Full Text Journal Articles by
Author Brigitte Bancel


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[Management of immune checkpoint inhibitors-induced liver toxicity in cancer].

Fanny Lebossé, Brigitte Bancel, Massimo Levrero, Philippe Merle,

Pharmacological immune checkpoint inhibitors (ICI) restore the anti-tumor properties of T-lymphocytes, but unfortunately can engender auto-immune-like disorders. Those, frequent and of variable severity, sometimes target the liver parenchyma. Liver toxicity of ICI firstly leads to alteration of liver function tests (ALFT) with a risk of clinical decompensation. The appearance of ... Read more >>

Bull Cancer (Bulletin du cancer)
[2020, :]

Cited: 0 times

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Cholangitis lenta: An underdiagnosed lesion associated with severe cholestasis following liver transplantation.

Mathieu Bonal, Mohamed Mourad, Brigitte Bancel, Valérie Hervieu, Fanny Lebossé, Laurent Heyer, Christian Ducerf, Mickaël Lesurtel, Jean-Yves Mabrut, Kayvan Mohkam,

BACKGROUND:Cholangitis lenta (CL) represents a specific histological lesion associated with severe cholestasis and related to sepsis. Despite being well known by pathologists, CL has been poorly studied in liver transplantation (LT). METHODS:We performed a retrospective 12-year analysis of the incidence, risk factors, and outcome of CL in LT recipients. Biopsy ... Read more >>

Clin Transplant (Clinical transplantation)
[2020, :e14016]

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Corrigendum to "Toll-like receptor 3 downregulation is an escape mechanism from apoptosis during hepatocarcinogenesis" [J Hepatol 71 (2019) 763-772].

Marc Bonnin, Nadim Fares, Barbara Testoni, Yann Estornes, Kathrin Weber, Béatrice Vanbervliet, Lydie Lefrançois, Amandine Garcia, Alain Kfoury, Floriane Pez, Isabelle Coste, Pierre Saintigny, Alain Viari, Kévin Lang, Baptiste Guey, Virginie Petrilli, Valérie Hervieu, Brigitte Bancel, Birke Bartosch, David Durantel, Toufic Renno, Philippe Merle, Serge Lebecque,

J. Hepatol. (Journal of hepatology)
[2020, 72(3):594]

Cited: 0 times

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In vitro transformation of primary human hepatocytes: Epigenetic changes and stemness properties.

Floriane Pez, Patricia Gifu, Davide Degli-Esposti, Nadim Fares, Anaïs Lopez, Lydie Lefrançois, Maud Michelet, Michel Rivoire, Brigitte Bancel, Bakary S Sylla, Zdenko Herceg, Philippe Merle, Claude Caron de Fromentel,

Human hepatocarcinogenesis is a complex process with many unresolved issues, including the cell of origin (differentiated and/or progenitor/stem cells) and the initial steps leading to tumor development. With the aim of providing new tools for studying hepatocellular carcinoma initiation and progression, we developed an innovative model based on primary human ... Read more >>

Exp. Cell Res. (Experimental cell research)
[2019, 384(2):111643]

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Toll-like receptor 3 downregulation is an escape mechanism from apoptosis during hepatocarcinogenesis.

Marc Bonnin, Nadim Fares, Barbara Testoni, Yann Estornes, Kathrin Weber, Béatrice Vanbervliet, Lydie Lefrançois, Amandine Garcia, Alain Kfoury, Floriane Pez, Isabelle Coste, Pierre Saintigny, Alain Viari, Kévin Lang, Baptiste Guey, Valérie Hervieu, Brigitte Bancel, Birke Bartoch, David Durantel, Toufic Renno, Philippe Merle, Serge Lebecque,

BACKGROUND & AIMS:Low levels of toll-like receptor 3 (TLR3) in patients with hepatocellular carcinoma (HCC) are associated with poor prognosis, primarily owing to the loss of inflammatory signaling and subsequent lack of immune cell recruitment to the liver. Herein, we explore the role of TLR3-triggered apoptosis in HCC cells. METHODS:Quantitative ... Read more >>

J. Hepatol. (Journal of hepatology)
[2019, 71(4):763-772]

Cited: 1 time

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Alteration of splicing factors' expression during liver disease progression: impact on hepatocellular carcinoma outcome.

