Full Text Journal Articles by
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Leptomeningeal Relapse of Embryonal Rhabdomyosarcoma after 15 years.

S Chew, J P Gleeson, A McCarthy, G A Watson, R O'Dwyer, S Nicholson, M Capra, C Owens, M McDermott, P Daly, C Grant,

Aim Rhabdomyosarcoma (RMS) is the most common malignant soft tissue tumour of childhood. We present the case of a late relapse of RMS to the leptomeninges after 15 years. Methods A 20 year old male presented with a 3 week history of headaches and nausea. He previously had RMS of ... Read more >>

Ir Med J (Irish medical journal)
[2020, 112(10):1026]

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A case of human cystic echinococcosis acquired in Ireland.

Caroline Conlon, Conor Grant, Helen Tuite, Catherine Fleming, Eoin Slattery,

Cystic echinococcosis (CE) is caused by the cestodes of the Echinococcus granulosus sensu lato complex and, in the majority of cases, is associated with hepatic or pulmonary involvement. Human CE is not thought to be endemic in Ireland. We describe the first reported case of human CE possibly acquired in ... Read more >>

Parasitol Int (Parasitology international)
[2020, 81:102249]

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Presenteeism during the COVID-19 pandemic: risks and solutions.

Gail Kinman, Christine Grant,

Occup Med (Lond) (Occupational medicine (Oxford, England))
[2020, :]

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Antireflux Surgery at National Surgical Quality Improvement Program-Pediatric Hospitals.

Emilie K Johnson, David J Chalmers, Caleb P Nelson, Isaac Li, Marie Iwaniuk, Catherine Grant, Claudia Byrd, Shawn J Rangel, Jacqueline M Saito, Douglas C Barnhart, Bruce L Hall, Vijaya M Vemulakonda, Travis W Groth, Jonathan S Ellison, Nicolette K Janzen, Adam B Hittelman, Heather N DiCarlo, Paul A Merguerian, Stacy T Tanaka, Michaella M Prasad,

PURPOSE:This study aims to examine contemporary practice patterns and compare short-term outcomes for vesicoureteral reflux procedures (ureteral reimplant/endoscopic injection) using National Surgical Quality Improvement Program-Pediatric data. MATERIALS AND METHODS:Procedure-specific variables for antireflux surgery were developed to capture data not typically collected in National Surgical Quality Improvement Program-Pediatric (eg, vesicoureteral reflux ... Read more >>

J Urol (The Journal of urology)
[2020, :101097JU0000000000001439]

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Impact of the COVID-19 nonpharmaceutical interventions on influenza and other respiratory viral infections in New Zealand

Sue Huang, Tim Wood, Lauren Jelley, Tineke Jennings, Sarah Jefferies, Karen Daniells, Annette Nesdale, Tony Dowell, Nikki Turner, Priscilla Campbell-Stokes, Michelle Balm, Hazel Dobinson, Cameron Grant, Shelley James, Nayyereh Aminisani, Jacqui Ralston, Wendy Gunn, Judy Bocacao, Jessica Danielewicz, Tessa Moncrieff, Andrea McNeill, Liza Lopez, Ben Waite, Tomasz Kiedrzynski, Hannah Schrader, Rebekah Gray, Kayla Cook, Danielle Currin, Chaune Engelbrecht, Whitney Tapurau, Leigh Emmerton, Maxine Martin, Michael Baker, Susan Taylor, Adrian Trenholme, Conroy Wong, Shirley Lawrence, Colin McArthur, Alicia Stanley, Sally Roberts, Fahimeh Ranama, Jenny Bennett, Chris Mansell, Meik Dilcher, Anja Werno, Jennifer Grant, Antje van der Linden, Ben Youngblood, Paul Thomas, Richard Webby,

Abstract Stringent nonpharmaceutical interventions (NPIs) such as lockdowns and border closures are not currently recommended for pandemic influenza control. New Zealand used these NPIs to eliminate coronavirus disease 2019 during its first wave. Using multiple surveillance systems, we observed a parallel and unprecedented reduction of influenza and other respiratory viral ... Read more >>

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Dietary intake of amino acids and vitamins compared to NRC requirements in obese cats undergoing energy restriction for weight loss.

