Full Text Journal Articles by
Author Bryan E Shepherd

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Multiple Imputation Variance Estimation in Studies with Missing or Misclassified Inclusion Criteria.

Mark J Giganti, Bryan E Shepherd,

In observational studies using routinely collected data, a variable with a high level of missingness or misclassification may determine whether an observation is included in the analysis. In settings where inclusion criteria are assessed after imputation, the popular multiple imputation variance estimator proposed by Rubin ("Rubin's rules" (RR)) is biased ... Read more >>

Am. J. Epidemiol. (American journal of epidemiology)
[2020, :]

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The Population Impact of Late Presentation With Advanced HIV Disease and Delayed Antiretroviral Therapy in Adults Receiving HIV Care in Latin America.

Pablo F Belaunzarán-Zamudio, Yanink N Caro-Vega, Bryan E Shepherd, Peter F Rebeiro, Brenda E Crabtree-Ramírez, Claudia P Cortes, Beatriz Grinsztejn, Eduardo Gotuzzo, Fernando Mejia, Denis Padgett, Jean W Pape, Vanessa Rouzier, Valdilea Veloso, Sandra Wagner Cardoso, Catherine C McGowan, Juan G Sierra-Madero, ,

Late presentation to care and antiretroviral therapy (ART) initiation with advanced human immunodeficiency virus (HIV) disease are common in Latin America. We estimated the impact of these conditions on mortality in the region. We included adults enrolled during 2001-2014 at HIV care clinics. We estimated the adjusted attributable risk (AR) ... Read more >>

Am. J. Epidemiol. (American journal of epidemiology)
[2020, 189(6):564-572]

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Frequency of non-communicable diseases in people 50 years of age and older receiving HIV care in Latin America.

Pablo F Belaunzaran-Zamudio, Yanink Caro-Vega, Mark J Giganti, Jessica L Castilho, Brenda E Crabtree-Ramirez, Bryan E Shepherd, Fernando Mejía, Carina Cesar, Rodrigo C Moreira, Marcelo Wolff, Jean W Pape, Denis Padgett, Catherine C McGowan, Juan G Sierra-Madero, ,

BACKGROUND:A growing population of older adults with HIV will increase demands on HIV-related healthcare. Nearly a quarter of people receiving care for HIV in Latin America are currently 50 years or older, yet little is known about the frequency of comorbidities in this population. We estimated the prevalence and incidence ... Read more >>

PLoS ONE (PloS one)
[2020, 15(6):e0233965]

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Increased Mortality After Tuberculosis Treatment Completion in Persons Living With Human Immunodeficiency Virus in Latin America.

Serena P Koenig, Ahra Kim, Bryan E Shepherd, Carina Cesar, Valdilea Veloso, Claudia P Cortes, Denis Padgett, Brenda Crabtree-Ramírez, Eduardo Gotuzzo, Catherine C McGowan, Timothy R Sterling, Jean W Pape,

We assessed the association between cured tuberculosis (TB) and mortality among persons living with human immunodeficiency virus (HIV) in Latin America. We compared survival among persons with and without TB at enrollment in HIV care, starting 9 months after clinic enrollment. In multivariable analysis, TB was associated with higher long-term ... Read more >>

Clin. Infect. Dis. (Clinical infectious diseases : an official publication of the Infectious Diseases Society of America)
[2020, 71(1):215-217]

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Mood Disorders and Increased Risk of Noncommunicable Disease in Adults With HIV.

Jessica L Castilho, Peter F Rebeiro, Bryan E Shepherd, Robertson Nash, Rodney S Adams, Megan Turner, Sally S Furukawa, Todd Hulgan, John R Koethe, Timothy R Sterling,

BACKGROUND:People living with HIV (PLWH) experience high rates of mood disorders (major depression and bipolar affective disorder) which in the general population have been associated with noncommunicable disease (NCD) risk. We examined whether prevalent mood disorders are associated with incident NCDs and multimorbidity (accumulation of ≥2 NCDs) in PLWH. SETTING:Adult ... Read more >>

J. Acquir. Immune Defic. Syndr. (Journal of acquired immune deficiency syndromes (1999))
[2020, 83(4):397-404]

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Self-reported Cannabis Use and Changes in Body Mass Index, CD4 T-Cell Counts, and HIV-1 RNA Suppression in Treated Persons with HIV.

