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Thermochemical energy storage performance of zinc destabilized calcium hydride at high-temperatures.

Sruthy Balakrishnan, M Veronica Sofianos, Terry D Humphries, Mark Paskevicius, Craig E Buckley,

CaH2 has 20 times the energy density of molten salts and was patented in 2010 as a potential solar thermal energy storage material. Unfortunately, its high operating temperature (>1000 °C) and corrosivity at that temperature make it challenging to use as a thermal energy storage (TES) material in concentrating solar ... Read more >>

Phys Chem Chem Phys (Physical chemistry chemical physics : PCCP)
[2020, 22(44):25780-25788]

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Non-steroidal anti-inflammatory drugs and susceptibility to COVID-19.

Joht Singh Chandan, Dawit Tefra Zemedikun, Rasiah Thayakaran, Nathan Byne, Samir Dhalla, Dionisio Acosta-Mena, Krishna M Gokhale, Tom Thomas, Christopher Sainsbury, Anuradhaa Subramanian, Jennifer Cooper, Astha Anand, Kelvin O Okoth, Jingya Wang, Nicola J Adderley, Thomas Taverner, Alastair K Denniston, Janet Lord, G Neil Thomas, Christopher D Buckley, Karim Raza, Neeraj Bhala, Krishnarajah Nirantharakumar, Shamil Haroon,

OBJECTIVES:To identify whether active use of non-steroidal anti-inflammatory drugs (NSAIDs) increases susceptibility to developing suspected or confirmed COVID-19 compared to the use of other common analgesics. METHODS:We performed a propensity score-matched cohort study with active comparators using a large UK primary care dataset. The cohort consisted of adult patients aged ... Read more >>

Arthritis Rheumatol (Arthritis & rheumatology (Hoboken, N.J.))
[2020, :]

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Quantifying Reliable Walking Activity with a Wearable Device in Aged Residential Care: How Many Days Are Enough?

Christopher Buckley, Alana Cavadino, Silvia Del Din, Sue Lord, Lynne Taylor, Lynn Rochester, Ngaire Kerse,

Strong associations exist between quality of life and physical activity for those living in aged residential care (ARC). Suitable and reliable tools are required to quantify physical activity for descriptive and evaluative purposes. We calculated the number of days required for reliable walking outcomes indicative of physical activity in an ... Read more >>

Sensors (Basel) (Sensors (Basel, Switzerland))
[2020, 20(21):]

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Status Dystonicus, Oculogyric Crisis and Paroxysmal Dyskinesia in a 25 Year-Old Woman with a Novel KCNMA1 Variant, K457E.

Cliona Buckley, Jennifer Williams, Tudor Munteanu, Mary King, Su Mi Park, Andrea L Meredith, Timothy Lynch,

The diagnosis of a paroxysmal dyskinesia is difficult and status dystonicus is a rare life threatening movement disorder characterised by severe, frequent or continuous episodes of dystonic spasms. A 25 year old woman with chronic ataxia and paroxysmal dyskinesia presented with facial twitching, writhing of arms, oculogyric crisis and visual ... Read more >>

Tremor Other Hyperkinet Mov (N Y) (Tremor and other hyperkinetic movements (New York, N.Y.))
[2020, 10:49]

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Routine testing of close contacts of confirmed COVID-19 cases – National COVID-19 Contact Management Programme, Ireland, May to August 2020

C. Carroll, R. Conway, D. O’Donnell, C. Norton, E. Hogan, M. Browne, C.M. Buckley, P. Kavanagh, J. Martin, S. Doyle,

Objectives To inform public health practitioners who are designing, adapting and implementing testing and tracing strategies for COVID-19 control. Study design Monitoring and evaluation of a national public health protection programme. Methods All close contacts of laboratory confirmed cases of COVID-19 identified between the 19th May and 2nd August were ... Read more >>

Public Health (Public health)
[2020, :]

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Psychosocial Impact of COVID-19 Nursing Home Restrictions on Visitors of Residents With Cognitive Impairment: A Cross-Sectional Study as Part of the Engaging Remotely in Care (ERiC) Project.