Caitlin E Grant, Anna K Shoveller, Shauna Blois, Marica Bakovic, Gabrielle Monteith, Adronie Verbrugghe,

BACKGROUND:This study aimed to determine if obese cats undergoing energy restriction for weight loss would meet the National Research Council's (NRC) indispensable amino acid and vitamin recommendations when fed a purpose-formulated diet. Thirty cats were placed into one of two groups; obese (BCS 8 to 9/9; n = 16) and lean (BCS ... Read more >>

BMC Vet Res (BMC veterinary research)
[2020, 16(1):426]

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ECMO Transport without Physicians or Additional Clinicians.

Anna Condella, Jeremy B Richards, Michael A Frakes, Christian J Grant, Jason E Cohen, Susan R Wilcox,

BACKGROUND:Extracorporeal membrane oxygenation (ECMO) has accelerated rapidly for patients in severe cardiac or respiratory failure. As a result, ECMO networks are being developed across the world using a "hub and spoke" model. Current guidelines call for all patients transported on ECMO to be accompanied by a physician during transport. However, ... Read more >>

Prehosp Disaster Med (Prehospital and disaster medicine)
[2020, :1-7]

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Drug checking identifies counterfeit alprazolam tablets.

Samuel Tobias, Aaron M Shapiro, Cameron J Grant, Priya Patel, Mark Lysyshyn, Lianping Ti,

BACKGROUND:Non-prescribed benzodiazepine use is increasing in North America, especially among youth. Owing to increasing demand, counterfeit benzodiazepine tablets are mass-produced in clandestine, unregulated environments and sold as legitimate pharmaceuticals. This study aimed to examine the contents of counterfeit alprazolam tablets available in the unregulated drug market in British Columbia, Canada. ... Read more >>

Drug Alcohol Depend (Drug and alcohol dependence)
[2020, :108300]

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Author Correction: Large-scale targeted sequencing identifies risk genes for neurodevelopmental disorders.

Tianyun Wang, Kendra Hoekzema, Davide Vecchio, Huidan Wu, Arvis Sulovari, Bradley P Coe, Madelyn A Gillentine, Amy B Wilfert, Luis A Perez-Jurado, Malin Kvarnung, Yoeri Sleyp, Rachel K Earl, Jill A Rosenfeld, Madeleine R Geisheker, Lin Han, Bing Du, Chris Barnett, Elizabeth Thompson, Marie Shaw, Renee Carroll, Kathryn Friend, Rachael Catford, Elizabeth E Palmer, Xiaobing Zou, Jianjun Ou, Honghui Li, Hui Guo, Jennifer Gerdts, Emanuela Avola, Giuseppe Calabrese, Maurizio Elia, Donatella Greco, Anna Lindstrand, Ann Nordgren, Britt-Marie Anderlid, Geert Vandeweyer, Anke Van Dijck, Nathalie Van der Aa, Brooke McKenna, Miroslava Hancarova, Sarka Bendova, Marketa Havlovicova, Giovanni Malerba, Bernardo Dalla Bernardina, Pierandrea Muglia, Arie van Haeringen, Mariette J V Hoffer, Barbara Franke, Gerarda Cappuccio, Martin Delatycki, Paul J Lockhart, Melanie A Manning, Pengfei Liu, Ingrid E Scheffer, Nicola Brunetti-Pierri, Nanda Rommelse, David G Amaral, Gijs W E Santen, Elisabetta Trabetti, Zdeněk Sedláček, Jacob J Michaelson, Karen Pierce, Eric Courchesne, R Frank Kooy, , Magnus Nordenskjöld, Corrado Romano, Hilde Peeters, Raphael A Bernier, Jozef Gecz, Kun Xia, Evan E Eichler,

An amendment to this paper has been published and can be accessed via a link at the top of the paper. ... Read more >>

Nat Commun (Nature communications)
[2020, 11(1):5398]

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Mucopolysaccharidosis type I newborn screening: Importance of second tier testing for ethnically diverse populations.