James T Lee, Lauren A Saag, Aaron M Kipp, James Logan, Bryan E Shepherd, John R Koethe, Megan Turner, Sally Bebawy, Timothy R Sterling, Todd Hulgan,

Cannabis use is prevalent among HIV-positive persons, but evidence regarding the impact of cannabis in HIV-positive persons is limited. We conducted a retrospective cohort study of HIV-positive adults initiating their first antiretroviral therapy (ART) regimen. A dedicated intake form assessed self-reported cannabis use in the preceding 7 days at each visit. ... Read more >>

AIDS Behav (AIDS and behavior)
[2020, 24(4):1275-1280]

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Discussion on "Assessing the goodness of fit of logistic regression models in large samples: A modification of the Hosmer-Lemeshow test" by Giovanni Nattino, Michael L. Pennell, and Stanley Lemeshow.

Dandan Liu, Bryan E Shepherd,

Biometrics (Biometrics)
[2020, 76(2):572-574]

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The impact of data quality and source data verification on epidemiologic inference: a practical application using HIV observational data.

Mark J Giganti, Bryan E Shepherd, Yanink Caro-Vega, Paula M Luz, Peter F Rebeiro, Marcelle Maia, Gaetane Julmiste, Claudia Cortes, Catherine C McGowan, Stephany N Duda,

BACKGROUND:Data audits are often evaluated soon after completion, even though the identification of systematic issues may lead to additional data quality improvements in the future. In this study, we assess the impact of the entire data audit process on subsequent statistical analyses. METHODS:We conducted on-site audits of datasets from nine ... Read more >>

BMC Public Health (BMC public health)
[2019, 19(1):1748]

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Directly observed therapy and risk of unfavourable tuberculosis treatment outcomes among an international cohort of people living with HIV in low- and middle-income countries.

April C Pettit, Cathy A Jenkins, Meridith Blevins Peratikos, Marcel Yotebieng, Lameck Diero, Cuong D Do, Jeremy Ross, Valdilea G Veloso, Denise Hawerlander, Olivier Marcy, Bryan E Shepherd, Lukas Fenner, Timothy R Sterling, ,

INTRODUCTION:Identification of persons living with human immunodeficiency virus (HIV)-associated tuberculosis (TB) at increased risk for unfavourable TB outcomes would inform efforts to improve such outcomes. We sought to identify factors associated with a decreased risk of unfavourable TB treatment outcomes among people living with HIV-infection (PLHIV) in low- and middle-income ... Read more >>

J Int AIDS Soc (Journal of the International AIDS Society)
[2019, 22(12):e25423]

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Self-audits as alternatives to travel-audits for improving data quality in the Caribbean, Central and South America network for HIV epidemiology.

Sarah C Lotspeich, Mark J Giganti, Marcelle Maia, Renalice Vieira, Daisy Maria Machado, Regina Célia Succi, Sayonara Ribeiro, Mario Sergio Pereira, Maria Fernanda Rodriguez, Gaetane Julmiste, Marco Tulio Luque, Yanink Caro-Vega, Fernando Mejia, Bryan E Shepherd, Catherine C McGowan, Stephany N Duda,

Introduction:Audits play a critical role in maintaining the integrity of observational cohort data. While previous work has validated the audit process, sending trained auditors to sites ("travel-audits") can be costly. We investigate the efficacy of training sites to conduct "self-audits." Methods:In 2017, eight research groups in the Caribbean, Central, and ... Read more >>

J Clin Transl Sci (Journal of clinical and translational science)
[2020, 4(2):125-132]

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Temporal changes in ART initiation in adults with high CD4 counts in Latin America: a cohort study.

