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A single-arm phase II study of olaparib maintenance with pembrolizumab and bevacizumab in BRCA non-mutated patients with platinum-sensitive recurrent ovarian cancer (OPEB-01).

Yong Jae Lee, Myong Cheol Lim, Byoung Gie Kim, Natalie Yl Ngoi, Chel Hun Choi, Sang Yoon Park, David Sp Tan, Yunjung Go, Jung Yun Lee,

<h4>Background</h4>The optimal treatment of <i>BRCA</i> wild-type patients with platinum-sensitive recurrent ovarian cancer remains unknown. Recently, there is an increase in the evidence to support the role of the combination of a poly(adenosine diphosphate-ribose) polymerase inhibitor, anti-angiogenic agents, and immunotherapy as maintenance therapy in <i>BRCA</i> wild-type patients with platinum-sensitive recurrence. We ... Read more >>

J Gynecol Oncol (Journal of gynecologic oncology)
[2021, 32(2):e31]

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Survival Effects of Cytoreductive Surgery for Refractory Patients after Neoadjuvant Chemotherapy in Advanced Epithelial Ovarian Cancer.

Wonkyo Shin, Joseph J Noh, Sang Soo Seo, Sokbom Kang, Chel Hun Choi, Sang Yoon Park, Byoung Gie Kim, Myong Cheol Lim,

<h4>Purpose</h4>Salvage second-line chemotherapy is usually recommended for patients with advanced epithelial ovarian cancer (AEOC) who develop progressive disease (PD) after neoadjuvant chemotherapy (NAC). Herein, we investigated the role of cytoreductive surgery (CRS) for such patients.<h4>Materials and methods</h4>We retrospectively reviewed the medical records of 36 patients with AEOC who developed PD ... Read more >>

Yonsei Med J (Yonsei medical journal)
[2020, 61(11):935-941]

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Olaparib tablets as maintenance therapy in patients with platinum-sensitive relapsed ovarian cancer and a BRCA1/2 mutation (SOLO2/ENGOT-Ov21): a final analysis of a double-blind, randomised, placebo-controlled, phase 3 trial.

Andrés Poveda, Anne Floquet, Jonathan A Ledermann, Rebecca Asher, Richard T Penson, Amit M Oza, Jacob Korach, Tomasz Huzarski, Sandro Pignata, Michael Friedlander, Alessandra Baldoni, Tjoung-Won Park-Simon, Kenji Tamura, Gabe S Sonke, Alla Lisyanskaya, Jae-Hoon Kim, Elias Abdo Filho, Tsveta Milenkova, Elizabeth S Lowe, Phil Rowe, Ignace Vergote, Eric Pujade-Lauraine, ,

<h4>Background</h4>Olaparib, a poly (ADP-ribose) polymerase (PARP) inhibitor, has previously been shown to extend progression-free survival versus placebo when given to patients with relapsed high-grade serous or endometrioid ovarian cancer who were platinum sensitive and who had a BRCA1 or BRCA2 (BRCA1/2) mutation, as part of the SOLO2/ENGOT-Ov21 trial. The aim ... Read more >>

Lancet Oncol (The Lancet. Oncology)
[2021, :]

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Metabolic syndrome and persistent cervical human papillomavirus infection.

Jieun Lee, Hye Seung Kim, Kyunga Kim, Duk-Soo Bae, Byoung-Gie Kim, Chel Hun Choi,

<h4>Objective</h4>Few studies have been conducted on the relationship between metabolic syndrome (MetS) and persistent human papillomavirus (HPV) infection. We investigated whether MetS and associated factors can predict the persistence of HPV infection.<h4>Patients and methods</h4>We performed a retrospective cohort study of 80,993 female cases undergoing general medical screenings at Samsung Medical ... Read more >>

Gynecol Oncol (Gynecologic oncology)
[2021, :]

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Early Metabolic Response Assessed Using 18F-FDG-PET/CT for Image-Guided Intracavitary Brachytherapy Can Better Predict Treatment Outcomes in Patients with Cervical Cancer.

