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Describing motivation for health and treatment decisions and communication choices of calf-care workers on western United States dairies.

D A Moore, C C Blackburn, J A Afema, D R Kinder, W M Sischo,

On large dairy farms, animal health assessments and treatments are made by farm employees. Little is known about how employees make decisions about illness detection or treatment, information critical to improving antimicrobial stewardship. The objectives of this study were to describe calf-care employee motivations for decisions associated with preweaned calf ... Read more >>

J Dairy Sci (Journal of dairy science)
[2021, :]

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The NYCKidSeq project: study protocol for a randomized controlled trial incorporating genomics into the clinical care of diverse New York City children.

Jacqueline A Odgis, Katie M Gallagher, Sabrina A Suckiel, Katherine E Donohue, Michelle A Ramos, Nicole R Kelly, Gabrielle Bertier, Christina Blackburn, Kaitlyn Brown, Lena Fielding, Jessenia Lopez, Karla Lopez Aguiniga, Estefany Maria, Jessica E Rodriguez, Monisha Sebastin, Nehama Teitelman, Dana Watnick, Nicole M Yelton, Avinash Abhyankar, Noura S Abul-Husn, Aaron Baum, Laurie J Bauman, Jules C Beal, Toby Bloom, Charlotte Cunningham-Rundles, George A Diaz, Siobhan Dolan, Bart S Ferket, Vaidehi Jobanputra, Patricia Kovatch, Thomas V McDonald, Patricia E McGoldrick, Rosamond Rhodes, Michael L Rinke, Mimsie Robinson, Arye Rubinstein, Lisa H Shulman, Christian Stolte, Steven M Wolf, Elissa Yozawitz, Randi E Zinberg, John M Greally, Bruce D Gelb, Carol R Horowitz, Melissa P Wasserstein, Eimear E Kenny,

<h4>Background</h4>Increasingly, genomics is informing clinical practice, but challenges remain for medical professionals lacking genetics expertise, and in access to and clinical utility of genomic testing for minority and underrepresented populations. The latter is a particularly pernicious problem due to the historical lack of inclusion of racially and ethnically diverse populations ... Read more >>

Trials (Trials)
[2021, 22(1):56]

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Fetal alcohol spectrum disorders: an overview of current evidence and activities in the UK.

Lisa Schölin, Raja A S Mukherjee, Neil Aiton, Carolyn Blackburn, Sarah Brown, Kate M Flemming, Paul R Gard, Helen Howlett, Moira Plant, Alan D Price, Jennifer Shields, Lesley A Smith, Michael Suttie, David C Zammitt, Penny A Cook, ,

Estimates for the UK suggest that alcohol consumption during pregnancy and prevalence of fetal alcohol spectrum disorder (FASD)-the most common neurodevelopmental condition-are high. Considering the significant health and social impacts of FASD, there is a public health imperative to prioritise prevention, interventions and support. In this article, we outline the ... Read more >>

Arch Dis Child (Archives of disease in childhood)
[2021, :]

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The NYCKidSeq project: study protocol for a randomized controlled trial incorporating genomics into the clinical care of diverse New York City children

Jacqueline Odgis, Katie Gallagher, Sabrina Suckiel, Katherine Donohue, Michelle Ramos, Nicole Kelly, Gabrielle Bertier, Christina Blackburn, Kaitlyn Brown, Lena Fielding, Jessenia Lopez, Karla Lopez Aguiniga, Estefany Maria, Jessica Rodriguez, Monisha Sebastin, Nehama Teitelman, Dana Watnick, Nicole Yelton, Avinash Abhyankar, Noura Abul-Husn, Aaron Baum, Laurie Bauman, Jules Beal, Toby Bloom, Charlotte Cunningham-Rundles, George Diaz, Siobhan Dolan, Bart Ferket, Vaidehi Jobanputra, Patricia Kovatch, Thomas McDonald, Patricia McGoldrick, Rosamond Rhodes, Michael Rinke, Mimsie Robinson, Arye Rubinstein, Lisa Shulman, Christian Stolte, Steven Wolf, Elissa Yozawitz, Randi Zinberg, John Greally, Bruce Gelb, Carol Horowitz, Melissa Wasserstein, Eimear Kenny,

<h4>Background: </h4> Increasingly, genomics is informing clinical practice, but challenges remain for medical professionals lacking genetics expertise, and in access to and clinical utility of genomic testing for minority and underrepresented populations. The latter is a particularly pernicious problem due to the historical lack of inclusion of racially and ethnically ... Read more >>

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Non-full-length Water-Soluble CXCR4QTY and CCR5QTY Chemokine Receptors: Implication for Overlooked Truncated but Functional Membrane Receptors.

