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Author Bruno Giordani

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Impact of Patient Mild Cognitive Impairment on Physician Decision-Making for Treatment.

Emilie Blair, Darin Zahuranec, Kenneth M Langa, Jane Forman, Bailey K Reale, Colleen Kollman, Bruno Giordani, Deborah A Levine,

BACKGROUND:Older patients with mild cognitive impairment (MCI) should receive evidence-based treatments when clinically indicated. However, patients with MCI appear less likely than cognitively normal patients to receive evidence-based treatments. OBJECTIVE:To explore the influence of a patient's MCI diagnosis on physician decision-making. METHODS:Qualitative study of 18 physicians from cardiology, neurology, and ... Read more >>

J Alzheimers Dis (Journal of Alzheimer's disease : JAD)
[2020, :]

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Correction: Is age a risk factor for cognitive changes following hematopoietic cell transplantation?

John Stratton, Allison Sylvia, Flora Hoodin, Sung Won Choi, Attaphol Pawarode, Bruno Giordani, Kristen Votruba,

An amendment to this paper has been published and can be accessed via a link at the top of the paper. ... Read more >>

Bone Marrow Transplant (Bone marrow transplantation)
[2020, :]

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Is age a risk factor for cognitive changes following hematopoietic cell transplantation?

John Stratton, Allison Sylvia, Flora Hoodin, Sung Won Choi, Attaphol Pawarode, Bruno Giordani, Kristen Votruba,

Cognitive deficits following hematopoietic cell transplantation (HCT) are common and affect post-HCT treatment regimen adherence and quality-of-life. Little is known about effects of age on cognition following HCT. The current study aimed to identify the effects of age on cognition one-year post-HCT, compared to pre-HCT baseline functioning. Participants were 78 ... Read more >>

Bone Marrow Transplant (Bone marrow transplantation)
[2020, :]

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Mild cognitive impairment and receipt of procedures for acute ischemic stroke in older adults.

Deborah A Levine, Andrzej Galecki, Mohammed Kabeto, Brahmajee K Nallamothu, Darin B Zahuranec, Lewis B Morgenstern, Lynda D Lisabeth, Bruno Giordani, Kenneth M Langa,

BACKGROUND AND PURPOSE:Older patients with pre-existing mild cognitive impairment (MCI) receive less evidence-based care after acute myocardial infarction, however, whether they receive less care after acute ischemic stroke (AIS) is unknown. We compared receipt of guideline-concordant procedures after AIS between older adults with pre-existing MCI and normal cognition. METHODS:Prospective study ... Read more >>

J Stroke Cerebrovasc Dis (Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association)
[2020, 29(10):105083]

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Computerized Cognitive Rehabilitation Training for Ugandan Seniors Living with HIV: A Validation Study.

Amara E Ezeamama, Alla Sikorskii, Parvathy R Sankar, Noeline Nakasujja, Michael Ssonko, Norbert E Kaminski, David Guwatudde, Michael J Boivin, Bruno Giordani,

The feasibility, acceptability and preliminary efficacy of computerized cognitive rehabilitation therapy (CCRT) for mitigating neurocognitive decline was evaluated in African adults ≥50 years old. Eighty-one Ugandans with (n = 40) and without (n = 41) chronic human immunodeficiency viruses (HIV) were allocated CCRT-i.e., 20-45-min cognitive training sessions with culturally adapted ... Read more >>

J Clin Med (Journal of clinical medicine)
[2020, 9(7):]

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Sleep-Wake Disturbances and Episodic Memory in Older Adults.

An-Yun Yeh, Susan J Pressler, Donna Algase, Laura M Struble, Bunny J Pozehl, Ann M Berger, Bruno J Giordani,

Sleep-wake disturbances have been associated with episodic memory loss, but past studies were limited by use of single measures of objective or perceived disturbances. Notably, cognitive reserve and depressive symptoms have been associated with sleep-wake disturbances and poorer episodic memory in older adults. The aims of this study were to ... Read more >>

Biol Res Nurs (Biological research for nursing)
[2020, :1099800420941601]

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Association Between Blood Pressure and Later-Life Cognition Among Black and White Individuals.

Deborah A Levine, Alden L Gross, Emily M Briceño, Nicholas Tilton, Mohammed U Kabeto, Stephanie M Hingtgen, Bruno J Giordani, Jeremy B Sussman, Rodney A Hayward, James F Burke, Mitchell S V Elkind, Jennifer J Manly, Andrew E Moran, Erin R Kulick, Rebecca F Gottesman, Keenan A Walker, Yuichiro Yano, Darrell J Gaskin, Stephen Sidney, Kristine Yaffe, Ralph L Sacco, Clinton B Wright, Veronique L Roger, Norrina Bai Allen, Andrzej T Galecki,

Importance:Black individuals are more likely than white individuals to develop dementia. Whether higher blood pressure (BP) levels in black individuals explain differences between black and white individuals in dementia risk is uncertain. Objective:To determine whether cumulative BP levels explain racial differences in cognitive decline. Design, Setting, and Participants:Individual participant data ... Read more >>

JAMA Neurol (JAMA neurology)
[2020, 77(7):810-819]

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Cohort discovery and risk stratification for Alzheimer's disease: an electronic health record-based approach.

