Full Text Journal Articles by
Author Bryan E Welm

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ETV4 Is Necessary for Estrogen Signaling and Growth in Endometrial Cancer Cells.

Adriana C Rodriguez, Jeffery M Vahrenkamp, Kristofer C Berrett, Kathleen A Clark, Katrin P Guillen, Sandra D Scherer, Chieh-Hsiang Yang, Bryan E Welm, Margit M Janát-Amsbury, Barbara J Graves, Jason Gertz,

Estrogen signaling through estrogen receptor alpha (ER) plays a major role in endometrial cancer risk and progression, however, the molecular mechanisms underlying ER's regulatory role in endometrial cancer are poorly understood. In breast cancer cells, ER genomic binding is enabled by FOXA1 and GATA3, but the transcription factors that control ... Read more >>

Cancer Res. (Cancer research)
[2020, 80(6):1234-1245]

Cited: 0 times

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Publisher Correction: Protective autophagy elicited by RAF→MEK→ERK inhibition suggests a treatment strategy for RAS-driven cancers.

Conan G Kinsey, Soledad A Camolotto, Amelie M Boespflug, Katrin P Guillen, Mona Foth, Amanda Truong, Sophia S Schuman, Jill E Shea, Michael T Seipp, Jeffrey T Yap, Lance D Burrell, David H Lum, Jonathan R Whisenant, G Weldon Gilcrease, Courtney C Cavalieri, Kaitrin M Rehbein, Stephanie L Cutler, Kajsa E Affolter, Alana L Welm, Bryan E Welm, Courtney L Scaife, Eric L Snyder, Martin McMahon,

In the version of this article initially published, the label over the bottom schematic in Fig. 1a was "pH > 5.0"; it should have been "pH < 5.0". Further, the original article misspelt the surname of Katrin P. Guillen as "Gullien". These errors have been corrected in the print, PDF ... Read more >>

Nat. Med. (Nature medicine)
[2019, 25(5):861]

Cited: 1 time

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Protective autophagy elicited by RAF→MEK→ERK inhibition suggests a treatment strategy for RAS-driven cancers.

Conan G Kinsey, Soledad A Camolotto, Amelie M Boespflug, Katrin P Guillen, Mona Foth, Amanda Truong, Sophia S Schuman, Jill E Shea, Michael T Seipp, Jeffrey T Yap, Lance D Burrell, David H Lum, Jonathan R Whisenant, G Weldon Gilcrease, Courtney C Cavalieri, Kaitrin M Rehbein, Stephanie L Cutler, Kajsa E Affolter, Alana L Welm, Bryan E Welm, Courtney L Scaife, Eric L Snyder, Martin McMahon,

Pancreatic ductal adenocarcinoma (PDA) was responsible for ~ 44,000 deaths in the United States in 2018 and is the epitome of a recalcitrant cancer driven by a pharmacologically intractable oncoprotein, KRAS1-4. Downstream of KRAS, the RAF→MEK→ERK signaling pathway plays a central role in pancreatic carcinogenesis5. However, paradoxically, inhibition of this pathway ... Read more >>

Nat. Med. (Nature medicine)
[2019, 25(4):620-627]

Cited: 17 times

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A Cancer-Selective Zinc Ionophore Inspired by the Natural Product Naamidine A.

Rachel M Vaden, Katrin P Guillen, Justin M Salvant, Celine B Santiago, Joseph B Gibbons, Satya S Pathi, Sasi Arunachalam, Matthew S Sigman, Ryan E Looper, Bryan E Welm,

We present data demonstrating the natural product mimic, zinaamidole A (ZNA), is a modulator of metal ion homeostasis causing cancer-selective cell death by specifically inducing cellular Zn2+-uptake in transformed cells. ZNA's cancer selectivity was evaluated using metastatic, patient-derived breast cancer cells, established human breast cancer cell lines, and three-dimensional organoid ... Read more >>

ACS Chem. Biol. (ACS chemical biology)
[2019, 14(1):106-117]

Cited: 0 times

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Reparameterization of PAM50 Expression Identifies Novel Breast Tumor Dimensions and Leads to Discovery of a Genome-Wide Significant Breast Cancer Locus at 12q15.