Kerri Bosfield, Debra S Regier, Sarah Viall, Rebecca Hicks, Natasha Shur, Christina L Grant,

Mucopolysaccharidosis type I (MPS I)/Hurler syndrome newborn screening was added to the recommended uniform screening panel (RUSP) in 2016. As states have added screening for MPS I, programs have reported increased rates of false positives. Reasons for false positive screens include carrier status, true false positive, late-onset/attenuated forms, and in ... Read more >>

Am J Med Genet A (American journal of medical genetics. Part A)
[2020, :]

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Slow Growth and Increased Spontaneous Mutation Frequency in Respiratory Deficient afo1- Yeast Suppressed by a Dominant Mutation in ATP3.

Jing Li, Mark Rinnerthaler, Johannes Hartl, Manuela Weber, Thomas Karl, Hannelore Breitenbach-Koller, Michael Mülleder, Jakob Vowinckel, Hans Marx, Michael Sauer, Diethard Mattanovich, Özge Ata, Sonakshi De, Gregor P Greslehner, Florian Geltinger, Bill Burhans, Chris Grant, Victoria Doronina, Meryem Ralser, Maria Karolin Streubel, Christian Grabner, Stefanie Jarolim, Claudia Moßhammer, Campbell W Gourlay, Jiri Hasek, Paul J Cullen, Gianni Liti, Markus Ralser, Michael Breitenbach,

A yeast deletion mutation in the nuclear-encoded gene, AFO1, which codes for a mitochondrial ribosomal protein, led to slow growth on glucose, the inability to grow on glycerol or ethanol, and loss of mitochondrial DNA and respiration. We noticed that afo1- yeast readily obtains secondary mutations that suppress aspects of ... Read more >>

G3 (Bethesda) (G3 (Bethesda, Md.))
[2020, :]

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Association between early childhood oral health impact scale (ECOHIS) scores and pediatric dental surgery wait times.

Victor H K Lee, Cameron G Grant, Betty-Anne Mittermuller, Sarbjeet Singh, Brenda Weiss, Jeanette M Edwards, Robert J Schroth,

BACKGROUND:Severe Early Childhood Caries (S-ECC) is an aggressive form of tooth decay that often requires pediatric dental rehabilitative surgery. The Early Childhood Oral Health Impact Scale (ECOHIS) measures oral health-related quality of life (OHRQL). The purpose of this study was to determine whether there is an association between ECOHIS scores ... Read more >>

BMC Oral Health (BMC oral health)
[2020, 20(1):285]

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User Perspectives of Mood-Monitoring Apps Available to Young People: Qualitative Content Analysis.

Emily Widnall, Claire Ellen Grant, Tao Wang, Lauren Cross, Sumithra Velupillai, Angus Roberts, Robert Stewart, Emily Simonoff, Johnny Downs,

BACKGROUND:Mobile health apps are increasingly available and used in a clinical context to monitor young people's mood and mental health. Despite the benefits of accessibility and cost-effectiveness, consumer engagement remains a hurdle for uptake and continued use. Hundreds of mood-monitoring apps are publicly available to young people on app stores; ... Read more >>

JMIR Mhealth Uhealth (JMIR mHealth and uHealth)
[2020, 8(10):e18140]

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Lymphadenopathy in children: A streamlined approach for the surgeon - A report from the APSA Cancer Committee.

Christa N Grant, Jennifer Aldrink, Timothy B Lautz, Elisabeth T Tracy, Daniel S Rhee, Reto M Baertschiger, Roshni Dasgupta, Peter F Ehrlich, David A Rodeberg,

BACKGROUND/PURPOSE:Lymphadenopathy is a common complaint in children. Pediatric surgeons are often called upon to evaluate, treat, and/or biopsy enlarged lymph nodes. With many nonsurgical causes in the differential diagnosis, the surgeon plays the important role of providing reassurance and timely diagnosis while minimizing the pain and morbidity associated with surgical ... Read more >>

J Pediatr Surg (Journal of pediatric surgery)
[2020, :]

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CRISPR-Cas9 Genome-Wide Knockout Screen Identifies Mechanism of Selective Activity of Dehydrofalcarinol in Mesenchymal Stem-like Triple-Negative Breast Cancer Cells.