Rónán O'Caoimh, Mark R O'Donovan, Margaret P Monahan, Caroline Dalton O'Connor, Catherine Buckley, Caroline Kilty, Serena Fitzgerald, Irene Hartigan, Nicola Cornally,

Background: COVID-19 has disproportionately affected older people. Visiting restrictions introduced since the start of the pandemic in residential care facilities (RCFs) may impact negatively on visitors including close family, friends, and guardians. We examined the effects of COVID-19 visiting restrictions on measures of perceived loneliness, well-being, and carer quality of ... Read more >>

Front Psychiatry (Frontiers in psychiatry)
[2020, 11:585373]

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Derivation and utility of an Aβ-PET pathology accumulation index to estimate Aβ load.

Antoine Leuzy, Johan Lilja, Christopher J Buckley, Rik Ossenkoppele, Sebastian Palmqvist, Mark Battle, Gill Farrar, Dietmar R Thal, Shorena Janelidze, Erik Stomrud, Olof Strandberg, Ruben Smith, Oskar Hansson,

OBJECTIVE:To evaluate a novel β-amyloid (Aβ)-PET-based quantitative measure (Aβ accumulation index [Aβ index]), including the assessment of its ability to discriminate between participants based on Aβ status using visual read, CSF Aβ42/Aβ40, and post-mortem neuritic plaque burden as standards of truth. METHODS:One thousand one hundred twenty-one participants (with and without ... Read more >>

Neurology (Neurology)
[2020, 95(21):e2834-e2844]

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The effect of emergency manuals on team performance during two different simulated perioperative crises: A prospective, randomized controlled trial.

Richard D Urman, David A August, Scott Chung, Amanda H Jiddou, Carolyn Buckley, Kara G Fields, J Bradley Morrison, Janice C Palaganas, Daniel Raemer,

STUDY OBJECTIVE:Whether having an emergency manual (EM) available for use during perioperative crises enhances or detracts from team performance, especially for multi-factorial diagnostic situations that do not explicitly match a chapter of the EM. DESIGN:A simulation-based, prospective randomized trial based upon two perioperative crises, one involving a patient with a ... Read more >>

J Clin Anesth (Journal of clinical anesthesia)
[2020, 68:110080]

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Radiation-induced Bystander Effect (RIBE) alters mitochondrial metabolism using a human rectal cancer ex vivo explant model.

Aisling B Heeran, Helen P Berrigan, Croí E Buckley, Heleena Moni Bottu, Orla Prendiville, Amy M Buckley, Niamh Clarke, Noel E Donlon, Timothy S Nugent, Michael Durand, Cara Dunne, John O Larkin, Brian Mehigan, Paul McCormick, Lorraine Brennan, Niamh Lynam-Lennon, Jacintha O'Sullivan,

Locally advanced rectal cancer is treated with neoadjuvant-chemoradiotherapy, however only 22% of patients achieve a complete response. Resistance mechanisms are poorly understood. Radiation-induced Bystander Effect (RIBE) describes the effect of radiation on neighbouring unirradiated cells. We investigated the effects of ex vivo RIBE-induction from normal and rectal cancer tissue on ... Read more >>

Transl Oncol (Translational oncology)
[2020, 14(1):100882]

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μSPIM Toolset: A software platform for selective plane illumination microscopy.

Daniel Saska, Paul Pichler, Chen Qian, Christopher L Buckley, Leon Lagnado,

BACKGROUND:Selective Plane Illumination Microscopy (SPIM) is a fluorescence imaging technique that allows volumetric imaging at high spatio-temporal resolution to monitor neural activity in live organisms such as larval zebrafish. A major challenge in the construction of a custom SPIM microscope using a scanned laser beam is the control and synchronization ... Read more >>

J Neurosci Methods (Journal of neuroscience methods)
[2020, 347:108952]

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The "round the houses" sign and "zig-zag" sign in progressive supranuclear palsy and other conditions.