Michael J Madsen, Stacey Knight, Carol Sweeney, Rachel Factor, Mohamed Salama, Inge J Stijleman, Venkatesh Rajamanickam, Bryan E Welm, Sasi Arunachalam, Brandt Jones, Rakesh Rachamadugu, Kerry Rowe, Melissa H Cessna, Alun Thomas, Lawrence H Kushi, Bette J Caan, Philip S Bernard, Nicola J Camp,

Background: Breast tumor subtyping has failed to provide impact in susceptibility genetics. The PAM50 assay categorizes breast tumors into: Luminal A, Luminal B, HER2-enriched and Basal-like. However, tumors are often more complex than simple categorization can describe. The identification of heritable tumor characteristics has potential to decrease heterogeneity and increase ... Read more >>

Cancer Epidemiol. Biomarkers Prev. (Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology)
[2018, 27(6):644-652]

Cited: 0 times

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Clinical and Genomic Crosstalk between Glucocorticoid Receptor and Estrogen Receptor α In Endometrial Cancer.

Jeffery M Vahrenkamp, Chieh-Hsiang Yang, Adriana C Rodriguez, Aliyah Almomen, Kristofer C Berrett, Alexis N Trujillo, Katrin P Guillen, Bryan E Welm, Elke A Jarboe, Margit M Janat-Amsbury, Jason Gertz,

Steroid hormone receptors are simultaneously active in many tissues and are capable of altering each other's function. Estrogen receptor α (ER) and glucocorticoid receptor (GR) are expressed in the uterus, and their ligands have opposing effects on uterine growth. In endometrial tumors with high ER expression, we surprisingly found that ... Read more >>

Cell Rep (Cell reports)
[2018, 22(11):2995-3005]

Cited: 8 times

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Synthesis of Naamidine A and Selective Access to N(2)-Acyl-2-aminoimidazole Analogues.

Joseph B Gibbons, Justin M Salvant, Rachel M Vaden, Ki-Hyeok Kwon, Bryan E Welm, Ryan E Looper,

A short and scalable synthesis of naamidine A, a marine alkaloid with a selective ability to inhibit epidermal growth factor receptor (EGFR)-dependent cellular proliferation, has been achieved. A key achievement in this synthesis was the development of a regioselective hydroamination of a monoprotected propargylguanidine to deliver N(3)-protected cyclic ene-guanidines. This ... Read more >>

J. Org. Chem. (The Journal of organic chemistry)
[2015, 80(20):10076-10085]

Cited: 5 times

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Transformation of enriched mammary cell populations with polyomavirus middle T antigen influences tumor subtype and metastatic potential.

Daria Drobysheva, Brittni Alise Smith, Maria McDowell, Katrin P Guillen, Huseyin Atakan Ekiz, Bryan E Welm,

Breast cancer exhibits significant molecular, histological, and pathological diversity. Factors that impact this heterogeneity are poorly understood; however, transformation of distinct normal cell populations of the breast may generate different tumor phenotypes. Our previous study demonstrated that the polyomavirus middle T antigen (PyMT) oncogene can establish diverse tumor subtypes when ... Read more >>

Breast Cancer Res. (Breast Cancer Research : BCR)
[2015, 17(1):132]

Cited: 2 times

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Dioxin exposure blocks lactation through a direct effect on mammary epithelial cells mediated by the aryl hydrocarbon receptor repressor.

