Full Text Journal Articles by
Author Brooke Wanrooy


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Dynamic roles of neutrophils in post-stroke neuroinflammation.

Brooke J Wanrooy, Shu Wen Wen, Connie Hy Wong,

Clinical trials involving the blockage of peripheral inflammatory leukocyte recruitment into the brain have puzzlingly led to either no significant improvement in stroke outcome, or even worsened outcomes and increased mortality, prompting a re-evaluation of our understanding into the neuroinflammatory processes after stroke. Whilst traditionally understood as simple effectors of ... Read more >>

Immunol Cell Biol (Immunology and cell biology)
[2021, :]

Cited: 0 times

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Deficiency of Dietary Fiber Modulates Gut Microbiota Composition, Neutrophil Recruitment and Worsens Experimental Colitis.

Sj Shen, Kathryn Prame Kumar, Shu Wen Wen, Raymond Shim, Brooke J Wanrooy, Dragana Stanley, Robert J Moore, Thi Thu Hao Van, Remy Robert, Michael J Hickey, Connie H Y Wong,

Ulcerative colitis is an inflammatory disease of the colon that is associated with colonic neutrophil accumulation. Recent evidence indicates that diet alters the composition of the gut microbiota and influences host-pathogen interactions. Specifically, bacterial fermentation of dietary fiber produces metabolites called short-chain fatty acids (SCFAs), which have been shown to ... Read more >>

Front Immunol (Frontiers in immunology)
[2021, 12:619366]

Cited: 0 times

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Experimental traumatic brain injury does not lead to lung infection.

Mujun Sun, Rhys D Brady, Brooke Wanrooy, Richelle Mychasiuk, Glenn R Yamakawa, Pablo M Casillas-Espinosa, Connie H Y Wong, Sandy R Shultz, Stuart J McDonald,

Traumatic brain injury (TBI) patients often experience post-traumatic infections, especially in the lung. Pulmonary infection is associated with unfavorable outcomes and increased mortality rates in TBI patients; however, our understanding of the underlying mechanisms is poor. Here we used a lateral fluid percussion injury (LFPI) model in rats to investigate ... Read more >>

J Neuroimmunol (Journal of neuroimmunology)
[2020, 343:577239]

Cited: 1 time

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Stroke Severity, and Not Cerebral Infarct Location, Increases the Risk of Infection.

Raymond Shim, Shu Wen Wen, Brooke J Wanrooy, Michelle Rank, Tharani Thirugnanachandran, Luke Ho, Tara Sepehrizadeh, Michael de Veer, Velandai K Srikanth, Henry Ma, Thanh G Phan, Christopher G Sobey, Connie H Y Wong,

Infection is a leading cause of death in patients with stroke; however, the impact of cerebral infarct size or location on infectious outcome is unclear. To examine the effect of infarct size on post-stroke infection, we utilised the intraluminal middle-cerebral artery occlusion (MCAO) mouse model of ischemic stroke and adjusted ... Read more >>

Transl Stroke Res (Translational stroke research)
[2020, 11(3):387-401]

Cited: 4 times

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Advanced age promotes colonic dysfunction and gut-derived lung infection after stroke.

Shu Wen Wen, Raymond Shim, Luke Ho, Brooke J Wanrooy, Yogitha N Srikhanta, Kathryn Prame Kumar, Alyce J Nicholls, S J Shen, Tara Sepehrizadeh, Michael de Veer, Velandai K Srikanth, Henry Ma, Thanh G Phan, Dena Lyras, Connie H Y Wong,

Bacterial infection a leading cause of death among patients with stroke, with elderly patients often presenting with more debilitating outcomes. The findings from our retrospective study, supported by previous clinical reports, showed that increasing age is an early predictor for developing fatal infectious complications after stroke. However, exactly how and ... Read more >>

Aging Cell (Aging cell)
[2019, 18(5):e12980]

Cited: 5 times

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Distinct contributions of hyperglycemia and high-fat feeding in metabolic syndrome-induced neuroinflammation.

Brooke J Wanrooy, Kathryn Prame Kumar, Shu Wen Wen, Cheng Xue Qin, Rebecca H Ritchie, Connie H Y Wong,

<h4>Background</h4>High-fat feeding and hyperglycemia, key risk factors for the development of metabolic syndrome (MetS), are emerging to associate with increased risk of developing dementia and cognitive decline. Despite this, clinical and experimental studies have yet to elucidate the specific contributions of either high-fat feeding or hyperglycemia to potential neuroinflammatory components. ... Read more >>

J Neuroinflammation (Journal of neuroinflammation)
[2018, 15(1):293]

Cited: 9 times

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