Full Text Journal Articles by
Author Bridget M Nugent

Advertisement

Find full text journal articles








Heterogeneity in treatment effects across diverse populations.

Bridget M Nugent, Rajanikanth Madabushi, Barbara Buch, Vasum Peiris, Victor Crentsil, Virginia M Miller, Jonca Bull, Marjorie R Jenkins,

Differences in patient characteristics, including age, sex, and race influence the safety and effectiveness of drugs, biologic products, and medical devices. Here we provide a summary of the topics discussed during the opening panel at the 2018 Johns Hopkins Center for Excellence in Regulatory Science and Innovation symposium on Assessing ... Read more >>

Pharm Stat (Pharmaceutical statistics)
[2021, 20(5):929-938]

Cited: 0 times

View full text PDF listing >>



Brain and placental transcriptional responses as a readout of maternal and paternal preconception stress are fetal sex specific.

Yasmine M Cissé, Jennifer C Chan, Bridget M Nugent, Caitlin Banducci, Tracy L Bale,

<h4>Introduction</h4>Despite a wealth of epidemiological evidence that cumulative parental lifetime stress experiences prior to conception are determinant of offspring developmental trajectories, there is a lack of insight on how these previous stress experiences are stored and communicated intergenerationally. Preconception experiences may impact offspring development through alterations in transcriptional regulation of ... Read more >>

Placenta (Placenta)
[2020, 100:164-170]

Cited: 1 time

View full text PDF listing >>



Advertisement

Experimentally induced variation in neuroendocrine processes affects male reproductive behaviour, sperm characteristics and social interactions.

Bridget M Nugent, Kelly A Stiver, Hans A Hofmann, Suzanne H Alonzo,

While extensive research has focused on how social interactions evolve, the fitness consequences of the neuroendocrine mechanisms underlying these interactions have rarely been documented, especially in the wild. Here, we measure how the neuroendocrine mechanisms underlying male behaviour affect mating success and sperm competition in the ocellated wrasse (Symphodus ocellatus). ... Read more >>

Mol Ecol (Molecular ecology)
[2019, 28(15):3464-3481]

Cited: 1 time

View full text PDF listing >>



Placental H3K27me3 establishes female resilience to prenatal insults.

Bridget M Nugent, Carly M O'Donnell, C Neill Epperson, Tracy L Bale,

Although sex biases in disease presentation are well documented, the mechanisms mediating vulnerability or resilience to diseases are unknown. In utero insults are more likely to produce detrimental health outcomes for males versus females. In our mouse model of prenatal stress, male offspring experience long-term dysregulation of body weight and ... Read more >>

Nat Commun (Nature communications)
[2018, 9(1):2555]

Cited: 32 times

View full text PDF listing >>



Parental Advisory: Maternal and Paternal Stress Can Impact Offspring Neurodevelopment.

Jennifer C Chan, Bridget M Nugent, Tracy L Bale,

Parental stress exposures are implicated in the risk for offspring neurodevelopmental and neuropsychiatric disorders, prompting critical examination of preconception and prenatal periods as vulnerable to environmental insults such as stress. Evidence from human studies and animal models demonstrates the influence that both maternal and paternal stress exposures have in changing ... Read more >>

Biol Psychiatry (Biological psychiatry)
[2018, 83(10):886-894]

Cited: 38 times

View full text PDF listing >>



Neuroimmunology and neuroepigenetics in the establishment of sex differences in the brain.

Margaret M McCarthy, Bridget M Nugent, Kathryn M Lenz,

The study of sex differences in the brain is a topic of neuroscientific study that has broad reaching implications for culture, society and biomedical science. Recent research in rodent models has led to dramatic shifts in our views of the mechanisms underlying the sexual differentiation of the brain. These include ... Read more >>

Nat Rev Neurosci (Nature reviews. Neuroscience)
[2017, 18(8):471-484]

Cited: 58 times

View full text PDF listing >>



Corrigendum: Brain feminization requires active repression of masculinization via DNA methylation.

Bridget M Nugent, Christopher L Wright, Amol C Shetty, Georgia E Hodes, Kathryn M Lenz, Anup Mahurkar, Scott J Russo, Scott E Devine, Margaret M McCarthy,

Nat Neurosci (Nature neuroscience)
[2017, 20(6):896]

Cited: 1 time

View full text PDF listing >>



A Role for Oxytocin-Like Receptor in Social Habituation in a Teleost.