Kaitlin J Basham, Christopher J Leonard, Collin Kieffer, Dawne N Shelton, Maria E McDowell, Vasudev R Bhonde, Ryan E Looper, Bryan E Welm,

In mammals, lactation is a rich source of nutrients and antibodies for newborn animals. However, millions of mothers each year experience an inability to breastfeed. Exposure to several environmental toxicants, including 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), has been strongly implicated in impaired mammary differentiation and lactation. TCDD and related polyhalogenated aromatic hydrocarbons are ... Read more >>

Toxicol. Sci. (Toxicological sciences : an official journal of the Society of Toxicology)
[2015, 143(1):36-45]

Cited: 7 times

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The small molecule C-6 is selectively cytotoxic against breast cancer cells and its biological action is characterized by mitochondrial defects and endoplasmic reticulum stress.

Rachel M Vaden, Keith M Gligorich, Ranjan Jana, Matthew S Sigman, Bryan E Welm,

The establishment of drug resistance following treatment with chemotherapeutics is strongly associated with poor clinical outcome in patients, and drugs that target chemoresistant tumors have the potential to increase patient survival. In an effort to identify biological pathways of chemoresistant breast cancers that can be targeted therapeutically, a small molecule ... Read more >>

Breast Cancer Res. (Breast cancer research : BCR)
[2014, 16(6):472]

Cited: 2 times

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Bis-aryloxadiazoles as effective activators of the aryl hydrocarbon receptor.

Kaitlin J Basham, Vasudev R Bhonde, Collin Kieffer, James B C Mack, Matthew Hess, Bryan E Welm, Ryan E Looper,

Bis-aryloxadiazoles are common scaffolds in medicinal chemistry due to their wide range of biological activities. Previously, we identified a 1,2,4-bis-aryloxadiazole that blocks mammary branching morphogenesis through activation of the aryl hydrocarbon receptor (AHR). In addition to defects in mammary differentiation, AHR stimulation induces toxicity in many other tissues. We performed ... Read more >>

Bioorg. Med. Chem. Lett. (Bioorganic & medicinal chemistry letters)
[2014, 24(11):2473-2476]

Cited: 3 times

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Development of a screen to identify selective small molecules active against patient-derived metastatic and chemoresistant breast cancer cells.

Keith M Gligorich, Rachel M Vaden, Dawne N Shelton, Guoying Wang, Cindy B Matsen, Ryan E Looper, Matthew S Sigman, Bryan E Welm,

High failure rates of new investigational drugs have impaired the development of breast cancer therapies. One challenge is that excellent activity in preclinical models, such as established cancer cell lines, does not always translate into improved clinical outcomes for patients. New preclinical models, which better replicate clinically-relevant attributes of cancer, ... Read more >>

Breast Cancer Res. (Breast cancer research : BCR)
[2013, 15(4):R58]

Cited: 8 times

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Synthesis of the reported structures for kealiinines B and C.

Joseph B Gibbons, Keith M Gligorich, Bryan E Welm, Ryan E Looper,

Syntheses of the reported structures of kealiinines B and C have been executed. An intermolecular electrophile-induced cyclization of a pendant arene on an ene-guanidine affords the tetracyclic, oxidized naphthimidazole cores. ... Read more >>

Org. Lett. (Organic letters)
[2012, 14(18):4734-4737]

Cited: 16 times

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Overview of human primary tumorgraft models: comparisons with traditional oncology preclinical models and the clinical relevance and utility of primary tumorgrafts in basic and translational oncology research.

David H Lum, Cindy Matsen, Alana L Welm, Bryan E Welm,

Laboratory models that accurately replicate human tumor initiation and characteristics are integral to advancing knowledge in cancer research. However, comparative studies between commonly employed laboratory models and human tumors have demonstrated that some models have molecular and genomic alterations dissimilar to the cancer type they attempt to replicate. In contrast, ... Read more >>

Curr Protoc Pharmacol (Current protocols in pharmacology)
[2012, Chapter 14:Unit 14.22]

Cited: 9 times

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Chemical genetic screen reveals a role for desmosomal adhesion in mammary branching morphogenesis.

