Full Text Journal Articles by
Author C Quinn

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Relationship between self-perceptions of aging and 'living well' among people with mild-to-moderate dementia: Findings from the ideal programme.

Serena Sabatini, Obioha C Ukoumunne, Anthony Martyr, Clive Ballard, Ruth A Lamont, Rachel Collins, Claire Pentecost, Anna Hunt, Catherine Quinn, Jeanette M Thom, Linda Clare, ,

<h4>Objective</h4>A primary goal for dementia research is to understand how to best support people to live well with dementia. Among cognitively healthy older individuals, more positive attitudes toward their own aging (ATOA) and/or feeling younger than their chronological age (i.e. having a younger subjective age: SA) are associated with better ... Read more >>

Arch Gerontol Geriatr (Archives of gerontology and geriatrics)
[2021, 94:104328]

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Correlates of depression among Black girls exposed to violence.

Bernadine Waller, Camille R Quinn, Donte Boyd, Ralph DiClemente, Dexter R Voisin,

Depression rates for youth remanded to juvenile detention is double that of the general population and Black girls are especially vulnerable. A dearth of literature analyzes the factors that are correlated with depression among system-involved Black girls, ages 12-17 years old. We utilized personal agency to examine the relationship between risk ... Read more >>

J Racial Ethn Health Disparities (Journal of racial and ethnic health disparities)
[2021, :]

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Fujifilm SILVAMP TB LAM assay on cerebrospinal fluid for the detection of tuberculous meningitis in HIV-infected adults.

Carson M Quinn, Enock Kagimu, Michael Okirworth, Ananta S Bangdiwala, Gerald Mugumya, Prashanth S Ramachandran, Michael R Wilson, David B Meya, Fiona V Cresswell, Nathan C Bahr, David R Boulware,

<h4>Background</h4>Tuberculous meningitis (TBM) has a high fatality rate with inadequate diagnostic tests being a major contributor. The rollout of Xpert MTB/Rif and Xpert MTB/Rif Ultra (Xpert Ultra) have improved time-to-diagnosis with sensitivities similar to culture, yet test availability and sensitivity are inadequate. The TB lipoarabinomannan lateral flow assay (AlereLAM) offers ... Read more >>

Clin Infect Dis (Clinical infectious diseases : an official publication of the Infectious Diseases Society of America)
[2021, :]

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An Evaluation of Empirical Approaches for Defining Cognitive Impairment in Amyotrophic Lateral Sclerosis

Corey McMillan, Joanne Wuu, Katya Rascovsky, Stephanie Cosentino, Murray Grossman, Lauren Elman, Colin Quinn, Luis Rosario, Jessica Stark, Volkan Granit, Hannah Briemberg, Sneha Chenji, Annie Dionne, Angela Genge, Wendy Johnston, Lawrence Korngut, Christen Shoesmith, Lorne Zinman, Sanjay Kalra, Michael Benatar, ,

<h4>Importance</h4> Amyotrophic lateral sclerosis (ALS) is a multi-system disorder characterized primarily by motor neuron degeneration, but may be accompanied by cognitive dysfunction. Statistically appropriate criteria for establishing cognitive impairment (CI) in ALS are lacking. <h4>Objective</h4> Define thresholds for CI in ALS using quantile regression (QR) that accounts for age and ... Read more >>

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Congenital dyserythropoietic anemia type I: First report from the Congenital Dyserythropoietic Anemia Registry of North America (CDAR).

Omar Niss, Robert B Lorsbach, Mikaela Berger, Satheesh Chonat, Morgan McLemore, David Buchbinder, Timothy McCavit, Linda G Shaffer, Jessica Simpson, Jeffrey H Schwartz, Jessica Meznarich, Myesa Emberesh, Katie G Seu, Wenying Zhang, Theodosia A Kalfa, ,

Congenital dyserythropoietic anemias (CDAs) are characterized by ineffective erythropoiesis and distinctive erythroblast abnormalities; the diagnosis is often missed or delayed due to significant phenotypic heterogeneity. We established the CDA Registry of North America (CDAR) to study the natural history of CDA and create a biorepository to investigate the pathobiology of ... Read more >>

Blood Cells Mol Dis (Blood cells, molecules & diseases)
[2020, 87:102534]

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The Collaborative Aging Research Using Technology Initiative: An Open, Sharable, Technology-Agnostic Platform for the Research Community.

