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Vulnerability to COVID-19-Related Disability: The Impact of Posttraumatic Stress Symptoms on Psychosocial Impairment During the Pandemic.

Danielle M Morabito, Carter E Bedford, Savannah Woller, Norman B Schmidt,

As a result of the COVID-19 pandemic, many individuals have experienced disruptions in social, occupational, and daily life activities. Individuals with mental health difficulties, particularly those with elevated posttraumatic stress symptoms (PTSS), may be especially vulnerable to increased impairment as a result of COVID-19. Additionally, demographic factors, such as age, ... Read more >>

J Trauma Stress (Journal of traumatic stress)
[2021, :]

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Lopinavir-ritonavir and hydroxychloroquine for critically ill patients with COVID-19: REMAP-CAP randomized controlled trial.

Yaseen M Arabi, Anthony C Gordon, Lennie P G Derde, Alistair D Nichol, Srinivas Murthy, Farah Al Beidh, Djillali Annane, Lolowa Al Swaidan, Abi Beane, Richard Beasley, Lindsay R Berry, Zahra Bhimani, Marc J M Bonten, Charlotte A Bradbury, Frank M Brunkhorst, Meredith Buxton, Adrian Buzgau, Allen Cheng, Menno De Jong, Michelle A Detry, Eamon J Duffy, Lise J Estcourt, Mark Fitzgerald, Rob Fowler, Timothy D Girard, Ewan C Goligher, Herman Goossens, Rashan Haniffa, Alisa M Higgins, Thomas E Hills, Christopher M Horvat, David T Huang, Andrew J King, Francois Lamontagne, Patrick R Lawler, Roger Lewis, Kelsey Linstrum, Edward Litton, Elizabeth Lorenzi, Salim Malakouti, Daniel F McAuley, Anna McGlothlin, Shay Mcguinness, Bryan J McVerry, Stephanie K Montgomery, Susan C Morpeth, Paul R Mouncey, Katrina Orr, Rachael Parke, Jane C Parker, Asad E Patanwala, Kathryn M Rowan, Marlene S Santos, Christina T Saunders, Christopher W Seymour, Manu Shankar-Hari, Steven Y C Tong, Alexis F Turgeon, Anne M Turner, Frank Leo Van de Veerdonk, Ryan Zarychanski, Cameron Green, Scott Berry, John C Marshall, Colin McArthur, Derek C Angus, Steven A Webb, ,

<h4>Purpose</h4>To study the efficacy of lopinavir-ritonavir and hydroxychloroquine in critically ill patients with coronavirus disease 2019 (COVID-19).<h4>Methods</h4>Critically ill adults with COVID-19 were randomized to receive lopinavir-ritonavir, hydroxychloroquine, combination therapy of lopinavir-ritonavir and hydroxychloroquine or no antiviral therapy (control). The primary endpoint was an ordinal scale of organ support-free days. Analyses ... Read more >>

Intensive Care Med (Intensive care medicine)
[2021, 47(8):867-886]

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A longitudinal investigation of trauma-specific rumination and PTSD symptoms: The moderating role of interpersonal trauma experience.

Thomas J Preston, Julia Y Gorday, Carter E Bedford, Brittany M Mathes, Norman B Schmidt,

<h4>Background</h4>Interpersonal trauma (IPT) is one of the most commonly reported types of traumatic experiences and has the greatest likelihood of resulting in a diagnosis of posttraumatic stress disorder (PTSD). Relative to other types of trauma, victims of IPT report greater trauma-specific rumination, whereby they focus on negative consequences of the ... Read more >>

J Affect Disord (Journal of affective disorders)
[2021, 292:142-148]

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A study on the use of thermal imaging as a diagnostic tool for the detection of digital dermatitis in dairy cattle.

A Anagnostopoulos, M Barden, J Tulloch, K Williams, B Griffiths, C Bedford, M Rudd, A Psifidi, G Banos, G Oikonomou,

Our aims were to (1) determine how interdigital skin temperature (IST), measured using infrared thermography, was associated with different stages of digital dermatitis (DD) lesions and (2) develop and validate models that can use IST measurements to identify cows with an active DD lesion. Between March 2019 and March 2020, ... Read more >>

J Dairy Sci (Journal of dairy science)
[2021, :]

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Assessing the impact on pharmacists’ time by introducing a technician screening process for clinical trial prescriptions

D Mistry, S Awan, E Lundy, C Bedford, H Thorp, K Houseman, J Chapman, P Smalley, J Stradling,

Abstract <h4>Introduction</h4> Various national guidance from the Lord Carter 2016 report to the NHS Long term plan have emphasised the need to transform traditional hospital pharmacy and make work streams more efficient.[1] A clinical trials pharmacist has historically validated clinical trial medicines. Whilst this is good practice for non-chemotherapy prescriptions, ... Read more >>

Int J Pharm Pract (The International journal of pharmacy practice)
[2021, 29(Suppl 1):i46-i47]

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Interleukin-6 Receptor Antagonists in Critically Ill Patients with Covid-19.