Corena V Grant, Shengxin Cai, April L Risinger, Huiyun Liang, Barry R O'Keefe, John G Doench, Robert H Cichewicz, Susan L Mooberry,

There are no targeted therapies available for triple-negative breast cancers (TNBCs) in part because they represent a heterogeneous group of tumors with diverse oncogenic drivers. Our goal is to identify targeted therapies for subtypes of these cancers using a mechanism-blind screen of natural product extract libraries. An extract from Desmanthodium ... Read more >>

J Nat Prod (Journal of natural products)
[2020, 83(10):3080-3092]

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Large-scale targeted sequencing identifies risk genes for neurodevelopmental disorders.

Tianyun Wang, Kendra Hoekzema, Davide Vecchio, Huidan Wu, Arvis Sulovari, Bradley P Coe, Madelyn A Gillentine, Amy B Wilfert, Luis A Perez-Jurado, Malin Kvarnung, Yoeri Sleyp, Rachel K Earl, Jill A Rosenfeld, Madeleine R Geisheker, Lin Han, Bing Du, Chris Barnett, Elizabeth Thompson, Marie Shaw, Renee Carroll, Kathryn Friend, Rachael Catford, Elizabeth E Palmer, Xiaobing Zou, Jianjun Ou, Honghui Li, Hui Guo, Jennifer Gerdts, Emanuela Avola, Giuseppe Calabrese, Maurizio Elia, Donatella Greco, Anna Lindstrand, Ann Nordgren, Britt-Marie Anderlid, Geert Vandeweyer, Anke Van Dijck, Nathalie Van der Aa, Brooke McKenna, Miroslava Hancarova, Sarka Bendova, Marketa Havlovicova, Giovanni Malerba, Bernardo Dalla Bernardina, Pierandrea Muglia, Arie van Haeringen, Mariette J V Hoffer, Barbara Franke, Gerarda Cappuccio, Martin Delatycki, Paul J Lockhart, Melanie A Manning, Pengfei Liu, Ingrid E Scheffer, Nicola Brunetti-Pierri, Nanda Rommelse, David G Amaral, Gijs W E Santen, Elisabetta Trabetti, Zdeněk Sedláček, Jacob J Michaelson, Karen Pierce, Eric Courchesne, R Frank Kooy, , Magnus Nordenskjöld, Corrado Romano, Hilde Peeters, Raphael A Bernier, Jozef Gecz, Kun Xia, Evan E Eichler,

Most genes associated with neurodevelopmental disorders (NDDs) were identified with an excess of de novo mutations (DNMs) but the significance in case-control mutation burden analysis is unestablished. Here, we sequence 63 genes in 16,294 NDD cases and an additional 62 genes in 6,211 NDD cases. By combining these with published ... Read more >>

Nat Commun (Nature communications)
[2020, 11(1):4932]

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Effects of a monocarboxylate transport 1 inhibitor, AZD3965, on retinal and visual function in the rat.

Annette E Allen, Elizabeth A Martin, Katherine Greenwood, Claire Grant, Peter Vince, Robert J Lucas, William S Redfern,

BACKGROUND AND PURPOSE:Inhibition of monocarboxylate transport 1 (MCT1) is of interest in targeting highly glycolytic tumours. However, MCT1 is expressed in retina, and so inhibition of MCT1 could affect retinal function. EXPERIMENTAL APPROACH:AZD3965, an MCT1 inhibitor selected for clinical development, and two additional MCT1 inhibitors were evaluated for effects on ... Read more >>

Br J Pharmacol (British journal of pharmacology)
[2020, 177(20):4734-4749]

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Racial/Ethnic Variation in Nasal Gene Expression of Transmembrane Serine Protease 2 (TMPRSS2).

Supinda Bunyavanich, Chantal Grant, Alfin Vicencio,

JAMA (JAMA)
[2020, :]

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Informing the development of an E-platform for monitoring wellbeing in schools: involving young people in a co-design process.

Claire Grant, Emily Widnall, Lauren Cross, Emily Simonoff, Johnny Downs,

Background:The use of new technologies and methodologies in young people's mental health research is needed to allow more frequent and reliable sampling. Mobile applications and e-platforms create exciting potential for the collection of large-scale cohort data, however there are various feasibility and ethical issues to consider. Consultation with young people ... Read more >>

Res Involv Engagem (Research involvement and engagement)
[2020, 6:51]

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Let Their Voices Be Seen.