Rui Qing, Fei Tao, Pranam Chatterjee, Gaojie Yang, Qiuyi Han, Haeyoon Chung, Jun Ni, Bernhard P Suter, Jan Kubicek, Barbara Maertens, Thomas Schubert, Camron Blackburn, Shuguang Zhang,

It was posited that functionalities of GPCRs require full-length sequences that are negated by residue deletions. Here we report that significantly truncated nfCCR5<sup>QTY</sup> and nfCXCR4<sup>QTY</sup> still bind native ligands. Receptor-ligand interactions were discovered from yeast 2-hybrid screening and confirmed by mating selection. Two nfCCR5<sup>QTY</sup> (SZ218a, SZ190b) and two nfCXCR4<sup>QTY</sup> (SZ158a, ... Read more >>

iScience (iScience)
[2020, 23(12):101670]

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Does socioeconomic position affect knowledge of the risk factors and warning signs of stroke in the WHO European region? A systematic literature review.

Katie Stack, Wendy Robertson, Clare Blackburn,

<h4>Background</h4>Strokes are one of the leading causes of death worldwide. People with a lower socioeconomic position (SEP) (i.e. with regards to education, income and occupation) are at a higher risk of having a stroke and have worse clinical outcomes compared to the general population. Good knowledge levels about stroke risk ... Read more >>

BMC Public Health (BMC public health)
[2020, 20(1):1473]

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Interface of Phospholipase Activity, Immune Cell Function, and Atherosclerosis

Robert Schilke, Cassidy Blackburn, Temitayo Bamgbose, Matthew Woolard,

Phospholipases are a family of lipid altering enzymes that can either reduce or increase bioactive lipid levels. Bioactive lipids elicit signaling responses, activate transcription factors, promote g-coupled protein activity, and modulate membrane fluidity that mediate cellular function. Phospholipases and the bioactive lipids they produce are important regulators on immune cell ... Read more >>

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The NYCKidSeq project: study protocol for a randomized controlled trial incorporating genomics into the clinical care of diverse New York City children

Jacqueline Odgis, Katie Gallagher, Sabrina Suckiel, Katherine Donohue, Michelle Ramos, Nicole Kelly, Gabrielle Bertier, Christina Blackburn, Kaitlyn Brown, Lena Fielding, Jessenia Lopez, Karla Lopez Aguiniga, Estefany Maria, Jessica Rodriguez, Monisha Sebastin, Nehama Teitelman, Dana Watnick, Nicole Yelton, Avinash Abhyankar, Noura Abul-Husn, Aaron Baum, Laurie Bauman, Jules Beal, Toby Bloom, Charlotte Cunningham-Rundles, George Diaz, Siobhan Dolan, Bart Ferket, Vaidehi Jobanputra, Patricia Kovatch, Thomas McDonald, Patricia McGoldrick, Rosamond Rhodes, Michael Rinke, Mimsie Robinson, Arye Rubinstein, Lisa Shulman, Christian Stolte, Steven Wolf, Elissa Yozawitz, Randi Zinberg, John Greally, Bruce Gelb, Carol Horowitz, Melissa Wasserstein, Eimear Kenny,

<h4>Background: </h4> Increasingly, genomics is informing clinical practice, but challenges remain for medical professionals lacking genetics expertise, and in access to and clinical utility of genomic testing for minority and underrepresented populations. The latter is a particularly pernicious problem due to the historical lack of inclusion of racially and ethnically ... Read more >>

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Does Socioeconomic Position Affect Knowledge of the Risk Factors and Warning Signs of Stroke in the WHO European Region? A Systematic Literature Review

Katie Stack, Wendy Robertson, Clare Blackburn,

<h4>Background: </h4> Strokes are one of the leading causes of death worldwide. People with a lower socioeconomic position (SEP) (i.e. with regards to education, income and occupation) are at a higher risk of having a stroke and have worse clinical outcomes compared to the general population. Good knowledge levels about ... Read more >>

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The utility of ketones at triage: a prospective cohort study.

Sheena Durnin, Jennifer Jones, Emer Ryan, Ruth Howard, Sean Walsh, Ian Dawkins, Carol Blackburn, Sinead M O'Donnell, Michael J Barrett,

<h4>Objective</h4>To establish the relationship between serum point-of-care (POC) ketones at triage and moderate-to-severe dehydration based on the validated Gorelick Scales.<h4>Design, setting and patients</h4>Prospective unblinded study from April 2016 to February 2017 in a paediatric emergency department. Patients aged 1 month to 5 years, with vomiting and/or diarrhoea and/or decreased intake with ... Read more >>

Arch Dis Child (Archives of disease in childhood)
[2020, 105(12):1157-1161]

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Canonical Notch signaling controls the early thymic epithelial progenitor cell state and emergence of the medullary epithelial lineage in fetal thymus development.