Conor Fearon, Robert Field, Eoghan Donlon, Olwen C Murphy, Simon Cronin, Cliona Buckley, Laura Williams, Yudy Llamas, Sean O'Dowd, Sean S O'Sullivan, Daniel R Gold, Daniel R Gold, Richard Walsh, Daniel G Healy, Niall Quinn, Timothy Lynch,

Parkinsonism Relat Disord (Parkinsonism & related disorders)
[2020, 81:94-95]

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Covid-19 Estimating the burden of symptomatic disease in the community and the impact of public health measures on physical, mental and social wellbeing: a study protocol

Isabela Troya, Ali Khashan, Patricia Kearney, Ella Arensman, Philipp Hoevel, Claire Buckley, Margaret Fitzgerald, Rory Humphries, Elizabeth Kiely, Kieran Mulchrone, Mike Murphy, Lois O'Connor, Joan O'Donnell, Eilis O’Reilly, Micheal O'Riordain, Mary Spillane, Sebastian Wieczorek, Ivan Perry,

Introduction : Covid-19 was declared a pandemic in March 2020. Since then, governments have implemented unprecedented public health measures to contain the virus. This study will provide evidence to inform responses to the pandemic by: i) estimating population prevalence and trends of self-reported symptoms of Covid-19 and the proportions of ... Read more >>

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Injectable Disc-Derived ECM Hydrogel Functionalised with Chondroitin Sulfate for Intervertebral Disc Regeneration.

Chiara Borrelli, Conor T Buckley,

Low back pain resulting from intervertebral disc (IVD) degeneration is a significant socioeconomic burden. The main effect of the degeneration process involves the alteration of the nucleus pulposus (NP) via cell-mediated enzymatic breakdown of key extracellular matrix (ECM) components. Thus, the development of injectable and biomimetic biomaterials that can instruct ... Read more >>

Acta Biomater (Acta biomaterialia)
[2020, 117:142-155]

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Enhanced molecular surveillance in response to the detection of extensively resistant gonorrhoea in Australia.

Ella Trembizki, Amy V Jennison, Cameron Buckley, Amy Bright, Judith Holds, Alison Ward, John Pitt, Stella Pendle, Rob Baird, Kevin Freeman, Jenny Robson, Lebogang Mhango, Kym Lowry, Monica Lahra, David Whiley,

J Antimicrob Chemother (The Journal of antimicrobial chemotherapy)
[2020, :]

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Relation of outcomes to ABC (Atrial Fibrillation Better Care) pathway adherent care in European patients with atrial fibrillation: an analysis from the ESC-EHRA EORP Atrial Fibrillation General Long-Term (AFGen LT) Registry.

Marco Proietti, Gregory Y H Lip, Cécile Laroche, Laurent Fauchier, Francisco Marin, Michael Nabauer, Tatjana Potpara, Gheorghe-Andrei Dan, Zbigniew Kalarus, Luigi Tavazzi, Aldo Pietro Maggioni, Giuseppe Boriani, ,

AIMS:There has been an increasing focus on integrated, multidisciplinary, and holistic care in the treatment of atrial fibrillation (AF). The 'Atrial Fibrillation Better Care' (ABC) pathway has been proposed to streamline integrated care in AF. We evaluated the impact on outcomes of an ABC adherent management in a contemporary real-life ... Read more >>

Europace (Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology)
[2020, :]

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Epidemiology, morbidity and mortality in Behçet's disease: a cohort study using The Health Improvement Network (THIN).