Chelsea A Weitekamp, Tessa K Solomon-Lane, Pamela Del Valle, Zegni Triki, Bridget M Nugent, Hans A Hofmann,

Oxytocin (OT) mediates social habituation in rodent model systems, but its role in mediating this effect in other vertebrates is unknown. We used males of the African cichlid fish, Astatotilapia burtoni, to investigate two aspects of isotocin (IT; an OT homolog) signaling in social habituation. First, we examined the expression ... Read more >>

Brain Behav Evol (Brain, behavior and evolution)
[2017, 89(3):153-161]

Cited: 4 times

View full text PDF listing >>



Sperm competition shapes gene expression and sequence evolution in the ocellated wrasse.

Rebecca Dean, Alison E Wright, Susan E Marsh-Rollo, Bridget M Nugent, Suzanne H Alonzo, Judith E Mank,

Gene expression differences between males and females often underlie sexually dimorphic phenotypes, and the expression levels of genes that are differentially expressed between the sexes are thought to respond to sexual selection. Most studies on the transcriptomic response to sexual selection treat sexual selection as a single force, but postmating ... Read more >>

Mol Ecol (Molecular ecology)
[2017, 26(2):505-518]

Cited: 6 times

View full text PDF listing >>



At the frontier of epigenetics of brain sex differences.

Margaret M McCarthy, Bridget M Nugent,

The notion that epigenetics may play an important role in the establishment and maintenance of sex differences in the brain has garnered great enthusiasm but the reality in terms of actual advances has been slow. Two general approaches include the comparison of a particular epigenetic mark in males vs. females ... Read more >>

Front Behav Neurosci (Frontiers in behavioral neuroscience)
[2015, 9:221]

Cited: 46 times

View full text PDF listing >>



The omniscient placenta: Metabolic and epigenetic regulation of fetal programming.

Bridget M Nugent, Tracy L Bale,

Fetal development could be considered a sensitive period wherein exogenous insults and changes to the maternal milieu can have long-term impacts on developmental programming. The placenta provides the fetus with protection and necessary nutrients for growth, and responds to maternal cues and changes in nutrient signaling through multiple epigenetic mechanisms. ... Read more >>

Front Neuroendocrinol (Frontiers in neuroendocrinology)
[2015, 39:28-37]

Cited: 74 times

View full text PDF listing >>



Brain feminization requires active repression of masculinization via DNA methylation.

Bridget M Nugent, Christopher L Wright, Amol C Shetty, Georgia E Hodes, Kathryn M Lenz, Anup Mahurkar, Scott J Russo, Scott E Devine, Margaret M McCarthy,

The developing mammalian brain is destined for a female phenotype unless exposed to gonadal hormones during a perinatal sensitive period. It has been assumed that the undifferentiated brain is masculinized by direct induction of transcription by ligand-activated nuclear steroid receptors. We found that a primary effect of gonadal steroids in ... Read more >>

Nat Neurosci (Nature neuroscience)
[2015, 18(5):690-697]

Cited: 158 times

View full text PDF listing >>



Microglia are essential to masculinization of brain and behavior.

Kathryn M Lenz, Bridget M Nugent, Rachana Haliyur, Margaret M McCarthy,

Brain sexual differentiation in rodents results from the perinatal testicular androgen surge. In the preoptic area (POA), estradiol aromatized from testosterone upregulates the production of the proinflammatory molecule, prostaglandin E(2) (PGE(2)) to produce sex-specific brain development. PGE(2) produces a two-fold greater density of dendritic spines in males than in females ... Read more >>

J Neurosci (The Journal of neuroscience : the official journal of the Society for Neuroscience)
[2013, 33(7):2761-2772]

Cited: 174 times

View full text PDF listing >>



Hormonal programming across the lifespan.

B M Nugent, S A Tobet, H E Lara, A B Lucion, M E Wilson, S E Recabarren, A H Paredes,

Hormones influence countless biological processes across an animal's lifespan. Many hormone-mediated events occur within developmental sensitive periods, during which hormones have the potential to cause permanent tissue-specific alterations in anatomy and physiology. There are numerous selective critical periods in development with different targets being affected during different periods. This review ... Read more >>

Horm Metab Res (Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme)
[2012, 44(8):577-586]

Cited: 33 times

View full text PDF listing >>



Sexual differentiation of the rodent brain: dogma and beyond.

Kathryn M Lenz, Bridget M Nugent, Margaret M McCarthy,

Steroid hormones of gonadal origin act on the neonatal brain to produce sex differences that underlie adult reproductive physiology and behavior. Neuronal sex differences occur on a variety of levels, including differences in regional volume and/or cell number, morphology, physiology, molecular signaling, and gene expression. In the rodent, many of ... Read more >>

Front Neurosci (Frontiers in neuroscience)
[2012, 6:26]

Cited: 68 times

View full text PDF listing >>



Kinases SPAK and OSR1 are upregulated by estradiol and activate NKCC1 in the developing hypothalamus.

