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Assessing Human Health Risks from Per- and Polyfluoroalkyl Substance (PFAS)-Impacted Vegetable Consumption: A Tiered Modeling Approach.

Juliane B Brown, Jason M Conder, Jennifer A Arblaster, Christopher P Higgins,

Irrigation water or soil contaminated with per- and polyfluoroalkyl substances (PFASs) raises concerns among regulators tasked with protecting human health from potential PFAS-contaminated food crops, with several studies identifying crop uptake as an important exposure pathway. We estimated daily dietary exposure intake of individual PFASs in vegetables for children and ... Read more >>

Environ Sci Technol (Environmental science & technology)
[2020, :]

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Adding team-based financial incentives to the Carrot Rewards physical activity app increases daily step count on a population scale: a 24-week matched case control study.

Emma Pearson, Harry Prapavessis, Christopher Higgins, Robert Petrella, Lauren White, Marc Mitchell,

BACKGROUND:Mobile health applications (mHealth apps) targeting physical inactivity have increased in popularity yet are usually limited by low engagement. This study examined the impact of adding team-based incentives (Step Together Challenges, STCs) to an existing mHealth app (Carrot Rewards) that rewarded individual physical activity achievements. METHODS:A 24-week quasi-experimental study (retrospective ... Read more >>

Int J Behav Nutr Phys Act (The international journal of behavioral nutrition and physical activity)
[2020, 17(1):139]

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Effect of Hydroxychloroquine on Clinical Status at 14 Days in Hospitalized Patients With COVID-19: A Randomized Clinical Trial.