Dong Liu, Anastasia I Kousa, Kathy E O'Neill, Paul Rouse, Martyna Popis, Alison M Farley, Simon R Tomlinson, Svetlana Ulyanchenko, Francois Guillemot, Philip A Seymour, Mette C Jørgensen, Palle Serup, Ute Koch, Freddy Radtke, C Clare Blackburn,

Thymus function depends on the epithelial compartment of the thymic stroma. Cortical thymic epithelial cells (cTECs) regulate T cell lineage commitment and positive selection, while medullary (m) TECs impose central tolerance on the T cell repertoire. During thymus organogenesis, these functionally distinct sub-lineages are thought to arise from a common ... Read more >>

Development (Development (Cambridge, England))
[2020, 147(12):]

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Paediatric Head Injury and Traumatic Brain Injury.

E Ryan, T Bolger, M J Barrett, C Blackburn, I Okafor, R McNamara, E J Molloy,

Aim To determine prevalence of head injury presenting to paediatric emergency departments (PEDs) and characterise by demographics, triage category, disposition neuroimaging or re-attendance. Methods Presentations in 2014 and 2015, with diagnoses of head injury, intracranial bleed, skull fracture including single or re-attendances within 28 days post head injury to all ... Read more >>

Ir Med J (Irish medical journal)
[2020, 113(6):94]

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Lipin-1 regulates lipid catabolism in pro-resolving macrophages

Robert Schilke, Cassidy M.R. Blackburn, Shashanka Rao, David Krzywanski, Brian Finck, Matthew Woolard,

Macrophages reprogram their metabolism to promote appropriate responses. Pro-resolving macrophages primarily utilize fatty acid oxidation as an energy source. Metabolites generated during the catabolism of fatty acids aid in the resolution of inflammation and tissue repair, but the regulatory mechanisms that control lipid metabolism in macrophages is not fully elucidated. ... Read more >>

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Macrophage-associated lipin-1 transcriptional co-regulatory activity is involved in atherosclerosis

Cassidy M.R. Blackburn, Robert Schilke, Aimee Vozenilek, Brian Finck, Matthew Woolard,

During atherosclerosis, macrophages engulf and break down deposited modified low-density lipoproteins (modLDLs) into lipids and free fatty acids. The lipids and free fatty acids from these modLDLs either need to be stored during a process called glycerolipid synthesis or broken down during β-oxidation. In addition, free fatty acids can activate ... Read more >>

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Sampling, analysis and modelling technologies for large-scale nuclear emergencies affecting food and agriculture.

Gerd Dercon, Carl Blackburn, Yuichi Onda, Takuro Shinano, Lieve Sweeck, Amelia Lee Zhi Yi, Sergey Fesenko,

J Environ Radioact (Journal of environmental radioactivity)
[2020, 218:106174]

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Too old for a paediatric emergency department? It's complex.

Michael Bennett, Claudio Dalla Vecchia, Carol Blackburn, Sean Walsh, Michael J Barrett,

<h4>Background</h4>In Ireland, the paediatric emergency department (PED) is tasked with acute healthcare provision to children and adolescents under 16 years of age. The population > 15 years attending the PED remains undescribed.<h4>Aims</h4>The objective of the study is to describe the presentations of patients > 15 years to the PED of a national tertiary academic paediatric ... Read more >>

Ir J Med Sci (Irish journal of medical science)
[2020, 189(4):1429-1433]

Cited: 2 times

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Conflict and Cholera: Yemen's Man-Made Public Health Crisis and the Global Implications of Weaponizing Health.

Christine Crudo Blackburn, Paul E Lenze, Rachel Paige Casey,

The cholera epidemic in Yemen, which began in October 2016 and reached its peak in 2017, was the largest disease outbreak in modern history. Suspected cases topped 1 million, and there were more than 2,000 confirmed deaths in the first 8 months of the outbreak. Although cholera is an ancient ... Read more >>

Health Secur (Health security)
[2020, 18(2):125-131]

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Does socioeconomic position affect knowledge of the risk factors and warning signs of stroke in the WHO European region? A systematic literature review