Bridget M Nugent, Carla V Valenzuela, Timothy J Simons, Margaret M McCarthy,

In immature neurons the amino acid neurotransmitter, GABA provides the dominant mode for neuronal excitation by inducing membrane depolarization due to Cl(-) efflux through GABA(A) receptors (GABA(A)Rs). The driving force for Cl(-) is outward because the Na(+)-K(+)-2Cl(-) cotransporter (NKCC1) elevates the Cl(-) concentration in these cells. GABA-induced membrane depolarization and ... Read more >>

J Neurosci (The Journal of neuroscience : the official journal of the Society for Neuroscience)
[2012, 32(2):593-598]

Cited: 21 times

View full text PDF listing >>



Histone deacetylation during brain development is essential for permanent masculinization of sexual behavior.

Ken Ichi Matsuda, Hiroko Mori, Bridget M Nugent, Donald W Pfaff, Margaret M McCarthy, Mitsuhiro Kawata,

Epigenetic histone modifications are emerging as important mechanisms for conveyance of and maintenance of effects of the hormonal milieu to the developing brain. We hypothesized that alteration of histone acetylation status early in development by sex steroid hormones is important for sexual differentiation of the brain. It was found that ... Read more >>

Endocrinology (Endocrinology)
[2011, 152(7):2760-2767]

Cited: 66 times

View full text PDF listing >>



Epigenetic underpinnings of developmental sex differences in the brain.

Bridget M Nugent, Margaret M McCarthy,

Sexual differentiation of the brain is a crucial developmental process that enables the lifelong expression of sexually dimorphic behaviors, including those necessary for successful reproduction. During a perinatal sensitive period, gonadal hormones defeminize and masculinize the male brain, and a lack of gonadal steroids allows for feminization in the female. ... Read more >>

Neuroendocrinology (Neuroendocrinology)
[2011, 93(3):150-158]

Cited: 56 times

View full text PDF listing >>



Hormonally mediated epigenetic changes to steroid receptors in the developing brain: implications for sexual differentiation.

Bridget M Nugent, Jaclyn M Schwarz, Margaret M McCarthy,

The establishment of sex-specific neural morphology, which underlies sex-specific behaviors, occurs during a perinatal sensitive window in which brief exposure to gonadal steroid hormones produces permanent masculinization of the brain. In the rodent, estradiol derived from testicular androgens is a principal organizational hormone. The mechanism by which transient estradiol exposure ... Read more >>

Horm Behav (Hormones and behavior)
[2011, 59(3):338-344]

Cited: 37 times

View full text PDF listing >>



Developmental and hormone-induced epigenetic changes to estrogen and progesterone receptor genes in brain are dynamic across the life span.

Jaclyn M Schwarz, Bridget M Nugent, Margaret M McCarthy,

Sexual differentiation of the rodent brain occurs during a perinatal critical period when androgen production from the male testis is locally converted to estradiol in neurons, resulting in masculinization of adult sexual behavior. Adult brain responses to hormones are programmed developmentally by estradiol exposure, but the mechanism(s) by which these ... Read more >>

Endocrinology (Endocrinology)
[2010, 151(10):4871-4881]

Cited: 103 times

View full text PDF listing >>



The epigenetics of sex differences in the brain.

Margaret M McCarthy, Anthony P Auger, Tracy L Bale, Geert J De Vries, Gregory A Dunn, Nancy G Forger, Elaine K Murray, Bridget M Nugent, Jaclyn M Schwarz, Melinda E Wilson,

Epigenetic changes in the nervous system are emerging as a critical component of enduring effects induced by early life experience, hormonal exposure, trauma and injury, or learning and memory. Sex differences in the brain are largely determined by steroid hormone exposure during a perinatal sensitive period that alters subsequent hormonal ... Read more >>

J Neurosci (The Journal of neuroscience : the official journal of the Society for Neuroscience)
[2009, 29(41):12815-12823]

Cited: 220 times

View full text PDF listing >>



Masculinization induced by neonatal exposure to PGE(2) or estradiol alters c-fos induction by estrous odors in adult rats.

Bridget M Nugent, Christopher L Wright, Susan L Zup, Margaret M McCarthy,

Processing of relevant olfactory and pheromonal cues has long been known as an important process necessary for social and sexual behavior in rodents. Several nuclei that receive input from the vomeronasal projection pathway are involved in sexual behavior and show changes in immediate early gene expression after stimulation with a ... Read more >>

Physiol Behav (Physiology & behavior)
[2009, 96(2):383-388]

Cited: 3 times

View full text PDF listing >>





Advertisement


Disclaimer

1.0639 s