Brenda E Crabtree-Ramírez, Yanink Caro-Vega, Pablo F Belaunzarán-Zamudio, Bryan E Shepherd, Peter F Rebeiro, Valdilea Veloso, Claudia P Cortes, Denis Padgett, Eduardo Gotuzzo, Juan Sierra-Madero, Catherine C McGowan, Anna K Person, ,

INTRODUCTION:In 2013, the World Health Organization (WHO) recommended initiating combination ART (cART) in all adults with HIV and CD4+ lymphocyte counts (CD4) <500 cells/mm3 . In 2015, this was updated to recommend cART initiation in all patients with HIV, regardless of CD4 count. Implementation of these guidelines in real-world settings has ... Read more >>

J Int AIDS Soc (Journal of the International AIDS Society)
[2019, 22(12):e25413]

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An empirical comparison of two novel transformation models.

Yuqi Tian, Torsten Hothorn, Chun Li, Frank E Harrell, Bryan E Shepherd,

Continuous response variables are often transformed to meet modeling assumptions, but the choice of the transformation can be challenging. Two transformation models have recently been proposed: semiparametric cumulative probability models (CPMs) and parametric most likely transformation models (MLTs). Both approaches model the cumulative distribution function and require specifying a link ... Read more >>

Stat Med (Statistics in medicine)
[2020, 39(5):562-576]

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Clinic-Level Factors Associated with Retention in Care among People Living with HIV in a Multi-Site United States Cohort, 2010-2016.

Cassandra D Oliver, Peter F Rebeiro, Bryan E Shepherd, Jeanne Keruly, Kenneth H Mayer, W Christopher Mathews, Bulent Turan, Richard D Moore, Heidi M Crane, Elvin Geng, Sonia Napravnik, Mari M Kitahata, Michael J Mugavero, April C Pettit, ,

BACKGROUND:Retention in care (RIC) leads to reduced HIV transmission and mortality. Few studies have investigated the availability of clinic services and RIC among people living with HIV (PLWH) in the United States (US). We conducted a multi-site retrospective cohort study to identify clinic services associated with RIC from 2010-2016 in ... Read more >>

Clin. Infect. Dis. (Clinical infectious diseases : an official publication of the Infectious Diseases Society of America)
[2019, :]

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CD4/CD8 Ratio and CD4 Nadir Predict Mortality Following Noncommunicable Disease Diagnosis in Adults Living with HIV.

Jessica L Castilho, Megan Turner, Bryan E Shepherd, John R Koethe, Sally S Furukawa, Carmen E Bofill, Stephen Raffanti, Timothy R Sterling,

Incidence of noncommunicable diseases (NCDs), including cardiovascular disease (CVD), cirrhosis, and non-AIDS-defining cancers (NADCs), have been associated with HIV viremia, CD4 cell counts, and CD4/CD8 ratio in persons living with HIV (PLWH). This study examined the importance of these markers to mortality risk following NCD diagnosis. We examined factors associated ... Read more >>

AIDS Res. Hum. Retroviruses (AIDS research and human retroviruses)
[2019, 35(10):960-967]

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Diagnosis and clinical outcomes of extrapulmonary tuberculosis in antiretroviral therapy programmes in low- and middle-income countries: a multicohort study.

Kathrin Zürcher, Marie Ballif, Sasisopin Kiertiburanakul, Henri Chenal, Marcel Yotebieng, Beatriz Grinsztejn, Denna Michael, Timothy R Sterling, Kapella M Ngonyani, Anna M Mandalakas, Matthias Egger, April C Pettit, Lukas Fenner, ,

INTRODUCTION:Extrapulmonary tuberculosis (EPTB) is difficult to confirm bacteriologically and requires specific diagnostic capacities. Diagnosis can be especially challenging in under-resourced settings. We studied diagnostic modalities and clinical outcomes of EPTB compared to pulmonary tuberculosis (PTB) among HIV-positive adults in antiretroviral therapy (ART) programmes in low- and middle-income countries (LMIC). METHODS:We ... Read more >>

J Int AIDS Soc (Journal of the International AIDS Society)
[2019, 22(9):e25392]

Cited: 3 times

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Trends and Disparities in Mortality and Progression to AIDS in the Highly Active Antiretroviral Therapy Era: Tennessee, 1996-2016.