, Anthony C Gordon, Paul R Mouncey, Farah Al-Beidh, Kathryn M Rowan, Alistair D Nichol, Yaseen M Arabi, Djillali Annane, Abi Beane, Wilma van Bentum-Puijk, Lindsay R Berry, Zahra Bhimani, Marc J M Bonten, Charlotte A Bradbury, Frank M Brunkhorst, Adrian Buzgau, Allen C Cheng, Michelle A Detry, Eamon J Duffy, Lise J Estcourt, Mark Fitzgerald, Herman Goossens, Rashan Haniffa, Alisa M Higgins, Thomas E Hills, Christopher M Horvat, Francois Lamontagne, Patrick R Lawler, Helen L Leavis, Kelsey M Linstrum, Edward Litton, Elizabeth Lorenzi, John C Marshall, Florian B Mayr, Daniel F McAuley, Anna McGlothlin, Shay P McGuinness, Bryan J McVerry, Stephanie K Montgomery, Susan C Morpeth, Srinivas Murthy, Katrina Orr, Rachael L Parke, Jane C Parker, Asad E Patanwala, Ville Pettilä, Emma Rademaker, Marlene S Santos, Christina T Saunders, Christopher W Seymour, Manu Shankar-Hari, Wendy I Sligl, Alexis F Turgeon, Anne M Turner, Frank L van de Veerdonk, Ryan Zarychanski, Cameron Green, Roger J Lewis, Derek C Angus, Colin J McArthur, Scott Berry, Steve A Webb, Lennie P G Derde,

<h4>Background</h4>The efficacy of interleukin-6 receptor antagonists in critically ill patients with coronavirus disease 2019 (Covid-19) is unclear.<h4>Methods</h4>We evaluated tocilizumab and sarilumab in an ongoing international, multifactorial, adaptive platform trial. Adult patients with Covid-19, within 24 hours after starting organ support in the intensive care unit (ICU), were randomly assigned to ... Read more >>

N Engl J Med (The New England journal of medicine)
[2021, 384(16):1491-1502]

Cited: 116 times

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Feasibility of reporting results of large randomised controlled trials to participants: experience from the Fluoxetine Or Control Under Supervision (FOCUS) trial.

Gillian Mead, Martin Dennis, ,

<h4>Objectives</h4>Informing research participants of the results of studies in which they took part is viewed as an ethical imperative. However, there is little guidance in the literature about how to do this. The Fluoxetine Or Control Under Supervision trial randomised 3127 patients with a recent acute stroke to 6 months of ... Read more >>

BMJ Open (BMJ open)
[2020, 10(11):e040492]

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A longitudinal investigation of the association between rumination, hostility, and PTSD symptoms among trauma-exposed individuals.

Brittany M Mathes, Grace A Kennedy, Danielle M Morabito, Alex Martin, Carter E Bedford, Norman B Schmidt,

<h4>Background</h4>Rumination, defined as perseverative thinking regarding the causes and consequences of psychological symptoms, is a risk and maintaining factor for PTSD. Existing work has largely focused on the extent to which rumination functions as a coping strategy used to avoid traumatic memories and associated emotions. However, rumination may also maintain ... Read more >>

J Affect Disord (Journal of affective disorders)
[2020, 277:322-328]

Cited: 1 time

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Hyperarousal symptoms and perceived burdensomeness interact to predict suicidal ideation among trauma-exposed individuals.

Danielle M Morabito, Joseph W Boffa, Carter E Bedford, Jimmy P Chen, Norman B Schmidt,

The association between posttraumatic stress disorder (PTSD) and suicidal ideation is well-established and recent prospective studies have demonstrated the unique role of hyperarousal symptoms. In particular, over-arousal may elevate suicide risk in the presence of interpersonal vulnerability factors including thwarted belongingness, perceived burdensomeness, and acquired capability. Therefore, the current study ... Read more >>

J Psychiatr Res (Journal of psychiatric research)
[2020, 130:218-223]

Cited: 0 times

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Dissociative Symptoms In Posttraumatic Stress Disorder: A Systematic Review.