Nalee Kim, Won Park, Won Kyung Cho, Duk-Soo Bae, Byoung-Gie Kim, Jeong-Won Lee, Tae-Joong Kim, Chel Hun Choi, Yoo-Young Lee, Young Seok Cho,

<h4>Purpose</h4>This study aimed to identify the prognostic value of early metabolic response assessed using 18F-fluorodeoxyglucose positron emission tomography/computed tomography (FDG-PET/CT) during radiation therapy (RT) for cervical cancer.<h4>Materials and methods</h4>We identified 116 patients treated with definitive RT, including FDG-PET/CT-guided intracavitary brachytherapy, between 2009 and 2018. We calculated parameters including maximum (SUVmax) ... Read more >>

Cancer Res Treat (Cancer research and treatment)
[2020, :]

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Polygenic Risk Modelling for Prediction of Epithelial Ovarian Cancer Risk

Eileen Dareng, Jonathan Tyrer, Daniel Barnes, Michelle Jones, Xin Yang, Katja K.H. Aben, Muriel Adank, Simona Agata, Irene Andrulis, Hoda Anton-Culver, Natalia Antonenkova, Gerasimos Aravantinos, Banu Arun, Annelie Augustinsson, Judith Balmaña, Elisa Bandera, Rosa Barkardottir, Daniel Barrowdale, Matthias Beckmann, Alicia Beeghly-Fadiel, Javier Benitez, Marina Bermisheva, Marcus Bernardini, Line Bjorge, Amanda Black, Natalia Bogdanova, Bernardo Bonanni, Ake Borg, James Brenton, Agnieszka Budzilowska, Ralf Butzow, Saundra Buys, Hui Cai, Maria Caligo, Ian Campbell, Rikki Cannioto, Hayley Cassingham, Jenny Chang-Claude, Stephen Chanock, Kexin Chen, Yoke-Eng Chiew, Wendy Chung, Kathleen B.M. Claes, Sarah Colanna, Linda Cook, Fergus Couch, Mary Daly, Fanny Dao, Eleanor Davies, Miguel de la Hoya, Robin de Putter, Joe Dennis, Allison DePersia, Peter Devilee, Orland Diez, Yuan Chun Ding, Jennifer Doherty, Susan Domchek, Thilo Dörk, Andreas du Bois, Matthias Dürst, Diana Eccles, Heather Eliassen, Christoph Engel, Gareth Evans, Peter Fasching, James Flanagan, Lenka Foretova, Renée Fortner, Eitan Friedman, Patricia Ganz, Judy Garber, Francesca Gensini, Graham Giles, Gord Glendon, Andrew Godwin, Marc Goodman, Mark Greene, Jacek Gronwald, Eric Hahnen, Christopher Haiman, Niclas Håkansson, Ute Hamann, Thomas V.O. Hansen, Holly Harris, Mikael Hartman, Florian Heitz, Michelle A.T. Hildebrandt, Estrid Høgdall, Claus Høgdall, John Hopper, Ruea-Yea Huang, Chad Huff, Peter Hulick, David Huntsman, Evgeny Imyanitov, Claudine Isaacs, Anna Jakubowska, Paul James, Ramunas Janavicius, Allan Jensen, Oskar Th. Johannsson, Esther John, Michael Jones, Daehee Kang, Beth Karlan, Anthony Karnezis, Linda Kelemen, Elza Khusnutdinova, Lambertus Kiemeney, Byoung-Gie Kim, Susanne Kjaer, Ian Komenaka, Jolanta Kupryjanczyk, Allison Kurian, Ava Kwong, Diether Lambrechts, Melissa Larson, Conxi Lazaro, Nhu Le, Goska Leslie, Jenny Lester, Fabienne Lesueur, Douglas Levine, Lian Li, Jingmei Li, Jennifer Loud, Karen Lu, Jan Lubiński, Eva Machackova, Phuong Mai, Siranoush Manoukian, Jeffrey Marks, Rayna Kim Matsuno, Keitaro Matsuo, Taymaa May, Lesley McGuffog, John McLaughlin, Iain McNeish, Noura Mebirouk, Usha Menon, Austin Miller, Roger Milne, Albina Minlikeeva, Francesmary Modugno, Marco Montagna, Kirsten Moysich, Elizabeth Munro, Katherine Nathanson, Susan Neuhausen, Heli Nevanlinna, Joanne Ngeow Yuen Yie, Henriette Roed Nielsen, Finn Nielsen, Liene Nikitina-Zake, Kunle Odunsi, Kenneth Offit, Edith Olah, Siel Olbrecht, Olufunmilayo Olopade, Sara Olson, Håkan Olsson, Ana Osorio, Laura Papi, Sue Park, Michael Parsons, Harsha Pathak, Inge Sokilde Pedersen, Ana Peixoto, Tanja Pejovic, Pedro Perez-Segura, Jennifer Permuth, Beth Peshkin, Paolo Peterlongo, Anna Piskorz, Darya Prokofyeva, Paolo Radice, Johanna Rantala, Marjorie Riggan, Harvey Risch, Cristina Rodriguez-Antona, Eric Ross, Mary Anne Rossing, Ingo Runnebaum, Dale Sandler, Marta Santamariña, Penny Soucy, Rita Schmutzler, Wendy Setiawan, Kang Shan, Weiva Sieh, Jacques Simard, Christian Singer, Anna Sokolenko, Honglin Song, Melissa Southey, Helen Steed, Dominique Stoppa-Lyonnet, Rebecca Sutphen, Anthony Swerdlow, Yen Yen Tan, Manuel Teixeira, Soo Hwang Teo, Kathryn Terry, Mary Beth Terry, Mads Thomassen, Pamela Thompson, Liv Cecilie Vestrheim Thomsen, Darcy Thull, Marc Tischkowitz, Linda Titus, Amanda Toland, Diana Torres, Britton Trabert, Ruth Travis, Nadine Tung, Shelley Tworoger, Ellen Valen, Anne van Altena, Annemieke van der Hout, Els Van Nieuwenhuysen, Elizabeth van Rensburg, Ana Vega, Digna Velez Edwards, Robert Vierkant, Frances Wang, Barbara Wappenschmidt, Penelope Webb, Clarice Weinberg, Jeffrey Weitzel, Nicolas Wentzensen, Emily White, Alice S,