Amanda J Young, Frances Richardson, Dawn Fitzgerald, Benjamin S Heavrin, Brooke Tweddell, Lydia Gettings, Ashley Cooper, Cori Cohen Grant,

STUDY OBJECTIVE:The mutual distrust, in part caused by misunderstanding and bias, between sickle cell disease (SCD) patients and their emergency department (ED) providers has been widely documented in the SCD literature. This study seeks to illustrate the perceptions and experiences of adult sickle cell patients who have had at least ... Read more >>

Ann Emerg Med (Annals of emergency medicine)
[2020, 76(3S):S73-S77]

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Fire Service Organizational-Level Characteristics Are Associated With Adherence to Contamination Control Practices in Florida Fire Departments: Evidence From the Firefighter Cancer Initiative.

Paola Louzado-Feliciano, Kevin A Griffin, Katerina M Santiago, Natasha Schaefer Solle, Tulay Koru-Sengul, Casey Grant, Neal Niemczyk, David J Lee, Erin N Kobetz, Alberto J Caban-Martinez,

OBJECTIVES:To characterize the types of contamination control practices followed by Florida fire departments and examine the association between fire department organizational-level characteristics and adherence to contamination control practices. METHODS:Using a cross-sectional study design, a survey was administered to 142 Florida firefighters. Validated survey measures assessed organizational level characteristics and 32 ... Read more >>

J Occup Environ Med (Journal of occupational and environmental medicine)
[2020, 62(9):e508-e514]

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Factors Associated With the Use of Supervised Consumption Facilities Among Women Who Inject Drugs in a Canadian Setting.

Sarah Ickowicz, Cameron Grant, Ekaterina Nosova, Jade Boyd, Rupinder Brar, M-J Milloy, Kanna Hayashi, Seonaid Nolan,

BACKGROUND:Supervised consumption facilities (SCFs) are evidence-based harm reduction interventions that have been shown to reduce the risk of social and health-related harms associated with injection drug use. Previous qualitative studies have highlighted important motivations for SCF use among women who use drugs. However, factors associated with SCF use among women ... Read more >>

J Addict Med (Journal of addiction medicine)
[2020, 14(5):e226-e232]

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Long-term benefits of providing transitional services to youth aging-out of the child welfare system: Evidence from a cohort of young people who use drugs in Vancouver, Canada.

Brittany Barker, Jean Shoveller, Cameron Grant, Thomas Kerr, Kora DeBeck,

BACKGROUND:Youth aging-out of the child welfare system (CWS) experience numerous vulnerabilities including, elevated rates of substance use and substance use disorders. Calls to improve services to transition youth to independence are common; however, evidence of the long-term impacts associated with transitional service utilization is scarce. Further, existing services frequently lack ... Read more >>

Int J Drug Policy (The International journal on drug policy)
[2020, 85:102912]

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Respiratory syncytial virus hospitalisations among young children: a data linkage study - Erratum.

Namrata Prasad, E Claire Newbern, Adrian A Trenholme, Tim Wood, Mark G Thompson, Nayyereh Aminisani, Q Sue Huang, Cameron C Grant,

Epidemiol Infect (Epidemiology and infection)
[2020, 148:e179]

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The Veterans Aging Cohort Study (VACS) Index predicts mortality in a community-recruited cohort of HIV-positive people who use illicit drugs.

Hudson Reddon, Cameron Grant, Ekaterina Nosova, Nadia Fairbairn, Rolando Barrios, Amy C Justice, Seonaid Nolan, M Eugenia Socias, M-J Milloy,

The Veterans Aging Cohort Study (VACS) index combines commonly collected clinical biomarkers to estimate HIV disease severity. Among a prospective cohort of HIV-positive people who use illicit drugs (PWUD) (n=948), we found that the VACS index was significantly associated with mortality over a 20-year study period. ... Read more >>

Clin Infect Dis (Clinical infectious diseases : an official publication of the Infectious Diseases Society of America)
[2020, :]

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