Wesley H Self, Matthew W Semler, Lindsay M Leither, Jonathan D Casey, Derek C Angus, Roy G Brower, Steven Y Chang, Sean P Collins, John C Eppensteiner, Michael R Filbin, D Clark Files, Kevin W Gibbs, Adit A Ginde, Michelle N Gong, Frank E Harrell, Douglas L Hayden, Catherine L Hough, Nicholas J Johnson, Akram Khan, Christopher J Lindsell, Michael A Matthay, Marc Moss, Pauline K Park, Todd W Rice, Bryce R H Robinson, David A Schoenfeld, Nathan I Shapiro, Jay S Steingrub, Christine A Ulysse, Alexandra Weissman, Donald M Yealy, B Taylor Thompson, Samuel M Brown, , Jay Steingrub, Howard Smithline, Bogdan Tiru, Mark Tidswell, Lori Kozikowski, Sherell Thornton-Thompson, Leslie De Souza, Peter Hou, Rebecca Baron, Anthony Massaro, Imoigele Aisiku, Lauren Fredenburgh, Raghu Seethala, Lily Johnsky, Richard Riker, David Seder, Teresa May, Michael Baumann, Ashley Eldridge, Nathan Shapiro, Daniel Talmor, Thomas O’Mara, Charlotte Kirk, Kelly Harrison, Lisa Kurt, Margaret Schermerhorn, Valerie Banner-Goodspeed, Katherine Boyle, Nicole Dubosh, Michael Filbin, Kathryn Hibbert, Blair Parry, Kendall Lavin-Parsons, Natalie Pulido, Brendan Lilley, Carl Lodenstein, Justin Margolin, Kelsey Brait, Alan Jones, James Galbraith, Rebekah Peacock, Utsav Nandi, Taylor Wachs, Michael Matthay, Kathleen Liu, Kirsten Kangelaris, Ralph Wang, Carolyn Calfee, Kimberly Yee, Gregory Hendey, Steven Chang, George Lim, Nida Qadir, Andrea Tam, Rebecca Beutler, Joseph Levitt, Jenny Wilson, Angela Rogers, Rosemary Vojnik, Jonasel Roque, Timothy Albertson, James Chenoweth, Jason Adams, Skyler Pearson, Maya Juarez, Eyad Almasri, Mohamed Fayed, Alyssa Hughes, Shelly Hillard, Ryan Huebinger, Henry Wang, Elizabeth Vidales, Bela Patel, Adit Ginde, Marc Moss, Amiran Baduashvili, Jeffrey McKeehan, Lani Finck, Carrie Higgins, Michelle Howell, Ivor Douglas, Jason Haukoos, Terra Hiller, Carolynn Lyle, Alicia Cupelo, Emily Caruso, Claudia Camacho, Stephanie Gravitz, James Finigan, Christine Griesmer, Pauline Park, Robert Hyzy, Kristine Nelson, Kelli McDonough, Norman Olbrich, Mark Williams, Raj Kapoor, Jean Nash, Meghan Willig, Henry Ford, Jayna Gardner-Gray, Mayur Ramesh, Montefiore Moses, Michelle Ng Gong, Michael Aboodi, Ayesha Asghar, Omowunmi Amosu, Madeline Torres, Savneet Kaur, Montefiore Weiler, Jen-Ting Chen, Aluko Hope, Brenda Lopez, Kathleen Rosales, Jee Young You, Jarrod Mosier, Cameron Hypes, Bhupinder Natt, Bryan Borg, Elizabeth Salvagio, R. Duncan Hite, Kristin Hudock, Autumn Cresie, Faysal Alhasan, Jose Gomez-Arroyo, Abhijit Duggal, Omar Mehkri, Andrei Hastings, Debasis Sahoo, Francois Abi Fadel, Susan Gole, Valerie Shaner, Allison Wimer, Yvonne Meli, Alexander King, Thomas Terndrup, Matthew Exline, Sonal Pannu, Emily Robart, Sarah Karow, Catherine Hough, Bryce Robinson, Nicholas Johnson, Daniel Henning, Monica Campo, Stephanie Gundel, Sakshi Seghal, Sarah Katsandres, Sarah Dean, Akram Khan, Olivia Krol, Milad Jouzestani, Peter Huynh, Alexandra Weissman, Donald Yealy, Denise Scholl, Peter Adams, Bryan McVerry, David Huang, Derek Angus, Jordan Schooler, Steven Moore, D. Clark Files, Chadwick Miller, Kevin Gibbs, Mary LaRose, Lori Flores, Lauren Koehler, Caryn Morse, John Sanders, Caitlyn Langford, Kristen Nanney, Masiku MdalaGausi, Phyllis Yeboah, Peter Morris, Jamie Sturgill, Sherif Seif, Evan Cassity, Sanjay Dhar, Marjolein de Wit, Jessica Mason, Andrew Goodwin, Greg Hall, Abbey Grady, Amy Chamberlain, Samuel Brown, Joseph Bledsoe, Lindsay Leither, Ithan Peltan, Nathan Starr, Melissa Fergus, Valerie Aston, Quinn Montgomery, Rilee Smith, Mardee Merrill, Katie Brown, Brent Armbruster, Estelle Harris, Elizabeth Middleton, Robert Paine, Stacy Johnson, Macy Barrios, John Eppensteiner, Alexander Limkakeng, Lauren McGowan, Tedra Porter, Andrew Bouffler, J. Clancy Leahy, Bennet deBoisblanc, Matthew Lammi, Kyle Happel, Paula Lauto, Wesley Self, Jonathan Case, Matthew Semler, Sean Collins, Frank Harrell, Christopher Lindsell, Todd Rice, William Stubblefield, Christopher Gray, Jakea Johnson, Megan Roth, Margaret Hays, Donna Torr, Arwa Zakaria, David Schoenfeld, B. Taylor Thompson, Douglas Hayden, Nancy Ringwood, Cathryn Oldmixon, Christine Ulysse, Richard Morse, Ariela Muzikansky, Laura Fitzgerald, Samuel Whitaker, Adrian Lagakos, Lora Reineck, Neil Aggarwal, Karen Bienstock, Michelle Freemer, Myron Maclawiw, Gail Weinmann, Laurie Morrison, Mark Gillespie, Richard Kryscio, Daniel Brodie, Wojciech Zareba, Anne Rompalo, Michael Boeckh, Polly Parsons, Jason Christie, Jesse Hall, Nicholas Horton, Laurie Zoloth, Neal Dickert, Deborah Diercks,