Donna Tjandra, Raymond Q Migrino, Bruno Giordani, Jenna Wiens,

Background:We sought to leverage data routinely collected in electronic health records (EHRs), with the goal of developing patient risk stratification tools for predicting risk of developing Alzheimer's disease (AD). Method:Using EHR data from the University of Michigan (UM) hospitals and consensus-based diagnoses from the Michigan Alzheimer's Disease Research Center, we ... Read more >>

Alzheimers Dement (N Y) (Alzheimer's & dementia (New York, N. Y.))
[2020, 6(1):e12035]

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Exploring Representation of Diverse Samples in fMRI Studies Conducted in Patients With Cardiac-Related Chronic Illness: A Focused Systematic Review.

Lenette M Jones, Emily Ginier, Joseph Debbs, Jarrod L Eaton, Catherine Renner, Jaclynn Hawkins, Rosanna Rios-Spicer, Emily Tang, Catherine Schertzing, Bruno Giordani,

Introduction/Purpose: Cardiovascular disease (CVD) is the leading cause of death worldwide, and in the United States alone, CVD causes nearly 840,000 deaths annually. Using functional magnetic resonance imaging (fMRI), a tool to assess brain activity, researchers have identified some brain-behavior connections and predicted several self-management behaviors. The purpose of this ... Read more >>

Front Hum Neurosci (Frontiers in human neuroscience)
[2020, 14:108]

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Association of Blood Pressure and Cognition after Stroke.

Deborah A Levine, Andrzej T Galecki, Dolorence Okullo, Emily M Briceño, Mohammed U Kabeto, Lewis B Morgenstern, Kenneth M Langa, Bruno Giordani, Robert Brook, Brisa N Sanchez, Lynda D Lisabeth,

BACKGROUND AND AIM:It is unclear whether blood pressure (BP) is associated with cognition after stroke. We examined associations between systolic and diastolic BP (SBP, DBP), pulse pressure (PP), mean arterial pressure (MAP), and cognition, each measured 90 days after stroke. METHODS:Cross-sectional analysis of prospectively obtained data of 432 dementia-free subjects ... Read more >>

J Stroke Cerebrovasc Dis (Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association)
[2020, 29(7):104754]

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Toxic Stress and Quality of Life in Early School-Aged Ugandan Children With and Without Perinatal Human Immunodeficiency Virus Infection.

Amara E Ezeamama, Sarah K Zalwango, Robert Tuke, Ricki Lauren Pad, Michael J Boivin, Philippa M Musoke, Bruno Giordani, Alla Sikorskii,

Caregiver's and child's self-reported quality of life (QOL) was defined using standardized questionnaires in a sample (N = 277) of 6-10 years old HIV-infected, HIV-exposed uninfected, and HIV-unexposed uninfected children from Uganda. Psychosocial stress (acute stress and cumulative lifetime adversity) and physiologic stress (dysregulations across 13 biomarkers), perinatal HIV status, ... Read more >>

New Dir Child Adolesc Dev (New directions for child and adolescent development)
[2020, 2020(171):15-38]

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Psychosocial Adjustment in Ugandan Children: Coping With Human Immunodeficiency Virus Exposure, Lifetime Adversity, and Importance of Social Support.

Robert Tuke, Alla Sikorskii, Sarah K Zalwango, Kyle D Webster, Alexander Ismail, Ruth A Pobee, Jennifer L Barkin, Michael J Boivin, Bruno Giordani, Amara E Ezeamama,

Cumulative lifetime adversity and social support were investigated as determinants of psychosocial adjustment (esteem, distress, hopefulness, positive outlook/future aspirations, and sense of purpose) over 12 months in 6-10-years-old HIV-infected, HIV-exposed uninfected and HIV-unexposed uninfected children from Uganda. Each determinant and psychosocial adjustment indicator was self-reported using standardized questionnaires administered at ... Read more >>

New Dir Child Adolesc Dev (New directions for child and adolescent development)
[2020, 2020(171):55-75]

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Neuropsychological assessment of mild cognitive impairment in Latinx adults: A scoping review.