Rachel Atchley, Carter Bedford,

<b>Objectives</b>: Research on dissociative symptomatology in the context of Posttraumatic Stress Disorder (PTSD) has been gaining traction, with dissociation being studied as a set of complex symptoms following trauma exposure and as a specific subtype of PTSD. The aims of this review are to summarize the literature as it stands, ... Read more >>

J Trauma Dissociation (Journal of trauma & dissociation : the official journal of the International Society for the Study of Dissociation (ISSD))
[2021, 22(1):69-88]

Cited: 0 times

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Mindfulness-oriented recovery enhancement reduces opioid misuse risk via analgesic and positive psychological mechanisms: A randomized controlled trial.

Eric L Garland, Adam W Hanley, Michael R Riquino, Sarah E Reese, Anne K Baker, Karen Salas, Brooke P Yack, Carter E Bedford, Myranda A Bryan, Rachel Atchley, Yoshio Nakamura, Brett Froeliger, Matthew O Howard,

OBJECTIVE:Despite the heightened urgency of the current prescription opioid crisis, few psychotherapies have been evaluated for chronic pain patients receiving long-term opioid analgesics. Current psychological pain treatments focus primarily on ameliorating negative affective processes, yet basic science suggests that risk for opioid misuse is linked with a dearth of positive ... Read more >>

J Consult Clin Psychol (Journal of consulting and clinical psychology)
[2019, 87(10):927-940]

Cited: 18 times

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The Impact of Psychological Interventions on Posttraumatic Stress Disorder and Pain Symptoms: A Systematic Review and Meta-Analysis.

Ellen Goldstein, Christina McDonnell, Rachel Atchley, Kathleen Dorado, Carter Bedford, Roger L Brown, Aleksandra E Zgierska,

<h4>Objectives</h4>Posttraumatic stress disorder (PTSD) and pain often co-occur, introducing clinical challenges and economic burden. Psychological treatments are considered effective for each condition, yet it is not known which therapies have the potential to concurrently address PTSD and pain-related symptoms.<h4>Materials and methods</h4>To conduct a systematic review and meta-analysis, databases were searched ... Read more >>

Clin J Pain (The Clinical journal of pain)
[2019, 35(8):703-712]

Cited: 2 times

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Adverse childhood experiences predict autonomic indices of emotion dysregulation and negative emotional cue-elicited craving among female opioid-treated chronic pain patients.

Eric L Garland, Sarah E Reese, Carter E Bedford, Anne K Baker,

Through autonomic and affective mechanisms, adverse childhood experiences (ACEs) may disrupt the capacity to regulate negative emotions, increasing craving and exacerbating risk for opioid use disorder (OUD) among individuals with chronic pain who are receiving long-term opioid analgesic pharmacotherapy. This study examined associations between ACEs, heart rate variability (HRV) during ... Read more >>

Dev Psychopathol (Development and psychopathology)
[2019, 31(3):1101-1110]

Cited: 3 times

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Environmental contamination following the Grenfell Tower fire.

Anna A Stec, Kathryn Dickens, Jessica L J Barnes, Clare Bedford,

The Grenfell Tower fire in central London, started within a flat, engulfed the whole 24 storey building in flames, killed 72 people and spread toxic effluent via the plume and particulate deposits. Soil samples from 6 locations up to 1,2 km from the Tower, together with semi-burnt fire debris and char ... Read more >>

Chemosphere (Chemosphere)
[2019, 226:576-586]

Cited: 2 times

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Effects of fluoxetine on functional outcomes after acute stroke (FOCUS): a pragmatic, double-blind, randomised, controlled trial.

,

<h4>Background</h4>Results of small trials indicate that fluoxetine might improve functional outcomes after stroke. The FOCUS trial aimed to provide a precise estimate of these effects.<h4>Methods</h4>FOCUS was a pragmatic, multicentre, parallel group, double-blind, randomised, placebo-controlled trial done at 103 hospitals in the UK. Patients were eligible if they were aged 18 ... Read more >>

Lancet (Lancet (London, England))
[2019, 393(10168):265-274]

Cited: 41 times

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Adjunctive rifampicin for Staphylococcus aureus bacteraemia (ARREST): a multicentre, randomised, double-blind, placebo-controlled trial.