Importance:Data on the efficacy of hydroxychloroquine for the treatment of coronavirus disease 2019 (COVID-19) are needed. Objective:To determine whether hydroxychloroquine is an efficacious treatment for adults hospitalized with COVID-19. Design, Setting, and Participants:This was a multicenter, blinded, placebo-controlled randomized trial conducted at 34 hospitals in the US. Adults hospitalized with ... Read more >>

JAMA (JAMA)
[2020, :]

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Abnormalities of Aspiration and Swallowing Function in Survivors of Acute Respiratory Failure.

Susan E Langmore, Gintas P Krisciunas, Heather Warner, S David White, Daniel Dvorkin, Daniel Fink, Edel McNally, Rebecca Scheel, Carrie Higgins, Joseph E Levitt, Jeffrey McKeehan, Sandra Deane, Jonathan M Siner, Rosemary Vojnik, Marc Moss,

The mechanisms responsible for aspiration are relatively unknown in patients recovering from acute respiratory failure (ARF) who required mechanical ventilation. Though many conditions may contribute to swallowing dysfunction, alterations in laryngeal structure and swallowing function likely play a role in the development of aspiration. At four university-based tertiary medical centers, ... Read more >>

Dysphagia (Dysphagia)
[2020, :]

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Immunotoxicity of an Electrochemically Fluorinated Aqueous Film-Forming Foam.

Carrie A McDonough, Chastity Ward, Qing Hu, Samuel Vance, Christopher P Higgins, Jamie C DeWitt,

Aqueous film-forming foams (AFFFs) are complex per- and polyfluoroalkyl substance (PFAS)-containing mixtures used extensively as fire suppressants. AFFF-impacted groundwater and surface water have contaminated drinking water with PFASs in many communities, raising concerns about health effects from drinking water exposures. As individual PFASs have been identified as immune hazards, the ... Read more >>

Toxicol Sci (Toxicological sciences : an official journal of the Society of Toxicology)
[2020, 178(1):104-114]

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Healthcare costs and quality of life associated with the long-term outcome of anxiety disorders.

Cassie Higgins, Julie A Chambers, Kirsten Major, Robert C Durham,

BACKGROUND AND OBJECTIVES:Anxiety disorders are costly; however, the relationship with treatment outcome has been neglected. This study examined healthcare costs and quality of life by diagnostic status (treatment outcome and the presence of comorbidity) at long-term follow-up. DESIGN AND METHODS:This cohort study comprized 317 patients entering treatment for at least ... Read more >>

Anxiety Stress Coping (Anxiety, stress, and coping)
[2020, :1-14]

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Adding team-based financial incentives to the Carrot Rewards physical activity app increases daily step count on a population scale: A 24-week matched case control study

Emma Pearson, Harry Prapavessis, Christopher Higgins, Robert Petrella, Lauren White, Marc Mitchell,

Abstract Background: Mobile health applications (mHealth apps) targeting physical inactivity have increased in popularity yet are usually limited by low engagement. This study examined the impact of adding team-based incentives (Step Together Challenges, STCs) to an existing mHealth app (Carrot Rewards) that rewarded individual physical activity achievements. Methods: A 24-week ... Read more >>

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Mendelian randomization of dyslipidemia on cognitive impairment among older Americans

Mingzhou Fu, Kelly Bakulski, Cesar Higgins, Erin Ware,

Abstract Background Altered lipid metabolism may be a risk factor for dementia, and blood cholesterol level has a strong genetic component. We tested the hypothesis that dyslipidemia (either low levels of high-density lipoprotein cholesterol (HDL-C) or high total cholesterol) is associated with cognitive status and domains, and assessed inferred causality ... Read more >>

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Maternal Depressive Symptoms and Developmental Delay at Age 2: A Diverse Population-Based Longitudinal Study.