Polygenic risk scores (PRS) for epithelial ovarian cancer (EOC) have the potential to improve risk stratification. Joint estimation of Single Nucleotide Polymorphism (SNP) effects in models could improve predictive performance over standard approaches of PRS construction. Here, we implemented computationally-efficient, penalized, logistic regression models (lasso, elastic net, stepwise) to individual ... Read more >>

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Pembrolizumab plus GX-188E therapeutic DNA vaccine in patients with HPV-16-positive or HPV-18-positive advanced cervical cancer: interim results of a single-arm, phase 2 trial.

Jin Won Youn, Soo-Young Hur, Jung Won Woo, Yong-Man Kim, Myong Cheol Lim, Sang Yoon Park, Sang Soo Seo, Jae Hong No, Byoung-Gie Kim, Jae-Kwan Lee, So Jin Shin, Kyungun Kim, Marya F Chaney, Yoon-Jeong Choi, You Suk Suh, Jong Sup Park, Young Chul Sung,

<h4>Background</h4>Survival outcomes for patients with recurrent or advanced cervical cancer are poor. Pembrolizumab has been approved for the treatment of recurrent or metastatic cervical cancer, with an overall response rate of 14·3%. GX-188E vaccination has been shown to induce human papillomavirus (HPV) E6-specific and E7-specific T-cell responses and cervical lesion ... Read more >>

Lancet Oncol (The Lancet. Oncology)
[2020, 21(12):1653-1660]

Cited: 3 times

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Prognostic Significance of Tumor Regression Rate during Concurrent Chemoradiotherapy in Locally Advanced Cervix Cancer: Analysis by Radiation Phase and Histologic Type.