Kaitlin J Basham, Collin Kieffer, Dawne N Shelton, Christopher J Leonard, Vasudev R Bhonde, Hariprasad Vankayalapati, Brett Milash, David J Bearss, Ryan E Looper, Bryan E Welm,

During the process of branching morphogenesis, the mammary gland undergoes distinct phases of remodeling to form an elaborate ductal network that ultimately produces and delivers milk to newborn animals. These developmental events rely on tight regulation of critical cellular pathways, many of which are probably disrupted during initiation and progression ... Read more >>

J. Biol. Chem. (The Journal of biological chemistry)
[2013, 288(4):2261-2270]

Cited: 11 times

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On the shoulders of giants: a historical perspective of unique experimental methods in mammary gland research.

Brittni A Smith, Alana L Welm, Bryan E Welm,

While most organs undergo development in utero, the mouse mammary gland orchestrates five major developmental stages following birth: pre-puberty, puberty, pregnancy, lactation, and involution. Induced by both local and systemic factors, these five developmental stages transpire with dramatic alterations in glandular morphology and cellular function. As an experimental system, the ... Read more >>

Semin. Cell Dev. Biol. (Seminars in cell & developmental biology)
[2012, 23(5):583-590]

Cited: 2 times

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Synthesis and Preliminary Biological Study of Bisindolylmethanes Accessed by an Acid-Catalyzed Hydroarylation of Vinylindoles.

Tejas P Pathak, Jaroslaw G Osiak, Rachel M Vaden, Bryan E Welm, Matthew S Sigman,

An acid-catalyzed hydroarylation reaction of vinyl indoles is reported, which tolerates a wide range of heterocycles as the exogenous nucleophile such as indoles, pyrroles, and indolizines. The method rapidly accesses the biologically relevant bisindolylmethane scaffold in good to excellent yields. Evaluation of the biological activity of several synthesized analogues reveals ... Read more >>

Tetrahedron (Tetrahedron)
[2012, 68(26):5203-5208]

Cited: 5 times

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Tumor grafts derived from women with breast cancer authentically reflect tumor pathology, growth, metastasis and disease outcomes.

Yoko S DeRose, Guoying Wang, Yi-Chun Lin, Philip S Bernard, Saundra S Buys, Mark T W Ebbert, Rachel Factor, Cindy Matsen, Brett A Milash, Edward Nelson, Leigh Neumayer, R Lor Randall, Inge J Stijleman, Bryan E Welm, Alana L Welm,

Development and preclinical testing of new cancer therapies is limited by the scarcity of in vivo models that authentically reproduce tumor growth and metastatic progression. We report new models for breast tumor growth and metastasis in the form of transplantable tumors derived directly from individuals undergoing treatment for breast cancer. ... Read more >>

Nat. Med. (Nature medicine)
[2011, 17(11):1514-1520]

Cited: 386 times

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A pharmacogenomic method for individualized prediction of drug sensitivity.

Adam L Cohen, Raffaella Soldi, Haiyu Zhang, Adam M Gustafson, Ryan Wilcox, Bryan E Welm, Jeffrey T Chang, Evan Johnson, Avrum Spira, Stefanie S Jeffrey, Andrea H Bild,

Identifying the best drug for each cancer patient requires an efficient individualized strategy. We present MATCH (Merging genomic and pharmacologic Analyses for Therapy CHoice), an approach using public genomic resources and drug testing of fresh tumor samples to link drugs to patients. Valproic acid (VPA) is highlighted as a proof-of-principle. ... Read more >>

Mol. Syst. Biol. (Molecular systems biology)
[2011, 7:513]

Cited: 24 times

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In situ analysis of cell populations: long-term label-retaining cells.

