identification of a novel missense mutation and treatment with fresh frozen plasma.

Rezan Topaloglu, Ekim Z Taskiran, Cagman Tan, Baran Erman, Fatih Ozaltin, Ozden Sanal,

A Turkish patient with C1q deficiency presented with a lupus-like disease, and a new missense mutation at A chain is presented. To characterize the genetic defect, all exons of the genes for the A, B, and C chains of C1q were sequenced in the patient. This revealed a missense mutation ... Read more >>

Clin Rheumatol (Clinical rheumatology)
[2012, 31(7):1123-1126]

Cited: 7 times

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The role of human leucocyte antigens in children with hydatid disease: their association with clinical condition and prognosis.

Ebru Yalcin, Nural Kiper, Cagman Tan, Ugur Ozcelik, Deniz Dogru, Nazan Cobanoglu, Mehmet Kose, Sevgi Pekcan, Ayse Tana Aslan, Fugen Ersoy,

Hydatid disease (HD) is a parasitosis caused by Echinococcus granulosus, which is still an important health problem worldwide, and our country is an endemic region for HD. There is little information regarding the role of human leucocyte antigen (HLA) in genetic susceptibility or resistance to HD. In this study, we ... Read more >>

Parasitol Res (Parasitology research)
[2010, 106(4):795-800]

Cited: 4 times

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Increased availability of family donors for hematopoietic stem cell transplantation in a population with increased incidence of consanguinity.

Yasemin I Balcı, Betul Tavil, Cagman S Tan, Tuba T Ozgur, Burcu Bulum, Mualla Cetin, Mustafa Balcı, Songul Yalcın, Ilhan Tezcan, Duygu Uckan,

The study was planned to determine the frequency of parental and non-sibling family donor transplants in our center and to investigate the rate of familial donor availability at two HLA-typing laboratories in Turkey. Among 203 patients who underwent hematopoietic stem cell transplantation (HSCT), 151 (74.4%) received stem cells from siblings, ... Read more >>

Clin Transplant (Clinical transplantation)
[2011, 25(3):475-480]

Cited: 7 times

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