Jun-Hyeok Kang, Won Kyung Cho, Hie Jun Yeo, Soo Young Jeong, Joseph J Noh, Jung In Shim, Yoo-Young Lee, Tae-Joong Kim, Jeong-Won Lee, Byoung-Gie Kim, Duk-Soo Bae, Won Park, Chel Hun Choi,

This study aimed to evaluate the prognostic significance of tumor regression rate according to radiation phase and histologic subtype in patients with locally advanced cervical cancer (LACC) treated with chemoradiation. We retrospectively reviewed the medical records of 398 patients with FIGO stage IIB-IVA cervical cancer treated with concurrent chemoradiotherapy (CCRT) ... Read more >>

J Clin Med (Journal of clinical medicine)
[2020, 9(11):]

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Real-World Experience of Pembrolizumab Monotherapy in Patients with Recurrent or Persistent Cervical Cancer: A Korean Multi-Center Retrospective Study (KGOG1041).

Min Chul Choi, Yong-Man Kim, Jeong-Won Lee, Yong Jae Lee, Dong Hoon Suh, Sung Jong Lee, Taek Sang Lee, Maria Lee, Dong Choon Park, Min Kyu Kim, Jong-Min Lee, Seung-Hyuk Shim, Seob Jeon, Kyung Jin Min, Mi Kyung Kim, Bo Wook Kim, Jeong Yeol Park, Byoung-Gie Kim, Dae Yeon Kim, Moon-Hong Kim, Hyun-Soo Kim, Jung-Yun Lee,

This study investigated the antitumor activity and safety of pembrolizumab in patients with recurrent cervical cancer in real-world practice. We conducted a multi-center retrospective study of patients with recurrent or persistent cervical cancer treated with pembrolizumab at sixteen institutions in Korea between January 2016 and March 2020. The primary endpoints ... Read more >>

Cancers (Basel) (Cancers)
[2020, 12(11):]

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A phase II study of neoadjuvant chemotherapy plus durvalumab and tremelimumab in advanced-stage ovarian cancer: a Korean Gynecologic Oncology Group Study (KGOG 3046), TRU-D.

Jung Yun Lee, Jae Weon Kim, Myong Cheol Lim, Sunghoon Kim, Hee Seung Kim, Chel Hun Choi, Ju Yeon Yi, Sang Yoon Park, Byoung Gie Kim, ,

<h4>Background</h4>A single-arm phase II study of neoadjuvant chemotherapy plus durvalumab and tremelimumab in the treatment of advanced-stage ovarian cancer has begun in Korea. We hypothesized that adding durvalumab (anti-programmed death-ligand 1 antibody) and tremelimumab (anti-cytotoxic T-lymphocyte-associated protein 4 antibody) to chemotherapy in treating this cancer can increase progression-free survival (PFS) ... Read more >>

J Gynecol Oncol (Journal of gynecologic oncology)
[2019, 30(6):e112]

Cited: 2 times

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Anti-Cancer Activity of As4O6 and its Efficacy in a Series of Patient-Derived Xenografts for Human Cervical Cancer.

Joseph J Noh, Myeong-Seon Kim, Young-Jae Cho, Soo-Young Jeong, Yoo-Young Lee, Ji-Yoon Ryu, Jung-Joo Choi, Illju Bae, Zhaoyan Wu, Byoung-Gie Kim, Jae Ryoung Hwang, Jeong-Won Lee,

<h4>Purpose</h4>To investigate the anti-cancer effects of tetraarsenic hexoxide (TAO, As<sub>4</sub>O<sub>6</sub>) in cervical cancer cell lines and in a series of patient-derived xenograft (PDX) mouse models.<h4>Methods</h4>Human cervical cancer cell lines, including HeLa, SiHa and CaSki, and human umbilical vein endothelial cells (HUVECs), were used to evaluate the anti-cancer activity of TAO. ... Read more >>

Pharmaceutics (Pharmaceutics)
[2020, 12(10):]

Cited: 2 times

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A multicentre, randomised, open-label, parallel-group Phase 2b study of belotecan versus topotecan for recurrent ovarian cancer.