Peter F Rebeiro, April C Pettit, Lindsey Sizemore, Samantha A Mathieson, Carolyn Wester, Aaron Kipp, Bryan E Shepherd, Timothy R Sterling,

Objectives. To use statewide surveillance data to examine trends and disparities in mortality and progression from HIV to AIDS comprehensively in Tennessee over the past 20 years.Methods. Individuals diagnosed with HIV in Tennessee from 1996 to 2016 were identified through the Tennessee Department of Health Enhanced HIV/AIDS Reporting System. Clinical ... Read more >>

Am J Public Health (American journal of public health)
[2019, 109(9):1266-1272]

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Optimal management of HIV- positive adults at risk for kidney disease in Nigeria (Renal Risk Reduction "R3" Trial): protocol and study design.

Muktar H Aliyu, Usman J Wudil, Donna J Ingles, Bryan E Shepherd, Wu Gong, Baba M Musa, Hamza Muhammad, Mahmoud U Sani, Aliyu Abdu, Aisha M Nalado, Akinfenwa Atanda, Aima A Ahonkhai, Talat A Ikizler, Cheryl A Winkler, Jeffrey B Kopp, Paul L Kimmel, C William Wester,

BACKGROUND:Individuals with two copies of the apolipoprotein-1 (APOL1) gene risk variants are at high risk (HR) for non-diabetic kidney disease. The presence of these risk variants is highest in West Africa, specifically in Nigeria. However, there is limited availability of dialysis and kidney transplantation in Nigeria, and most individuals will ... Read more >>

Trials (Trials)
[2019, 20(1):341]

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Treatment of drug-susceptible tuberculosis among people living with human immunodeficiency virus infection: an update.

April C Pettit, Bryan E Shepherd, Timothy R Sterling,

PURPOSE OF REVIEW:The present review describes recent advances in the treatment of drug-susceptible tuberculosis (DS-TB) among people living with human immunodeficiency virus (PLWH). RECENT FINDINGS:Higher than standard rifampicin doses (>10 mg/kg/day) are well tolerated and have improved sterilizing activity. Standard pyrazinamide doses may result in low drug exposures; modeling reveals that ... Read more >>

Curr Opin HIV AIDS (Current opinion in HIV and AIDS)
[2018, 13(6):469-477]

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Early Retention in Care Neither Mediates Nor Modifies the Effect of Sex and Sexual Mode of HIV Acquisition on HIV Survival in the Americas.

Lara Coelho, Peter F Rebeiro, Jessica L Castilho, Yanink Caro-Vega, Fernando A Mejia, Carina Cesar, Claudia P Cortes, Denis Padgett, Catherine C McGowan, Valdiléa G Veloso, Timothy R Sterling, Beatriz Grinsztejn, Bryan E Shepherd, Paula M Luz,

Early retention in care, sex, and sexual mode of HIV acquisition has been associated with mortality risk among persons living with HIV (PLWH). We assessed whether early retention in care mediates or modifies the association between mortality and sex and sexual mode of HIV acquisition among PLWH on antiretroviral therapy ... Read more >>

AIDS Patient Care STDS (AIDS patient care and STDs)
[2018, 32(8):306-313]

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Brief Report: Circulating Markers of Immunologic Activity Reflect Adiposity in Persons With HIV on Antiretroviral Therapy.

John R Koethe, Cathy A Jenkins, Briana D Furch, Jordan E Lake, Louise Barnett, Cindy C Hager, Rita Smith, Todd Hulgan, Bryan E Shepherd, Spyros A Kalams,

BACKGROUND:Obesity alters adipose tissue immunology, and these changes may be reflected in circulating soluble inflammatory biomarker and T-cell subset profiles measured in HIV research studies. METHODS:We recruited 70 adults with HIV (50% obese) on efavirenz, tenofovir, and emtricitabine, virologic suppression for >2 years, and no rheumatologic or other known inflammatory ... Read more >>

J. Acquir. Immune Defic. Syndr. (Journal of acquired immune deficiency syndromes (1999))
[2018, 79(1):135-140]

Cited: 2 times

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Survival after cancer diagnosis in a cohort of HIV-positive individuals in Latin America.