Tamar Nazerian Chorbadjian, Alexis Deavenport-Saman, Chandra Higgins, Shin Margaret Chao, Jeffrey H Yang, Irene Koolwijk, Douglas L Vanderbilt,

OBJECTIVES:Children raised by depressed mothers perform lower on measures of cognitive, emotional, and behavioral skills, compared to children of non-depressed mothers. It is unclear how maternal depressive symptoms (MDS), which persist and accrue over time, impact child development. The purpose of this study was to determine whether cumulative MDS from ... Read more >>

Matern Child Health J (Maternal and child health journal)
[2020, 24(10):1267-1277]

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Examination of the clinical factors associated with attendance at emergency departments for chronic pain management and the cost of treatment relative to that of other significant medical conditions.

Cassie Higgins, Blair H Smith, Lesley Colvin,

Little is known about risk factors for emergency department (ED) attendance for chronic pain (CP) management and the relative service burden. We examined emergency department (ED) utilisation in patients with chronic pain (CP), identified risk factors associated with attendance for chronic musculoskeletal pain (CMP) and estimated the comparative cost of ... Read more >>

Pain (Pain)
[2020, :]

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Per- and polyfluoroalkyl substances (PFASs) in contaminated coastal marine waters of the Saudi Arabian Red Sea: a baseline study.

Aasim M Ali, Christopher P Higgins, Walied M Alarif, Sultan S Al-Lihaibi, Mohammed Ghandourah, Roland Kallenborn,

Per- and polyfluoroalkyl substances (PFASs) are today considered important constituents of the continuously growing substance group of persistent contaminants of emerging environmental concern (PCEC). Here, we report for the first time the concentrations of 12 relevant PFASs in 28 marine water samples from the Saudi Arabian coastal waters of the ... Read more >>

Environ Sci Pollut Res Int (Environmental science and pollution research international)
[2020, :]

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Influenza virus repurposes the antiviral protein IFIT2 to promote translation of viral mRNAs.

Vy Tran, Mitchell P Ledwith, Thiprampai Thamamongood, Christina A Higgins, Shashank Tripathi, Max W Chang, Christopher Benner, Adolfo García-Sastre, Martin Schwemmle, Adrianus C M Boon, Michael S Diamond, Andrew Mehle,

Cells infected by influenza virus mount a large-scale antiviral response and most cells ultimately initiate cell-death pathways in an attempt to suppress viral replication. We performed a CRISPR-Cas9-knockout selection designed to identify host factors required for replication after viral entry. We identified a large class of presumptive antiviral factors that ... Read more >>

Nat Microbiol (Nature microbiology)
[2020, 5(12):1490-1503]

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Effect of Chitosan Microparticles on the Uterine Microbiome of Dairy Cows with Metritis.

Klibs N Galvão, Eduardo B de Oliveira, Federico Cunha, Rodolfo Daetz, Kristi Jones, Zhengxin Ma, Kwangcheol C Jeong, Rodrigo C Bicalho, Catherine H Higgins, Marjory X Rodrigues, Candelaria Gonzalez Moreno, Soojin Jeon,

The objective of this study was to evaluate the effect of chitosan microparticles on the uterine microbiome of cows with metritis. Dairy cows with metritis (n = 89) were assigned to 1 of 3 treatments: chitosan microparticles (n = 21), in which the cows received an intrauterine infusion of chitosan microparticles at metritis diagnosis ... Read more >>

Appl Environ Microbiol (Applied and environmental microbiology)
[2020, 86(18):]

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Optimal Timing of CT Scanning in the Rapid Access Lung Cancer Clinic.