Zachary Beattie, Lyndsey M Miller, Carlos Almirola, Wan-Tai M Au-Yeung, Hannah Bernard, Kevin E Cosgrove, Hiroko H Dodge, Charlene J Gamboa, Ona Golonka, Sarah Gothard, Sam Harbison, Stephanie Irish, Judith Kornfeld, Jonathan Lee, Jennifer Marcoe, Nora C Mattek, Charlie Quinn, Christina Reynolds, Thomas Riley, Nathaniel Rodrigues, Nicole Sharma, Mary Alice Siqueland, Neil W Thomas, Timothy Truty, Rachel Wall, Katherine Wild, Chao-Yi Wu, Jason Karlawish, Nina B Silverberg, Lisa L Barnes, Sara Czaja, Lisa C Silbert, Jeffrey Kaye,

<h4>Introduction</h4>Future digital health research hinges on methodologies to conduct remote clinical assessments and in-home monitoring. The Collaborative Aging Research Using Technology (CART) initiative was introduced to establish a digital technology research platform that could widely assess activity in the homes of diverse cohorts of older adults and detect meaningful change ... Read more >>

Digit Biomark (Digital biomarkers)
[2020, 4(Suppl 1):100-118]

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Machine learning suggests polygenic risk for cognitive dysfunction in amyotrophic lateral sclerosis.

Katerina Placek, Michael Benatar, Joanne Wuu, Evadnie Rampersaud, Laura Hennessy, Vivianna M Van Deerlin, Murray Grossman, David J Irwin, Lauren Elman, Leo McCluskey, Colin Quinn, Volkan Granit, Jeffrey M Statland, Ted M Burns, John Ravits, Andrea Swenson, Jon Katz, Erik P Pioro, Carlayne Jackson, James Caress, Yuen So, Samuel Maiser, David Walk, Edward B Lee, John Q Trojanowski, Philip Cook, James Gee, Jin Sha, Adam C Naj, Rosa Rademakers, , Wenan Chen, Gang Wu, J Paul Taylor, Corey T McMillan,

Amyotrophic lateral sclerosis (ALS) is a multi-system disease characterized primarily by progressive muscle weakness. Cognitive dysfunction is commonly observed in patients; however, factors influencing risk for cognitive dysfunction remain elusive. Using sparse canonical correlation analysis (sCCA), an unsupervised machine-learning technique, we observed that single nucleotide polymorphisms collectively associate with baseline ... Read more >>

EMBO Mol Med (EMBO molecular medicine)
[2020, :e12595]

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Commentary.

Christine L Quinn,

Due to the ongoing nature of the COVID-19 pandemic, I have decided to print the following commentary to help provide another alternative for reducing potential exposure to and incidental transmission of SARS-CoV-2 during the provision of anesthesia for dentistry. -Kyle J. Kramer, Editor-in-Chief. ... Read more >>

Anesth Prog (Anesthesia progress)
[2020, 67(4):245-247]

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Bi-level positive airway pressure (biPAP) for non-invasive respiratory support of foals

Sharanne Raidal, Lexi Burgmeestre, Chee Sum Melanie Catanchin, Chris Quinn,

Respiratory insufficiency and pulmonary health are important considerations in equine neonatal care, as the majority of foals are bred for athletic function. The administration of supplementary oxygen is readily implemented in equine practice settings, but this does not address respiratory insufficiency due to inadequate ventilation and is no longer considered ... Read more >>

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Hydroxyurea Optimization through Precision Study (HOPS): study protocol for a randomized, multicenter trial in children with sickle cell anemia.