Emily M Briceño, Roshanak Mehdipanah, Xavier Fonz Gonzales, Kenneth M Langa, Deborah A Levine, Nelda M Garcia, Ruth Longoria, Bruno J Giordani, Steven G Heeringa, Lewis B Morgenstern,

Objective: Latinx populations are rapidly growing and aging in the United States. There is a critical need to accurately and efficiently detect those at risk for dementia, particularly those with mild cognitive impairment (MCI). MCI diagnosis often relies on neuropsychological assessment, although cultural, demographic, and linguistic characteristics may impact test ... Read more >>

Neuropsychology (Neuropsychology)
[2020, 34(5):493-510]

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Physician decision-making and recommendations for stroke and myocardial infarction treatments in older adults with mild cognitive impairment.

Deborah A Levine, Kenneth M Langa, Angela Fagerlin, Lewis B Morgenstern, Brahmajee K Nallamothu, Jane Forman, Andrzej Galecki, Mohammed U Kabeto, Colleen D Kollman, Tolu Olorode, Bruno Giordani, Lynda D Lisabeth, Darin B Zahuranec,

Evidence suggests that older adults with mild cognitive impairment (MCI) might not receive evidence-based treatments. We explored the impact of patient MCI on physician decision-making and recommendations for acute ischemic stroke (AIS) and acute myocardial infarction (AMI) in a pilot concurrent mixed-methods study of physicians recruited from one academic center. ... Read more >>

PLoS One (PloS one)
[2020, 15(3):e0230446]

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Effective differentiation of mild cognitive impairment by functional brain graph analysis and computerized testing.

Rok Požar, Bruno Giordani, Voyko Kavcic,

Community-dwelling African American elders are twice as likely to develop mild cognitive impairment (MCI) or Alzheimer's disease and related dementias than older white Americans and therefore represent a significant at-risk group in need of early monitoring. More extensive imaging or cerebrospinal fluid studies represent significant barriers due to cost and ... Read more >>

PLoS One (PloS one)
[2020, 15(3):e0230099]

Cited: 1 time

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The Prevalence and Determinants of Cognitive Deficits and Traditional Diabetic Complications in the Severely Obese.

Brian C Callaghan, Evan L Reynolds, Mousumi Banerjee, Ericka Chant, Emily Villegas-Umana, Thomas W Gardner, Kristen Votruba, Bruno Giordani, Rodica Pop-Busui, Subramaniam Pennathur, Eva L Feldman,

OBJECTIVE:To determine the prevalence of cognitive deficits and traditional diabetic complications and the association between metabolic factors and these outcomes. RESEARCH DESIGN AND METHODS:We performed a cross-sectional study in severely obese individuals before bariatric surgery. Lean control subjects were recruited from a research website. Cognitive deficits were defined by the ... Read more >>

Diabetes Care (Diabetes care)
[2020, 43(3):683-690]

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Fidelity and feasibility of a multicomponent physical activity intervention in a retirement community.

Zhanjia Zhang, Bruno Giordani, Weiyun Chen,

This pilot study examined the fidelity and feasibility of a multicomponent physical activity intervention in a retirement community. Eighteen older adults participated in an 8-week intervention. The intervention included offering group exercise lessons, combined with providing participants wearable activity trackers. Quantitative and qualitative data were collected to assess the feasibility ... Read more >>

Geriatr Nurs (Geriatric nursing (New York, N.Y.))
[2020, 41(4):394-399]

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TASK-SPECIFIC METACOGNITIVE ACCURACY DECLINES ACROSS THE DEMENTIA-ALZHEIMER’S TYPE SPECTRUM.

Annalise M Rahman-Filipiak, Arijit Bhaumik, Bruno Giordani, Henry Paulson, Benjamin M Hampstead,

AbstractSubjective cognitive complaints (SCCs) remain part of the diagnostic criteria for amnestic mild cognitive impairment (aMCI), the prodromal stage of dementia - Alzheimer’s type (DAT), despite weak relationships between self-reported and objectively-measured functioning. Most metacognitive measures focus on ratings of global retrospective memory rating only; greater subtlety in measurement of ... Read more >>

Innov Aging (Innovation in aging)
[2019, 3(Suppl 1):S2-S2]

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The utility of cognitive changes in identifying those with acute graft vs. host disease following allogeneic hematopoietic cell transplant.

John Stratton, Allison Sylvia, Flora Hoodin, Sung Won Choi, Attaphol Pawarode, Bruno Giordani, Kristen Votruba,

Objectives: Acute graft versus host disease (aGVHD) is a common complication of allogeneic hematopoietic cell transplant (HCT) and is associated with morbidity and mortality. Identifying those at risk for developing aGVHD is crucial for early intervention. The current study assessed whether scores on a brief cognitive screening measure could identify ... Read more >>

Clin Neuropsychol (The Clinical neuropsychologist)
[2020, 34(5):969-980]

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Mild Cognitive Impairment and Receipt of Treatments for Acute Myocardial Infarction in Older Adults.