M Hennessy, D Ryan, S Clarke, C Higgins, M Logan, E O’Brien, R Morgan,

Aims To investigate whether a ‘CT first’ approach to Rapid Access Lung Cancer Clinic (RALC) review could be feasible in an Irish context. Methods A retrospective review of our institution’s Lung Cancer Database was performed. All RALC first attendances from 2012-2018 were identified. Timing of CT was assessed as well ... Read more >>

Ir Med J (Irish medical journal)
[2020, 113(7):121]

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Development of an Accurate Bedside Swallowing Evaluation Decision Tree Algorithm for Detecting Aspiration in Acute Respiratory Failure Survivors.

Marc Moss, S David White, Heather Warner, Daniel Dvorkin, Daniel Fink, Stephanie Gomez-Taborda, Carrie Higgins, Gintas P Krisciunas, Joseph E Levitt, Jeffrey McKeehan, Edel McNally, Alix Rubio, Rebecca Scheel, Jonathan M Siner, Rosemary Vojnik, Susan E Langmore,

BACKGROUND:The bedside swallowing evaluation (BSE) is an assessment of swallowing function and airway safety during swallowing. After extubation, the BSE often is used to identify the risk of aspiration in acute respiratory failure (ARF) survivors. RESEARCH QUESTION:We conducted a multicenter prospective study of ARF survivors to determine the accuracy of ... Read more >>

Chest (Chest)
[2020, 158(5):1923-1933]

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Financial Toxicity After Acute Respiratory Distress Syndrome: A National Qualitative Cohort Study.

Katrina E Hauschildt, Claire Seigworth, Lee A Kamphuis, Catherine L Hough, Marc Moss, Joanne M McPeake, Theodore J Iwashyna, ,

OBJECTIVES:The financial burdens and subsequent related distress of medical care, referred to as financial toxicity, may limit access to beneficial treatments. However, financial toxicity after acute care is less described-and may be an important but underexplored mechanism preventing full recovery after critical illnesses such as acute respiratory distress syndrome. We ... Read more >>

Crit Care Med (Critical care medicine)
[2020, 48(8):1103-1110]

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Impact of substandard and falsified antimalarials in Zambia: application of the SAFARI model.

Kathryn D Jackson, Colleen R Higgins, Sarah K Laing, Chiluba Mwila, Tamaki Kobayashi, Matthew M Ippolito, Sean Sylvia, Sachiko Ozawa,

BACKGROUND:Many countries are striving to become malaria-free, but global reduction in case estimates has stagnated in recent years. Substandard and falsified medicines may contribute to this lack of progress. Zambia aims to eliminate their annual burden of 1.2 million pediatric malaria cases and 2500 child deaths due to malaria. We ... Read more >>

BMC Public Health (BMC public health)
[2020, 20(1):1083]

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Electronic linkage and interrogation of administrative health, social care, and criminal justice datasets: feasibility concerning process and content.

Cassie Higgins, Keith Matthews,

The objective was to test the feasibility of a novel model of electronic linkage and interrogation of large, sensitive, administrative datasets derived from health care, social care, and criminal justice. Participants comprised all individuals having completed suicide or drug-related death in Tayside between 2009 and 2014. Data were hosted, linked, ... Read more >>

Inform Health Soc Care (Informatics for health & social care)
[2020, 45(4):444-460]

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Importance of medicine quality in achieving universal health coverage.

Sachiko Ozawa, Colleen R Higgins, Tatenda T Yemeke, Jude I Nwokike, Lawrence Evans, Mustapha Hajjou, Victor S Pribluda,

OBJECTIVE:To assess the importance of ensuring medicine quality in order to achieve universal health coverage (UHC). METHODS:We developed a systems map connecting medicines quality assurance systems with UHC goals to illustrate the ensuing impact of quality-assured medicines in the implementation of UHC. The association between UHC and medicine quality was ... Read more >>

PLoS One (PloS one)
[2020, 15(7):e0232966]

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Replay bursts coincide with activation of the default mode and parietal alpha network

Cameron Higgins, Yunzhe Liu, Diego Vidaurre, Zeb Kurth-Nelson, Ray Dolan, Timothy Behrens, Mark Woolrich,

Abstract Our brains at rest spontaneously replay recently acquired information, but how this process is orchestrated to avoid interference with ongoing cognition is an open question. We investigated whether replay coincided with spontaneous patterns of whole brain activity. We found, in two separate datasets, that replay sequences were packaged into ... Read more >>

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Effect of produced water treatment technologies on irrigation-induced metal and salt accumulation in wheat (Triticum aestivum) and sunflower (Helianthus annuus).