Emily R Meier, Susan E Creary, Matthew M Heeney, Min Dong, Abena O Appiah-Kubi, Stephen C Nelson, Omar Niss, Connie Piccone, Maa-Ohui Quarmyne, Charles T Quinn, Kay L Saving, John P Scott, Ravi Talati, Teresa S Latham, Amanda Pfeiffer, Lisa M Shook, Alexander A Vinks, Adam Lane, Patrick T McGann,

<h4>Background</h4>Sickle cell disease (SCD) is a severe and devastating hematological disorder that affects over 100,000 persons in the USA and millions worldwide. Hydroxyurea is the primary disease-modifying therapy for the SCD, with proven benefits to reduce both short-term and long-term complications. Despite the well-described inter-patient variability in pharmacokinetics (PK), pharmacodynamics, ... Read more >>

Trials (Trials)
[2020, 21(1):983]

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Sex-dependent effects of developmental hypoxia on cardiac mitochondria from adult murine offspring.

Kim T Hellgren, Hajani Premanandhan, Callum J Quinn, Andrew W Trafford, Gina L J Galli,

Insufficient oxygen supply (hypoxia) during fetal and embryonic development can lead to latent phenotypical changes in the adult cardiovascular system, including altered cardiac function and increased susceptibility to ischemia reperfusion injury. While the cellular mechanisms underlying this phenomenon are largely unknown, several studies have pointed towards metabolic disturbances in the ... Read more >>

Free Radic Biol Med (Free radical biology & medicine)
[2020, :]

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Hydroxyurea Optimization through Precision Study (HOPS): study protocol for a randomized, multicenter trial in children with sickle cell anemia

Emily Meier, Susan Creary, Matthew Heeney, Min Dong, Abena Appiah‐Kubi, Stephen Nelson, Omar Niss, Connie Piccone, Maa-Ohui Quarmyne, Charles Quinn, Kay Saving, John Scott, Ravi Talati, Teresa Latham, Amanda Pfeiffer, Lisa Shook, Alexander Vinks, Adam Lane, Patrick McGann,

<h4>Background: </h4> : Sickle cell disease (SCD) is a severe and devastating hematological disorder that affects over 100,000 persons in the United States and millions worldwide. Hydroxyurea is the primary disease-modifying therapy for the SCD, with proven benefits to reduce both short-term and long-term complications. Despite the well-described inter-patient variability ... Read more >>

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Metaplastic carcinomas of the breast without evidence of epithelial differentiation: a diagnostic approach for management.

Emad A Rakha, Cecily M Quinn, Maria Pia Foschini, Monica Muñoz Martin, David J Dabbs, Sunil Lakhani, Zsuzsanna Varga, Sarah E Pinder, Fernando C Schmitt, Jorge S Reis-Filho, Stephen B Fox, Ian O Ellis, Puay-Hoon Tan, Raluca Mihai,

<h4>Aims</h4>Although rare, malignant sarcomatoid breast tumours without evidence of epithelial differentiation comprise a diagnostic challenge with management implications. Earlier studies have generally considered these to be primary breast sarcomas; however, supporting evidence is lacking and management remains variable. This study aimed to provide an evidence-based approach to improve the consistency ... Read more >>

Histopathology (Histopathology)
[2020, :]

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Long-term survival of participants in the CENTAUR trial of sodium phenylbutyrate-taurursodiol in amyotrophic lateral sclerosis.