Hee Seung Kim, Sang-Yoon Park, Chan-Yong Park, Young Tae Kim, Beob-Jong Kim, Yong Jung Song, Byoung-Gie Kim, Yong Beom Kim, Chi-Heum Cho, Jong-Hyeok Kim, Yong Sang Song,

<h4>Background</h4>This Phase 2b study compared the efficacy and toxicity of belotecan and topotecan in recurrent ovarian cancer.<h4>Methods</h4>Patients with platinum-sensitive recurrent or platinum-resistant recurrent ovarian cancer (PRROC) were randomised 1:1 to receive belotecan 0.5 mg/m<sup>2</sup> or topotecan 1.5 mg/m<sup>2</sup> for five consecutive days every 3 weeks. The primary endpoint was overall response rate ... Read more >>

Br J Cancer (British journal of cancer)
[2021, 124(2):375-382]

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Feasibility of Single-Port Access (SPA) Laparoscopy for Large Ovarian Tumor Suspected to Be Borderline Ovarian Tumor.

Jun-Hyeok Kang, Joseph J Noh, Soo Young Jeong, Jung In Shim, Yoo-Young Lee, Chel Hun Choi, Jeong-Won Lee, Byoung-Gie Kim, Duk-Soo Bae, Hyun-Soo Kim, Tae-Joong Kim,

<h4>Objectives</h4>To compare the surgical, pathological and oncological outcomes of single-port access (SPA) laparoscopy against laparotomy for large ovarian tumor (>15 cm) suspected to be a borderline ovarian tumor (BOT) on preoperative imaging.<h4>Methods</h4>A retrospective review of the patients who underwent SPA laparoscopy (SPA Group) or laparotomy (Laparotomy Group) for suspected BOT ... Read more >>

Front Oncol (Frontiers in oncology)
[2020, 10:583515]

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Efficacy of Maintenance Olaparib for Patients With Newly Diagnosed Advanced Ovarian Cancer With a BRCA Mutation: Subgroup Analysis Findings From the SOLO1 Trial.

Paul DiSilvestro, Nicoletta Colombo, Giovanni Scambia, Byoung-Gie Kim, Ana Oaknin, Michael Friedlander, Alla Lisyanskaya, Anne Floquet, Alexandra Leary, Gabe S Sonke, Charlie Gourley, Susana Banerjee, Amit Oza, Antonio González-Martín, Carol A Aghajanian, William H Bradley, Cara A Mathews, Joyce Liu, Elizabeth S Lowe, Ralph Bloomfield, Kathleen N Moore,

<h4>Purpose</h4>In SOLO1, maintenance olaparib (300 mg twice daily) significantly improved progression-free survival (PFS) for patients with newly diagnosed <i>BRCA1</i>- and/or <i>BRCA2</i>-mutated advanced ovarian cancer compared with placebo (hazard ratio [HR], 0.30; 95% CI, 0.23 to 0.41; median not reached <i>v</i> 13.8 months). We investigated PFS in SOLO1 for subgroups of ... Read more >>

J Clin Oncol (Journal of clinical oncology : official journal of the American Society of Clinical Oncology)
[2020, 38(30):3528-3537]

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Ovarian Gynandroblastoma with a Juvenile Granulosa Cell Tumor Component in a Postmenopausal Woman.

Soohyun Hwang, Byoung-Gie Kim, Sang Yong Song, Hyun-Soo Kim,

Ovarian gynandroblastoma (GAB) is an extremely rare sex cord-stromal tumor showing morphological evidence of both female (granulosa cell tumor) and male (Sertoli-Leydig cell tumor (SLCT)) components. Almost all GAB cases have been reported in children, adolescents, or women of reproductive age, and most of them typically have adult granulosa cell ... Read more >>

Diagnostics (Basel) (Diagnostics (Basel, Switzerland))
[2020, 10(8):]

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Prediction of survival outcomes in patients with epithelial ovarian cancer using machine learning methods.

E Sun Paik, Jeong Won Lee, Jeong Yeol Park, Ju Hyun Kim, Mijung Kim, Tae Joong Kim, Chel Hun Choi, Byoung Gie Kim, Duk Soo Bae, Sung Wook Seo,

<h4>Objectives</h4>The aim of this study was to develop a new prognostic classification for epithelial ovarian cancer (EOC) patients using gradient boosting (GB) and to compare the accuracy of the prognostic model with the conventional statistical method.<h4>Methods</h4>Information of EOC patients from Samsung Medical Center (training cohort, n=1,128) was analyzed to optimize ... Read more >>

J Gynecol Oncol (Journal of gynecologic oncology)
[2019, 30(4):e65]

Cited: 5 times

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Identification of Candidate Genes Associated with Susceptibility to Ovarian Clear Cell Adenocarcinoma Using cis-eQTL Analysis.