Guy E Thwaites, Matthew Scarborough, Alexander Szubert, Emmanuel Nsutebu, Robert Tilley, Julia Greig, Sarah A Wyllie, Peter Wilson, Cressida Auckland, Janet Cairns, Denise Ward, Pankaj Lal, Achyut Guleri, Neil Jenkins, Julian Sutton, Martin Wiselka, Gonzalez-Ruiz Armando, Clive Graham, Paul R Chadwick, Gavin Barlow, N Claire Gordon, Bernadette Young, Sarah Meisner, Paul McWhinney, David A Price, David Harvey, Deepa Nayar, Dakshika Jeyaratnam, Tim Planche, Jane Minton, Fleur Hudson, Susan Hopkins, John Williams, M Estee Török, Martin J Llewelyn, Jonathan D Edgeworth, A Sarah Walker, ,

<h4>Background</h4>Staphylococcus aureus bacteraemia is a common cause of severe community-acquired and hospital-acquired infection worldwide. We tested the hypothesis that adjunctive rifampicin would reduce bacteriologically confirmed treatment failure or disease recurrence, or death, by enhancing early S aureus killing, sterilising infected foci and blood faster, and reducing risks of dissemination and ... Read more >>

Lancet (Lancet (London, England))
[2018, 391(10121):668-678]

Cited: 35 times

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Reappraisal deficits promote craving and emotional distress among chronic pain patients at risk for prescription opioid misuse.

Eric L Garland, Adam W Hanley, Carter E Bedford, Jon-Kar Zubieta, Matthew O Howard, Yoshio Nakamura, Gary W Donaldson, Brett Froeliger,

<b>Background</b>: A subset of chronic pain patients misuse prescription opioids as a means of regulating negative emotions. However, opioid misuse may result in deficits in emotion regulation strategies like reappraisal by virtue of the deleterious effects of chronic opioid exposure. <b>Aims:</b> The aim of this study was to characterize differences ... Read more >>

J Addict Dis (Journal of addictive diseases)
[2018, 37(1-2):14-22]

Cited: 3 times

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Intracerebral hemorrhage location and outcome among INTERACT2 participants.

Candice Delcourt, Shoichiro Sato, Shihong Zhang, Else Charlotte Sandset, Danni Zheng, Xiaoying Chen, Maree L Hackett, Hisatomi Arima, Jun Hata, Emma Heeley, Rustam Al-Shahi Salman, Thompson Robinson, Leo Davies, Pablo M Lavados, Richard I Lindley, Christian Stapf, John Chalmers, Craig S Anderson, ,

<h4>Objective</h4>To clarify associations between intracerebral hemorrhage (ICH) location and clinical outcomes among participants of the main phase Intensive Blood Pressure Reduction in Acute Cerebral Hemorrhage Trial (INTERACT2).<h4>Methods</h4>Associations between ICH sites and poor outcomes (death [6] or major disability [3-5] of modified Rankin Scale) and European Quality of Life Scale (EQ-5D) ... Read more >>

Neurology (Neurology)
[2017, 88(15):1408-1414]

Cited: 25 times

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LRRK2 Regulates Voltage-Gated Calcium Channel Function.

Cade Bedford, Catherine Sears, Maria Perez-Carrion, Giovanni Piccoli, Steven B Condliffe,

Voltage-gated Ca(2+) (CaV) channels enable Ca(2+) influx in response to membrane depolarization. CaV2.1 channels are localized to the presynaptic membrane of many types of neurons where they are involved in triggering neurotransmitter release. Several signaling proteins have been identified as important CaV2.1 regulators including protein kinases, G-proteins and Ca(2+) binding ... Read more >>

Front Mol Neurosci (Frontiers in molecular neuroscience)
[2016, 9:35]

Cited: 20 times

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Prognostic Significance of Hyponatremia in Acute Intracerebral Hemorrhage: Pooled Analysis of the Intensive Blood Pressure Reduction in Acute Cerebral Hemorrhage Trial Studies.

Cheryl Carcel, Shoichiro Sato, Danni Zheng, Emma Heeley, Hisatomi Arima, Jie Yang, Guojun Wu, Guofang Chen, Shihong Zhang, Candice Delcourt, Pablo Lavados, Thompson Robinson, Richard I Lindley, Xia Wang, John Chalmers, Craig S Anderson, ,

<h4>Objectives</h4>To determine the association of hyponatremia at presentation with clinical and imaging outcomes in patients with acute intracerebral hemorrhage.<h4>Design</h4>Retrospective pooled analysis of prospectively collected data from 3,243 participants of the pilot and main phases of the Intensive Blood Pressure Reduction in Acute Cerebral Hemorrhage Trials 1 and 2 (international, multicenter, ... Read more >>

Crit Care Med (Critical care medicine)
[2016, 44(7):1388-1394]

Cited: 5 times

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Estimated GFR and the Effect of Intensive Blood Pressure Lowering After Acute Intracerebral Hemorrhage.