Sabrina Paganoni, Suzanne Hendrix, Samuel P Dickson, Newman Knowlton, Eric A Macklin, James D Berry, Michael A Elliott, Samuel Maiser, Chafic Karam, James B Caress, Margaret Ayo Owegi, Adam Quick, James Wymer, Stephen A Goutman, Daragh Heitzman, Terry D Heiman-Patterson, Carlayne E Jackson, Colin Quinn, Jeffrey D Rothstein, Edward J Kasarskis, Jonathan Katz, Liberty Jenkins, Shafeeq Ladha, Timothy M Miller, Stephen N Scelsa, Tuan H Vu, Christina N Fournier, Jonathan D Glass, Kristin M Johnson, Andrea Swenson, Namita A Goyal, Gary L Pattee, Patricia L Andres, Suma Babu, Marianne Chase, Derek Dagostino, Meghan Hall, Gale Kittle, Matthew Eydinov, Michelle McGovern, Joseph Ostrow, Lindsay Pothier, Rebecca Randall, Jeremy M Shefner, Alexander V Sherman, Maria E St Pierre, Eric Tustison, Prasha Vigneswaran, Jason Walker, Hong Yu, James Chan, Janet Wittes, Zi-Fan Yu, Joshua Cohen, Justin Klee, Kent Leslie, Rudolph E Tanzi, Walter Gilbert, Patrick D Yeramian, David Schoenfeld, Merit E Cudkowicz,

An orally administered, fixed-dose coformulation of sodium phenylbutyrate-taurursodiol (PB-TURSO) significantly slowed functional decline in a randomized, placebo-controlled, phase 2 trial in ALS (CENTAUR). Herein we report results of a long-term survival analysis of participants in CENTAUR. In CENTAUR, adults with ALS were randomized 2:1 to PB-TURSO or placebo. Participants completing ... Read more >>

Muscle Nerve (Muscle & nerve)
[2021, 63(1):31-39]

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Coherence of marine alien species biosecurity legislation: A study of England and Wales.

Caitriona Shannon, Claire H Quinn, Alison M Dunn, Paul D Stebbing,

The marine environment is particularly at risk from the intentional and unintentional introduction and spread of invasive alien species (IAS); preventing their introduction and spread from occurring is therefore, a key component in the on-going management of marine IAS. Ensuring legislation is coherent and consistent is essential to the success ... Read more >>

Mar Pollut Bull (Marine pollution bulletin)
[2020, 161(Pt B):111796]

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How current assay approval policies are leading to unintended imprecision medicine.

Roberto Salgado, Andrew M Bellizzi, David Rimm, John M S Bartlett, Torsten Nielsen, Moch Holger, Anne-Vibeke Laenkholm, Cecily Quinn, Gábor Cserni, Isabela W Cunha, Isabel Alvarado-Cabrero, Ian Cree,

Lancet Oncol (The Lancet. Oncology)
[2020, 21(11):1399-1401]

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Correction: Dynamic classification of personal microenvironments using a suite of wearable, low-cost sensors.

Casey Quinn, G Brooke Anderson, Sheryl Magzamen, Charles S Henry, John Volckens,

The original version of this Article featured an incorrect supplementary figure file. This error has been rectified in the PDF and HTML versions of this Article. ... Read more >>

J Expo Sci Environ Epidemiol (Journal of exposure science & environmental epidemiology)
[2020, 30(6):1032]

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Tuberculosis IRIS: Pathogenesis, Presentation, and Management across the Spectrum of Disease.

Carson M Quinn, Victoria Poplin, John Kasibante, Kyle Yuquimpo, Jane Gakuru, Fiona V Cresswell, Nathan C Bahr,

Antiretroviral therapy (ART), while essential in combatting tuberculosis (TB) and HIV coinfection, is often complicated by the TB-associated immune reconstitution inflammatory syndrome (TB-IRIS). Depending on the TB disease site and treatment status at ART initiation, this immune-mediated worsening of TB pathology can take the form of paradoxical TB-IRIS, unmasking TB-IRIS, ... Read more >>

Life (Basel) (Life (Basel, Switzerland))
[2020, 10(11):]

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A Journey of Hope: giving research participants a voice to share their experiences and improve community engagement around advanced HIV disease in Uganda

Fiona Cresswell, John Kasibante, Emily Martyn, Lillian Tugume, Gavin Stead, Kenneth Ssembambulidde, Morris Rutakingirwa, Enock Kagimu, Laura Nsangi, Carol Namuju, Jane Ndyetukira, Cynthia Ahimbisibwe, Florence Kugonza, Alisat Sadiq, Alice Namudde, Joanna Dobbin, Diksha Srishyla, Carson Quinn, Mable Kabahubya, Conrad Muzoora, Stephen Watiti, David Meya, Alison Elliott,

Over the last decade excellent progress has been made globally in HIV management thanks to antiretroviral therapy (ART) rollout and international guidelines now recommending immediate initiation of ART in people living with HIV. Despite this, advanced HIV disease (CD4 less than 200 cells/mL) and opportunistic infections remain a persistent challenge ... Read more >>

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Consumers living with psychosis: Perspectives on sexuality.