Hualin Wang, Bouchra Lekbaby, Nadim Fares, Jeremy Augustin, Tarik Attout, Aurelie Schnuriger, Anne-Marie Cassard, Ganna Panasyuk, Gabriel Perlemuter, Ivan Bieche, Sophie Vacher, Janick Selves, Jean-Marie Péron, Brigitte Bancel, Philippe Merle, Dina Kremsdorf, Janet Hall, Isabelle Chemin, Patrick Soussan,

PURPOSE:Trans-acting splicing factors (SF) shape the eukaryotic transcriptome by regulating alternative splicing (AS). This process is recurrently modulated in liver cancer suggesting its direct contribution to the course of liver disease. The aim of our study was to investigate the relationship between the regulation of SFs expression and liver damage. ... Read more >>

Hepatol Int (Hepatology international)
[2019, 13(4):454-467]

Cited: 2 times

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A systematic review of the anatomical findings of multiple gallbladders.

Benjamin Darnis, Kayvan Mohkam, François Cauchy, Jean-Baptiste Cazauran, Brigitte Bancel, Agnès Rode, Christian Ducerf, Mickaël Lesurtel, Jean-Yves Mabrut,

BACKGROUND:Multiple gallbladders (MG) are a rare malformation, with no clear data on its clinical impact, therapeutic indications or risk for malignancy. METHODS:A systematic review of all published literature between 1990 and 2017 was performed using the PRISMA guidelines. RESULTS:Data of 181 patients extracted from 153 studies were reviewed. MG were ... Read more >>

HPB (Oxford) (HPB : the official journal of the International Hepato Pancreato Biliary Association)
[2018, 20(11):985-991]

Cited: 0 times

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Polymorphic multiple hepatocellular adenoma including a non-steatotic HNF1α-inactivated variant.

Kayvan Mohkam, Benjamin Darnis, Jean-Baptiste Cazauran, Agnès Rode, Anne-Frédérique Manichon, Christian Ducerf, Brigitte Bancel, Jean-Yves Mabrut,

HBPD INT (Hepatobiliary & pancreatic diseases international : HBPD INT)
[2017, 16(5):552-555]

Cited: 1 time

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ROC-king onwards: intraepithelial lymphocyte counts, distribution & role in coeliac disease mucosal interpretation.

Kamran Rostami, Michael N Marsh, Matt W Johnson, Hamid Mohaghegh, Calvin Heal, Geoffrey Holmes, Arzu Ensari, David Aldulaimi, Brigitte Bancel, Gabrio Bassotti, Adrian Bateman, Gabriel Becheanu, Anna Bozzola, Antonio Carroccio, Carlo Catassi, Carolina Ciacci, Alexandra Ciobanu, Mihai Danciu, Mohammad H Derakhshan, Luca Elli, Stefano Ferrero, Michelangelo Fiorentino, Marilena Fiorino, Azita Ganji, Kamran Ghaffarzadehgan, James J Going, Sauid Ishaq, Alessandra Mandolesi, Sherly Mathews, Roxana Maxim, Chris J Mulder, Andra Neefjes-Borst, Marie Robert, Ilaria Russo, Mohammad Rostami-Nejad, Angelo Sidoni, Masoud Sotoudeh, Vincenzo Villanacci, Umberto Volta, Mohammad R Zali, Amitabh Srivastava,

OBJECTIVES:Counting intraepithelial lymphocytes (IEL) is central to the histological diagnosis of coeliac disease (CD), but no definitive 'normal' IEL range has ever been published. In this multicentre study, receiver operating characteristic (ROC) curve analysis was used to determine the optimal cut-off between normal and CD (Marsh III lesion) duodenal mucosa, ... Read more >>

Gut (Gut)
[2017, 66(12):2080-2086]

Cited: 16 times

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Molecular Classification of Hepatocellular Adenoma Associates With Risk Factors, Bleeding, and Malignant Transformation.

Jean-Charles Nault, Gabrielle Couchy, Charles Balabaud, Guillaume Morcrette, Stefano Caruso, Jean-Frederic Blanc, Yannick Bacq, Julien Calderaro, Valérie Paradis, Jeanne Ramos, Jean-Yves Scoazec, Viviane Gnemmi, Nathalie Sturm, Catherine Guettier, Monique Fabre, Eric Savier, Laurence Chiche, Philippe Labrune, Janick Selves, Dominique Wendum, Camilla Pilati, Alexis Laurent, Anne De Muret, Brigitte Le Bail, Sandra Rebouissou, Sandrine Imbeaud, , Paulette Bioulac-Sage, Eric Letouzé, Jessica Zucman-Rossi,

Hepatocellular adenomas (HCAs) are benign liver tumors that can be assigned to molecular subtypes based on inactivating mutations in hepatocyte nuclear factor 1A, activating mutations in β-catenin, or activation of inflammatory signaling pathways. We aimed to update the classification system for HCA and associate the subtypes with disease risk factors ... Read more >>

Gastroenterology (Gastroenterology)
[2017, 152(4):880-894.e6]

Cited: 43 times

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Traumatic biliary neuroma after orthotopic liver transplantation: a possible cause of "unexplained" anastomotic biliary stricture.