Danni Zheng, Shoichiro Sato, Hisatomi Arima, Emma Heeley, Candice Delcourt, Yongjun Cao, John Chalmers, Craig S Anderson, ,

<h4>Background</h4>The kidney-brain interaction has been a topic of growing interest. Past studies of the effect of kidney function on intracerebral hemorrhage (ICH) outcomes have yielded inconsistent findings. Although the second, main phase of the Intensive Blood Pressure Reduction in Acute Cerebral Hemorrhage Trial (INTERACT2) suggests the effectiveness of early intensive ... Read more >>

Am J Kidney Dis (American journal of kidney diseases : the official journal of the National Kidney Foundation)
[2016, 68(1):94-102]

Cited: 9 times

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Low Ambient Temperature and Intracerebral Hemorrhage: The INTERACT2 Study.

Danni Zheng, Hisatomi Arima, Shoichiro Sato, Antonio Gasparrini, Emma Heeley, Candice Delcourt, Serigne Lo, Yining Huang, Jiguang Wang, Christian Stapf, Thompson Robinson, Pablo Lavados, John Chalmers, Craig S Anderson, ,

<h4>Background</h4>Rates of acute intracerebral hemorrhage (ICH) increase in winter months but the magnitude of risk is unknown. We aimed to quantify the association of ambient temperature with the risk of ICH in the Intensive Blood Pressure Reduction in Acute Cerebral Haemorrhage Trial (INTERACT2) participants on an hourly timescale.<h4>Methods</h4>INTERACT2 was an ... Read more >>

PLoS One (PloS one)
[2016, 11(2):e0149040]

Cited: 4 times

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Determinants and Prognostic Significance of Hematoma Sedimentation Levels in Acute Intracerebral Hemorrhage.

Shoichiro Sato, Candice Delcourt, Shihong Zhang, Hisatomi Arima, Emma Heeley, Danni Zheng, Rustam Al-Shahi Salman, Christian Stapf, Christophe Tzourio, Thompson Robinson, Richard I Lindley, John Chalmers, Craig S Anderson, ,

<h4>Background</h4>This study aimed at identifying the determinants and prognostic significance of a sedimentation level (fluid-blood level) in the hematoma among patients with acute intracerebral hemorrhage (ICH) who participated in the main Intensive Blood Pressure Reduction in Acute Cerebral Hemorrhage Trial (INTERACT2).<h4>Methods</h4>Post-hoc analysis of the INTERACT2 dataset, a randomized controlled trial ... Read more >>

Cerebrovasc Dis (Cerebrovascular diseases (Basel, Switzerland))
[2016, 41(1-2):80-86]

Cited: 7 times

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Effect of alteplase on the CT hyperdense artery sign and outcome after ischemic stroke.

Grant Mair, Rüdiger von Kummer, Zoe Morris, Anders von Heijne, Nick Bradey, Lesley Cala, André Peeters, Andrew J Farrall, Alessandro Adami, Gillian Potter, Geoff Cohen, Peter A G Sandercock, Richard I Lindley, Joanna M Wardlaw, ,

<h4>Objective</h4>To investigate whether the location and extent of the CT hyperdense artery sign (HAS) at presentation affects response to IV alteplase in the randomized controlled Third International Stroke Trial (IST-3).<h4>Methods</h4>All prerandomization and follow-up (24-48 hours) CT brain scans in IST-3 were assessed for HAS presence, location, and extent by masked ... Read more >>

Neurology (Neurology)
[2016, 86(2):118-125]

Cited: 9 times

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Off-Hour Admission and Outcomes in Patients with Acute Intracerebral Hemorrhage in the INTERACT2 Trial.

Shoichiro Sato, Hisatomi Arima, Emma Heeley, Yoichiro Hirakawa, Candice Delcourt, Richard I Lindley, Thompson Robinson, Yining Huang, Lewis Morgenstern, Christian Stapf, Jiguang Wang, John Chalmers, Craig S Anderson, ,

<h4>Background</h4>Conflicting data exist of an association between off-hour (weekend, holiday, or night-time) hospital admission and adverse outcome in intracerebral hemorrhage (ICH). We determined the association between off-hour admissions and poor clinical outcome, and of any differential effect of early intensive blood pressure (BP) lowering treatment between off- and on-hour admissions, ... Read more >>

Cerebrovasc Dis (Cerebrovascular diseases (Basel, Switzerland))
[2015, 40(3-4):114-120]

Cited: 3 times

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