Alicia M Evans, Chris Quinn, Brian McKenna, Karen Willis,

Mental health clinicians work within a recovery framework that is rights based and emphasizes positive and respectful approaches to working with mental health consumers. Mental health nurses' practice is also predicated on holism and inclusiveness, yet consumers' sexuality is sometimes neglected and rights in this area overlooked. Also overlooked is ... Read more >>

Int J Ment Health Nurs (International journal of mental health nursing)
[2020, :]

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Engineered RNA-Interacting CRISPR Guide RNAs for Genetic Sensing and Diagnostics.

Roberto Galizi, John N Duncan, William Rostain, Charlotte M Quinn, Marko Storch, Manish Kushwaha, Alfonso Jaramillo,

CRISPR guide RNAs (gRNAs) can be programmed with relative ease to allow the genetic editing of nearly any DNA or RNA sequence. Here, we propose novel molecular architectures to achieve RNA-dependent modulation of CRISPR activity in response to specific RNA molecules. We designed and tested, in both living <i>Escherichia coli</i> ... Read more >>

CRISPR J (The CRISPR journal)
[2020, 3(5):398-408]

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Amyotrophic Lateral Sclerosis and Other Motor Neuron Diseases.

Colin Quinn, Lauren Elman,

<h4>Purpose of review</h4>This article reviews the clinical features, diagnostic approach, and treatments available for amyotrophic lateral sclerosis (ALS) and other motor neuron diseases. The article also provides an update on the genetics and pathophysiology of ALS.<h4>Recent findings</h4>ALS remains a clinical diagnosis without a unique biomarker. The areas of greatest progress ... Read more >>

Continuum (Minneap Minn) (Continuum (Minneapolis, Minn.))
[2020, 26(5):1323-1347]

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Severe infusion-related reaction to crizanlizumab in an adolescent with sickle cell disease.

Kristine Karkoska, Charles T Quinn, Kelly Clapp, Patrick T McGann,

Am J Hematol (American journal of hematology)
[2020, 95(12):E338-E339]

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Experiences of Serving and Ex-Serving Members With the PTSD Coach Australia App: Mixed Methods Study.

Jane Shakespeare-Finch, Karolina K Alichniewicz, Esben Strodl, Kelly Brown, Catherine Quinn, Leanne Hides, Angela White, Gabrial Gossage, Loretta Poerio, Dimitri Batras, Samantha Jackson, Jess Styles, David Kavanagh,

<h4>Background</h4>PTSD Coach Australia is an app for serving and ex-serving defense members and was adapted for the Australian context in 2013 from PTSD Coach, which was created in the United States.<h4>Objective</h4>This study aimed to provide a user-centered evaluation of the app from the perspective of serving and ex-serving members of ... Read more >>

J Med Internet Res (Journal of medical Internet research)
[2020, 22(10):e18447]

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Exosomes as Biomarkers of Human and Feline Mammary Tumours; A Comparative Medicine Approach to Unravelling the Aggressiveness of TNBC.

Jane Howard, Cathy Wyse, David Argyle, Cecily Quinn, Pamela Kelly, Amanda McCann,

Comparative oncology is defined as the discipline that integrates naturally occurring cancers seen in veterinary medicine, into more general studies of cancer biology and therapy in humans, including the study of cancer-pathogenesis and new cancer treatments. While experimental studies in mice and rodents offer several advantages, including a wealth of ... Read more >>

Biochim Biophys Acta Rev Cancer (Biochimica et biophysica acta. Reviews on cancer)
[2020, 1874(2):188431]

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