Julie Navez, Nicolas Golse, Brigitte Bancel, Agnès Rode, Christian Ducerf, Salim Mezoughi, Kayvan Mohkam, Jean-Yves Mabrut,

Traumatic biliary neuromas (TBNs) represent a rare cause of biliary stricture (BS) after orthotopic liver transplantation (OLT). Diagnosis is challenging preoperatively and is most often made at pathology after resection. Herein, we report a 20-year experience of TBN-related BS.Medical records of 1030 adult patients undergoing OLT from 1991 to 2014 ... Read more >>

Clin Transplant (Clinical transplantation)
[2016, 30(10):1366-1369]

Cited: 5 times

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Identification of novel long non-coding RNAs deregulated in hepatocellular carcinoma using RNA-sequencing.

Davide Degli Esposti, Hector Hernandez-Vargas, Catherine Voegele, Nora Fernandez-Jimenez, Nathalie Forey, Brigitte Bancel, Florence Le Calvez-Kelm, James McKay, Philippe Merle, Zdenko Herceg,

Functional characterization of long non-coding RNAs (lncRNAs) and their pathological relevance is still a challenging task. Abnormal expression of a few long non-coding RNAs have been found associated with hepatocellular carcinoma, with potential implications to both improve our understanding of molecular mechanism of liver carcinogenesis and to discover biomarkers for ... Read more >>

Oncotarget (Oncotarget)
[2016, 7(22):31862-31877]

Cited: 32 times

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Focal nodular hyperplasia and hepatocellular adenoma: The value of shear wave elastography for differential diagnosis.

Thomas Brunel, Aymeric Guibal, Camille Boularan, Christian Ducerf, Jean-Yves Mabrut, Brigitte Bancel, Loïc Boussel, Agnès Rode,

This study assessed the clinical usefulness of shear wave elastography (SWE) during ultrasound for differentiating between focal nodular hyperplasias (FNHs) and hepatocellular adenomas (HAs).SWE was performed on 56 patients presenting with 76 liver lesions (57 FNHs and 19HAs) that were confirmed by MRI and contrast-enhanced ultrasound (CEUS) (n=55) or by ... Read more >>

Eur J Radiol (European journal of radiology)
[2015, 84(11):2059-2064]

Cited: 7 times

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Liver-infiltrating CD8(+) lymphocytes as prognostic factor for tumour recurrence in hepatitis C virus-related hepatocellular carcinoma.

Muhammad Ramzan, Nathalie Sturm, Thomas Decaens, Paulette Bioulac-Sage, Brigitte Bancel, Philippe Merle, Jeanne Tran Van Nhieu, Rémy Slama, Christian Letoublon, Jean-Pierre Zarski, Evelyne Jouvin-Marche, Patrice N Marche, Vincent Leroy,

Chronic liver inflammation and immune/inflammatory response promote hepatocellular carcinoma. The aim of this study was to characterize the immune status of HCV-related cirrhosis in patients with hepatocellular carcinoma (HCV-HCC) as compared to HCV patients without hepatocellular carcinoma.Immune markers (CD3, CD4, CD8, CD20, CD56, TCRγδ, FoxP3) and gene expression profiles (CD8α, ... Read more >>

Liver Int. (Liver international : official journal of the International Association for the Study of the Liver)
[2016, 36(3):434-444]

Cited: 14 times

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KIT Mutation and Loss of 14q May Be Sufficient for the Development of Clinically Symptomatic Very Low-Risk GIST.

Olaf Karl Klinke, Tuba Mizani, Gouri Baldwin, Brigitte Bancel, Mojgan Devouassoux-Shisheboran, Jean-Yves Scoazec, Pierre-Paul Bringuier, Regina Feederle, Anna Jauch, Katrin Hinderhofer, Philippe Taniere, Henri-Jacques Delecluse,

The aim of this study was to determine the minimal set of genetic alterations required for the development of a very low risk clinically symptomatic gastro-intestinal stromal tumour within the stomach wall. We studied the genome of a very low-risk gastric gastro-intestinal stromal tumour by whole-genome sequencing, comparative genomic hybridisation ... Read more >>

PLoS ONE (PloS one)
[2015, 10(6):e0130149]

Cited: 3 times

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Diversity of hepatocellular carcinoma clones bearing hematopoietic malignancies-related chromosomal translocation.