Katie Stack, Wendy Robertson, Clare Blackburn,

Background Strokes are one of the leading causes of death worldwide. People with a lower socioeconomic position (SEP) (i.e. with regards to education, income and occupation) are at a higher risk of having a stroke and have worse clinical outcomes compared to the general population. Good knowledge levels about stroke ... Read more >>

BMC Public Health (BMC public health)
[2020, 20(1):]

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Lipin-1 contributes to IL-4 mediated macrophage polarization

Sunitha Chandran, Robert Schilke, Cassidy M.R. Blackburn, Aila Yurochko, Rusella Mirza, Rona Scott, Brian Finck, Matthew Woolard,

<h4>ABSTRACT</h4> Macrophage responses contribute to a diverse array of pathologies ranging from infectious disease to sterile inflammation. Polarization of macrophages determines their cellular function within biological processes. Lipin-1 is a phosphatidic acid phosphatase in which its enzymatic activity contributes to macrophage pro-inflammatory responses. Lipin-1 also possesses transcriptional co-regulator activity and ... Read more >>

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Contact us for more information: an analysis of public enquiries about stem cells.

Amy Zarzeczny, Claire Tanner, Jan Barfoot, Clare Blackburn, Anna Couturier, Megan Munsie,

Aim: This study examines online enquiries received by two prominent stem cell science initiatives operating in different geographical jurisdictions. Materials & methods: Combined quantitative and qualitative analysis undertaken of internet-based queries (n = 1047) received by Stem Cells Australia and EuroStemCell from members of the public over a two-year period (May 2014-2016). ... Read more >>

Regen Med (Regenerative medicine)
[2019, 14(12):1137-1150]

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Student perspectives on barriers to performance for black and minority ethnic graduate-entry medical students: a qualitative study in a West Midlands medical school.

Nariell Morrison, Michelle Machado, Clare Blackburn,

OBJECTIVE:To explore graduate-entry medical students experiences of undergraduate training in the context of academic underperformance of medical students from ethnic minority backgrounds. DESIGN:Qualitative study using semi-structured focus groups. SETTING:A West Midlands medical school. PARTICIPANTS:24 graduate-entry MBChB students were recruited using volunteer and snowball sampling; all students self-identified as being from ... Read more >>

BMJ Open (BMJ open)
[2019, 9(11):e032493]

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Association of Cost Savings and Surgical Quality With Single-Vendor Procurement for Spinal Implants.

Collin W Blackburn, Nicolas R Thompson, Joseph E Tanenbaum, Allen J Passerallo, Thomas E Mroz, Michael P Steinmetz,

<h4>Importance</h4>Significant cost savings can be achieved from consolidating purchases of spinal implants with a single vendor. However, it is currently unknown whether sole-source contracting or vendor rationalization more broadly affects patient care.<h4>Objectives</h4>To describe the single-vendor procurement of spinal implants, characterize the economic benefits of sole-source contracting, and gauge whether vendor ... Read more >>

JAMA Netw Open (JAMA network open)
[2019, 2(11):e1915567]

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Family members' perceptions of a Singing Medicine project in a children's hospital.

Carolyn Blackburn,

AIM:The aim of this study was to explore family members' perceptions of a Singing Medicine project undertaken by children with long-term conditions in one children's hospital. METHOD:A qualitative approach was used involving semi-structured interviews with the family members of children aged 3-14 years who had long-term conditions and were being ... Read more >>

Nurs Child Young People (Nursing children and young people)
[2020, 32(1):23-29]

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Current Methods of Maxillofacial Tissue Engineering.

James C Melville, Victoria A Mañón, Caleb Blackburn, Simon Young,

For several decades, the multidisciplinary field of tissue engineering has striven to improve conventional methods of dental, oral, and craniofacial rehabilitation for millions of people annually. Several bone tissue engineering strategies are now readily available in the clinic. Enrichment of autologous products, growth factors, and combination approaches are discussed as ... Read more >>

Oral Maxillofac Surg Clin North Am (Oral and maxillofacial surgery clinics of North America)
[2019, 31(4):579-591]

Cited: 1 time

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Parent psychology and the decision to delay childhood vaccination.

Timothy Callaghan, Matthew Motta, Steven Sylvester, Kristin Lunz Trujillo, Christine Crudo Blackburn,

<h4>Objective</h4>The study of vaccine hesitancy identifies parental decisions to delay childhood vaccinations as an important public health issue, with consequences for immunization rates, the pursuit of nonmedical exemptions in states, and disease outbreaks. While prior work has explored the demographic and social underpinnings of parental decisions to delay childhood vaccinations, ... Read more >>

Soc Sci Med (Social science & medicine (1982))
[2019, 238:112407]

Cited: 4 times

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