Rodrigo Fernandez-Gonzalez, Irineu Illa-Bochaca, Dawne N Shelton, Bryan E Welm, Mary Helen Barcellos-Hoff, Carlos Ortiz-de-Solorzano,

The mammary gland consists of an epithelial ductal tree embedded in a fat pad. Adult mammary epithelium has been demonstrated to have outstanding regenerative potential, consistent with the presence of resident, adult stem cells. However, there are currently no bona fide markers to identify these cells within their tissue context. ... Read more >>

Methods Mol. Biol. (Methods in molecular biology (Clifton, N.J.))
[2010, 621:1-28]

Cited: 4 times

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Limiting-dilution transplantation assays in mammary stem cell studies.

Irineu Illa-Bochaca, Rodrigo Fernandez-Gonzalez, Dawne N Shelton, Bryan E Welm, Carlos Ortiz-de-Solorzano, Mary Helen Barcellos-Hoff,

Mammary reconstitution assays can be used to measure the stem cell frequency within an epithelial population by transplanting increasingly diluted single-cell preparations of the population of interest. There are fundamental steps in the single-cell isolation protocol which are directly related to the number of single epithelial cells obtained. Once single-cell ... Read more >>

Methods Mol. Biol. (Methods in molecular biology (Clifton, N.J.))
[2010, 621:29-47]

Cited: 9 times

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Mapping mammary gland architecture using multi-scale in situ analysis.

Rodrigo Fernandez-Gonzalez, Irineu Illa-Bochaca, Bryan E Welm, Markus C Fleisch, Zena Werb, Carlos Ortiz-de-Solorzano, Mary Helen Barcellos-Hoff,

We have built a novel computational microscopy platform that integrates image acquisition, storage, processing and analysis to study cell populations in situ. This platform allows high-content studies where multiple features are measured and linked at multiple scales. We used this approach to study the cellular composition and architecture of the ... Read more >>

Integr Biol (Camb) (Integrative biology : quantitative biosciences from nano to macro)
[2009, 1(1):80-89]

Cited: 14 times

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Use of stem cell markers in dissociated mammary populations.

Dawne N Shelton, Rodrigo Fernandez-Gonzalez, Irineu Illa-Bochaca, Carlos Ortiz-de-Solorzano, Mary Helen Barcellos-Hoff, Bryan E Welm,

The regenerative potential of mammary epithelium facilitates assessment of the "stemness" of any epithelial subpopulation in transplantation assays. Thus, mammary tissue can be dissociated into single cells, stained for cell surface markers of interest and classified using fluorescence-activated cell sorting. The selected cells can then be transplanted into epithelium-devoided fat ... Read more >>

Methods Mol. Biol. (Methods in molecular biology (Clifton, N.J.))
[2010, 621:49-55]

Cited: 6 times

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Synthesis and preliminary biological studies of 3-substituted indoles accessed by a palladium-catalyzed enantioselective alkene difunctionalization reaction.

Tejas P Pathak, Keith M Gligorich, Bryan E Welm, Matthew S Sigman,

A unique alkene difunctionalization reaction that allows rapid construction of molecular complexity around the biologically relevant indole framework has been developed. The reaction proceeds with up to 87% yield, 99:1 er, and >20:1 dr. Evaluation of several of the compounds revealed promising anticancer activity against MCF-7 cells. ... Read more >>

J. Am. Chem. Soc. (Journal of the American Chemical Society)
[2010, 132(23):7870-7871]

Cited: 71 times

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Visualizing stromal cell dynamics in different tumor microenvironments by spinning disk confocal microscopy.

Mikala Egeblad, Andrew J Ewald, Hanne A Askautrud, Morgan L Truitt, Bryan E Welm, Emma Bainbridge, George Peeters, Matthew F Krummel, Zena Werb,

The tumor microenvironment consists of stromal cells and extracellular factors that evolve in parallel with carcinoma cells. To gain insights into the activities of stromal cell populations, we developed and applied multicolor imaging techniques to analyze the behavior of these cells within different tumor microenvironments in the same live mouse. ... Read more >>

Dis Model Mech (Disease models & mechanisms)
[2008, 1(2-3):155-67; discussion 165]

Cited: 98 times

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