Tom Thomas, Joht Singh Chandan, Anuradhaa Subramanian, Krishna Gokhale, George Gkoutos, Lorraine Harper, Christopher Buckley, Priyanka Chandratre, Karim Raza, Deva Situnayake, Krishnarajah Nirantharakumar,

OBJECTIVES:The epidemiology of Behçet's disease (BD) has not been well characterized in the UK. Evidence on the risk of cardiovascular disease, thromboembolic disease and mortality in patients with BD compared with the general population is scarce. METHODS:We used a large UK primary care database to investigate the epidemiology of BD. ... Read more >>

Rheumatology (Oxford) (Rheumatology (Oxford, England))
[2020, 59(10):2785-2795]

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Telehealth for delivery of haemophilia comprehensive care during the COVID-19 pandemic.

Mairead O'Donovan, Catherine Buckley, Julie Benson, Sheila Roche, Mark McGowan, Laura Parkinson, Patricia Byrne, Gloria Rooney, Catherine Bergin, Deirdre Walsh, Rachel Bird, Feargal McGroarty, Helen Fogarty, Elizabeth Smyth, Saad Ahmed, James S O'Donnell, Kevin Ryan, Brian O'Mahony, Alison Dougall, Niamh M O'Connell,

INTRODUCTION:The COVID-19 pandemic caused an unprecedented impact to haemophilia healthcare delivery. In particular, rapid implementation of telehealth solutions was required to ensure continued access to comprehensive care. AIMS:To explore patient and healthcare provider (HCP) experience of telehealth in a European Haemophilia Comprehensive Care Centre. METHOD:A systematic evaluation was performed to ... Read more >>

Haemophilia (Haemophilia : the official journal of the World Federation of Hemophilia)
[2020, :]

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Telehealth for delivery of haemophilia comprehensive care during the COVID‐19 pandemic

Mairead O’Donovan, Catherine Buckley, Julie Benson, Sheila Roche, Mark McGowan, Laura Parkinson, Patricia Byrne, Gloria Rooney, Catherine Bergin, Deirdre Walsh, Rachel Bird, Feargal McGroarty, Helen Fogarty, Elizabeth Smyth, Saad Ahmed, James S. O’Donnell, Kevin Ryan, Brian O'Mahony, Alison Dougall, Niamh M. O’Connell,

Abstract Introduction The COVID‐19 pandemic caused an unprecedented impact to haemophilia healthcare delivery. In particular, rapid implementation of telehealth solutions was required to ensure continued access to comprehensive care. Aims To explore patient and healthcare provider (HCP) experience of telehealth in a European Haemophilia Comprehensive Care Centre. Method A systematic ... Read more >>

Haemophilia (Haemophilia : the official journal of the World Federation of Hemophilia)
[2020, :]

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Associations Between Mean Arterial Pressure and Poor ICU Outcomes in Critically Ill Patients With Cirrhosis: Is 65 The Sweet Spot?

Kavish R Patidar, Jennifer Lynn Peng, Francis Pike, Eric S Orman, Mathew Glick, Carla D Kettler, Lauren D Nephew, Archita P Desai, Kavitha Nair, Babar A Khan, Caitriona A Buckley, Roberto F Machado, Naga P Chalasani, Marwan S Ghabril,

OBJECTIVES:Mean arterial pressure is critically important in patients with cirrhosis in the ICU, however, there is limited data to guide therapies and targets. DESIGN:Retrospective observational study. SETTING:Tertiary care ICU. PATIENTS:Two hundred and seventy-three critically ill patients with cirrhosis. INTERVENTIONS:None. MEASUREMENTS AND MAIN RESULTS:We performed a comprehensive time-weighted mean arterial pressure ... Read more >>

Crit Care Med (Critical care medicine)
[2020, 48(9):e753-e760]

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Optimization of Cathode Functional Layers of Solid Oxide Electrolysis Cells.