Jihye Kim, Joon-Yong Chung, Jae Ryoung Hwang, Yoo-Young Lee, Tae-Joong Kim, Jeong-Won Lee, Byoung-Gie Kim, Duk-Soo Bae, Chel Hun Choi, Stephen M Hewitt,

Ovarian clear cell adenocarcinoma (Ov-CCA) has a higher prevalence in the Japanese ancestry than other populations. The ancestral disparities in Ov-CCA prevalence suggests the presence of Ov-CCA-specific genetic alterations and may provide an opportunity to identify the novel genes associated with Ov-CCA tumorigenesis. Using 94 previously reported genes as the ... Read more >>

J Clin Med (Journal of clinical medicine)
[2020, 9(4):]

Cited: 1 time

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Comparison of Laparoscopy and Laparotomy for Para-Aortic Lymphadenectomy in Women With Presumed Stage I-II High-Risk Endometrial Cancer.

E Sun Paik, Seung Hun Baek, Jun Hyeok Kang, Soo Young Jeong, Myeong Seon Kim, Woo Young Kim, Yoo-Young Lee, Chel Hun Choi, Jeong-Won Lee, Byoung-Gie Kim, Duk-Soo Bae, Tae-Joong Kim,

<b>Objective:</b> To compare laparoscopic surgery to laparotomy for harvesting para-aortic lymph nodes in presumed stage I-II, high-risk endometrial cancer patients. <b>Methods:</b> Patients with histologically proven endometrial cancer, presumed stage I-II with high-risk tumor features who had undergone hysterectomy, bilateral salpingoophorectomy, or pelvic and para-aortic lymphadenectomy by either laparoscopy or laparotomy ... Read more >>

Front Oncol (Frontiers in oncology)
[2020, 10:451]

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Preclinical assessment of the VEGFR inhibitor axitinib as a therapeutic agent for epithelial ovarian cancer.

E Sun Paik, Tae-Hyun Kim, Young Jae Cho, Jiyoon Ryu, Jung-Joo Choi, Yoo-Young Lee, Tae-Joong Kim, Chel-Hun Choi, Woo Young Kim, Jason K Sa, Jin-Ku Lee, Byoung-Gie Kim, Duk-Soo Bae, Hee Dong Han, Hyung Jun Ahn, Jeong-Won Lee,

Axitinib, small molecule tyrosine kinase inhibitor, demonstrates anti-cancer activity for various solid tumors. We investigated anti-cancer effect of axitinib in epithelial ovarian cancer (EOC). We treated EOC cells (A2780, HeyA8, RMG1, and HeyA8-MDR) with axitinib to evaluate its effects on cell viabilty, apoptosis and migration. Western blots were performed to ... Read more >>

Sci Rep (Scientific reports)
[2020, 10(1):4904]

Cited: 1 time

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Chemoradiotherapy response prediction model by proteomic expressional profiling in patients with locally advanced cervical cancer.

Chel Hun Choi, Joon-Yong Chung, Jun Hyeok Kang, E Sun Paik, Yoo-Young Lee, Won Park, Sun-Ju Byeon, Eun Joo Chung, Byoung-Gie Kim, Stephen M Hewitt, Duk-Soo Bae,

<h4>Objective</h4>Resistance to chemo-radiation therapy is a substantial obstacle that compromises treatment of advanced cervical cancer. The objective of this study was to investigate if a proteomic panel associated with radioresistance could predict survival of patients with locally advanced cervical cancer.<h4>Methods</h4>A total of 181 frozen tissue samples were prospectively obtained from ... Read more >>

Gynecol Oncol (Gynecologic oncology)
[2020, 157(2):437-443]

Cited: 1 time

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Combination of a pulmonary recruitment maneuver and intraperitoneal bupivacaine for the reduction of postoperative shoulder pain in gynecologic laparoscopy: a randomized, controlled trial.