Romain Parent, Marie-Laure Plissonnier, Brigitte Bancel, Wan-Li Liao, Sylvie Rumin, Remal Asaad, Marianne Till, Damien Sanlaville, Fabien Zoulim, Christian Trépo, Marie-Jeanne Marion,

Interpatient heterogeneity of hepatocellular carcinoma has been in-depth addressed. Intrapatient heterogeneity is less known. Four clones were freshly isolated from an Edmondson grade I HCV-associated hepatocellular carcinoma. Biochemical approaches, functional assays and cytogenetics were used. Albumin inducibility was uncoupled from canonical cytokeratin profiles, suggesting pathological combinations of hepatospecific and biliary ... Read more >>

J. Cell. Biochem. (Journal of cellular biochemistry)
[2014, 115(4):666-677]

Cited: 0 times

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Ocular sarcoidosis: when should labial salivary gland biopsy be performed?

Claire Bernard, Laurent Kodjikian, Brigitte Bancel, Sylvie Isaac, Christiane Broussolle, Pascal Seve,

To assess the usefulness of a labial salivary gland biopsy (LSGB) in subsets of patients with uveitis.A retrospective study of 115 consecutive patients with uveitis for whom a LSGB had been done because of suspected ocular sarcoidosis (n = 86) or unexplained uveitis (n = 29). Eighty-six patients had a ... Read more >>

Graefes Arch. Clin. Exp. Ophthalmol. (Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie)
[2013, 251(3):855-860]

Cited: 4 times

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Immunohistochemical markers on needle biopsies are helpful for the diagnosis of focal nodular hyperplasia and hepatocellular adenoma subtypes.

Paulette Bioulac-Sage, Gaelle Cubel, Saïd Taouji, Jean-Yves Scoazec, Emmanuelle Leteurtre, Valérie Paradis, Nathalie Sturm, Jeanne Tran Van Nhieu, Dominique Wendum, Brigitte Bancel, Jeanne Ramos, François Paraf, Marie Christine Saint Paul, Sophie Michalak, Monique Fabre, Catherine Guettier, Brigitte Le Bail, Jessica Zucman-Rossi, Charles Balabaud,

Phenotypic identification of focal nodular hyperplasia (FNH) and hepatocellular adenoma (HCA) subtypes using immunohistochemical markers has been developed from their molecular characteristics. Our objective was to evaluate the sensitivity of these markers in the definitive diagnosis of these lesions by core needle biopsies. A total of 239 needle biopsies paired ... Read more >>

Am. J. Surg. Pathol. (The American journal of surgical pathology)
[2012, 36(11):1691-1699]

Cited: 51 times

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Hepatocellular adenoma: evaluation with contrast-enhanced ultrasound and MRI and correlation with pathologic and phenotypic classification in 26 lesions.

Anne-Frédérique Manichon, Brigitte Bancel, Marion Durieux-Millon, Christian Ducerf, Jean-Yves Mabrut, Marie-Annick Lepogam, Agnès Rode,

Purpose. To review the contrast-enhanced ultrasonographic (CEUS) and magnetic resonance (MR) imaging findings in 25 patients with 26 hepatocellular adenomas (HCAs) and to compare imaging features with histopathologic results from resected specimen considering the new immunophenotypical classification. Material and Methods. Two abdominal radiologists reviewed retrospectively CEUS cineloops and MR images ... Read more >>

HPB Surg (HPB surgery : a world journal of hepatic, pancreatic and biliary surgery)
[2012, 2012:418745]

Cited: 13 times

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Impact of diffusion-weighted MR imaging on the characterization of small hepatocellular carcinoma in the cirrhotic liver.

François Le Moigne, Marion Durieux, Brigitte Bancel, Nawele Boublay, Loïc Boussel, Christian Ducerf, Yves Berthezène, Agnès Rode,

PURPOSE: The purpose of this study was to determine whether or not adding diffusion-weighted magnetic resonance imaging (DWI) to conventional magnetic resonance (MR) imaging sequences improves the characterization of small hepatocellular carcinoma (HCC) (≤2 cm) in the setting of cirrhotic liver compared to conventional sequences alone. MATERIALS AND METHODS: A ... Read more >>

Magn Reson Imaging (Magnetic resonance imaging)
[2012, 30(5):656-665]

Cited: 35 times

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[Malignant transformation of multiple isolated hepatocellular adenomas. Therapeutic implications of immunohistochemical and radiological findings].