Valeria I Fink, Cathy A Jenkins, Jessica L Castilho, Anna K Person, Bryan E Shepherd, Beatriz Grinsztejn, Juliana Netto, Brenda Crabtree-Ramirez, Claudia P Cortés, Denis Padgett, Karu Jayathilake, Catherine McGowan, Pedro Cahn, ,

Background:This study aimed to evaluate trends and predictors of survival after cancer diagnosis in persons living with HIV in the Caribbean, Central, and South America network for HIV epidemiology cohort. Methods:Demographic, cancer, and HIV-related data from HIV-positive adults diagnosed with cancer ≤ 1 year before or any time after HIV ... Read more >>

Infect. Agents Cancer (Infectious agents and cancer)
[2018, 13:16]

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Lower Concentrations of Circulating Medium and Long-Chain Acylcarnitines Characterize Insulin Resistance in Persons with HIV.

Samuel S Bailin, Cathy A Jenkins, Christopher Petucci, Jeffrey A Culver, Bryan E Shepherd, Joshua P Fessel, Todd Hulgan, John R Koethe,

In human immunodeficiency virus (HIV)-negative individuals, a plasma metabolite profile, characterized by higher levels of branched-chain amino acids (BCAA), aromatic amino acids, and C3/C5 acylcarnitines, is associated with insulin resistance and increased risk of diabetes. We sought to characterize the metabolite profile accompanying insulin resistance in HIV-positive persons to assess ... Read more >>

AIDS Res. Hum. Retroviruses (AIDS research and human retroviruses)
[2018, 34(6):536-543]

Cited: 2 times

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Partners-based HIV treatment for seroconcordant couples attending antenatal and postnatal care in rural Mozambique: A cluster randomized trial protocol.

Carolyn M Audet, Erin Graves, Ezequiel Barreto, Caroline De Schacht, Wu Gong, Bryan E Shepherd, Arifo Aboobacar, Lazaro Gonzalez-Calvo, Maria Fernanda Alvim, Muktar H Aliyu, Aaron M Kipp, Heather Jordan, K Rivet Amico, Matthew Diemer, Andrea Ciaranello, Caitlin Dugdale, Sten H Vermund, Sara Van Rompaey,

BACKGROUND:In resource-limited rural settings, scale-up of services to eliminate mother-to-child transmission of HIV has not been as effective as in better resourced urban settings. In sub-Saharan Africa, women often require male partner approval to access and remain engaged in HIV care. Our study will evaluate a promising male engagement intervention ... Read more >>

Contemp Clin Trials (Contemporary clinical trials)
[2018, 71:63-69]

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Multi-Donor Longitudinal Antibody Repertoire Sequencing Reveals the Existence of Public Antibody Clonotypes in HIV-1 Infection.

Ian Setliff, Wyatt J McDonnell, Nagarajan Raju, Robin G Bombardi, Amyn A Murji, Cathrine Scheepers, Rutendo Ziki, Charissa Mynhardt, Bryan E Shepherd, Alusha A Mamchak, Nigel Garrett, Salim Abdool Karim, Simon A Mallal, James E Crowe, Lynn Morris, Ivelin S Georgiev,

Characterization of single antibody lineages within infected individuals has provided insights into the development of Env-specific antibodies. However, a systems-level understanding of the humoral response against HIV-1 is limited. Here, we interrogated the antibody repertoires of multiple HIV-infected donors from an infection-naive state through acute and chronic infection using next-generation ... Read more >>

Cell Host Microbe (Cell host & microbe)
[2018, 23(6):845-854.e6]

Cited: 11 times

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Is substance use associated with HIV cascade outcomes in Latin America?

Raquel B De Boni, Meridith B Peratikos, Bryan E Shepherd, Beatriz Grinsztejn, Claudia Cortés, Denis Padgett, Eduardo Gotuzzo, Pablo F Belaunzarán-Zamudio, Peter F Rebeiro, Stephany N Duda, Catherine C McGowan, ,

The HIV care cascade has improved in Latin America over the last decade. However, the influence of alcohol and noninjected drug use (NIDU) on cascade outcomes is mostly unknown. This study estimated the association of alcohol and NIDU with retention in care, loss to follow up (LTFU), and virologic failure ... Read more >>

PLoS ONE (PloS one)
[2018, 13(3):e0194228]

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