Minae Cho, Chul Jung Kim, Tae Soo Hahm, Yoo-Young Lee, Tae-Joong Kim, Jeong-Won Lee, Byoung-Gie Kim, Duk-Soo Bae, Chel Hun Choi,

Objective:To compare the efficacy of a pulmonary recruitment maneuver using lower airway pressure (30 cm H2O) and intraperitoneal bupivacaine, alone or in combination, for reducing shoulder pain after gynecologic laparoscopy. Methods:A prospective controlled study was performed in a teaching hospital with patients who underwent elective gynecologic laparoscopic surgery. Two hundred ... Read more >>

Obstet Gynecol Sci (Obstetrics & gynecology science)
[2020, 63(2):187-194]

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Triplet chemotherapy vs doublet chemotherapy plus bevacizumab in metastatic, recurrent, and persistent cervical cancer.

Hyun-Jin Choi, Yoo-Young Lee, Chel Hun Choi, Tae-Joong Kim, Jeong-Won Lee, Ji Hye Bae, Duk-Soo Bae, Byoung-Gie Kim,

<h4>Objective</h4>The effectiveness of paclitaxel-cisplatin-ifosfamide triplet regimen (TIP) was reported to be superior to that of paclitaxel-cisplatin doublet. However, the efficacy of paclitaxel-cisplatin-bevacizumab triplet (TPA) and TIP has not been compared. Here, we compared the efficacy and safety of TIP and TPA in patients with metastatic, recurrent, or persistent cervical cancer.<h4>Methods</h4>We ... Read more >>

Curr Probl Cancer (Current problems in cancer)
[2020, 44(5):100557]

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Optimal cutoff age for predicting prognosis associated with serous epithelial ovarian cancer: what is the best age cutoff?

Jihye Kim, Youjean Chang, Tae Joong Kim, Jeong Won Lee, Byoung Gie Kim, Duk Soo Bae, Chel Hun Choi,

<h4>Objective</h4>Elderly age is one of the poor prognostic factors in epithelial ovarian cancer (EOC), but the optimal age cut-off is not known. The present study sought to identify the ideal age cutoff that represents a negative prognostic factor in EOC, considering the geriatric assessment.<h4>Methods</h4>Hazard ratios (HRs) with p-values were calculated ... Read more >>

J Gynecol Oncol (Journal of gynecologic oncology)
[2019, 30(1):e11]

Cited: 1 time

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Interval between secondary cytoreductive surgery and adjuvant chemotherapy is not associated with survivals in patients with recurrent ovarian cancer.

Soo Young Jeong, Chel Hun Choi, Tae Joong Kim, Jeong Won Lee, Byoung-Gie Kim, Duk Soo Bae, Yoo-Young Lee,

BACKGROUND:Secondary cytoreductive surgery (SCS) is possible in selected patients with recurrent epithelial ovarian cancer (EOC). The goal of SCS is complete resection, although chemotherapy is always followed. Delayed intervals between primary debulking surgery and adjuvant chemotherapy was reported to be associated with poorer survivals, however, the role of intervals in ... Read more >>

J Ovarian Res (Journal of ovarian research)
[2019, 13(1):1]

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CDK7 is a reliable prognostic factor and novel therapeutic target in epithelial ovarian cancer.

Jihye Kim, Young-Jae Cho, Ji-Yoon Ryu, Ilseon Hwang, Hee Dong Han, Hyung Jun Ahn, Woo Young Kim, Hanbyoul Cho, Joon-Yong Chung, Stephen M Hewitt, Jae-Hoon Kim, Byoung-Gie Kim, Duk-Soo Bae, Chel Hun Choi, Jeong-Won Lee,

OBJECTIVE:Cyclin-dependent kinase 7 (CDK7) engages tumor growth by acting as a direct link between the regulation of transcription and the cell cycle. Here, we investigated the clinical significance of CDK7 expression and its potential as a therapeutic target in epithelial ovarian cancer (EOC). METHODS:CDK7 expression was examined in 436 ovarian ... Read more >>

Gynecol Oncol (Gynecologic oncology)
[2020, 156(1):211-221]

Cited: 3 times

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