Deborah A Levine, Kenneth M Langa, Andrzej Galecki, Mohammed Kabeto, Lewis B Morgenstern, Darin B Zahuranec, Bruno Giordani, Lynda D Lisabeth, Brahmajee K Nallamothu,

BACKGROUND:Older adults with mild cognitive impairment (MCI) should receive evidence-based treatments when indicated. Providers and patients may overestimate the risk of dementia in patients with MCI leading to potential under-treatment. However, the association between pre-existing MCI and receipt of evidence-based treatments is uncertain. OBJECTIVE:To compare receipt of treatments for acute ... Read more >>

J Gen Intern Med (Journal of general internal medicine)
[2020, 35(1):28-35]

Cited: 1 time

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Serum Vitamin D is Differentially Associated with Socioemotional Adjustment in Early School-Aged Ugandan Children According to Perinatal HIV Status and In Utero/Peripartum Antiretroviral Exposure History.

William Yakah, Jenifer I Fenton, Alla Sikorskii, Sarah K Zalwango, Robert Tuke, Philippa Musoke, Michael J Boivin, Bruno Giordani, Amara E Ezeamama,

An impact of vitamin D in neurocognitive function has been theorized but it remains unknown whether vitamin-D insufficiency (VDI) is associated with worse socio-emotional adjustment (SEA) in vulnerable early school-aged children. This study examines the thesis that deficits in SEA are related to VDI using longitudinal data from 254 children ... Read more >>

Nutrients (Nutrients)
[2019, 11(7):]

Cited: 2 times

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Home-based Cognitive Prehabilitation in Older Surgical Patients: A Feasibility Study.

Phillip E Vlisides, Abhijit R Das, Allie M Thompson, Bryan Kunkler, Mackenzie Zierau, Michael J Cantley, Amy M McKinney, Bruno Giordani,

BACKGROUND:Cognitive training is beneficial in various clinical settings, although its perioperative feasibility and impact remain unknown. The objective of this pilot study was to determine the feasibility of home-based cognitive prehabilitation before major surgery in older adults. MATERIALS AND METHODS:Sixty-one patients were enrolled, randomized, and allocated to either a home-based ... Read more >>

J Neurosurg Anesthesiol (Journal of neurosurgical anesthesiology)
[2019, 31(2):212-217]

Cited: 5 times

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Caregiver socioemotional health as a determinant of child well-being in school-aged and adolescent Ugandan children with and without perinatal HIV exposure.

Kyle D Webster, Miko M de Bruyn, Sarah K Zalwango, Alla Sikorskii, Jennifer L Barkin, Itziar Familiar-Lopez, Philippa Musoke, Bruno Giordani, Michael J Boivin, Amara E Ezeamama,

OBJECTIVE:Caregiver socio-emotional attributes are major determinants of child well-being. This investigation in vulnerable school-aged Ugandan children estimates relationships between children's well-being and their caregiver's anxiety, depression and social support. METHODS:Perinatally HIV-infected, HIV-exposed uninfected and HIV-unexposed Ugandan children and their caregivers were enrolled. Perinatal HIV status was determined by 18 months of ... Read more >>

Trop. Med. Int. Health (Tropical medicine & international health : TM & IH)
[2019, 24(5):608-619]

Cited: 2 times

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Blood Pressure and Cognitive Decline Over 8 Years in Middle-Aged and Older Black and White Americans.

Deborah A Levine, Andrzej T Galecki, Kenneth M Langa, Frederick W Unverzagt, Mohammed U Kabeto, Bruno Giordani, Mary Cushman, Leslie A McClure, Monika M Safford, Virginia G Wadley,

Although the association between high blood pressure (BP), particularly in midlife, and late-life dementia is known, less is known about variations by race and sex. In a prospective national study of 22 164 blacks and whites ≥45 years without baseline cognitive impairment or stroke from the REGARDS cohort study (Reasons for ... Read more >>

Hypertension (Hypertension (Dallas, Tex. : 1979))
[2019, 73(2):310-318]

Cited: 3 times

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Neuropsychological Changes in Patients Undergoing Treatment of Unruptured Intracranial Aneurysms.

Angela F Caveney, Scott A Langenecker, Aditya S Pandey, Laura B Farah, J Alexis Ortiz, Nadia Huq, Runa Bhaumik, B Gregory Thompson, Bruno J Giordani, Donna Auer, Lewis B Morgenstern,

BACKGROUND:Evaluation of differences in neuropsychological outcomes in patients undergoing surgical clipping (SC) vs endovascular coiling (EC) for unruptured cerebral aneurysms is essential in guiding patients seeking treatment of asymptomatic cerebral aneurysms. OBJECTIVE:To perform a prospective longitudinal analysis of neuropsychological outcomes in patients who underwent microsurgery or coiling for unruptured cerebral ... Read more >>

Neurosurgery (Neurosurgery)
[2019, 84(3):581-587]

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