Erin M Sedlacko, Jacqueline M Chaparro, Adam L Heuberger, Tzahi Y Cath, Christopher P Higgins,

Produced water (PW), a wastewater resulting from hydraulic fracturing and oil and gas production, has been utilized in arid regions for irrigation purposes and potentially presents a new water source for crop irrigation in areas of increasing water scarcity. However, there is a potential for both synthetic and geogenic contaminants ... Read more >>

Sci Total Environ (The Science of the total environment)
[2020, 740:140003]

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Quantifying the Contribution of Habitats and Pathways to a Spatially Structured Population Facing Environmental Change.

Christine Sample, Joanna A Bieri, Benjamin Allen, Yulia Dementieva, Alyssa Carson, Connor Higgins, Sadie Piatt, Shirley Qiu, Summer Stafford, Brady J Mattsson, Darius J Semmens, Jay E Diffendorfer, Wayne E Thogmartin,

The consequences of environmental disturbance and management are difficult to quantify for spatially structured populations because changes in one location carry through to other areas as a result of species movement. We develop a metric, G, for measuring the contribution of a habitat or pathway to network-wide population growth rate ... Read more >>

Am Nat (The American naturalist)
[2020, 196(2):157-168]

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Subsurface transport potential of perfluoroalkyl acids (PFAAs): Column experiments and modeling.

Jennifer L Guelfo, Assaf Wunsch, John McCray, John F Stults, Christopher P Higgins,

Transport of ten perfluoroalkyl acids (PFAAs) was studied with one-dimensional (1-D) saturated column experiments using four soil types with an organic carbon fraction (foc) range of ~0-0.045. Columns were operated under conditions relevant to aqueous film-forming foam (AFFF)-impacted fire protection training areas to determine the ability of equilibrium transport parameters ... Read more >>

J Contam Hydrol (Journal of contaminant hydrology)
[2020, 233:103661]

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Recombinant protein subunit vaccine reduces puerperal metritis incidence and modulates the genital tract microbiome.

E B S Meira, R D Ellington-Lawrence, J C C Silva, C H Higgins, R Linwood, M X Rodrigues, L Bringhenti, H Korzec, Y Yang, M Zinicola, R C Bicalho,

The objective of this study was to evaluate the efficacy of 3 vaccine formulations containing proteins (FimH, leukotoxin, and pyolysin), inactivated whole cells (Escherichia coli, Fusobacterium necrophorum, and Trueperella pyogenes), or both, in the prevention of postpartum uterine diseases. A randomized clinical trial was conducted at a commercial dairy farm; ... Read more >>

J Dairy Sci (Journal of dairy science)
[2020, 103(8):7364-7376]

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Destruction of Per- and Polyfluoroalkyl Substances (PFASs) in Aqueous Film-Forming Foam (AFFF) with UV-Sulfite Photoreductive Treatment.

Raul Tenorio, Jinyong Liu, Xin Xiao, Andrew Maizel, Christopher P Higgins, Charles E Schaefer, Timothy J Strathmann,

Ultraviolet photochemical reaction of sulfite (SO32-) photosensitizer generates strongly reducing hydrated electrons (eaq-; NHE = -2.9 V) that have been shown to effectively degrade individual per- and polyfluoroalkyl substances (PFASs), including perfluorooctanesulfonic acid (PFOS) and perfluorooctanoic acid (PFOA). However, treatment of complex PFAS mixtures in aqueous film-forming foam (AFFF) remains ... Read more >>

Environ Sci Technol (Environmental science & technology)
[2020, 54(11):6957-6967]

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