Jacques Baulieux, Anne-Frédérique Manichon, Brigitte Bancel, Emmanuel D'Errico, Olivier Raspado, Christian Ducerf, Jean-Yves Mabrut, Agnés Rode,

Malignant transformation of hepatic adenoma (HA) is now a well-documented phenomenon. Recent pathological and immunophenotypic studies have identified several subtypes with different prognoses. In many cases the HA subtype can be determined by modern radiological methods, including contrast-enhanced ultrasonography (CEUS) and magnetic resonance imaging (MRI). Based on a series of ... Read more >>

Bull. Acad. Natl. Med. (Bulletin De L'Academie Nationale De Medecine)
[2012, 196(2):459-81; discussion 482-3]

Cited: 0 times

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Outcome of patients receiving chemotherapy for advanced biliary tract or gallbladder carcinoma.

Philippe A Cassier, Clémence Thevenet, Thomas Walter, Jacques Baulieux, Jean-Yves Scoazec, Brigitte Bancel, Mustapha Adham, Jean-Christophe Souquet, Thierry Ponchon, Catherine Lombard-Bohas,

PURPOSE: Patients with cholangiocarcinoma or gallbladder cancer have poor overall prognosis and their management is often complex. Currently, there is no standard chemotherapy for this disease, but several single agents and combinations have shown promising activity, most notably gemcitabine-based combinations. PATIENTS AND METHODS: We conducted a retrospective analysis of all ... Read more >>

Eur J Gastroenterol Hepatol (European journal of gastroenterology & hepatology)
[2010, 22(9):1111-1117]

Cited: 9 times

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Characterization of hepatocellular carcinoma and colorectal liver metastasis by means of perfusion MRI.

Siraj Saadaldin Abdullah, Jean Baptiste Pialat, Marlene Wiart, François Duboeuf, Jean-Yves Mabrut, Brigitte Bancel, Agnès Rode, Christian Ducerf, Jacques Baulieux, Yves Berthezene,

To characterize and compare hepatocellular carcinoma and liver metastases of colorectal metastatic cancer (CMC) by means of quantitative liver perfusion MRI.Liver perfusion was assessed in 26 HCC and CMC patients (50 nodules) by means of contrast-enhanced MRI. Six perfusion parameters-hepatic perfusion index (HPI), mean transit time (MTT), distribution volume (DV), ... Read more >>

J Magn Reson Imaging (Journal of magnetic resonance imaging : JMRI)
[2008, 28(2):390-395]

Cited: 34 times

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Lofgren syndrome and peritoneal involvement by sarcoidosis: case report.

Laure Bourdillon, Emilie Lanier-Gachon, Katia Stankovic, Brigitte Bancel, Véronique Lapras, Christiane Broussolle, Pascal Sève,

OBJECTIVE: An unusual case of a patient with Löfgren syndrome peritoneal involvement by sarcoidosis. PATIENT AND METHODS: A 36-year-old woman presented with Löfgren syndrome and an increase in liver enzyme levels. An abdominal CT scan showed multiple nodules on the peritoneum mimicking peritoneal carcinomatosis. Laparoscopy was conducted with biopsy of ... Read more >>

Chest (Chest)
[2007, 132(1):310-312]

Cited: 5 times

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[Ano-rectal symptoms, related to Epstein-Barr Virus-Associated Burkitt's lymphoma in an immunocompetent patient].

Stéphane Degeorges, Adeline Mesnil, Anne-Marie Marion-Audibert, Fadhéla Bouafia-Sauvy, Françoise Berger, Brigitte Bancel, Raphaëlle Barnoud, Agnès Rode, Denis Péré-Vergé, Jean-Christophe Souquet,

We report the case of an immunocompetent 23-year-old Caucasian woman, with symptoms including rectal bleeding, tenesmus and epreint, 6 months after an anal sexual trauma. The rectal examination showed a hardened, inflammatory and painful anal margin, associated with stenosis of the anal canal, suggesting abscess. The neurological examination showed numbing ... Read more >>

Gastroenterol. Clin. Biol. (Gastroenterologie clinique et biologique)
[2007, 31(4):442-444]

Cited: 1 time

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