Tengpeng Wang, Tianpei Li, Tao Wei, Xun Hu, Zhengmao Ye, Zhi Wang, Yi Wang, Yanxiang Zhang, C E Buckley, Dehua Dong,

Sluggish CO2 reduction on the cathodes of solid oxide electrolysis cells greatly affects electrolysis performance. However, there is no study systematically investigating the cathode functional layer (CFL), where the reduction occurs. Cathode supports equipped with fast gas diffusion channels were employed as a platform to investigate the CFL, including porosity, ... Read more >>

ACS Appl Mater Interfaces (ACS applied materials & interfaces)
[2020, 12(36):40917-40924]

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Nurse-led care for the management of rheumatoid arthritis: a review of the global literature and proposed strategies for implementation in Africa and the Middle East.

Imad Uthman, Hani Almoallim, Christopher D Buckley, Basel Masri, Chafia Dahou-Makhloufi, Yasser El Dershaby, Nancy Sunna, Karim Raza, Kanta Kumar, Huda Abu-Saad Huijer, Nabeeha Tashkandi, Ingrid Louw, Olufemi Adelowo,

Globally, increasing demand for rheumatology services has led to a greater reliance on non-physician healthcare professionals (HCPs), such as rheumatology nurse specialists, to deliver care as part of a multidisciplinary team. Across Africa and the Middle East (AfME), there remains a shortage of rheumatology HCPs, including rheumatology nurses, which presents ... Read more >>

Rheumatol Int (Rheumatology international)
[2020, :]

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Contamination of SARS-CoV-2 RT-PCR probes at the oligonucleotide manufacturer.

Claire Y T Wang, Cameron Buckley, Cheryl Bletchly, Patrick Harris, David Whiley,

Pathology (Pathology)
[2020, :]

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Disrupted endothelial cell heterogeneity and network organization impair vascular function in prediabetic obesity.

Calum Wilson, Xun Zhang, Matthew D Lee, Margaret MacDonald, Helen R Heathcote, Nasser M N Alorfi, Charlotte Buckley, Sharron Dolan, John G McCarron,

BACKGROUND:Obesity is a major risk factor for diabetes and cardiovascular diseases such as hypertension, heart failure, and stroke. Impaired endothelial function occurs in the earliest stages of obesity and underlies vascular alterations that give rise to cardiovascular disease. However, the mechanisms that link weight gain to endothelial dysfunction are ill-defined. ... Read more >>

Metabolism (Metabolism: clinical and experimental)
[2020, 111:154340]

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Covid-19 Estimating the burden of symptomatic disease in the community and the impact of public health measures on physical, mental and social wellbeing: a study protocol.

M Isabela Troya, Ali Khashan, Patricia Kearney, Ella Arensman, Philipp Hoevel, Claire Buckley, Margaret Fitzgerald, Rory Humphries, Elizabeth Kiely, Kieran Mulchrone, Mike Murphy, Lois O'Connor, Joan O'Donnell, Eilis O'Reilly, Micheal O'Riordain, Mary Spillane, Sebastian Wieczorek, Ivan J Perry,

Introduction: Covid-19 was declared a pandemic in March 2020. Since then, governments have implemented unprecedented public health measures to contain the virus. This study will provide evidence to inform responses to the pandemic by: i) estimating population prevalence and trends of self-reported symptoms of Covid-19 and the proportions of symptomatic ... Read more >>

HRB Open Res (HRB open research)
[2020, 3:49]

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Correction to: Different aspects of Alzheimer's disease-related amyloid β-peptide pathology and their relationship to amyloid positron emission tomography imaging and dementia.

Dietmar Rudolf Thal, Alicja Ronisz, Thomas Tousseyn, Ajeet Rijal Upadhaya, Karthikeyan Balakrishnan, Rik Vandenberghe, Mathieu Vandenbulcke, Christine A F von Arnim, Markus Otto, Thomas G Beach, Johan Lilja, Kerstin Heurling, Aruna Chakrabarty, Azzam Ismail, Christopher Buckley, Adrian P L Smith, Sathish Kumar, Gill Farrar, Jochen Walter,

An amendment to this paper has been published and can be accessed via the original article. ... Read more >>

Acta Neuropathol Commun (Acta neuropathologica communications)
[2020, 8(1):121]

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